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Low temperature thermoluminescence behaviour of Y_2O_3 nanoparticles

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Journal of Rare Earths 2019年第1期37卷 19-23,M0002页

作者： S.Delice m.Isik N.m.Gasanly Department of Physics Hitit University Department of Electrical and Electronics Engineering Atilim University Department of Physics Middle East Technical University Virtual International Scientific Research Centre Baku State University

Y_2O_3 nanoparticles were investigated using low temperature thermoluminescence (tL) experiments. tL glow curve recorded at constant heating rate of 0.4 K/s exhibits seven peaks around 19, 62, 91,115,162,196 and 215 K. Activation energies and characteristics of traps responsible for observed curves were revealed under the light of results of initial rise analyses and t_(max)-t_(stop) experimental methods. Analyses of tL curves obtained at different stopping temperatures resulted in presence of one quasi-continuously distributed trap with activation energies increasing from 18 to 24 meV and six single trapping centers at49, 117, 315, 409, 651 and 740 meV. Activation energies of all revealed centers were reported in the present paper. Structural characterization of Y_2O_3 nanoparticles was accomplished using X-ray diffraction and scanning electron microscopy measurements.

关键词： Y2O3 Luminescence thermoluminescence Defects Rare earths

Rab22a-NeoF1 fusion protein promotes osteosarcoma lung metastasis through its secretion into exosomes

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Signal transduction and targeted therapy 2021年第3期6卷 909-924页

作者： Li Zhong Dan Liao Jingjing Li Wenqiang Liu Jingxuan wang Cuiling Zeng Xin wang Zhiliang Cao Ruhua Zhang miao Li Kuntai Jiang Yi-Xin Zeng Jianhua Sui tiebang Kang State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouChina Department of Oncology The Fifth Affiliated Hospital of Sun Yat-Sen UniversityZhuhaiGuangdongChina National Institute of Biological Sciences BeijingChina Sun Yat-sen University School of medicine ShenzhenChina Zhongshan School of medicine Sun Yat-sen UniversityGuangzhouChina

It remains unknown for decades how some of the therapeutic fusion proteins positive in a small percentage of cancer cells account for patient ***,we report that osteosarcoma Rab22a-NeoF1 fusion protein,together with its binding partner PYK2,is sorted into exosomes by HSP90 via its KFERQ-like motif(RVLFLN^(142)).the exosomal Rab22a-NeoF1 fusion protein facilitates the pulmonary pre-metastatic niche formation by recruiting bone marrow-derived *** exosomal PYK2 activates RhoA in its negative recipient osteosarcoma cells and induces signal transducer and activator of transcription 3 activation in its recipient macrophages to increase m2 ***,lung metastases of its recipient osteosarcoma cells are promoted by this exosomal Rab22a-NeoF1 fusion protein,and this event can be targeted by disrupting its interaction with PYK2 using a designed internalizing RGD peptide.

关键词： osteosarcoma lung metastasis

Separation of spermatozoa fromerythrocytes using their tumblingmechanism in a pinch flow fractionationdevice

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microsystems & Nanoengineering 2019年第1期5卷 474-480页

作者： Johanna t.W.Berendsen Jan C.t.Eijkel Alex m.Wetzels Loes I.Segerink BIOS Lab on a Chip Group MESA+Institute for NanotechnologyTechnical Medical CentreUniversity of TwenteEnschedeThe Netherlands Department of Obstetrics and Gynaecology Radboud University Nijmegen Medical CentreNijmegenThe Netherlands

men suffering from azoospermia can father a child,by extracting spermatozoa from a testicular biopsy *** main complication in this procedure is the presence of an abundance of ***,the isolation of the few spermatozoa from the sample is manually performed due to ineffectiveness of filtering methods,making it time consuming and labor *** spermatozoa are smaller in both width and height than any other cell type found in the sample,with a very small difference compared with the erythrocyte for the smallest,making this not the feature to base the extraction ***,the length of the spermatozoon is 5×larger than the diameter of an erythrocyte and can be *** we propose a microfluidic chip,in which the tumbling behavior of spermatozoa in pinched flow fractionation is utilized to separate them from the *** show that we can extract 95%of the spermatozoa from a sample containing 2.5%spermatozoa,while removing around 90%of the *** adjusting the flow rates,we are able to increase the collection efficiency while slightly sacrificing the purity,tuning the solution for the available sample in the clinic.

关键词： erythrocytes flow utilized

Identification of an HLA-A^＊ 0201-restricted CD^8＋ t-cell epitope SSp-1 of SARS-CoV spike protein

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第二军医大学学报 2005年第11期26卷 1269-1269页

作者： wang B Chen H Jiang X Zhang m Wan t Li N Zhou X Wu Y Yang F Yu Y wang X Yang R Cao X Institute of Immunology Second Military Medical University Shanghai 200433 China

VX-765 reduces neuroinflammation after spinal cord injury in mice

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Neural Regeneration Research 2021年第9期16卷 1836-1847页

作者： Jing Chen Yu-Qing Chen Yu-Jiao Shi Shu-Qin Ding Lin Shen Rui wang Qi-Yi wang Cheng Zha Hai Ding Jian-Guo Hu He-Zuo Lü Clinical Laboratory the First Affiliated Hospital of Bengbu Medical CollegeBengbuAnhui ProvinceChina Anhui Key Laboratory of tissue transplantation the First Affiliated Hospital of Bengbu Medical CollegeBengbuAnhui ProvinceChina Department of Immunology Bengbu Medical Collegeand Anhui Key Laboratory of Infection and Immunity at Bengbu Medical CollegeBengbuAnhui ProvinceChina

Inflammation is a major cause of neuronal injury after spinal cord injury. We hypothesized that inhibiting caspase-1 activation may reduce neuroinflammation after spinal cord injury, thus producing a protective effect in the injured spinal cord. A mouse model of t9 contusive spinal cord injury was established using an Infinite Horizon Impactor, and VX-765, a selective inhibitor of caspase-1, was administered for 7 successive days after spinal cord injury. the results showed that:(1) VX-765 inhibited spinal cord injury-induced caspase-1 activation and interleukin-1β and interleukin-18 secretion.(2) After spinal cord injury, an increase in m1 cells mainly came from local microglia rather than infiltrating macrophages.(3) Pro-inflammatory th1 th17 cells were predominant in the th subsets. VX-765 suppressed total macrophage infiltration, m1 macrophages/microglia, th1 and th1 th17 subset differentiation, and cytotoxic t cells activation;increased m2 microglia;and promoted th2 and treg differentiation.(4) VX-765 reduced the fibrotic area, promoted white matter myelination, alleviated motor neuron injury, and improved functional recovery. these findings suggest that VX-765 can reduce neuroinflammation and improve nerve function recovery after spinal cord injury by inhibiting caspase-1/interleukin-1β/interleukin-18. this may be a potential strategy for treating spinal cord injury. this study was approved by the Animal Care Ethics Committee of Bengbu medical College(approval No. 2017-037) on February 23, 2017.

关键词： immune cell subsets immune function inflammasomes leukocyte infiltration macrophages microglia pathways spinal cord injury

male Sex Pheromone of Hepialid moth,Endoclita excrescens （Lepidoptera:Hepialidae）

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Male Sex Pheromone of Hepialid Moth,Endoclita excrescens （L...

Impact of COVID-19 on presentation,management,and outcomes of acute care surgery for gallbladder disease and acute appendicitis

the First Asia—Pacific Conference on Chemical Ecology

作者： t.NAKASHImA H.KItAJImA t SAtO m.tOKORO K.NAKAmUtA Forestry ＆ Forest Products Research Institute TsukubaIbaraki 305-3687JAPAN

＜正＞the hexane extract of hindlegs of male adults of Hepialid moth,Endoclita excrescens（Lepidoptera:Hepialidae）, induced the electrophysiological response on an antnna of the female moth but not on that of male *** GC/mS data suggested that the structure of the active compound is l,3,8-trimethy1-2,9-dioxabicyclo[3.3.1]non- *** has reported as one of the minor components of the hindleg extract of Hepialus hecta(Schulz et al.,

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来源： cnki会议评论

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World Journal of Gastrointestinal Surgery 2021年第8期13卷 859-870页

作者： Orly Nadell Farber Giselle I Gomez Ashley L titan Andrea t Fisher Christopher J Puntasecca Veronica toro Arana Arielle Kempinsky Clare E Wise Kovi E Bessoff mary t Hawn James R Korndorffer Jr Joseph D Forrester micaela m Esquivel Department of Surgery Stanford University School of MedicinePalo AltoCA 94305United States

BACKGROUND the ongoing coronavirus disease 2019(COVID-19)pandemic has significantly disrupted both elective and acute medical *** from the early months suggest that acute care patient populations deferred presenting to the emergency department(ED),portending more severe disease at the time of ***,care for this patient population trended towards initial non-operative *** to examine the presentation,management,and outcomes of patients who developed gallbladder disease or appendicitis during the *** A retrospective chart review of patients diagnosed with acute cholecystitis,symptomatic cholelithiasis,or appendicitis in two EDs affiliated with a single tertiary academic medical center in Northern California between march and June,2020 and in the same months of *** were selected through a research repository using international classification of diseases(ICD)-9 and ICD-10 *** both years,313 patients were identified with either type of gallbladder disease,while 361 patients were identified with acute *** primary outcome was overall incidence of *** outcomes included presentation,management,complications,and 30-d re-presentation *** between different variables were explored using Pearson’s r correlation *** were compared using the Welch’s t-test,Chi-squared tests,and Fisher’s exact test as *** Patients with gallbladder disease and appendicitis both had more severe presentations in *** respect to gallbladder disease,more patients in the COVID-19 cohort presented with acute cholecystitis compared to the control cohort[50%(80)vs 35%(53);P=0.01].Patients also presented with more severe cholecystitis in 2020 as indicated by higher mean tokyo Criteria Scores[mean(SD)1.39(0.56)vs 1.16(0.44);P=0.02].With respect to appendicitis,more patients were diagnosed with a perforated appendix at presentation in 2020[20%(36)vs 16%(29);P=0.0

关键词： COVID-19 Cholecystitis Biliary colic Appendicitis Acute care surgery

Promoter and coding sequence diversity of CsCCD1 may contribute to the differential accumulation of floralβ-ionone in fresh tea leaves

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Horticultural Plant Journal 2023年第4期9卷 837-847页

作者： Jingming wang mingyue Zhao ting Gao Yingying Feng Feiquan wang Yuting Pan Jieyang Jin tingting Jing mengqian Lu mengting Zhang Danyang Guo Xiaochun Wan Wilfried Schwab Chuankui Song State Key Laboratory of tea Plant Biology and Utilization International Joint Laboratory on Tea Chemistry and Health EffectsAnhui Agricultural UniversityHefeiAnhui 230036China Wuyi University WuyishanFujian 354300China Biotechnology of Natural Products Technische Universität MünchenLiesel-Beckmann-Str.1Freising 85354Germany

the carotenoid-derived volatileβ-ionone makes an important contribution to tea ***,we qualitatively and quantitatively analysed 15 carotenoids in tea leaves of 13 cultivars by UHPLC-APCI-mS/*** 13 cultivars were divided into two groups by PCA(Principal Component Analysis)clustering analysis of their carotenoid content,and OPLS-DA(Orthogonal projections to latent structures)indicated that the levels ofβ-carotene(VIP=2.89)and lutein(VIP=2.30)were responsible for much of the variation between the two ***,theβ-carotene toβ-ionone conversion rates in Group 1 were higher than in Group 2,while theβ-carotene content was significantly lower in Group 1 than in Group ***β-ionone content was significantly higher in Group *** Correlation Coefficient calculation between the transcription level of candidate genes(CsCCD1 and CsCCD4)and the accumulation ofβ-ionone indicated that CsCCD1 may involve in the formation ofβ-ionone in 13 *** expression and in vitro enzyme activity assays showed that‘Chuanhuang 1’had an amino acid mutation in carotenoid cleavage dioxygenases 1(CsCCD1)compared with‘Shuchazao’,resulting in a significantly higherβ-ionone content in‘Chuanhuang 1’.Sequence analysis showed that‘Chuanhuang 1’and‘Huangdan’had different CsCCD1 promoter sequences,leading to significantly higher CsCCD1 expression andβ-ionone accumulation in‘Chuanhuang 1’.these results indicated that the promoter and coding sequence diversity of CsCCD1 might contribute to the differential accumulation ofβ-ionone in different tea cultivars.

关键词： Camellia sinensis(L.)Kuntze Carotenoid cleavage dioxygenase β-carotene β-ionone Promoter Differential accumulation

A New Index Developed for Fast Diagnosis of meteorological Roles in Ground-Level Ozone Variations

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Advances in Atmospheric Sciences 2022年第3期39卷 403-414,558-563页

作者： Weihua CHEN Weiwen wang Shiguo JIA Jingying mAO Fenghua YAN Lianming ZHENG Yongkang WU Xingteng ZHANG Yutong DONG Lingbin KONG Buqing ZHONG ming CHANG min SHAO Xuemei wang Guangdong-Hongkong-macao Joint Laboratory of Collaborative Innovation for Environmental Quality Institute for Environmental and Climate ResearchJinan UniversityGuangzhou 510632China School of Atmospheric Sciences Guangdong Province Key Laboratory for Climate Change and Natural Disaster StudiesSun Yat-sen UniversityGuangzhou 510275China Key Laboratory of Vegetation Restoration and management of Degraded Ecosystems South China Botanical GardenChinese Academy of SciencesGuangzhou 510650China

China experienced worsening ground-level ozone(O_(2)) pollution from 2013 to 2019. In this study, meteorological parameters, including surface temperature(t_(2)), solar radiation(SW), and wind speed(WS), were classified into two aspects,(1) Photochemical Reaction Condition(PRC = t_(2)× SW) and(2) Physical Dispersion Capacity(PDC = WS). In this way, a meteorology Synthetic Index(mSI = PRC/PDC) was developed for the quantification of meteorology-induced ground-level O_(2)pollution. the positive linear relationship between the 90 th percentile of mDA8(maximum daily 8-h average) O_(2)concentration and mSI determined that the contribution of meteorological changes to ground-level O-3 varied on a latitudinal gradient, decreasing from ~40% in southern China to 10%–20% in northern China. Favorable photochemical reaction conditions were more important for ground-level O_(2)pollution. this study proposes a universally applicable index for fast diagnosis of meteorological roles in ground-level O_(2)variability, which enables the assessment of the observed effects of precursor emissions reductions that can be used for designing future control policies.

关键词： ground-level ozone meteorology synthetic index photochemical reaction condition physical dispersion capacity