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以黑色页岩为主岩的金矿床勘探标志——流体包裹体挥发物(英国北威尔士Dolgellau金矿带)

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国外铀金地质 1993年第4期10卷 339-343,350页

作者： t.J.Shepherd S.m.Bottrell m.F.miller 潘燕核工业北京地质研究院 100029

联合王国北威尔士Dolgellau金矿带脉石英中流体包裹体的质谱分析表明,含金流体和不含金流体有着某种差别。与贫矿脉中的石英相比,Clogau-St,Darids和Gwynfynydd矿区中富矿体的含金石英样品明显富含CH_4和N_2。包裹体的挥发物成分变化有... 详细信息

联合王国北威尔士Dolgellau金矿带脉石英中流体包裹体的质谱分析表明,含金流体和不含金流体有着某种差别。与贫矿脉中的石英相比,Clogau-St,Darids和Gwynfynydd矿区中富矿体的含金石英样品明显富含CH_4和N_2。包裹体的挥发物成分变化有力地说明了这样一种空间联系,即高品应矿带的分布、石墨页岩围岩(Clogau页岩)的存在和CH_4-N_2流体有关。虽然含甲烷流体出表示了区域变质石英脉的特征,但这种流体的N_2/(CH_4+CO_2+N_2)比值明显偏低。在成矿期间,流体和岩石的相互作用使碳和氮释放到成矿流体中;该过程产生了CH_4,CO_2和N_2。然而,氮气的产生导致了具有明显“CH_4-N_2”特征的含金流体的形成,氮气的产生被认为是由于层状硅酸盐围岩中NH_4^+交换的氧化作用所致。矿石的沉积被认为是由Au(HS)_2^-络合物的不稳定性引起的,这种不稳定性是由H_2S快速加入到成矿过程中产生的一种不混溶的富(CH_4N_2)流体相引起的。因此,挥发物特征、金的沉积作用和流体的不混容都与产生CH_4和N_2的反应有关。鉴于绿片岩相变质地体中以黑色页岩/片岩为主岩的金矿床在全球范围内广泛存在.对具有异常CH_4+N_2含量的流体包裹体的识别将成为一项可能的普查勘探技术。

关键词：黑色页岩金矿床矿物包体勘探

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Υ射线对有无自发易位多态性栽培黑麦的不同效应

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核农学通报 1985年第4期 8-11页

作者： m.t.Gonzalez-Jean 李玉琴

裁培黑麦 Ailes(Secale cereale L.)所表现出的相互易位结构杂合体的频率(15—20%)相当稳定。这种染色体结构在个体范围内是稳定并一致的,多态性是7条染色体中至少涉及到5条染色体的许多不同的相互易位的结果。试验资料已证明了突变体... 详细信息

裁培黑麦 Ailes(Secale cereale L.)所表现出的相互易位结构杂合体的频率(15—20%)相当稳定。这种染色体结构在个体范围内是稳定并一致的,多态性是7条染色体中至少涉及到5条染色体的许多不同的相互易位的结果。试验资料已证明了突变体选择平衡理论的假设;

关键词：杂合体相互易位栽培品种黑麦麦类作物双着丝点辐照处理多态性

the Pattern of Eosinophil Count among Nigerians with Frequent Use of the Commonly Available Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

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International Journal of Clinical medicine 2020年第10期11卷 605-617页

作者： P. K. Uduagbamen A. t. Oyelese A. O. Adebola Yusuf O. F. Salami C. m. Nwinee m. I. Ogunmola O. Ehioghae Division of Nephrology and Hypertension Department of Internal Medicine Ben Carson School of Medicine Babcock University/Babcock University Teaching Hospital Ilishan-Remo Nigeria Nephrology Unit Department of Internal Medicine Federal Medical Centre Abeokuta Nigeria Department of Haematology and Blood transfusion Ben Carson School of Medicine Babcock University/Babcock University Teach-ing Hospital Ilishan-Remo Nigeria Division of Radiology Department of Surgery Ben Carson School of Medicine Babcock University/Babcock University Teaching Hospital Ilishan-Remo Nigeria Intensive Care Unit Department of Surgery Ben Carson (Snr) School of Medicine Babcock University/Babcock University Teaching Hospital Ilishan-Remo Nigeria

Introduction: Non-steroidal anti-inflammatory drugs (NSAIDs) use is very common. NSAIDs use could be associated with elevated eosinophil count which could be a class effect or patient-related. Inflammation could be th... 详细信息

trong>Introduction: trong>Non-steroidal anti-inflammatory drugs (NSAIDs) use is very common. NSAIDs use could be associated with elevated eosinophil count which could be a class effect or patient-related. Inflammation could be the link between NSAIDs use and eosinophilia. trong>Aims: trong>to compare the pattern of eosinophil count in the peripheral blood of frequent users of NSAIDs and healthy controls. trong>methodology: trong>two hundred (one hundred frequent users of NSAIDs and 100 healthy controls) participants who had no known risk factor for kidney disease and had given informed consent were recruited. Blood was taken to determine the white cell count and differentials, serum electrolyte and creatinine, and random blood sugar. trong>Results:trong> the mean age of NSAIDs users was not significantly different from controls, P = 0.3. the mean eosinophil count was higher in males than females. the incidence of eosinophilia in NSAIDs users was 4%. the mean Eosinophil count of NSAIDs users was insignificantly higher than controls, 164.3 ± 51 6 vs 135. 6 ± 53.4, P = 0.4. the mean platelet count of NSAIDs users was significantly higher compared to controls, P = 0.04. the mean hematocrit of NSAIDs users was significantly lower than the controls, P = 0.02. Propionic acid derivatives were associated with the highest eosinophil count. Eosinophil count was positively related to age and serum creatinine and inversely related to blood glucose, hematocrit and glomerular filtration rate.trong> Conclusion: trong>the incidence of eosinophilia was 4%. the eosinophil count was higher in frequent NSAIDs users than occasional and non-users, in males than females and with use propionic acid derivatives compared to other NSAIDs. the Eosinophil count was positively related to age and platelet count. Being commoner in inflammatory states, the tissue destruction associated with elevated EC can be avoided by the prevention and prompt treatment of inflammatory con

关键词： Eosinophilia Kidney Function Non-Steroidal Anti-Inflammatory Drugs Hematocrit Platelet Count Propionic Acid

treatment with a JAK1/2 inhibitor ameliorates murine autoimmune cholangitis induced by IFN overexpression

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Cellular & molecular Immunology 2022年第10期19卷 1130-1140页

作者： tihong Shao Patrick S.C.Leung Weici Zhang Koichi tsuneyama William m.Ridgway Howard A.Young Zongwen Shuai Aftab A.Ansari m.Eric Gershwi Department of Rheumatology and Immunology The First Affiliated Hospital of Anhui Medical UniversityHefeiChina Division of Rheumatology Allergyand Clinical ImmunologySchool of MedicineUniversity of CaliforniaDavisCAUSA Department of Pathology and Laboratory medicine Institute of Biomedical SciencesTokushima University Graduate SchoolTokushimaJapan Center for Cancer Research National Cancer Institute-FrederickFrederickMDUSA

the interferon(IFN)signaling pathways are major immunological checkpoints with clinical significance in the pathogenesis of *** have generated a unique murine model named ARE-Del,with chronic overexpression of IFNγ,by altering IFNγ***,these mice develop an immunologic and clinical profile similar to patients with primary biliary cholangitis,including high titers of autoantibodies and portal *** hypothesized that the downregulation of IFN signaling pathways with a JAK1/2 inhibitor would inhibit the development and progression of *** study this hypothesis,ARE-Del^(+/−)mice were treated with the JAK1/2 inhibitor ruxolitinib and serially *** inhibition resulted in a significant reduction in portal inflammation and bile duct damage,associated with a significant reduction in splenic and hepatic CD4^(+)t cells and CD8^(+)t ***,ruxolitinib inhibited the secretion of the proinflammatory cytokines IFNγand tNF from splenic CD4^(+)t ***,ruxolitinib treatment also decreased the frequencies of germinal center B(GC B)cells and t follicular helper(tfh)cells and led to lower serological AmA *** note,liver and peritoneal macrophages were sharply decreased and polarized from m1 to m2 with a higher level of IRF4 expression after ruxolitinib ***,ruxolitinib inhibited the secretion of IL-6,tNF and mCP1 and the expression of StAt1 but promoted the expression of StAt6 in macrophages in vitro,indicating that m1 macrophage polarization to m2 occurred through activation of the StAt6-IRF4 *** data highlight the significance,both immunologically and clinically,of the JAK/StAt signaling pathway in autoimmune cholangitis.

关键词： Primary biliary cholangitis Autoimmunity Interferons Janus Kinase Inhibitors Ruxolitinib

隐源性卒中患者中Fabry病的患病率:一项前瞻性研究

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世界核心医学期刊文摘（眼科学分册） 2006年第3期2卷 9-10页

作者： Rolfs A Bttcher t Zschiesche m. 桑延智 Department of Neurology University of Rostock POB 100 888 18055 Rostock GermanyDr.

Background: Strokes are an important cause of morbidity and mortality in young adults. However, in most cases the cause of the stroke remains unclear. Anderson-Fabry disease is an X-linked recessive lysosomal storage disease resulting from deficient α-galactosidase and causes an endothelial vasculopathy followed by cerebral ischaemia. to determine the importance of Fabry disease in young people with stroke, we measured the frequency of unrecognised Fabry disease in a cohort of acute stroke patients. methods: Between February, 2001, and December, 2004, 721 German adults aged 18 to 55 years suffering from acute cryptogenic stroke were screened for Fabry disease. the plasma α-galactosidase activity in men was measured followed by sequencing of the entire α-GAL gene in those with low enzyme activity. By contrast, the entire α-GAL gene was genetically screened for mutations in women even if enzyme activity was normal. Findings: 21 of 432 (4.9%) male stroke patients and seven of 289 (2.4%) women had a biologically significant mutation within the α-GAL gene. the mean age at onset of symptomatic cerebrovascular disease was 38.4 years (SD 13.0) in the male stroke patients and 40.3 years (13.1) in the female group. the higher frequency of infarctions in the vertebrobasilar area correlated with more pronounced changes in the vertebrobasilar vessels like dolichoectatic pathology (42.9%vs 6.8%). Interpretation: We have shown a high frequency of Fabry disease in a cohort of patients with cryptogenic stroke, which corresponds to about 1.2%in young stroke patients. Fabry disease must be considered in all cases of unexplained stroke in young patients, especially in those with the combination of infarction in the vertebrobasilar artery system and proteinuria.

关键词： Anderson-Fabry病卒中患者前瞻性研究患病率隐源性溶酶体贮积病隐性遗传性原因不明半乳糖苷血管内皮

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Highly sensitive positive resist based on vinyl ether chemistry

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Highly sensitive positive resist based on vinyl ether chemis...