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Remembering your A, B, C’s: Alzheimer’s disease and ABCA1

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Acta Pharmaceutica Sinica B 2022年第3期12卷 995-1018页

作者： Cutler t.lewandowski Megan S.Laham Gregory R.J.thatcher Department of Pharmaceutical Sciences University of Illinois College of PharmacyChicagoIL 60612USA Department of Pharmacology and toxicology University of Arizona College of PharmacyTucsonAZ 85721USA

the function of AtP binding cassette protein A1(ABCA1)is central to cholesterol *** ABCA1 expression or activity is implicated in Alzheimer’s disease(AD)and other *** approaches to boost ABCA1 activity have yet to be translated successfully to the *** risk factors for AD development and progression,including comorbid disorders such as type2 diabetes and cardiovascular disease,highlight the intersection of cholesterol transport and *** of ABCA1 can positively impact APOE lipidation,insulin sensitivity,peripheral vascular and blood-brain barrier integrity,and anti-inflammatory *** strategies towards ABCA1-boosting compounds have been described,with a bias toward nuclear hormone receptor(NHR)*** agonists display beneficial preclinical effects;however,important side effects have limited *** particular,ligands that bind liver X receptor(LXR),the primary NHR that controls ABCA1 expression,have shown positive effects in AD mouse models;however,lipogenesis and unwanted increases in triglyceride production are often *** longstanding approach,focusing on LXRβ*** selectivity,is over-simplistic and has *** approaches such as phenotypic screening may lead to small molecule NHR modulators that elevate ABCA1 function without inducing lipogenesis and are clinically translatable.

关键词： Alzheimer’s disease Cardiovascular disease Cholesterol Drug discovery Liver X receptor Nuclear hormone receptor type 2 diabetes

Long-time turbulence Model Deduced from the Navier-Stokes Equations

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Chinese Annals of Mathematics,Series B 2015年第5期36卷 883-894页

作者： Roger lewandowski IRMAR and Fluminance team University of Rennes 1 and INRIA Campus Beaulieu

the author shows the existence of long-time averages to turbulent solutions of the Navier-Stokes equations and determines the equations satisfied by them, involving a Reynolds stress that is shown to be dissipative.

关键词： Navier-Stokes equations Weak solutions turbulence modeling Reynolds stress

A Variational Finite Element Model for Large-Eddy Simulations of turbulent Flows

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Chinese Annals of Mathematics,Series B 2013年第5期34卷 667-682页

作者： toma's Chac'on REBOLLO Roger lewandowski Dpto. EDAN & IMUS Universidad de SevillaC/Tarfias/n. 41012 SevillaSpain BCAM-Basque Center for Applied Mathematics AvdaMazarredo14. 48009 BilbaoSpain. Mathematical Research Institute of Rennes UMR CNRS 6625University of Rennes 1 & Fluminance teamINRIABat 22Campus Beaulieu35042 Rennes cedexFrance.

the authors introduce a new Large Eddy Simulation model in a channel, based on the projection on finite element spaces as filtering operation in its variationM form, for a given triangulation （th）h〉0. the eddy viscosity is expressed in terms of the friction velocity in the boundary layer due to the wall, and is of a standard sub grid-model form outside the boundary layer. the mixing length scale is locally equal to the grid size. the computational domain is the channel without the linear sub-layer of the boundary layer. the no-slip boundary condition （or BC for short） is replaced by a Navier （BC） at the computational wall. Considering the steady state case, the authors show that the variational finite element model they have introduced, has a solution （Vh,Ph）h〉O that converges to a solution of the steady state Navier-Stokes equation with Navier BC.

关键词： Navier-Stokes equations turbulence modeling Finite elements

Impact of Pollutant Concentration and Particle Deposition on the Radiative Flow of Casson-Micropolar Fluid between Parallel Plates

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 665-690页

作者： Ghaliah Alhamzi Badr Saad t.Alkahtani Ravi Shanker Dubey Vinutha Kalleshachar Neelima Nizampatnam Department of Mathematics and Statistics College of ScienceImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11564Saudi Arabia Department of Mathematics College of ScienceKing Saud UniversityRiyadh11989Saudi Arabia Department of Mathematics Amity School of Applied SciencesAmity University RajasthanJaipur302002RajasthanIndia Department of Studies in Mathematics Davangere UniversityDavangere577002India Department of Electronics and Communication Engineering Amrita School of EngineeringAmrita Vishwa VidyapeethamBengaluru560035India

Assessing the behaviour and concentration of waste pollutants deposited between two parallel plates is essential for effective environmental *** the effectiveness of treatment methods in reducing pollution scales is made easier by analysing waste discharge *** waste discharge concentration analysis is useful for assessing how effectively wastewater treatment techniques reduce pollution *** study aims to explore the Casson micropolar fluid flow through two parallel plates with the influence of pollutant concentration and thermophoretic particle *** explore the mass and heat transport features,thermophoretic particle deposition and thermal radiation are *** governing equations are transformed into ordinary differential equations with the help of suitable similarity *** Runge-Kutta-Fehlberg’s fourthfifth order technique and shooting procedure are used to solve the reduced set of equations and boundary *** integration of a neural network model based on the Levenberg-Marquardt algorithm serves to improve the accuracy of predictions and optimize the analysis of *** outcomes are displayed to analyze the characteristics of the relevant dimensionless parameters in the current *** reveal that concentration upsurges as the micropolar parameter *** concentration reduces with an upsurge in the thermophoretic *** upsurge in the external pollutant source variation and the local pollutant external source parameters enhances mass *** surface drag force declines for improved values of porosity and micropolar parameters.

关键词： Micropolar fluid thermal radiation porous medium thermophoretic particle deposition waste discharge concentration

Rotational Forms of Large Eddy Simulation turbulence Models:Modeling and Mathematical theory

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Chinese Annals of Mathematics,Series B 2021年第1期42卷 17-40页

作者： Luigi C.BERSELLI Roger lewandowski Dinh Duong NGUYEN Universita di Pisa Dipartimento di MatematicaVia Buonarroti 1/c1-56127 Pisa Italy IRMAR UMR CNRS 6625University of Rennes 1 and FLUMINANCE TeamINRIA RennesFrance

In this paper the authors present a derivation of a back-scatter rotational Large Eddy Simulation model,which is the extension of the Baldwin&Lomax model to nonequilibrium *** model is particularly designed to mathematically describe a fluid filling a domain with solid walls and consequently the differential operators appearing in the smoothing terms are degenerate at the *** the derivation of the model,the authors prove some of the mathematical properties coming from the weighted energy estimates,which allow to prove existence and uniqueness of a class of regular weak solutions.

关键词： Fluid mechanics turbulence models Rotational Large Eddy Simulation models Navier-Stokes equations

transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 177-192页

作者： M.NAVEED M.IMRAN t.ASGHAR Z.ABBAS Department of Mathematics Division of Science and TechnologyUniversity of Education Department of Mathematics The Islamia University of Bahawalpur

this paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. the influence of magnetic fields is also inspected in terms of their physical characteristics. to depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAM).the effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

关键词： Peclet number

the study of biological activity of transformation products of diclofenac and its interaction with chlorogenic acid

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Journal of Environmental Sciences 2020年第5期32卷 128-141页

作者： Marzena Matejczyk Piotr Ofman Katarzyna Dabrowska Renata Swislocka Wlodzimierz lewandowski Bialystok University of technology Faculty of Civil Engineering and Environmental SciencesDepartment of ChemistryBiology and Biotechnology15-341BialystokPoland Bialystok University of technology Department of Environmental Engineering TechnologyBialystok15-341Poland Waclaw Dabrowski Institute of Agricultural and Food Biotechnology Department of Microbiology02-532WarsawPoland

In the present work we compared the biological activity of DCF,4’-OHDCF and 5-OHDCF as molecules of most biodegradation pathways of DCF and selected transformation products(2-hydroxyphenylacetic acid;2,5-dihydroxyphenylacetic acid and 2,6-dichloroaniline)which are produced during AOPs,such as ozonation and UV/H2 *** also examined the interaction of DCF with chlorogenic acid(CGA).CGA is commonly used in human diet and entering the environment along with waste mainly from the processing and brewing of coffee and it can be toxic for microorganisms included in activated *** the present experiment the evaluation of following parameters was performed:*** K-12 cells viability,growth inhibition of *** K-12 culture,LC50 and mortality of Chironomus aprilinus,ge no toxicity,sodA promoter induction and ROS *** addition the reactivity of *** SM recA:luxCDABE biosensor strain in wastewater matrices was *** results showed the influence of DCF,4’-OHDCF and 5-OHDCF on *** K-12 cells viability and bacteria growth,comparable to AOPs *** highest toxicity was observed for selected,tested AOPs by-products,in comparison to the DCF,4’-OHDCF and *** assay indicated that 2,6-dichloroaniline(AOPs by-product)had the highest toxic *** oxidative stress assays revealed that the highest level of ROS generation and sodA promoter induction were obtained for DCF,4’-OHDCF and 5-OHDCF,compared to other tested *** have also found that there is an interaction between chlorogenic acid and DCF,which resulted in increased toxicity of the mixture of the both compounds to *** K-12,comparable to parent *** strongest response of *** SM biosensor strain with recA:luxCDABE genetic construct in filtered treated wastewaters,comparable to control sample was *** indicates,that *** SM recA:luxCDABE biosensor strains is a good tool for bacteria monitoring in wastewater *** to toxicity and biological

关键词： Diclofenac Biodegradation Chlorogenic acid Advances oxidation processes (AOPs) Wastewaters Microbial biosensors

the impact of alpha-fetoprotein(AFP),child-turcotte-pugh(CtP)score and disease staging on the survival of hepatocellular carcinoma(HCC)patients:a retrospective cohort from single oncology center

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Oncology Research 2025年第1期33卷 149-160页

作者： NASSER MULLA YOUSEF KAtIB ASIM M.ALMUGHAMSI DUAA S.ALKHAYAt MOHAMED MOSAAD SAMIR t.ALFOtIH RAWAN ALAOFI Department of Internal Medicine Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Department of Radiology Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Department of Surgery Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Department of Endemic and Infectious Diseases Suez Canal UniversityIsmailia41522Egypt King Salman bin Abdulaziz Medical City Madinah42311Saudi Arabia Prince Mohammed Bin Abdulaziz Hospital Madinah41511Saudi Arabia

Background:Hepatocellular carcinoma(HCC)is the most common cause of cancer-related death in Saudi *** study aimed to investigate the patterns of HCC and the effect of tNM staging,Alfa-fetoprotein(AFP),and Child-turcotte Pugh(CtP)on patients’overall survival(OS).Methods:A retrospective analysis was conducted on 43 HCC patients at a single oncology center in Saudi Arabia from 2015 to *** patients had to fulfill one of the following criteria:(a)a liver lesion reported as definitive HCC on dynamic imaging and/or(b)a biopsy-confirmed ***:the mean patient age of all HCC cases was 66.8 with a male-to-female ratio of 3.3:*** patients were stratified into two groups:viral HCC(n=22,51%)and non-viral HCC(n=21,49%).Among viral-HCC patients,55%were due to HBV and 45%due to *** was diagnosed in 79%of *** and sex did not significantly statistically differ in OS among viral and non-viral HCC patients(p-value>0.05).About 65%of patients had tumor size>5 cm during the diagnosis,with a significant statistical difference in OS(p-value=0.027).AFP was>400 ng/ml in 45%of the *** was a statistically significant difference in the OS in terms of AFP levels(p-value=0.021).A statistically significant difference was also observed between the CtP score and OS(p-value=0.02).CtP class B had the longest *** was the most common treatment provided to HCC patients followed by sorafenib *** was a significant statistical difference in OS among viral and non-viral HCC patients(p-value=0.008).Conclusions:the most common predictors for OS were the underlying cause of HCC,AFP,and tumor *** having non-viral etiology,a tumor size>5 cm,an AFP>400 ng/mL,and a CtP score class C were all negatively associated with OS.

关键词： Hepatocellular carcinoma Pattern Alpha-fetoprotein(AFP) Child-turcotte-pugh Progression free survival

A Damage-tolerant Bulk Metallic Glass at Liquid-nitrogen temperature

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Journal of Materials Science & technology 2014年第6期30卷 627-630页

作者： Jun Yi S.Mohsen Seifi Weihua Wang John J.lewandowski Department of Materials Science and Engineering Case Western Reserve UniversityClevelandOH 44106-7204 USA Institute of Physics Chinese Academy of Sciences

tensile tests and notch toughness tests were conducted on Zr61ti2Cu25Al12 glass （Zt） at room temperature and liquid-nitrogen temperature. the tensile strength of Zt was improved from 1.63 GPa at room temperature to 1.72 GPa at liquid-nitrogen temperature. Micro-notches with a root radius of 1-3μm were introduced to test the notch toughness of Zt at room temperature and liquid-nitrogen temperature. the test results revealed that the notch toughness of Zt at liquid-nitrogen temperature is comparable to that of Zt at room temperature. the combination of high yield strength and notch toughness of Zt at liquid-nitrogen temperature is comparable to that of the best cryogenic engineering materials.

关键词： Metallic glasses Yield strength Fracture toughness Liquid-nitrogen temperature