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Is intraprocedural intravenous aspirin safe for patients who require emergent extracranial stenting during mechanical thrombectomy?

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Stroke & Vascular Neurology 2024年第3期9卷 279-288,I0247页

作者： Adam Ingleton Marko Raseta Rui-en chung Kevin Jun Hui Kow Jake Weddell Sanjeev Nayak changez Jadun Zafar Hashim Noman Qayyum Phillip Ferdinand Indira Natarajan christine Roffe Neurosciences University Hospitals of North Midlands NHS TrustStoke-on TrentUK Statistics and Mathematical Modelling Department of Molecular GeneticsErasmus Medical CenterRotterdamZuid-HollandThe Netherlands Radiology University Hospitals of North Midlands NHS TrustStoke-on TrentUK School of Medicine Keele UniversityKeeleUK Interventional Radiology University Hospitals of North Midlands NHS TrustStoke-on TrentUK Stroke Research Keele UniversityKeeleUK

Background Intraoperative antiplatelet therapy is recommended for emergent stenting during mechanical thrombectomy(Mt).Most patients undergoing Mt are also given *** agents are contraindicated within 24 hours of *** evaluated outcomes and complications of patients stented with and without intravenous aspirin during *** All patients who underwent emergent extracranial stenting during Mt at the Royal Stoke University Hospital,UK between 2010 and 2020,were *** were thrombolysed before Mt,unless *** 500 mg intravenously was given intraoperatively at the discretion of the *** intracranial haemorrhage(sIcH)and the National Institutes for Health Stroke Scale score(NIHSS)were recorded at 7 days,and mortality and functional recovery(modified Rankin Scale:mRS≤2)at 90 *** Out of 565 patients treated by Mt 102 patients(median age 67 IQR 57–72 years,baseline median NIHSS 18 IQR 13–23,76(75%)thrombolysed)had a stent *** these 49(48%)were given aspirin and 53(52%)were *** treated with aspirin had greater NIHSS improvement(median 8 IQR 1–16 vs median 3 IQR-9–8 points,p=0.003),but there were no significant differences in sIcH(2/49(4%)vs 9/53(17%)),mRS≤2(25/49(51%)vs 19/53(36%))and mortality(10/49(20%)vs 12/53(23%))with and without *** improvement(median 12 IQR 4–18 vs median 7 IQR-7–10,p=0.01)was greater,and mortality was lower(4/33(12%)vs 6/15(40%),p=0.05)when aspirin was combined with thrombolysis,than for aspirin alone,with no increase in *** Our findings based on registry data derived from routine clinical care suggest that intraprocedural intravenous aspirin in patients undergoing emergent stenting during Mt does not increase sIcH and is associated with good clinical outcomes,even when combined with intravenous thrombolysis.

关键词： patients aspirin intravenous

Dramatic Difference Between cu_(20)H_(8)and cu_(20)H_(9)clusters in catalysis

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ccS chemistry 2024年第6期6卷 1581-1590页

作者： chun-Yu liu tong-Yu liu Zong-Jie Guan Song Wang Yuan-Yuan Dong Feng Hu De-en Jiang Quan-Ming Wang Department of chemistry Engineering Research Center of Advanced Rare Earth Materials(Ministry of Education)Tsinghua UniversityBeijing 100084 Jiangsu engineering Research centre for Digital textile Inkjet Printing Key laboratory of Eco-textile Jiangnan UniversityMinistry of EducationWuxiJiangsu 214122 Department of chemical and Biomolecular engineering Vanderbilt UniversityNashvilleTennessee 37235 Department of chemistry Vanderbilt UniversityNashvilleTennessee 37235 college of chemistry and chemical engineering Hunan UniversityChangsha 410082 Hefei National Research center for Physical Sciences at the Microscale School of Chemistry and Materials ScienceUniversity of Science and Technology of ChinaHefeiAnhui 230026

Sensitivity to structure and composition is very challenging to establish in nanocatalysis due to inadequate definition of structures that are very close in *** synthesized a pair of atomically precise copper clusters that are very close in composition,[cu_(20)H_(9)(tf-dpf)_(10)]·BF4(cu_(20)H_(9))and[cu_(20)H_(8)(tf-dpf)_(10)]·(BF_(4))_(2)(cu_(20)H_(8)),by using a pyridyl-functionalized flexible amidinate ligand,N,N′-di(5-trifluoromethyl-2-pyridyl)*** one-hydride difference in their composition leads to significant variation in geometric and electronic structures and,consequently,distinctly different optical and catalytic ***_(20)H_(8)exhibits 25 times higher catalytic activity than cu_(20)H_(9)(96.7%vs 3.7%in yield)in the selective hydrogenation of anα,β-unsaturated aldehyde(cinnamaldehyde)to saturated aldehyde(3-phenylpropanal).Electrospray ionization mass spectrometry combined with density functional theory calculations reveal that the greater ease of dissociation of one tf-dpf ligand compared to cu_(20)H_(8)is the key to its higher *** work demonstrates a clear case of structure and composition sensitivity in nanocatalysis and that one hydride,out of∼330 atoms in the nanoclusters,can make a huge difference in the catalytic *** insights will be useful in the design and synthesis of atomically precise nanocatalysts.

关键词： copper cluster hydride amidinate ligand structural transformation hydrogenation catalysis

the energy Sources and the Explosion Mechanism of ca-rich Supernova PtF 10iuv

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Research in Astronomy and Astrophysics 2024年第9期24卷 106-118页

作者： Qiu-Ping Huang Shan-Qin Wang tao Wang Wen-Pei Gan Deng-Wang Shi liu-Yi Wang en-Wei liang Guangxi Key laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China Department of Astronomy Beijing Normal UniversityBeijing 100875China Nanjing Hopes technology co. Ltd.Nanjing 210000China

In this paper,we perform the detailed modeling for the light curves(lcs)of PtF 10iuv which is a calcium-rich(ca-rich)supernova(SN)to constrain the physical properties of its ejecta and the energy sources,as well as the explosion *** find that the^(56)Ni model and the56Ni plus circumstellar interaction model fail to explain the lcs,while the four-element(^(56)Ni,^(48)cr,^(52)Fe,and^(44)ti)model can account for the *** ejecta mass of PtF10iuv derived by the model(1.52_(-0.25)^(+0.34)M_(⊙))is consistent with that of the merger of a sub-chandrasekhar mass white *** early-time lcs were mainly powered by^(56)Ni whose mass is~0.03 M_(⊙),while the contributions of^(48)cr and^(52)Fe can be *** derived^(44)ti mass(~0.25 M_(⊙))is~1.8 times the upper limit of the derived^(44)ti mass of ca-rich SN *** suggest that subtracting the contributions of the host-galaxy,which are unknown,and including the flux from other long-lived elements(e.g.,^(57)co,^(55)Fe,^(60)co)can reduce the amount of^(44)ti,and that this value can be regarded as an upper limit.

关键词： (stars:)supernovae:general (stars:)supernovae:individual(PtF 10iuv) (stars:)novae cataclysmic variables

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Research on the Application of Electromagnetic Method in the Exploration of Altered Rock-type Gold Deposits in the East Kunlun Metallogenic Belt

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Acta Geologica Sinica(english Edition) 2024年第S1期 18-21页

作者： DONG Ji'en ZHANG Huiqing WANG Peng lI Hua YE Gaofeng YU Xiaoliang lI Jie Qinghai Geological Survey MNR Technology Innovation Center for Exploration and Exploitation of Strategic Mineral Resources in Plateau Desert Region School of Geophysics and Information technology China University of Geosciences

Introduction the East Kunlun Orogenic Belt is located in the northeastern part of the Qinghai–tibet Plateau(li et al., 2007), stretching from the East Kunlun to the Elashan area in an east–west direction(Guo et al., 2018). It is an important part of the central Orogenic Belt(Xiong et al., 2023). It is considered one of the important gold mineralization regions in the tethys tectonic domain(Norbu et al., 2023) and an essential potential base for mineral resources in china. Wulonggou and Gouli gold mines have been discovered successively, earning the reputation of the "Golden Belt of Qinghai Province"(Feng et al., 2004; He et al., 2023).

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Beta-lactam antibiotic resistance among Escherichia coli isolates from patients with urinary tract infections in Vietnam:A systematic review and meta-analysis

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Asian Pacific Journal of tropical Medicine 2024年第6期17卷 243-255,I0001-I0003页

作者： Dat t Nguyen Princess Margaret cancer centre University Health NetworkTorontoOntarioCanada

Objective:to investigate the evolving patterns of antimicrobial resistance against beta-lactam antibiotics in Escherichia coli isolates from urinary tract infection patients in Vietnam,covering the period from 2005 to ***:29 Descriptive studies published between 2010 and 2022 in english and Vietnamese were included in the *** on resistance rates to beta-lactam antibiotics,including cephalosporins and carbapenems,were extracted and *** pooled resistance rates were calculated using random-effects *** trends in resistance were assessed using linear regression ***:Among the beta-lactam antibiotics studied,Escherichia coli exhibited varying levels of resistance,with cephalosporins showing higher resistance rates compared to *** pooled resistance rates were 66%for cefotaxime,65%for ceftriaxone,54%for ceftazidime,and 56%for *** contrast,carbapenems demonstrated lower resistance rates,with weighted pooled resistance rates ranging from 3%to 4%for meropenem,ertapenem,and *** rates were also observed for amoxicillin/clavulanate(35%),ticarcillin/clavulanate(26%),and piperacillin/tazobactam(12%).Significant annual increases in resistance were noted for imipenem(0.56%,Pconclusions:this study highlights the critical issue of antimicrobial resistance in urinary tract infections in Vietnam and emphasizes the importance of prudent antibiotic use and the regular monitoring of resistance *** insights are useful for guiding healthcare professionals in optimizing treatment strategies and for policymakers in formulating evidence-based clinical guidelines to combat antibiotic resistance effectively.

关键词： Antimicrobial resistance Urinary tract infection Vietnam

Modulating p-type doping of two-dimensional material palladium diselenide

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Nano Research 2024年第4期17卷 3232-3244页

作者： Jiali Yang Yu liu en-Yang Wang Jinbo Pang Shirong Huang thomas Gemming Jinshun Bi Alicja Bachmatiuk Hao Jia Shu-Xian Hu chongyun Jiang Hong liu Gianaurelio cuniberti Weijia Zhou Mark H Rümmeli Institute for Advanced Interdisciplinary Research(iAIR) University of JinanJinan 250022China Institute for Materials chemistry Leibniz Institute for Solid State and Materials Research Dresden(IFW Dresden)20 Helmholtz StrasseDresden 01069Germany State Key lab of transducer technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China college of energy Soochow Institute for Energy and Materials Innovations Soochow UniversitySuzhou 215006China Key laboratory of Advanced carbon Materials and Wearable energy technologies of Jiangsu Province Soochow UniversitySuzhou 215006China School of Integrated circuits University of Chinese Academy of SciencesBeijing 101408China Institute of Microelectronics of tianjin Binhai New Area Tianjin 300451China Institute of Microelectronics Chinese Academy of SciencesBeijing 100029China lukasiewicz Research Network PORT Polish Center for Technology DevelopmentStablowicka 147Wroclaw 54-066Poland School of Mathematics and Physics University of Science and Technology BeijingBeijing 100083China college of electronic information and optical engineering Nankai UniversityTianjin 300350China centre of Polymer and carbon Materials Polish Academy of SciencesM.Curie Sklodowskiej 34Zabrze 41-819Poland center for energy and environmental technologies VŠB-Technical University of Ostrava17.Listopadu 15Ostrava 70833Czech Republic State Key laboratory of crystal Materials Center of Bio&Micro/Nano Functional MaterialsShandong UniversityJinan 250100China Dresden center for computational Materials Science Technische Universität DresdenDresden 01062Germany Dresden center for Intelligent Materials(Gcl DcIM) Technische Universität DresdenDresden 01062Germany Institute for Materials Science and Max Bergmann center of Biomaterials Technische Universität DresdenDresden 01069Germany center for Advancing Electronics Dresden Technische Universität DresdenDresden 01069Germany

the van der Waals heterostructures have evolved as novel materials for complementing the Si-based semiconductor ***-10 noble metal dichalcogenides(e.g.,PtS_(2),PtSe_(2),PdS_(2),and PdSe_(2))have been listed into two-dimensional(2D)materials toolkit to assemble van der Waals *** them,PdSe_(2) demonstrates advantages of high stability in air,high mobility,and wide tunable ***,the regulation of p-type doping of PdSe_(2) remains unsolved problem prior to fabricating p–n junction as a fundamental platform of semiconductor ***,a quantitative method for the controllable doping of PdSe_(2) is yet to be *** this study,the doping level of PdSe_(2) was correlated with the concentration of lewis acids,for example,Sncl_(4),used for *** the transfer characteristics,the threshold voltage(the gate voltage corresponding to the minimum drain current)increased after Sncl_(4) soaking ***_(2) transistors were soaked in Sncl_(4) solutions with five different *** threshold voltages from the as-obtained transfer curves were extracted for linear fitting to the threshold voltage versus doping concentration correlation *** study provides in-depth insights into the controllable p-type doping of PdSe_(2).It may also push forward the research of the regulation of conductivity behaviors of 2D materials.

关键词： two-dimensional(2D)materials lewis acid treatment p-type doping field-effect transistors transfer characteristic

Effectiveness of mindfulness-based interventions on the well-being of healthcare workers:a systematic review and meta-analysis

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General Psychiatry 2024年第3期37卷 335-344页

作者： Natasha Yixuan Ong Finn Jing Jie teo Jane Zi Ying Ee chun en Yau Julian thumboo Hiang Khoon tan Qin Xiang Ng NUS Yong loo lin School of Medicine National University of SingaporeSingapore Health Services Research Unit Singapore General HospitalSingapore SingHealth Duke-NUS Medicine Academic clinical Programme Duke-NUS Medical SchoolSingapore Singhealth Duke-NUS Global Health Institute Singapore Duke Global Health Institute Duke UniversityDurhamNorth CarolinaUSA Division of Surgery and Surgical Oncology Singapore General HospitalSingapore Saw Swee Hock School of Public Health National University of Singapore and National University Health SystemSingapore

Background Growing evidence attests to the efficacy of mindfulness-based interventions(MBIs),but their effectiveness for healthcare workers remains *** to evaluate the evidence for MBIs in improving healthcare workers’psychological *** A systematic literature search was conducted on Medline,Embase,cumulative Index for Nursing and Allied Health literature,PsycINFO and cochrane central Register of controlled trials up to 31 August 2022 using the keywords‘healthcare worker’,‘doctor’,‘nurse’,‘allied health’,‘mindfulness’,‘wellness’,‘workshop’and‘program’.Randomised controlled trials with a defined MBI focusing on healthcare workers and quantitative outcome measures related to subjective or psychological well-being were eligible for inclusion.R V.4.0.3 was used for data analysis,with the standardised mean difference as the primary outcome,employing DerSimonian and laird’s random effects *** of Recommendations,Assessment,Development and Evaluation framework was used to evaluate the quality of ***’s Risk of Bias 2 tool was used to assess the risk of bias in the included *** A total of 27 studies with 2506 participants were included,mostly from the USA,involving various healthcare *** such as stress reduction programmes,apps,meditation and training showed small to large effects on anxiety,burnout,stress,depression,psychological distress and job strain outcomes of the *** effects were also seen in self-compassion,empathy,mindfulness and ***,long-term outcomes(1 month or longer postintervention)varied,and the effects were not consistently *** MBIs offer short-term benefits in reducing stress-related symptoms in healthcare *** review also highlights limitations such as intervention heterogeneity,reduced power in specific subgroup analyses and variable study quality.

关键词： nurse sustained workers

leading directions and effective distance of larch offspring dispersal at the upper treeline in the Northern and Polar Urals, Russia

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Forest Ecosystems 2024年第5期11卷 603-617页

作者： P.A.Moiseev V.l.Semerikov t.V.Semerikova D.S.Balakin I.B.Vorobiev S.O.Viuykhin Institute of Plant and Animal Ecology Ural BranchRussian Academy of SciencesEkaterinburg620144Russia center for Genetics and life Science Sirius University of Science and Technology354340SochiRussia

climate has changed sufficiently over the last 150 years and forced out upper treeline advance at the most studied sites around the *** rate of advance has been extremely variable–from tens to hundreds meters in *** is because the degree at which tree frontal populations respond to climate change depends on the complex interaction of biological and physical *** resulting stand pattern is the consequence of the interaction between dispersal and survival functions.A few publications have addressed the question of how this pattern is *** order to understand how the spatial structure of tree stands was formed at the upper limit of their distribution in the Ural Mountains,we assessed the distance and direction of dispersal of offspring from maternal *** found that in frontal larix sibirica ***,‘effective’dispersal of offspring ranges from 3 to 758 m(with a median of 20–33 m in open forest and 219 m in single-tree tundra in the Polar Urals and 107 m in open forest in the Northern Urals).We revealed that most of the offspring effectively dispersed not only in the direction of the prevailing winds,but also in the opposite direction up the slope,and the distance can reach 500–760 *** data obtained can be used to develop an individual-based model which is capable of simulating in detail the dynamics of tree stands at the upper limit of their growth and reliably predicting the future position and pattern of treeline ecotone as growth conditions continue to improve in the face of observed climate change.

关键词： Effective dispersal distance Upper treeline Parentage analysis Age estimation terrestrial laser scanning larix sibirica Ural mountains

Development of an ultrathin liquid sheet target for laser ion acceleration at high repetition rates in the kilohertz range

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High Power laser Science and engineering 2024年第3期12卷 134-145页

作者： M.Füle A.P.Kovács t.Gilinger M.Karnok P.Gaál S.Figul G.Marowsky K.Osvay National laser-Initiated transmutation laboratory University of SzegedSzegedHungary Department of Experimental Physics University of SzegedSzegedHungary ElI AlPS ELI-HU Non-Profit Ltd.SzegedHungary Department of Optics and Quantum Electronics University of SzegedSzegedHungary Advanced Microfluidic Systems GmbH GöttingenGermany

A colliding microjet liquid sheet target system was developed and tested for pairs of round nozzles of 10,11 and 18μm in *** sheet's position stability was found to be better than a few *** interaction with 50 mJ laser pulses,the 18μm jet has a resonance amplitude of 16μm at a repetition rate of 33 Hz,while towards 100 Hz it converges to 10μm for all nozzles.A white-light interferometric system was developed to measure the liquid sheet thickness in the target chamber both in air and in vacuum,with a measurement range of 182 nm±1μm and an accuracy of±3%.the overall shape and 3D shape of the sheet follow the Hasson±Peck model in *** vacuum versus air,the sheet gradually loses 10%of its thickness,so the thinnest sheet achieved was below 200 nm at a vacuum level of 10±4mbar,and remained stable for several hours of operation.

关键词： diagnostics laser ion acceleration nanometric liquid sheet targets vacuum test

维普期刊数据库