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补体片段C3f、DRC3f对皮肤成纤维细胞合成和分泌转化生长因子-β1的调节作用

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湖北民族学院学报（医学版） 2007年第1期24卷 10-13页

作者：向阳加藤智启湖北民族学院医学院附属医院风湿免疫科湖北恩施4450002 日本圣玛丽安娜医科大学风湿病研究中心

目的观察补体C3水解片段C3f和去精氨酸C3f(C3f-des-arginine,DRC3f)对皮肤成纤维细胞合成与分泌转化生长因子-β1(transforming growth factor-β1,tGF-β1)的影响。方法采用人工合成的C3f(17肽)和DRC3f(16肽)刺激培养的正常成人皮肤成... 详细信息

目的观察补体C3水解片段C3f和去精氨酸C3f(C3f-des-arginine,DRC3f)对皮肤成纤维细胞合成与分泌转化生长因子-β1(transforming growth factor-β1,tGF-β1)的影响。方法采用人工合成的C3f(17肽)和DRC3f(16肽)刺激培养的正常成人皮肤成纤维细胞(NHDF-Ad),通过半定量逆转录多聚酶链式反应方法(Rt-PCR)和酶联免疫法(ELISA)从mRNA和蛋白水平检测tGF-β1生成量。结果培养的正常成纤维细胞生成极微量tGF-β1(8 pg/ml)。C3f和DRC3f能够提高皮肤成纤维细胞tGF-β1生成量(PtGF-β1生成量的作用,可能对皮肤胶原纤维过度沉积起着促进作用。

关键词：补体片段C3f 去精氨酸C3f 转化生长因子β1 皮肤成纤维细胞

Severe Sinus Bradycardia in Anorexia Nervosa-A Case Report

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South China Journal of Cardiology 2007年第3期8卷 171-172页

作者： Yuichieo Yhchi Msasyuki kato Shouzou Ishise Ryozo tatami Ryoyu takeda Yoshikatu Nakai Isamu Miyamori Department of Cardiology Maizuru Kyosai Hospital Nakai Clinic Kyoto Prefecture Department f internal Medicine Fukui UniversityFukui Prefecture

A case of anorexia nervosa complicated with severe sinus bradycardia and low t3 syndrome was reported.

关键词： anorexia nervosa bradycardia low t3 syndrome

恒载和地震共同作用下单层网壳屈曲强度计算（英文）

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空间结构 2015年第4期21卷 79-86页

作者：柳澤利昌加藤史郎中澤祥二丰桥技术科学大学

讨论恒载和地震作用下单层网壳的屈曲强度.单层网壳由安装在刚性基础(如钢筋混凝土结构)的简支座支承.首先,介绍了线性屈曲荷载的近似计算公式,并讨论了该公式的精确性.接着,评价了基于线性屈曲分析的折减系数,并根据荷载峰值提出计算... 详细信息

讨论恒载和地震作用下单层网壳的屈曲强度.单层网壳由安装在刚性基础(如钢筋混凝土结构)的简支座支承.首先,介绍了线性屈曲荷载的近似计算公式,并讨论了该公式的精确性.接着,评价了基于线性屈曲分析的折减系数,并根据荷载峰值提出计算公式以估计导致坍塌的地震强度.然后,对比分析了分别采用有限元分析和采用修正邓克利公式的弹-塑性屈曲荷载.最后,讨论了对本文所提出的修正邓克利公式的评价方法.结果显示,有限元分析的结果高于修正邓克利公式所给结果,而且可很容易地采用修正邓克利公式计算屈曲荷载.

关键词：单层网壳屈曲强度恒载地震作用评估

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NIRS的ECR离子源现状(英文)

Chinese Physics C 2007年第S1期31卷 60-62页

作者： M.Muramatsu A.Kitagawa Y.Iwata K.Yamamoto H.Ogawa S.Hojo Y.Sakamoto t.Honma W.takasugi M.Wakaisami Y.Yoshida t.Kubo Y.kato S.Biri A.G.Drentje Graduate school of Engineering Toyo UniversityJapan National Institute of Radiological Sciences4-9-1 AnagawaInageChiba 263-8555Japan National Institute of Radiological Sciences 4-9-1 AnagawaInageChiba 263-8555Japan Accelerator Engineering Corporation Ltd.2-13-I KonakadaiInageChiba 263-0043Japan Department of Mechanical Engineering Toyo University2100 KujiraiKawagoeSaitarna 350-0815Japan Osaka University 2-1 Yamada-okaSuitaOsaka 565-0871Japan Institute of Nuclear Research (AtOMKI) H-4026 DebrecenBen ter 18/cHungary National Institute of Radiological Sciences 4-9-1 AnagawaInageChiba 263-8555Japan K.V.I.University of GroningenZernikelaan 259747AA GroningenNetherlands

Four ECR ion sources have been operated in National Institute of Radiological Sciences（NIRS）. two ECR ion sources supply various ion species for the Heavy Ion Medical Accelerator in Chiba（HIMAC）. the 10GHz NIRS-ECR ion source mainly produces C2+ ions for the heavy-ion *** of Si,Ar,Fe,Kr and Xe are usually produced by the 18GHz NIRS-HEC ion source for physical and biological *** other two compact ECR ion sources with all permanent magnet configuration have been developed for the new generation carbon therapy *** of these,the Kei-source,is a prototype which has been installed to the NIRS-930 cyclotron for axial *** other source,Kei2-source,is a demonstration source and utilized for the new generation *** addition,both Kei sources have been used to study fundamental properties. In this paper,present status of the ion sources and recent developments are reported.

关键词： heavy ion therapy ECR

Field Evaluation of LED Fluorescence Microscopy for Demonstration of <i>trypanosoma brucei rhodesiense</i>in Patient Blood

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Microscopy Research 2019年第1期7卷 1-9页

作者： Enock Matovu Andrew Edielu James Ojom Ann Nanteza Charles Drago kato Sylvain Biéler Joseph Mathu Ndung’u College of Veterinary Medicine Animal Resources and Biosecurity Makerere University Kampala Uganda Lwala Hospital Soroti Uganda Foundation for Innovative New Diagnostics (FIND) Campus Biotech Chemin des Mines 9 Geneva Switzerland

Diagnosis of trypanosoma brucei rhodesiense human African trypanosomiasis requires demonstration of parasites in body fluids by microscopy. the microscopy methods that are routinely used are difficult to deploy in resource-limited settings due to practical challenges, including lengthy and tedious procedures, and the need for specific equipment to centrifuge samples in glass capillary tubes. We report here on a study that was conducted in a rural region of eastern Uganda to evaluate new methods that take advantage of a field-deployable LED fluorescence microscope. Examination of acridine orange-stained blood smears by LED fluorescence microscopy resulted in a diagnostic accuracy that was similar to that of routine methods, while the time needed to identify parasites was shortened significantly. these findings make these new microscopy methods attractive alternatives to procedures that are currently used for diagnosis of t. b. rhodesiense human African trypanosomiasis.

关键词： Human African trypanosomiasis Rhodesiense LED Fluorescence Microscopy Red Blood Cell Lysis Diagnosis

Effect of herbal medicine Juzentaihoto on hepatic and intestinal heat shock gene expression requires intestinal microflora in mouse

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World Journal of Gastroenterology 2007年第16期13卷 2289-2297页

作者： Miho kato Atsushi Ishige Naoko Anjiki Masahiro Yamamoto Yoshifumi Irie Mitsue taniyama Ryoko Kibe Junichiro Oka Yoshimi Benno Kenji Watanabe Department of Kampo Medicine Keio University School of Medicine 35 Shinano-machi Shinjuku-ku Tokyo 160-8582 Japan Faculty of Pharmaceutical Science Tokyo University of Science 264 Yamazaki Noda City Chiba 278-8519 Japan Japan Collection of Microorganisms Riken 2-1 Hirosawa Wako-shi Saitama 351-0198 Japan Department of Kampo Medicine Keio University School of Medicine 35 Shinano-machi Shinjuku-ku Tokyo 160-8582 Japan Department of Kampo Medicine Keio University School of Medicine 35 Shinano-machi Shinjuku-ku Tokyo 160-8582 Japan Pharmacology Research Department Tsumura Research Institute Research Division 3586 Yoshiwara Ami-machi Inashiki-gun Ibaraki 300-1192 Japan Pharmacology Research Department Tsumura Research Institute Research Division 3586 Yoshiwara Ami-machi Inashiki-gun Ibaraki 300-1192 Japan Japan Collection of Microorganisms Riken 2-1 Hirosawa Wako-shi Saitama 351-0198 Japan Faculty of Pharmaceutical Science Tokyo University of Science 264 Yamazaki Noda City Chiba 278-8519 Japan

AIM: to evaluate the role of intestinal microflora in the effects of multi-herbal medicine on gene expression in the gut and liver. MEtHODS: the multi-herbal medicine Juzentaihoto (JtX) was administered to five germ-free mice and regular mice for 2 wk. Among the results of the comprehensive gene chip analysis of the intestine and liver, we featured heat shock proteins (HSPs) 70 and 105 because their gene expression changed only in the presence of microflora. Real-time Rt-PCR was performed to confirm the expression levels of these HSP genes. to determine whether JtX acts directly on the HSP genes, sodium arsenite (SA) was used to induce the heat shock proteins directly. to examine the change of the intestinal microflora with administration of JtX, the terminal restriction fragment polymorphism (t-RFLP) method was used. to identify the changed bacteria, DNA sequencing was performed. RESULtS: Heat shock protein gene expression,documented by gene chip and real-time Rt-PCR, changed with the administration of JtX in the regular mice but not in the germ-free mice. JtX did not suppress the direct induction of the HSPs by SA. t-RFLP suggested that JtX decreased unculturable bacteria and increased Lactobacillus johnsoni. these data suggested that JtX changed the intestinal microflora which, in turn, changed HSP gene expression. CONCLUSION: Intestinal microflora affects multi-herbal product JtX on the gene expression in the gut and liver.

关键词：十全大补汤草药肝脏肠道热休克蛋白基因表达小鼠小肠菌群

石棉作业工人的石棉肺与其他肺部纤维化的高分辨Ct表现及临床病理相关性

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国际医学放射学杂志 2016年第4期 454-455页

作者： H.Arakawa t.Kishimoto K.Ashizawa K.kato K.Okamoto K.Honma 卢宝兰 Department of Radiology Dokkyo Medical University

摘要目的观察研究石棉肺的特征性Ct表现,并探讨其与石棉沉积量的相关性。方法回顾性分析33例临床诊断为石棉肺病人(平均年龄73岁)的Ct及病理资料,其中30例经尸检证实,3例经肺叶切除证实。由2位放射科医生全盲独立分析病例的高分辨Ct征象... 详细信息

摘要目的观察研究石棉肺的特征性Ct表现,并探讨其与石棉沉积量的相关性。方法回顾性分析33例临床诊断为石棉肺病人(平均年龄73岁)的Ct及病理资料,其中30例经尸检证实,3例经肺叶切除证实。由2位放射科医生全盲独立分析病例的高分辨Ct征象,并为每个病例出现的征

关键词：石棉肺纤维化沉积量 Ct 高分辨相关性

胃癌:离体7.0tMR成像与组织病理学结果的相关性研究

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国际医学放射学杂志 2015年第4期 384-385页

作者： I.Yamada N.Miyasaka K.Hikishima K.kato K.Kojima t.Kawano 张冰 Departments of Diagnostic Radiology and Oncology Graduate School Tokyo Medical and Dental University

摘要目的确定7.0 t MR成像(体素体积为9.5～14.0 n L)所提供的影像细节及诊断信息能否用于评估离体胃癌胃壁的浸润深度。材料与方法本研究经机构伦理委员会批准,所

关键词：胃癌浸润深度胃壁胃肿瘤组织病理学病理组织学组织学离体

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砂质土和粘质土壤磷酸盐吸附动力学(摘要)

福建稻麦科技 1990年第3期8卷 58-63页

作者： Naoto kato Naoto Owa 翁伯琦唐建阳

应用不同P浓度溶液进行土壤平衡以测定灰色稻田土(Fujimi砂质土)和黄壤(takashigahara粘性土)P素吸附功力学变化状态。土/溶液比率接近7:2,较符合田间状况。通过实验资料的回归分析建立P素吸附动力学方程。经验方程as/at=KC^m S^n不能... 详细信息

应用不同P浓度溶液进行土壤平衡以测定灰色稻田土(Fujimi砂质土)和黄壤(takashigahara粘性土)P素吸附功力学变化状态。土/溶液比率接近7:2,较符合田间状况。通过实验资料的回归分析建立P素吸附动力学方程。经验方程as/at=KC^m S^n不能充分描述P素吸附动力学过程,该方程中S代表每单位土壤量中P吸附量,C代表土壤溶液中P的浓度,t为时间,k、m、n均为常数。Kuo的方程式S=a′C_0t^(b′)不适应于在田间湿润,尤其是P的初始浓度较低情况下P素吸附动力学的预测,该式中C_0为P的初始浓度,a′:b′均为常数。最适合本试验资料应用的是比率方程式S=at^bc^d,公式中a、b、d均为常数,该方程式相关系数大于0.99。

关键词：吸附动力学砂质土经验方程吸附量稻田土相关系数吸附等温线动力学方程滤布动力学模式