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COVID-19 vaccination produces exercise-responsive SArS-CoV-2 specific t-cells regardless of infection history

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journal of Sport and Health Science 2024年第1期13卷 99-107页

作者： Kyle A.Smith tiffany M.Zúñiga Forrest L.Baker Helena Batatinha Charles r.Pedlar Shane C.Burgess Michael P.Gustafson Emmanuel Katsanis richard j.Simpson School of Nutritional Sciences and Wellness The University of ArizonaTucsonAZ 85721USA Department of Pediatrics The University of ArizonaTucsonAZ 85724USA Faculty of Sport Allied Health and Performance ScienceSt.Mary's UniversityTwickenham TW14SXUK Institute of Sport Exercise and Health University College LondonLondon WC1E 7HUUK Department of Animal and Comparative Biomedical Sciences The University of ArizonaTucsonAZ 85721USA the University of Arizona Cancer Center The University of ArizonaTucsonAZ 85719USA Laboratory Medicine and Pathology Mayo Clinic ArizonaPhoenixAZ 85054USA Department of Immunobiology The University of ArizonaTucsonAZ 85724USA Department of Medicine The University of ArizonaTucsonAZ 85724USA Department of Pathology The University of ArizonaTucsonAZ 85724USA

Background:the mobilization and redistribution of severe acute respiratory syndrome coronavirus 2(SArS-CoV-2)specific t-cells and neutralizing antibodies(nAbs)during exercise is purported to increase immune surveillance and protect against severe coronavirus disease 2019(COVID-19).We sought to determine if COVID-19 vaccination would elicit exercise-responsive SArS-CoV-2 t-cells and transiently alter nAb ***:Eighteen healthy participants completed a 20-min bout of graded cycling exercise before and/or after receiving a COVID-19 *** major leukocyte subtypes were enumerated before,during,and after exercise by flow cytometry,and immune responses to SArS-CoV-2 were determined using whole blood peptide stimulation assays,t-cell receptor(tCr)-βsequencing,and SArS-CoV-2 nAb ***:COVID-19 vaccination had no effect on the mobilization or egress of major leukocyte subsets in response to intensity-controlled graded ***,non-infected participants had a significantly reduced mobilization of CD4+and CD8+naive t-cells,as well as CD4+central memory t-cells,after vaccination(synthetic immunity group);this was not seen after vaccination in those with prior SArS-CoV-2 infection(hybrid immunity group).Acute exercise after vaccination robustly mobilized SArS-CoV-2 specific t-cells to blood in an intensity-dependent *** groups mobilized t-cells that reacted to spike protein;however,only the hybrid immunity group mobilized t-cells that reacted to membrane and nucleocapsid *** increased significantly during exercise only in the hybrid immunity ***:these data indicate that acute exercise mobilizes SArS-CoV-2 specific t-cells that recognize spike protein and increases the redistribution of nAbs in individuals with hybrid immunity.

关键词： Anti-viral COVID-19 Exercise immunology SArS-CoV-2 t-Cells Vaccine

rescue from complications after pancreaticoduodenectomies at a low-volume Caribbean center:Value of tailored peri-pancreatectomy protocols

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World journal of Gastrointestinal Surgery 2024年第3期16卷 681-688页

作者： Shamir O Cawich Elijah Dixon Parul j Shukla Shailesh V Shrikhande rahul r Deshpande Fawwaz Mohammed Neil W Pearce Wesley Francis Shaneeta johnson johann Bujhawan Department of Surgery University of the West IndiesSt Augustine 000000Trinidad and Tobago Department of Surgery Faculty of MedicineUniversity of CalgaryCalgaryAlberta T2N2T9Canada Department of Surgery Weill Cornell Medical CollegeNew YorkNY 10065United States Department of Surgical Oncology Tata Memorial CenterHomi Bhabha National UniversityMumbai 400012India Department of Surgery Manchester Royal InfirmaryManchester M139WLUnited Kingdom University Surgical Unit Southampton General HospitalSouthampton SO166YDUnited Kingdom Department of Surgery University of the West IndiesNassau N-1184Bahamas Department of Surgery Morehouse School of MedicineAtlantaGA 30310United States Department of Surgery General Hospital in Port of SpainPort of Spain 000000Trinidad and Tobago

BACKGrOUND Pancreaticoduodenectomy(PD)is a technically complex operation,with a re-latively high risk for *** ability to rescue patients from post-PD complications is as a recognized quality *** protocols were instituted at our low volume facility in the year *** to document the rate of rescue from post-PD complications with tailored protocols in place as a measure of *** A retrospective audit was performed to collect data from patients who experienced major post-PD complications at a low volume pancreatic surgery unit in trinidad and tobago between january 1,2013 and june 30,***-dardized definitions from the International Study Group of Pancreatic Surgery were used to define post-PD complications,and the modified Clavien-Dindo classification was used to classify post-PD *** Over the study period,113 patients at a mean age of 57.5 years(standard deviation[SD]±9.23;range:30-90;median:56)underwent PDs at this *** complications were recorded in 33(29.2%)patients at a mean age of 53.8 years(SD:±7.9).twenty-nine(87.9%)patients who experienced major morbidity were salvaged after aggre-ssive treatment of their ***(3.5%)died from bleeding pseudoaneurysm(1),septic shock secondary to a bile leak(1),anastomotic leak(1),and myocardial infarction(1).there was a significantly greater salvage rate in patients with American Society of Anesthesiologists scores≤2(93.3%vs 25%;P=0.0024).CONCLUSION this paper adds to the growing body of evidence that volume alone should not be used as a marker of quality for patients requiring *** low volumes at our facility,we demonstrated that 87.9%of patients were rescued from major *** attributed this to several factors including development of rescue protocols,the competence of the pancreatic surgery teams and continuous,and adaptive learning by the entire institution,cul-minating in the development of tailored peri-pancreatectomy protoc

关键词： Pancreas Complication rescue Failure Morbidity Mortality Pancreaticoduodenectomy

Factors Associated with Overweight among Workers of the Ministry of Labor and Public Service in Benin in 2023

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Open journal of Internal Medicine 2024年第3期14卷 299-318页

作者： Lucile t. S. Bedie toïhen Géraud Padonou Charles jérôme Sossa Bayédjè Evrard Koutchoro Sègnon Eurydice Elvire Djossou Coovi Nonwanou Ignace tokpanoude Badirou Aguemon Ministry of Labor and Public Service Cotonou Benin Faculty of Health Sciences (FSS) University of Abomey-Calavi (UAC) Cotonou Benin Health Promotion Department Regional Institute of Public Health Ouidah Benin

Introduction: the problem of excess weight is pandemic and affects the majority of nations, regardless of their level of development. However, the prevalence of overweight among workers in Benin is very poorly documented. to fill this gap, the present study aimed to determine the prevalence and factors associated with overweight among workers of the Ministry of Labor and Public Service (MtFP) in 2023 in Benin. Materials and Methods: this is a descriptive cross-sectional study with analytical purposes carried out from August 16 to December 17, 2023, among MINIStrY OF LABOr AND PUBLIC SErVICE staff. the variables studied were overweight, sociodemographic, occupational and dietary characteristics, lifestyle, anthropometric factors and family history of obesity. An exhaustive recruitment of workers meeting our inclusion criteria and a questionnaire survey was carried out. Data were analyzed using r 4.0.4 software. A bivariate analysis followed by a multivariable analysis made it possible to identify the factors associated with overweight at the p results: In total, 379 workers were included in our study. the average age of the surveyed workers was 44.86 years ± 7.67 years, with 202 (53.30%) workers at least 45 years old. Men predominated with a number of 228 (60.16%). the prevalence of overweight was 63.32% (95% CI: [58.23 - 68.15]) and the associated factors after multivariate analysis were: female sex (Ora = 4.00;95% CI [2.11 - 7.76];p Conclusion: the prevalence of overweight is high among ministry of labor and public service workers. Education and awareness in the professional environment on the prevention and management of risk factors are essential for a long-term impact on a notable regression of this public health phenomenon.

关键词： Overweight Associated Factors Workers-Benin

Invasive ant learning is not affected by seven potential neuroactive chemicals

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Current Zoology 2024年第1期70卷 87-97页

作者： Henrique Galante tomer j.Czaczkes Department of Zoology and Evolutionary Biology Animal Comparative Economics LaboratoryUniversity of Regensburg93053 Regensburg Germany

Argentine ants Linepithema humile are one of the most damaging invasive alien species *** or disrupting cognitive abilities,such as learning,has the potential to improve management efforts,for example by increasing preference for a bait,or improving ants'ability to learn its characteristics or ***-feeding insects are often the victims of psychoactive manipulation,with plants lacing their nectar with secondary metabolites such as alkaloids and non-protein amino acids which often alter learning,foraging,or ***,the effect of neuroactive chemicals has seldomly been explored in ***,we test the effects of seven potential neuroactive chemicals-two alkaloids:caffeine and nicotine;two biogenic amines:dopamine and octopamine,and three nonprotein amino acids:β-alanine,GABA and taurineon the cognitive abilities of invasive *** using bifurcation *** results confirm that these ants are strong associative learners,requiring as little as one experience to develop an ***,we show no short-term effect of any of the chemicals tested on spatial learning,and in addition no effect of caffeine on short-term olfactory *** lack of effect is surprising,given the extensive reports of the tested chemicals affecting learning and foraging in *** mismatch could be due to the heavy bias towards bees in the literature,a positive result publicationbias,ordifferences inmethodology.

关键词： associativelearning caffeine memory neuroactivechemicals

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甘肃省熊蜂分布特征及其影响因素

中国蜂业 2024年第8期15卷 13-13页

作者：安建东 Naeem M Chen H Li W hughes AC Williams PH Bashir NH Miao Z Huang j An j 中国农业科学院蜜蜂研究所

近日，中国农业科学院蜜蜂研究所联合曲靖师范学院等单位科研人员发现甘肃省熊蜂呈现四大生物地理区系，净初级生产力是影响熊蜂多样性分布的最主要因素。该研究成果在线发表在《昆虫(Insects)》上。熊蜂是众多植物的传粉者，在陆地生... 详细信息

近日，中国农业科学院蜜蜂研究所联合曲靖师范学院等单位科研人员发现甘肃省熊蜂呈现四大生物地理区系，净初级生产力是影响熊蜂多样性分布的最主要因素。该研究成果在线发表在《昆虫(Insects)》上。熊蜂是众多植物的传粉者，在陆地生态系统中发挥着十分重要的作用。明确影响熊蜂分布的因素对于熊蜂多样性保护至关重要。

关键词： Gansu biodiversity biogeographic regionalization bumblebees canonical correspondence analysis

Analysis of the inflection points of height-diameter models

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Forest Ecosystems 2024年第4期11卷 414-422页

作者： tzeng Yih Lam Mark j.Ducey Department of Forest resources Management Faculty of ForestryThe University of British Columbia2045-2424 Main MallVancouverBCV6T 1Z4 Canada Department of Natural resources and the Environment University of New Hampshire114 James HallDurhamNH 03824USA

the inflection point is an important feature of sigmoidal height-diameter(H-D)*** is often cited as one of the properties favoring sigmoidal model ***,there are very few studies analyzing the inflection points of H-D *** goals of this study were to theoretically and empirically examine the behaviors of inflection points of six common H-D models with a regional *** six models were the Wykoff(WYK),Schumacher(SCH),Curtis(CUr),HossfeldⅣ(HOS),von Bertalanffy-richards(VBr),and Gompertz(GPZ)*** models were first fitted in their base forms with tree species as random effects and were then expanded to include functional traits and spatial *** distributions of the estimated inflection points were similar between the two-parameter models WYK,SCH,and CUr,but were different between the threeparameter models HOS,VBr,and *** produced some of the largest inflection *** and VBr produced concave H-D curves without inflection points for 12.7%and 39.7%of the tree *** species or decreasing shade tolerance resulted in larger inflection *** trends in the estimated inflection points of HOS and VBr were entirely opposite across the ***,HOS could produce concave H-D curves for portions of the *** on the studied behaviors,the choice between two-parameter models may not *** recommend comparing seve ral three-parameter model forms for consistency in estimated inflection points before deciding on *** sigmoidal models to have inflection points does not necessarily mean that they will produce fitted curves with *** study highlights the need to integrate analysis of inflection points into modeling H-D relationships.

关键词： Concavity Forest inventory and analysis Generalized height-diameter models Growth functions Height-diameter functions Mixed-effects modeling Points of inflection Species-specific models

HI in High Gas-phase Metallicity Dwarf Galaxy WISEA j230615.06+143927.9

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research in Astronomy and Astrophysics 2024年第1期24卷 292-299页

作者： Yan Guo C.Sengupta t.C.Scott P.Lagos Y.Luo Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China School of Astronomy and Space Sciences University of Science and Technology of ChinaHefei 230026China Institute of Astrophysics and Space Sciences(IA Porto) Rua das Estrelas4150-762PortoPortugal

We present resolved Giant Metrewave radio telescope H I observations of the high gas-phase metallicity dwarf galaxy WISEA j230615.06+143927.9(z = 0.005)(hereafter j2306) and investigate whether it could be a tidal Dwarf Galaxy(tDG) candidate. tDGs are observed to have higher metallicities than normal dwarfs. j2306 has an unusual combination of a blue g-r color of 0.23 mag, irregular optical morphology and high-metallicity(12 +log(O/H) = 8.68 ± 0.14), making it an interesting galaxy to study in more detail. We find j2306 to be an H I rich galaxy with a large extended, unperturbed rotating H I disk. Using our H I data we estimated its dynamical mass and found the galaxy to be dark matter(DM) dominated within its H I radius. the quantity of DM, inferred from its dynamical mass, appears to rule out j2306 as an evolved tDG. A wide area environment search reveals j2306 to be isolated from any larger galaxies which could have been the source of its high gas metallicity. Additionally, the H I morphology and kinematics of the galaxy show no indication of a recent merger to explain the *** detailed optical spectroscopic observations of j2306 might provide an answer to how a seemingly ordinary irregular dwarf galaxy achieved such a high level of metal enrichment.

关键词： galaxies:abundances galaxies:dwarf galaxies:irregular radio lines:galaxies radio lines:ISM

Amplitude analysis of the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)

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Chinese Physics C 2024年第8期48卷 6-33页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis X.C.Ai r.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban H.-r.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko r.A.Briere A.Brueggemann H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin j.F.Chang W.L.Chang G.r.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.S.Chen M.L.Chen S.j.Chen S.L.Chen S.M.Chen t.Chen X.r.Chen X.t.Chen Y.B.Chen Y.Q.Chen Z.j.Chen Z.Y.Chen S.K.Choi X.Chu G.Cibinetto F.Cossio j.j.Cui H.L.Dai j.P.Dai A.Dbeyssi r.E.de Boer D.Dedovich C.Q.Deng Z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori B.Fang S.S.Fang W.X.Fang Y.Fang Y.Q.Fang r.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng j.H.Feng Y.t.Feng K.Fischer M.Fritsch C.D.Fu j.L.Fu Y.W.Fu H.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia P.t.Ge Z.W.Ge C.Geng E.M.Gersabeck B.Ding X.X.Ding Y.Ding Y.Ding j.Dong L.Y.Dong M.Y.Dong X.Dong M.C.Du S.X.Du Z.H.Duan P.Egorov Y.H.Fan j.Fang jA.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl S.Gramigna M.Greco M.H.Gu Y.t.Gu C.Y.Guan Z.L.Guan A.Q.Guo L.B.Guo M.j.Guo r.P.Guo Y.P.Guo A.Guskov j.Gutierrez K.L.Han t.t.Han X.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz Y.K.Heng C.Herold t.Holtmann P.C.Hong G.Y.Hou X.t.Hou Y.r.Hou Z.L.Hou B.Y.Hu H.M.Hu j.F.Hu t.Hu Y.Hu G.S.Huang K.X.Huang L.Q.Huang X.t.Huang Y.P.Huang t.Hussain F.H\"olzken N.H\"usken N.in der Wiesche M.Irshad j.jackson S.janchiv j.H.jeong Q.ji Q.P.ji W.ji X.B.ji X.L.ji Y.Y.ji X.Q.jia Z.K.jia D.jiang H.B.jiang P.C.jiang S.S.jiang t.j.jiang X.S.jiang Y.jiang j.B.jiao j.K.jiao Z.jiao S.jin Y.jin M.Q.jing X.M.jing t.johansson S.Kabana N.Kalantar-Nayestanaki X.L.Kang X.S.Kang M.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz r.Kiuchi O.B.Kolcu B.Kopf M.Kuessner X.Kui A.Kupsc W.K\"uhn j.j.Lane P.Larin L.Lavezzi t.t.Lei Z.H.Lei H.Leithoff M.Lellmann t.Lenz C.Li C.Li C.H.Li Cheng Li D.M.Li F.Li G.Li H.Li H.B.Li H.j.Li H.N.Li Hui Li j.r.Li j.S.Li K.Li L.j.Li L.K.Li Lei Li M.H.Li P.r.Li Q.M.Li Q.X.Li r.Li S.X.Li t.Li W.D.Li W.G.Li X.Li X.H.Li X.L.Li X.Y.Li Y Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Beihang University Beijing 100191China Bochum ruhr-University D-44780 BochumGermany Budker Institute of Nuclear Physics SB rAS(BINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central South University Changsha 410083China China Center of Advanced Science and technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMSAtS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China GSI Helmholtzcentre for Heavy Ion research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University of Science and technology Luoyang 471003China Henan University of technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Physics Lanzhou 730000China Institute of Physics and technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de A

Using e^(+)e^(−)annihilation data corresponding to an integrated luminosity of 2.93 fb^(−1)taken at the center-of-mass energy√s=3.773 GeV with the BESIII detector,a joint amplitude analysis is performed on the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).the fit fractions of individual components are obtained,and large interferences among the dominant components of the decays D^(0)→a_(1)(1260)π,D^(0)→π(1300)π,D^(0)→ρ(770)ρ(770),and D^(0)→2(ππ)_(S)are observed in both *** the obtained amplitude model,the CP-even fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.2±1.1_(stat).±1.5_(syst.))%and(68.9±1.5_(stat).±2.4_(syst.))%,*** branching fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are measured to be(0.688±0.010_(stat.)±0.010_(syst.))%and(0.951±0.025_(stat.)±0.021_(syst.))%,*** amplitude analysis provides an important model for the binning strategy in measuring the strong phase parameters of D^(0)→4πwhen used to determine the CKM angleγ(ϕ_(3))via the B^(−)→DK^(−)decay.

关键词： BESIII D^(0)meson decays amplitude analysis CP-even fraction

Harnessing naturally occurring mutations for t-cell therapy:a potential new avenue to enhance treatment efficacy

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Signal transduction and targeted therapy 2024年第5期9卷 1799-1801页

作者： Michael Hiltensperger jürgen ruland Kilian Schober Mikrobiologisches Institut-Klinische Mikrobiologie Immunologie und HygieneFriedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany Institute of Clinical Chemistry and Pathobiochemistry School of MedicineTechnical University of MunichMunichGermany translatUM Center for Translational Cancer ResearchTechnical University of MunichMunichGermany German Cancer Consortium(DKtK) HeidelbergGermany German Center for Infection research(DZIF) partner site MunichMunichGermany FAU Profile Center Immunomedicine Friedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany

In a recent study published in Nature,Garcia et *** a sophisticated approach to identify fitness-enhancing mutations for t cells that was inspired by cancer evolution.1 the identified CArD11-PIK3r3 gene fusion enhanced tumor rejection and persistence of engineered t cells in multiple tumor models and might have the potential to improve efficacy of adoptive t-cell therapies in cancer patients.

关键词： cancer potential