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足部周围动脉硬化闭塞性疾病非强化的门控MR血管成像与增强MR血管成像及DSA对照研究

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国际医学放射学杂志 2016年第5期 595-595页

作者： t.Schubert M.takes M.Aschwanden M.Klarhoefer t.haas A.L.Jacob 高丽娟 Clinic of Radiology and Nuclear Medicine Basel University Hospital

摘要目的本研究旨在比较周围动脉硬化闭塞性疾病(PAOD)病人的足部血管高分辨非增强MRA(NAtIVE SPACE,NE-MRA)与增强MRA(CE-MRA)及DSA。材料与方法本前瞻性研究纳入20例PAOD。所有病人均在MRA检查次日行经皮腔内血管成像术或支架置入。结... 详细信息

摘要目的本研究旨在比较周围动脉硬化闭塞性疾病(PAOD)病人的足部血管高分辨非增强MRA(NAtIVE SPACE,NE-MRA)与增强MRA(CE-MRA)及DSA。材料与方法本前瞻性研究纳入20例PAOD。所有病人均在MRA检查次日行经皮腔内血管成像术或支架置入。结果 CE-MRA组75.7%血管节段显示良好、16.4%欠佳、7.9%不能用于诊断。

关键词：周围动脉硬化闭塞性疾病足部 MRA 病人血管成像 MR DSA

High Speed Rail Learning System(HSRLS)-taking Advantage of Online technologies in Railway Education

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International Journal of transportation Science and technology 2015年第2期4卷 179-196页

作者： Pasi t.Lautala Peter J.haas John L.Velat Michigan technological University Michigan tech transportation Institute Michigan Technological University

the United States has taken initial steps toward developing a high speed rail(HSR)network,but the domestic workforce experience and institutional knowledge necessary for the planning,design,construction,and operations of HSR is *** paper describes and provides preliminary assessment of the High Speed Rail Learning System(HSRLS),a demonstration project that seeks to address gaps in HSR knowledge and skills in the *** HSRLS developers designed an online education system to serve as a clearinghouse for railrelated information and content,connect teachers,trainers,and students at pre-,and postgraduate levels,and to collect demographic and professional information on groups and individuals interested in *** paper explores the technology review,selection process,and content *** visits and demographic information from over 4,000 unique individuals and 600 HSRLS course registrations are analyzed and assessed.

关键词： Higher education Workforce demand High Speed Rail Railroad education On-Line education Web-based teaching and learning

Experimentally validated atomistic simulation of the effect of relevant grinding parameters on work piece topography,internal stresses,and microstructure

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Friction 2022年第4期10卷 608-629页

作者： S.J.EDER P.G.GRÜtZMACHER t.SPENGER H.HECKES H.ROJACZ A.NEVOSAD F.haas AC2t research GmbH Viktor-Kaplan-Straße 2/CWiener Neustadt 2700Austria Institute of Engineering Design and Product Development TU WienLehárgasse 6-Objekt 7Vienna 1060Austria Institute of Production Engineering Graz University of TechnologyKopernikusgasse 24/IGraz 8010Austria tyrolit-Schleifmittelwerke Swarovski K.G. Swarovskistraße 33Schwaz 6130Austria

In this work,we present a fully atomistic approach to modeling a finishing process with the goal to shed light on aspects of work piece development on the microscopic scale,which are difficult or even impossible to observe in experiments,but highly relevant for the resulting material *** a large-scale simulative parametric study,we varied four of the most relevant grinding parameters:the work piece material,the abrasive shape,the temperature,and the infeed *** order to validate our model,we compared the normalized surface roughness,the power spectral densities,the steady-state contact stresses,and the microstructure with proportionally scaled macroscopic experimental *** the grain sizes vary by a factor of more than 1,000 between experiment and simulation,the characteristic process parameters were reasonably reproduced,to some extent even allowing predictions of surface quality degradation due to tool *** the experimentally validated model,we studied time-resolved stress profiles within the ferrite/steel work piece as well as maps of the microstructural changes occurring in the near-surface *** found that blunt abrasives combined with elevated temperatures have the greatest and most complex impact on near-surface microstructure and stresses,as multiple processes are in mutual competition here.

关键词： large-scale molecular dynamics surface quality microstructure Revolutions per minute-Synchronous Grinding(RPM-Synchronous Grinding) tool wear

Significance of feeding dysfunction in eosinophilic esophagitis

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World Journal of Gastroenterology 2014年第31期20卷 11019-11022页

作者： Calies Menard-Katcher Michelle Henry Glenn t Furuta Dan Atkins Nancy Creskoff Maune Angela M haas Department of Pediatrics Digestive Health Institute Section of Pediatric Gastroenterology Hepatology and Nutrition Children’s Hospital Colorado Gastrointestinal Eosinophilic Diseases Program University of Colorado School of MedicineAurora CO 80045 United States Department of Clinical Nutrition Children’s Hospital Colorado Gastrointestinal Eosinophilic Diseases ProgramAurora CO 80045 United States Department of Pediatrics Digestive Health Institute Section of Pediatric Gastroenterology Hepatology and Nutrition Children’s Hospital Colorado Gastrointestinal Eosinophilic Diseases Program Mucosal Inflammation Program University of Colorado School of MedicineAurora CO 80045 United States Section of Pediatric Allergy Children’s Hospital Colorado Gastrointestinal Eosinophilic Diseases Program Department of Pediatrics University of Colorado School of MedicineAurora CO 80045 United States Department of Occupational therapy Children’s Hospital ColoradoAurora CO80045 United States Department of Audiology Speech-Language Pathology Learning Services Children’s Hospital Colorado Aurora CO 80045 United States

Feeding dysfunction is a frequent presenting symptom of eosinophilic esophagitis(EoE). Here we present 3 children of various ages whose manifestations of EoE associated feeding dysfunction led to significant and life altering impact on their growth and development. Early identification of presenting symptoms of EoE will allow for prompt diagnosis and initiation of appropriate treatments. Recognition of salient features of dysfunction and treatment by feeding therapists and nutritionists led to symptom resolution and growth.

关键词： Eosinophilic esophagitis Eosinophilic oesophagitis Feeding dysfunction Feeding therapy oral motor skills Mealtime dynamics Esophagitis Oesophagitis

translational research in pancreatic ductal adenocarcinoma: current evidence and future concepts

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World Journal of Gastroenterology 2014年第31期20卷 10769-10777页

作者： Stephan Kruger Michael haas Steffen Ormanns Sibylle Bchmann Jens t Siveke thomas Kirchner Volker Heinemann Stefan Boeck Department of Internal Medicine Ⅲ and Comprehensive Cancer Center Klinikum Grosshadern Ludwig-Maximilians-University of Munich Department of Pathology Ludwig-Maximilians-University of Munich Department of Internal Medicine Ⅱ Klinikum Rechts der Isar Technical University of Munich

Pancreatic ductal adenocarcinoma(PDA) is one of the major causes for cancer death worldwide. treatment of metastatic disease remains challenging as only certain patients benefit from advances made with the intensified chemotherapy regimen folinic acid, irinotecan and oxaliplatin, the epidermal growth factor receptor inhibitor erlotinib or the recently FDA-approved nab-paclitaxel. Up to date, no established approach for prediction of treatment response or specific treatment allocation exists. translational research was able to identify a number of potential biomarkers that might help to improve the dismal prognosis of PDA by facilitating upfront treatment allocation. this topic highlight is focused on current evidence on potential biomarkers for tumor biology, prognosis and prediction of treatment efficacy.

关键词： Biomarker Erlotinib Gemcitabine Human equilibrative nucleoside transporter 1 KRAS Nab-paclitaxel p53 Pancreatic cancer SMAD4 SPARC

Disposition and Metabolism of 1 -Nitropropane in Rats and Chimpanzees

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Biomedical and Environmental Sciences 1989年第3期2卷 249-264页

作者： MARGREt.haas-JOBELIUS FRIEDHELM KORtE F.COULStON Gesellschaft Gesellschaft technische Universit t München Institut für Chemie Lehrstuhl für kologische Chemie Am L wentor D-8050 FreisingWeihenstephan Federal Republic of Germany and White Sands Research Center 2512 Christina Place Alamogordo New Mexico 88310 für Strahlen-und Umweltforschung mbH München Institut für kologische Chemie Ingolst dter Landstrasse 1 D-8042 Neuherberg Federal Republic of Germany

the metabolic fate of 1 -nitropropane (1-NP) has not been previously reported. In this study male rats and chimpanzees were given single doses of 40 mg/kg ip and 5 mg/kg iv 1-[1-^(14)C]NP, respectively. the quantitative extent of urinary and fecal elimination was similar in both species. the rats excreted 16.5% ofthedosein urine and 1.7% in feces. For chimpanzees the respective values were 14.8 and 1.2%. Experiments with rats demonstrated that the major route of elimination was by exhalation. With a total elimination via the lungs of 72.6%, rats expired 10.3% of the dose as unchanged 1-NP. Five polar metabolites were isolated from the urine of chimpanzees. the two major metabolites were identified as 3-hydroxypropionic acid and 7V-methyl-N-2-(methylsulfinyl)ethylpropionic acid amide (NMPA). Both substances were also excreted in rat urine. the two identified metabolites indicate that 1-NP was degraded to propionic acid, part of which was modified to 3-hydroxypropionic acid or NMPA. A hypothetical pathway for the biochemical generation of NMPA is suggested.(c)1989 Academic Press, Inc.

关键词： ppm Nitropropane in Rats and Chimpanzees Disposition and Metabolism of 1

Characterisation of Real-World Bus Acceleration and Deceleration Signals

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Journal of Signal and Information Processing 2014年第1期5卷 8-13页

作者： Marietta Kirchner Patric Schubert Christian t. haas Faculty of Health and Social Sciences Institute of Complex Health Research Fresenius University of Applied Sciences Idstein Germany

Public transportation by bus is an essential part of mobility. Braking and starting, e.g., approaching a bus stop, are documented as the main reason for non-collision incidents. these situations are evoked by the acceleration forces leading to perturbations of the passenger’s base of support. In laboratory studies perturbations are applied to getting insight into the postural control system and neuromuscular responses. However, bus perturbations diverge from laboratory ones with respect to duration, maximum and shape, and it was shown recently that these characteristics influence the postural response. thus, results from posturographic studies cannot be generalised and transferred to bus perturbations. In this study, acceleration (ACC) and deceleration (DEC) signals of real traffic situations were examined. A mathematical approach is proposed in order to identify characteristics of these signals and to quantify their similarity and complexity. typical characteristics (duration, maximum, and shape) of real-world driving manoeuvres concerning start and stop situations could be identified. A mean duration of 13.6 s for ACC and 9.8 s for DEC signals was found which is clearly longer than laboratory perturbations. ACC and DEC signals are more complex than the used signals for platform displacements in the laboratory. the proposed method enables the reconstruction of bus ACC and DEC signals. the data can be used as input for studies on postural control with high ecological validity.

关键词： Bus Acceleration Signal Complexity Index Similarity Legendre Polynomials Postural Control Perturbation Ecological Validity

About the structure of posturography: Sampling duration, parametrization, focus of attention (part II)

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Journal of Biomedical Science and Engineering 2012年第9期5卷 508-516页

作者： Patric Schubert Marietta Kirchner Dietmar Schmidtbleicher Christian t. haas Institute of Sport Sciences Johann Wolfgang Goethe University Frankfurt am Main Germany

there exists a great variety of posturographic parameters which complicates the evaluation of center of pressure (COP) data. Hence, recommendations were given to use a set of complementary parameters to explain most of the variance. However, it is unknown whether a dual task paradigm leads to different parametrization sets. On account of this problem an exploratory factor analysis approach was conducted in a dual task experiment. 16 healthy subjects stood on a force plate performing a posture-cognition dual task (Dt, focus of attention on a secondary task) with respect to different sampling durations. the subjects were not aware of being measured in contrast to a baseline task condition (Bt, internal focus of attention) in the previously published part I. In compareson to Bt a different factor loading pattern appears. In addition, factor loadings are strongly affected by different sampling durations. Dt reveals a change of factor loading structure with longer sampling durations compared to Bt. Specific recommendations concerning a framework of posturographic parametrization are given.

关键词： Center of Pressure Sample Duration Posturographic Parameters Exploratory Factor Analysis Nonlinear Methods Dual-task Focus of Attention

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南极威德尔海冬季冰脊形拖曳力

水科学进展 2012年第6期23卷 869-874页

作者：谭冰卢鹏李志军 haas Christian NICOLAUS Marcel 大连理工大学海岸和近海工程国家重点实验室南阳师范学院数学与统计学院 Department of Earth and Atmospheric Sciences University of AlbertaEdmonton T6G 2E3Canada Alfred Wegener Institute for Polar and Marine Research Bremerhaven 24 27570Germany

利用2006年南极威德尔海冬季科学考察期间由机载激光高度计测得的海冰上表面形态数据,以拖曳分割理论为基础研究了冰脊形拖曳力及其对冰-气总拖曳力的贡献以及中性条件下对应10 m高度处风速的冰-气拖曳系数Cdn(10)。结果显示,在密集冰区... 详细信息

利用2006年南极威德尔海冬季科学考察期间由机载激光高度计测得的海冰上表面形态数据,以拖曳分割理论为基础研究了冰脊形拖曳力及其对冰-气总拖曳力的贡献以及中性条件下对应10 m高度处风速的冰-气拖曳系数Cdn(10)。结果显示,在密集冰区,冰脊形拖曳力及其对总拖曳力的贡献随冰脊强度(脊高/脊距)的增大呈递增趋势,而随粗糙长度的增大而减小,对应于威德尔海冬季典型冰脊强度和粗糙长度,占总拖曳力的35%,说明了冰脊形拖曳力在冰-气界面动量交换中的重要作用。Cdn(10)随冰脊强度的增大而增大,但冰脊强度较小时,Cdn(10)随粗糙长度增大而增大;而对较大的冰脊强度,Cdn(10)则随粗糙长度增大而减小。

关键词：南极冰脊形拖曳力拖曳系数威德尔海