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Distribution of trace metal concentrations in paired cancerous and non-cancerous human stomach tissues

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World Journal of Gastroenterology 2007年第4期13卷 612-618页

作者： Mehmet Yaman gokce Kaya Hayrettin Yekeler Firat University Sciences and Arts Faculty Chemistry Department Elazig Turkey Chief of Staff in State Hospital Elazig Turkey

AIM: to assess whether trace metal concentrations (which influence metabolism as both essential and non-essential elements) are increased or decreased in cancerous tissues and to understand the precise role of these metals in carcinogenesis. MEtHODS: Concentrations of trace metals including Cd, Ni, Cu, Zn, Fe, Mg and Ca in both cancerous and non- cancerous stomach tissue samples were determined by atomic absorption spectrometry (AAS). tissue samples were digested using microwave energy. Slotted tube atom trap was used to improve the sensitivity of copper and cadmium in flame AAS determinations. RESULtS: From the obtained data in this study, the concentrations of nickel, copper and iron in the cancerous human stomach were found to be significantly higher than those in the non-cancerous tissues, by using t-test for the paired samples. Furthermore, the average calcium concentrations in the cancerous stomach tissue samples were found to be significantly lower than those in the non-cancerous stomach tissue samples by using t-test. Exceedingly high Zn concentrations (207-826 mg/ kg) were found in two paired stomach tissue samples from both cancerous and non-cancerous parts. CONCLUSION: In contrast to the literature data for Cu and Fe, the concentrations of copper, iron and nickel in cancerous tissue samples are higher than those in the non-cancerous samples. Furthermore, the Ca levels are lower in cancerous tissue samples than in non-cancerous tissue samples.

关键词： Cancer trace metals Human stomach Microwave energy Atomic absorption

Evaluation of ischemic lesions after carotid artery stenting with diffusion-weighted imaging

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World Journal of Clinical Cases 2020年第10期8卷 1859-1870页

作者： Murat Beyhan Berat Acu Erkan gokce Mehmet Murat Firat Department of Radiology Tokat Gaziosmanpasa University Faculty of MedicineTokat 60100Turkey Department of Radiology Eskisehir Osmangazi University Faculty of MedicineEskisehir 26480Turkey Department of Radiology Guven HospitalAnkara 06540Turkey

BACKGROUND Almost 90%of cerebral thromboembolism cases are caused by *** atherosclerosis is often observed at the carotid bifurcation and is responsible for 20%-30%of all stroke *** course of atherosclerotic carotid artery stenosis varies depending on the grade of stenosis and characteristics of the *** artery stenting(CAS)can be used as a less invasive method in patients with symptomatic and asymptomatic high-grade carotid artery ***-weighted imaging(DWI)is an effective method for detection of silent or symptomatic acute ischemic lesions that may arise due to CAS or carotid *** number and volume of new ischemic lesions are determined using *** to evaluate the number and volume of ischemic lesions and their cerebral parenchymal and vascular distribution after CAS using *** Forty-seven male(73.4%)and seventeen female(26.6%)patients(total,n=64)aged 42-84 years(mean 67.96±8.03 years)diagnosed with carotid stenosis between October 2006 and July 2012 were included in this retrospective *** of the cases(18.8%)were asymptomatic,while fifty-two(81.2%)were *** area where the stenosis was highest was measured,and the stenosis rate was determined using the North American Symptomatic Carotid Endarterectomy trial *** of the cases was evaluated by two radiologists experienced in neuroradiology(*** more than 15 years of experience,*** more than 10 years of experience).Routine DWI examinations were carried out by a 1.5 t MR device 1 h before and after the *** the ischemic lesions that developed in the first hour and in the follow-up period of 5-24 h were assumed to be due to CAS,all lesions within the first 24 h were considered as new *** In the present study,39 new ischemic lesions were detected in 20 *** average number of new lesions after all CAS operations was *** were mostly located in the occipital lobes,followed by

关键词： Carotid artery stenosis Carotid artery stenting Diffusion-weighted imaging Ischemia Stroke

Comment on survival analysis following early surgical success in intermittent exotropia surgery

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International Journal of Ophthalmology(English edition) 2016年第10期9卷 1532-1534页

作者： Onder Ayyildz Gokhan Ozge Cem Ozgonul gokcen gokce Fatih Mehmet Mutlu Department of Ophthalmology Gulhane Military Medical School Ankara 06010 Turkey Department of Ophthalmology Van Military Hospital Van65100 Turkey Department of Ophthalmology Kayseri Military HospitalKayseri 38100 Turkey

Dear Editor,We read the article by Lee et al with great *** would like to congratulate the authors for venturing into this area that assess the consecutive recurrence following early success of intermittent exotropia[X（t）]surgery and to determine the clinical factors that affect the ***,we would like to make the following *** the present study,it was discussed about the correlation of early postoperative overcorrection with long-term outcomes.

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Evaluation of pineal cysts with magnetic resonance imaging

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World Journal of Radiology 2018年第7期10卷 65-77页

作者： Erkan gokce Murat Beyhan Department of Radiology Gaziosmanpasa Uni-versitySchool of Medicine Department of Radiology Tokat State Hospital

AIM to evaluate radiological imaging findings of patients who had been found to have pineal cyst(PC) in brain magnetic resonance imaging(MRI).MEtHODS A total of 9546 patients who had brain MRI examination in March 2010-January 2018 period were *** patients(44 female and 12 male) found to have PC were *** of the patients had had follow-up examinations of 2-94 mo(mean 30.50 ± 28.83).PC dimensions and volume,radiological imaging features(signal intensities,contours,internal septationloculation and contrast-enhancement features) and natural history in cases who had been followed-up were evaluated by two *** Of 9546 patients,5555 were female(58.2%) and 3991 male(41.8%).Age range was 1-99(mean 43.18 ± 20.94).PC frequency was calculated to be 0.58%.Forty-four of the 56 patients(78.57%) with PC were female and 12 male(21.43%),and their age range was 5-61(mean 31.26 ± 12.73).thirty-five of the PCs were typical(62.50%) and 21(37.50%) were *** significant difference was found between initial and final imaging sizes of PCs which were monitored by follow-up examinations(P > 0.05).CONCLUSION PCs are cysts which do not show clear size and natural changes and are more frequently observed in females and in adult *** of them are isointense with cerebrospinal fluid on t1 and t2 A weighted images,hyperintense compared to cerebrospinal fluid on fluidattenuated inversion recovery; sequence and smoothly *** typical forms have peripheral rim and multilocular ones may have septal contrast-enhancement.

关键词： Magnetic resonance imaging Pineal cyst Pineal region

A targetable pathway to eliminate tRA-1-60^(+)/tRA-1-81^(+)chemoresistant cancer cells

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Journal of Molecular Cell Biology 2023年第6期15卷 25-39页

作者： Lei tan Xiaohua Duan Pratyusha Mutyala ting Zhou Sadaf Amin tuo Zhang Brian Herbst.gokce Askan tomer Itkin Zhaoying Xiang Fabrizio Michelassi Michael D.Lieberman Christine AIacobuzio-Donahue Steven DLeach todd Evans Shuibing Chen Department of Surgery Weill Cornell MedicineNew YorkNY 10065USA Center for Energy Metabolism and Reproduction Institute of Biomedicine and BiotechnologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Center for Genomic Health Weill Cornell MedicineNew YorkNY 10065USA the SKI Stem Cell Research Facility The Center for Stem Cell Biology and Developmental Biology ProgramMemorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Genomic Resource Core Facility Weill Cornell Medical CollegeNew YorkNY 10065USA Rubenstein Center for Pancreatic Cancer Research Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Division of Regenerative Medicine Hartman Institute for Therapeutic Organ RegenerationAnsary Stem Cell InstituteDepartment of MedicineWeill Cornell MedicineNew YorkNY 10065USA Dartmouth Cancer Center Darmouth CollegeHanoverNH 03755USA

Chemoresistance is a primary cause of treatment failure in pancreatic *** cell surface markers specifically expressed in chemoresistant cancer cells(CCCs)could facilitate targeted therapies to overcome *** performed an antibody-based screen and found that tRA-1-60 and tRA-1-81,two‘stemness’cell surface markers,are highly enriched in ***-more,tRA-1-60^(+)/tRA-1-81^(+)cells are chemoresistant compared to tRA-1-60^(-)/tRA-1-81^(-)*** profiling identified UGt1A10,shown to be both necessary and sufficient to maintain tRA-1-60/tRA-1-81 expression and *** a high-content chemical screen,we identified Cymarin,which downregulates UGt1A10,eliminates tRA-1-60/tRA-1-81 expression,and increases chemosensitivity both in vitro and in ***,tRA-1-60/tRA-1-81 expression is highly specific in primary cancer tissue and positively correlated with chemoresistance and short survival,which highlights their potentiality for targeted ***,we discovered a novel CCC surface marker regulated by a pathway that promotes chemoresistance,as well as a leading drug candidate to target this pathway.

关键词： pancreatic cancer tRA-1-60/tRA-1-81 chemoresistance UGt1A10 Cymarin