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Magnetotelluric investigation of lithospheric electrical structure beneath the Dharwar Craton in south India:Evidence for mantle suture and plume-continental interaction

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Geoscience Frontiers 2019年第5期10卷 1915-1930页

作者： D. Malleswari K. Veeraswamy K.K. Abdul Azeez A.K. Gupta Narendra Babu Prasanta K. Patro t. Harinarayana Mt Group CSIR - National Geophysical Research InstituteHyderabadIndia Crescent Institute of Science and technology ChennaiIndia

Broad-band and long period magnetotelluric measurements made at 63 locations along -500 km long Chikmagalur-Kavali profile,that cut across the Dharwar craton (DC) and Eastern Ghat Mobile Belt (EGMB) in south India,is modelled to examine the lithosphere architecture of the cratonic domain and define tectonic *** 2-D resistivity model shows moderately conductive features that intersperse a highly resistive background of crystalline rocks and spatially connect to the exposed schist belts or granitic intrusions in the *** features are therefore interpreted as images of fossil pathways of the volcanic emplacements associated with the greenstone belt and granite suite formation exposed in the region.A near vertical conductive feature in the upper mantle under the Chitradurga Shear Zone represents the Archean suture between the western and eastern blocks of *** thick (-200 km) cratonic (highly resistive) lithosphere is preserved,significant part of the cratonic lithosphere below the western DC is modified due to plume-continental lithosphere interactions during the Cretaceousetertiary period.A west-verging moderately conductive feature imaged beneath EGMB lithosphere is interpreted as the remnant of the Proterozoic collision process between the Indian land mass and East *** (-120 km) lithosphere is seen below the EGMB,which form the exterior margin of the India shield subsequent to its separation from East Antarctica through rifting and opening of the Indian Ocean in the Cretaceous.

关键词： Magnetotelluric Lithospheric structure Mantle plume Mantle suture Dharwar craton

Update on biologic therapies for juvenile idiopathic arthritis-associated uveitis

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Annals of Eye Science 2021年第2期6卷 78-88页

作者： Joanne thomas Sanjana Kuthyar Jessica G.Shantha Sheila t.Angeles-Han Steven Yeh Medical College of Georgia AugustaGAUSA Emory Eye Center Emory University School of MedicineAtlantaGAUSA Division of Rheumatology Cincinnati Children’s Hospital Medical CenterCincinnatiOHUSA

Juvenile idiopathic arthritis(JIA)is the most common rheumatic disease of childhood,and juvenile idiopathic associated uveitis(JIA-U)is the most frequently noted extra-articular ***-U can present asymptomatically and lead to ocular complications,so regular screening and monitoring are needed to prevent potentially sight-threatening *** glucocorticoids such as prednisolone acetate are usually the first line of treatment for anterior uveitis associated with JIA-U,but long-term use may be associated with cataract,ocular hypertension and *** modifying anti-rheumatic drugs(DMARDs)such as methotrexate allow tapering of the corticosteroids to prevent long-term *** therapies have been increasingly used as targeted therapies for JIA-U,particularly monoclonal antibodies targeting the proinflammatory cytokine tNF-αsuch as adalimumab and *** recent,multicenter,prospective,randomized clinical trial provided evidence of the efficacy of adalimumab with methotrexate for JIA-U compared to methotrexate *** clinical trial studying the interleukin-6 inhibitor tocilizumab for JIA-U showed promise in tapering topical ***,JAK inhibitors are emerging biologic therapies for JIA-U in patients refractory to tNF-αinhibitors,with a clinical trial assessing the efficacy of baricitinib for JIA-U *** clinical trials on these novel biologics are limited,further investigation of these agents may provide additional therapeutic options for JIA-U.

关键词： Juvenile idiopathic arthritis(JIA) uveitis biologics tumor necrosis factor alpha uveitis pediatric uveitis JAK inhibitor

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大逆袭！多肉就这么玩

作者：阿t

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向戴尔·卡耐基学做人

作者：云中t

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正交异性钢桥面板冷维护技术及评价方法

中国公路学报 2016年第8期29卷 50-58页

作者：王春生翟慕赛 HOUANKPO t N O 唐友明长安大学公路学院陕西西安710064 长安大学公路大型结构安全教育部工程研究中心陕西西安710064

为保证正交异性钢桥面板使用安全,合理延长其使用寿命与维护周期,在剖析疲劳损伤传统热维护技术方法不足的基础上,提出冷连接钢板、超高性能纤维混凝土组合层等具有零损伤或微损伤维护技术特征的冷维护方法,对钢桥面板疲劳开裂细节进行... 详细信息

为保证正交异性钢桥面板使用安全,合理延长其使用寿命与维护周期,在剖析疲劳损伤传统热维护技术方法不足的基础上,提出冷连接钢板、超高性能纤维混凝土组合层等具有零损伤或微损伤维护技术特征的冷维护方法,对钢桥面板疲劳开裂细节进行加固;开展正交异性钢桥面板足尺模型疲劳试验研究,分别采用止裂孔和粘贴钢板法维护纵肋拼接细节疲劳裂纹,将冷维护方法应用于某钢箱梁斜拉桥正交异性钢桥面板,对横隔板挖孔细节、纵肋与横隔板连接细节采用等边角钢进行加固,分别采用车辆加载测试、运营监测和数值断裂力学模拟等方法,对实桥正交异性钢桥面板冷维护效果进行评价。试验结果表明:止裂孔无法阻止裂纹扩展,而采用冷维护后钢板与纵肋协同工作状态良好,纵肋拼接细节疲劳寿命延长70%以上;实桥加载测试结果表明冷维护后疲劳裂纹尖端测试应力降低40.4%;根据动应变监测数据和S-N曲线评估结果,24h内横隔板开裂细节疲劳损伤降低79.6%;数值断裂力学分析表明冷维护后裂尖应力强度因子幅小于裂纹扩展的应力强度因子幅阈值,疲劳裂纹不再扩展;正交异性钢桥面板疲劳损伤冷维护技术工程可实施性强、安全可靠,可实现对原结构进行零损伤或微损伤维护的技术目标,为钢桥面板疲劳维护提供了新的技术选择。

关键词：桥梁工程正交异性钢桥面板疲劳试验冷维护技术冷连接钢板超高性能纤维混凝土组合层

Drought shifts soil nematode trophic groups and mediates the heterotrophic respiration

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Journal of Plant Ecology 2024年第2期17卷 100-109页

作者： Cancan Zhao Yuanhu Shao Huijie Lu Aimée t.Classen Zuyan Wang Ying Li Yanchun Liu Zhongling Yang Guoyong Li Shenglei Fu International Joint Research Laboratory for Global Change Ecology School of Life SciencesHenan UniversityKaifeng 475004China Henan Dabieshan National Field Observation and Research Station of Forest Ecosystem Zhengzhou 450046China Key Laboratory of Geospatial technology for the Middle and Lower Yellow River Regions Ministry of EducationCollege of Environment and PlanningHenan UniversityKaifeng 475004China Henan Key Laboratory of Integrated Air Pollution Control and Ecological Security Kaifeng 475004China Department of Ecology and Evolutionary Biology University of MichiganAnn ArborMI 48109USA South China Botanical Garden Chinese Academy of SciencesGuangzhou 510650China Department of Natural Resource of Henan Province Institute of Natural Resources Survey and PlanningZhengzhou 450000China

As the most diverse metazoan taxa,soil nematodes serve a diversity of functions in soil food webs and thus can regulate microbial community composition and affect organic matter decomposition and nutrient turnover *** nematodes depend on water flms to access food resources,drought can negatively affect nematode-microbial food webs,yet the impacts of drought on nematode diversity and abundance and how these changes may infuence food web members and their functions are hardly ***,we coupled research along a drought gradient in arid and semiarid grasslands with a detailed intact plant-soil microcosm experiment to explore the patterns and mechanisms of how drought impacts nematode abundance and carbon footprint,microbial phospholipid fatty acid(PLFA)and heterotrophic soil ***,in the feld and the microcosm experiments,we found that nematode abundance,carbon footprint and diversity,microbial PLFA and heterotrophic respiration were reduced under drier *** addition,drought altered nematode and microbial community composition,through reducing the nematode channel ratio and increasing the relative fungivorous nematode abundance and the fungal to bacterial *** soil decomposition channel shifted from a bacterial to a fungal pathway in response to drought,indicating decelerated heterotrophic respiration under *** results highlight the important contribution of soil nematodes and their associated microbial food web to soil carbon *** fndings underscore the need to incorporate key soil fauna into terrestrial ecosystem model evaluation.

关键词： soil biota fungal energy channel bacterial energy channel carbon footprint arid grassland

A validated stability-indicating LC method for the separation of enantiomer and potential impurities of Linezolid using polar organic mode

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Journal of Pharmaceutical Analysis 2012年第4期2卷 272-278页

作者： t.Satyanarayana Raju O.Vishweshwari Kutty V.Ganesh P.Yadagiri Swamy Dr.Reddy's Laboratories Ltd.Active Pharmaceutical Ingredients IPDOBachupallyHyderabad 500072A.PIndia Department of Chemistry University College of EngineeringOsmania University

Although a number of methods are available for evaluating Linezolid and its possible impurities, a common method for separation if its potential impurities, degradants and enantiomer in a single method with good efficiency remain unavailable. With the objective of developing an advanced method with shorter runtimes, a simple, precise, accurate stability-indicating LC method was developed for the determination of purity of Linezolid drug substance and drug products in bulk samples and pharmaceutical dosage forms in the presence of its impurities and degradation products. this method is capable of separating all the related substances of Linezolid along with the chiral impurity. this method can also be used for the estimation of assay of Linezolid in drug substance as well as in drug product. the method was developed using Chiralpak IA (250 mm 4.6 mm, 5 mm) column. A mixture of acetonitrile, ethanol, n-butyl amine and trifluoro acetic acid in 96:4:0.10:0.16 (v/v/v/v) ratio was used as a mobile phase. the eluted compounds were monitored at 254 nm. Linezolid was subjected to the stress conditions of oxidative, acid, base, hydrolytic, thermal and photolytic degradation. the degradation products were well resolved from main peak and its impurities, proving the stability-indicating power of the method. the developed method was validated as per International Conference on Harmonization (ICH) guidelines with respect to specificity, limit of detection, limit of quantification, precision, linearity, accuracy, robustness and system suitability.

关键词： HPLC Linezolid Validation Polar organic mode Stability-indicating

Fucoidan and topography modification improved in situ endothelialization on acellular synthetic vascular grafts

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Bioactive Materials 2023年第4期22卷 535-550页

作者： Yuan Yao Aung Moe Zaw Deirdre E.J.Anderson YeJin Jeong Joshua Kunihiro Monica t.Hinds Evelyn K.F.Yim Department of Chemical Engineering University of Waterloo200 University Avenue WestWaterlooONN2L 3G1Canada Department of Biomedical Engineering Oregon Health&Science UniversityPortlandOR97239USA Waterloo Institute for Nanotechnology University of Waterloo200 University Avenue WestWaterlooONN2L 3G1Canada Center for Biotechnology and Bioengineering University of Waterloo200 University Avenue WestWaterlooONN2L 3G1Canada

thrombogenesis remains the primary failure of synthetic vascular *** coverage is crucial to provide an antithrombogenic ***,most synthetic materials do not support cell adhesion,and transanastomotic endothelial migration is ***,a surface modification strategy using fucoidan and topography was developed to enable fast in situ endothelialization of polyvinyl alcohol,which is not endothelial *** three different immobilization approaches compared,conjugation of aminated-fucoidan promoted endothelial monolayer formation while minimizing thrombogenicity in both in vitro platelet rich plasma testing and ex vivo non-human primate shunt *** of six topographical patterns showed that 2μm gratings increased endothelial cell migration without inducing inflammation responses of endothelial *** studies demonstrated that fucoidan could attract fibronectin,enabling integrin binding and focal adhesion formation and activating focal adhesion kinase(FAK)signaling,and 2μm gratings further enhanced FAK-mediated cell *** a clinically relevant rabbit carotid artery end-to-side anastomosis model,60%in situ endothelialization was observed throughout the entire lumen of 1.7 mm inner diameter modified grafts,compared to 0%of unmodified graft,and the four-week graft patency also *** work presents a promising strategy to stimulate in situ endothelialization on synthetic materials for improving long-term performance.

关键词： Blood-contacting devices Small diameter vascular graft Endothelialization topography Fucoidan

SARS-CoV 2 infections and attitudes towards COVID-19 vaccines among healthcare workers in the New York Metropolitan area,USA

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Family Medicine and Community Health 2022年第3期10卷 27-38页

作者： Israel t Agaku Alisa Dimaggio Avigal Fishelov Alianne Brathwaite Saief Ahmed Michelle Malinowski theodore Long Oral Health Policy and Epidemiology Harvard School of Dental MedicineBostonMassachusettsUSA COVID-19 test and trace Corps New YorkNew YorkUSA

Objective Because of their increased interaction with patients,healthcare workers(HCWs)face greater vulnerability to COVID-19 exposure than the general *** examined prevalence and correlates of ever COVID-19 diagnosis and vaccine uncertainty among *** Cross-sectional data from the Household Pulse Survey(HPS)conducted during July to October *** HPS is designed to yield representative estimates of the US population aged≥18 years nationally,by state and across selected metropolitan *** Our primary analytical sample was adult HCWs in the New York Metropolitan area(n=555),with HCWs defined as individuals who reported working in a‘Hospital’;‘Nursing and residential healthcare facility’;‘Pharmacy’or‘Ambulatory healthcare setting’.In the entire national sample,n=25909 HCWs completed the *** analyses were performed with HCW data from the New York Metropolitan area,the original epicentre of the *** logistic regression analyses were performed on pooled national HCW data to explore how HCW COVID-19-related experiences,perceptions and behaviours varied as a function of broader geographic,clinical and sociodemographic *** Of HCWs surveyed in the New York Metropolitan area,92.3%reported being fully vaccinated,and 20.9%had ever been diagnosed of *** the subset of HCWs in the New York Metropolitan area not yet fully vaccinated,41.8%were vaccine unsure,4.5%planned to get vaccinated for the first time soon,1.6%had got their first dose but were not planning to receive the remaining dose,while 52.1%had got their first dose and planned to receive the remaining *** pooled multivariable analysis of the national HCW sample,personnel in nursing/residential facilities were less likely to be fully vaccinated(adjusted OR,AOR 0.79,95%CI 0.63 to 0.98)and more likely to report ever COVID-19 diagnosis(AOR 1.35,95%CI 1.13 to 1.62),than those working in *** HCWs not yet vaccinated

关键词： Pharmacy likely workers