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Crushing and embedment of proppant packs under cyclic loading: An insight to enhanced unconventional oil/gas recovery

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Geoscience Frontiers 2021年第6期12卷 376-393页

作者： K.M.A.S.Bandara P.G.Ranjith t.d.rathnaweera W.A.M.Wanniarachchi S.Q.Yang department of Civil Engineering Monash UniversityBuilding 60MelbourneVictoria3800Australia State Key Laboratory for Geomechanics and deep Underground Engineering School of Mechanics and Civil EngineeringChina University of Mining and TechnologyXuzhou 221116China

Crushing and embedment are two critical downhole proppant degradation mechanisms that lead to a significant drop in production outputs in unconventional oil/gas stimulation projects. these persistent production drops due to the non-linear responses of proppants under reservoir conditions put the future utilization of such advanced stimulation techniques in unconventional energy extraction in doubt. the aim of this study is to address these issues by conducting a comprehensive experimental approach. According to the results, whatever the type of proppant, all proppant packs tend to undergo significant plastic deformation under the first loading ***, the utilization of ceramic proppants(which retain proppant pack porosity up to 75%), larger proppant sizes(which retain proppant pack porosity up to 15.2%) and higher proppant concentrations(which retain proppant pack porosity up to 29.5%) in the fracturing stimulations with higher in-situ stresses are recommended to de-escalate the critical consequences of crushing associated issues. Similarly, the selection of resin-coated proppants over ceramic and sand proppants may benefit in terms of obtaining reduced proppant *** addition, selection of smaller proppant sizes and higher proppant concentrations are suggested for stimulation projects at depth with sedimentary formations and lower in-situ stresses where proppant embedment predominates. Furthermore, correlation between proppant embedment with repetitive loading cycles was ***, microstructural analysis of the proppant-embedded siltstone rock samples revealed that the initiation of secondary induced fractures. Finally, the findings of this study can greatly contribute to accurately select optimum proppant properties(proppant type, size and concentration) depending on the oil/gas reservoir characteristics to minimize proppant crushing and embedment effects.

关键词： Proppant Micro-Ct analysis Proppant crushing Proppant embedment Secondary induced fractures Cyclic loading

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Experimental study on the influence of temperature cycle on low-rank coal permeability

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Science China(technological Sciences) 2020年第6期63卷 1055-1065页

作者： ZOU JunPeng JIAO YuYong rathnaweera t d WANG Hao Faculty of Engineering China University of GeosciencesWuhan 430074China department of Civil Engineering Monash UniversityMelbourne VIC 3800Australia State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan 430071China

the formation temperature is a key factor affecting coalbed methane(CBM)migration in *** the prediction of CBM production and prevention of mine gas disasters require the understanding on the controlling mechanism of temperature on coal *** experimentally examined the evolution of permeability for natural low-rank coal samples under various stresses and cyclic temperature *** permeability and intrinsic permeability decrease significantly when the temperature increases and they only partially recover after the temperature *** permeability loss decreases greatly with the increasing number of temperature *** permeability loss due to the rising temperature and the irreversible permeability loss for a whole temperature cycle decrease prominently with increasing confining *** impacts of swelling/shrinking of coal matrix,roughness of surface,pore compressibility and weakly bound water in coal on temperature sensitivity of coal permeability are investigated.

关键词： low-rank coal permeability temperature cycle temperature sensitivity

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未固结流砂地层采油过程中出砂情况模拟实验

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石油勘探与开发 2017年第5期44卷 811-816页

作者： PERERA M S A RANJItH P G rathnaweera t d dE SILVA G P d LIU t department of Civil Engineering Monash University department of Infrastructure Engineering The University of Melbourne

为了研究未固结流砂储集层在采油过程中的出砂情况和影响出砂的主要因素,进行了不同条件下的出砂过程模拟实验。使用水洗白砂、黏土(高岭土)和蒸馏水制成未固结流砂地层模型,利用新开发的出砂模拟装置进行了模拟实验,并分析了作用于地... 详细信息

为了研究未固结流砂储集层在采油过程中的出砂情况和影响出砂的主要因素,进行了不同条件下的出砂过程模拟实验。使用水洗白砂、黏土(高岭土)和蒸馏水制成未固结流砂地层模型,利用新开发的出砂模拟装置进行了模拟实验,并分析了作用于地层的拖曳力和地层胶结特征对出砂的影响。研究表明,随着拖曳力的增加,出砂速度和产油速度都加快;随着胶结物含量的增加,出砂量和产油量明显降低,甚至在胶结物含量较高的情况下出砂量几乎为零。地层压力大的油藏在开采期间由于产生了较大的拖曳力更可能出砂,而拖曳力和有效地层应力共同影响油藏的总体产油量。可以根据地层黏土含量估计出砂情况,从而通过采取适当的防砂措施尽可能减少出砂量。某些情况下油藏比气藏更容易出砂。

关键词：流砂地层出砂采油工艺黏土含量胶结程度拖曳力

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Cytomorphological Variations of Leishman-donovan Bodies Found in Cutaneous Leishmaniasis Patients in Sri Lanka

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Infectious Microbes & diseases 2023年第2期5卷 93-100页

作者： Arumugam Murugananthan Kanchana P.Amarasinghe Gayanie W.rathnaweera Ponnathurai t.Amalraajan Rajadurai Arulenthiran department of Parasitology Faculty of MedicineUniversity of JaffnaJaffnaSri Lanka department of Zoology Faculty of ScienceUniversity of JaffnaJaffnaSri Lanka dermatology Unit National HospitalColomboSri Lanka.

Leishmania parasites undergo a dimorphic life *** of cutaneous leishmaniasis(CL)is primarily made by the microscopic identification of the amastigote form of the parasite in a ***,correct identification of Leishman-donovan(Ld)bodies in smears is crucial for CL *** aim of this study was to provide a broad overview of different cytomorphologies of Ld bodies to improve the sensitivity of microscopic detection of Leishmania donovani,which causes CL in Sri Lanka.A total of 125 smears,prepared from patients who met the positive diagnostic criteria of CL,were Giemsa stained and examined *** density,cellular location and all possible cytomorphological forms of the parasite were documented.A total of 10 different cytomorphological forms of Ld bodies were *** them,the round form was observed only *** other morphological forms,namely the pear shape,cigarette shape,candle flame form,embryo shape,flagellate form,binary form and rosette form,were found only *** spindle form and lens shape were observed in both intracellular and extracellular *** amastigotes have a wide range of morphologies besides their classical *** Leishmania are considered as obligatory intracellular parasites,theymanage to survive successfully within the extracellular hostile conditions as ***,having a broader view of different morphological forms for Leishmania parasites may help to improve diagnosis of CL.

关键词： cutaneous leishmaniasis Leishmania donovani cytomorphology amastigote diagnostic microscopy

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Biochemical dissection of StAt3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： StAt3 dissection sclerosis

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Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

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Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

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transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 177-192页

作者： M.NAVEEd M.IMRAN t.ASGHAR Z.ABBAS department of Mathematics Division of Science and TechnologyUniversity of Education department of Mathematics The Islamia University of Bahawalpur

this paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. the influence of magnetic fields is also inspected in terms of their physical characteristics. to depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PdEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAM).the effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

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treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi James d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA the Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

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Fecal microbiota transplantation in allergic diseases

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World Journal of Methodology 2025年第2期15卷 83-91页

作者： Ece tüsüzÖnata ÖnerÖzdemir division of Pediatric Allergy and Immunology Medical FacultySakarya UniversityAdapazarı54100SakaryaTürkiye

Microorganisms such as bacteria,fungi,viruses,parasites living in the human intestine constitute the human intestinal *** refers to composi-tional and quantitative changes that negatively affect healthy gut *** recent years,with the demonstration that many diseases are associated with dysbiosis,treatment strategies targeting the correction of dysbiosis in the treat-ment of these diseases have begun to be *** microbiota trans-plantation(FMt)is the process of transferring faeces from a healthy donor to another recipient in order to restore the gut microbiota and provide a therapeutic *** studies have gained popularity after probiotic,prebiotic,symbiotic studies in the treatment of dysbiosis and related *** has emerged as a potential new therapy in the treatment of allergic diseases as it is associated with the maintenance of intestinal microbiota and immunological balance(t helper 1/t helper 2 cells)and thus suppression of allergic *** this article,the definition,application,safety and use of FMt in allergic diseases will be discussed with current data.

关键词： Microbiota dysbiosis Faecal microbiota transplantation Allergic diseases

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