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Cutting edge preparation of microdrills by shear thickening polishing for improved hole quality in electronic PCBs

Frontiers of Mechanical Engineering 2024年第2期19卷 99-107页

作者： Jiahuan WANG Mingfeng ke Jiepei LIAO Yu ZHOU Saurav GOEL Jaya VERMA Xu WANG Weigang GUO Julong YUAN Binghai LYU College of Mechanical Engineering Zhejiang University of TechnologyHangzhou 310000China Ultra-precision Machining Center Key Laboratory of Special Purpose Equipment and Advanced Manufacturing TechnologyZhejiang University of TechnologyHangzhou 310000China School of Engineering London South Bank UniversityLondon SE10AAUK Shenzhen Jinzhou Precision technology Corporation Shenzhen 518116China Department of Mechanical Engineering University of Petroleum and Energy StudiesDehradun 248007India Special Equipment Institute Hangzhou Vocational&Technical CollegeHangzhou 310018China

Printed circuit boards(PCBs)are representative composite materials,and their high-quality drilling machining remains a persistent challenge in the *** finishing of the cutting edge of a microdrill is crucial to drill performance in machining fine-quality holes with a prolonged tool *** miniature size involving submicron scale geometric dimensions,a complex flute shape,and low fracture toughness makes the cutting edge of microdrills susceptible to breakage and has been the primary limiting factor in edge preparation for *** this study,a newly developed cutting edge preparation method for microdrills was tested experimentally on electronic printed circuit *** proposed method,namely,shear thickening polishing,limited the cutting edge burrs and chipping on the cutting edge,and this in turn transformed the cutting edge’s radius from being sharp to ***,the edge–edge radius could be regulated by adjusting the processing *** drilling experiments were conducted to investigate the influence of different cutting edge radii on wear,hole position accuracy,nail head value,and hole wall *** proposed approach showed 20%enhancement in hole position accuracy,33%reduction in the nail head value,and 19%reduction in hole wall roughness compared with the original ***,a threshold is needed;without it,excessive shear thickening polishing will result in a blunt edge,which may accelerate the wear of the *** was identified as the primary factor that reduced hole *** study indicates that in printed circuit board machining,microdrills should effectively eliminate grinding defects and maintain the sharpness of the cutting edge as much as possible to obtain excellent drilling ***,shear thickening polishing is a promising method for cutting edge preparation of *** research and optimization can lead to additional improvements in microdrill performance and contribute to the conti

关键词： microdrill shear thickening polishing cutting edge preparation electronic printed circuit boards hole quality

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DNA of neutrophil extracellular traps promote NF-κBdependent autoimmunity via cGAS/tLR9 in chronic obstructive pulmonary disease

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Signal transduction and targeted therapy 2024年第7期9卷 3040-3055页

作者： Jun Chen tao Wang Xiaoou Li Lijuan Gao ke Wang Mengxin Cheng Zijian Zeng Lei Chen Yongchun Shen Fuqiang Wen Department of Respiratory and Critical Care Medicine West China HospitalWest China School of Medicineand Division of Pulmonary DiseasesState Key Laboratory of BiotherapySichuan UniversityChengduSichuan 610041China

Chronic obstructive pulmonary disease(COPD)is characterised by persistent airway inflammation even after cigarette smoking *** extracellular traps(NEts)have been implicated in COPD severity and acute airway inflammation induced by short-term cigarette smoke(CS).However,whether and how NEts contribute to sustained airway inflammation in COPD remain *** study aimed to elucidate the immunoregulatory mechanism of NEts in COPD,employing human neutrophils,airway epithelial cells(AECs),dendritic cells(DCs),and a long-term CS-induced COPD mouse model,alongside cyclic guanosine monophosphate-adenosine monophosphate synthase and toll-like receptor 9 knockout mice(cGAS-^(−/−)tLR9^(−/−));Additionally,bronchoalveolar lavage fluid(BALF)of COPD patients was *** from COPD patients released greater cigarette smoke extract(CSE)-induced NEts(CSE-NEts)due to mitochondrial respiratory chain *** CSE-NEts,containing oxidatively-damaged DNA(NEts-DNA),promoted AECs proliferation,nuclear factor kappa B(NF-κB)activation,NF-κB-dependent cytokines and type-I interferons production,and DC maturation,which were ameliorated/reversed by silencing/inhibition of cGAS/*** the COPD mouse model,blocking NEts-DNA-sensing via cGAS^(−/−)and tLR9^(−/−)mice,inhibiting NEtosis using mitotEMPO,and degrading NEts-DNA with DNase-I,respectively,reduced NEts infiltrations,airway inflammation,NF-κB activation and NF-κBdependent cytokines,but not type-I interferons due to IFN-α/βreceptor *** NEts components(myeloperoxidase and neutrophil elastase activity)in BALF of COPD smokers correlated with disease severity and NF-κB-dependent cytokine levels,but not type-I interferon *** conclusion,NEts-DNA promotes NF-κB-dependent autoimmunity via cGAS/tLR9 in long-term CS exposure-induced ***,targeting NEts-DNA and cGAS/tLR9 emerges as a potential strategy to alleviate persistent airway inflammation in COPD.

关键词： inflammation tLR9 neutrophil

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Diagnostic Value of Endoscopic Ultrasound in Staging Rectal Cancer

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Proceedings of Anticancer Research 2024年第4期8卷 48-53页

作者： Linxia Liu ke Chen Nantong tumor Hospital Nantong 226300Jiangsu ProvinceChina Department of Endoscopy Cancer Hospital Affiliated to Fudan UniversityShanghai 200000China

Objective:to explore the diagnostic value of endoscopic ultrasound(EUS)in the staging of rectal ***:Fifty patients with rectal cancer,treated at the Department of Endoscopy,Cancer Hospital Affiliated to Fudan University,from March 2023 to June 2024,were *** patients underwent EUS and computed tomography(Ct)examination within two weeks before *** postoperative pathological staging was used as the standard to compare the accuracy of tumor tN staging using EUS and/or ***:the accuracy rates of t and N staging by abdominal spiral Ct were 72.00%and 76.00%,respectively,while those by EUS were 88.00%and 74%,*** was a significant difference in the accuracy of t staging between the two methods(both Ptic value in the staging of rectal cancer,providing important reference information for clinicians,aiding in the development of personalized treatment plans,and assessing patient prognosis.

关键词： Endoscopic ultrasound Rectal cancer Diagnostic value

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致密碳酸盐岩气藏裂缝预测与主控因素分析——以四川盆地高石梯地区灯影组储层为例

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矿业科学学报 2024年第3期9卷 327-341页

作者：徐珂中国石油塔里木油田分公司勘探开发研究院新疆库尔勒841000

天然裂缝是致密碳酸盐岩气藏重要的储集空间和渗流通道,定量预测其发育程度与分布规律、揭示主控地质因素,对气藏开发具有重要实践意义。本文以四川盆地中部乐山—龙女寺古隆起的高石梯地区灯影组致密碳酸盐岩储层为研究对象,在裂缝参... 详细信息

天然裂缝是致密碳酸盐岩气藏重要的储集空间和渗流通道,定量预测其发育程度与分布规律、揭示主控地质因素,对气藏开发具有重要实践意义。本文以四川盆地中部乐山—龙女寺古隆起的高石梯地区灯影组致密碳酸盐岩储层为研究对象,在裂缝参数表征基础上建立应力场-能量-裂缝参数的计算模型,结合多期裂缝叠加算法定量预测裂缝发育分布规律,并重点分析了岩性、断层和构造形态对裂缝发育的影响。结果表明:①高石梯地区灯影组储层裂缝表现为张剪缝为主、高角度缝、半充填特征,裂缝优势走向为NW-SE与近N-S方向,裂缝密度在0~2条/m,高值区主要分布在断层带及中部地区;②高石梯地区的天然裂缝长度与裂缝密度呈负指数幂关系,裂缝发育具层间差异性,灰岩储层的缝发育程度高,泥岩对裂缝延伸具阻挡作用;③裂缝发育规模及产状发育受断层、褶皱影响显著,断层周围裂缝密度大、开度大、长度小,剪切缝与走滑断层近于平行或呈低角度,张性缝与主走滑断层呈高角度;褶皱主要通过构造曲率影响裂缝开度,弯曲变形程度高的构造部位裂缝开度大,翼部变形小,裂缝开度小。研究成果可为研究区及其他类似地质条件地区气藏高效勘探开发提供参考与借鉴。

关键词：裂缝预测主控因素致密碳酸盐岩地应力四川盆地

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therapeutic genome editing of an aberrant splice site inβ-thalassemia by CRISPR/Cas9 with multiple sgRNAs

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Genes & Diseases 2024年第1期11卷 15-18页

作者： Fei Yang Shuqian Xu Chao Huang Zhiqiang Shao Yuefen Hu Yang Yang Yongrong Lai Qing ke Dan Liang Yuxuan Wu Shanghai key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghai 200241China Department of Obstetrics and Gynecology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China NHC key Laboratory of Study on Abnormal Gametes and Reproductive tract(Anhui Medical University) HefeiAnhui 230032China Department of Hematology Qilu HospitalCheeloo College of MedicineShandong UniversityJinanShandong 250012China BRLMedicine Inc. Shanghai 201108China Department of Hematology The First Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530000China Department of Neurology The First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310003China

Genetic mutations cause aberrant splicing,one of the important molecular mechanisms in human ***2-654,a mutation causing aberrant splicing ofβ-globin premRNA and contributing toβ-globin deficiency,is one of the most common diseases in Southeast Asia and China."In our previous work,we found a tttV protospacer adjacent motif(PAM)by the Cas12a system and the editing efficiency of Ivs2-654 C>t achieving 76.7%.

关键词： CRISPR/Cas9 China thalassemia

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Mitigating Lattice Distortion of High‑Voltage LiCoO_(2)via Core‑Shell Structure Induced by Cationic Heterogeneous Co‑Doping for Lithium‑Ion Batteries

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Nano-Micro Letters 2024年第3期16卷 169-182页

作者： Zezhou Lin ke Fan tiancheng Liu Zhihang Xu Gao Chen Honglei Zhang Hao Li Xuyun Guo Xi Zhang Ye Zhu Peiyu Hou Haitao Huang Department of Applied Physics and Research Institute for Smart Energy The Hong Kong Polytechnic UniversityHong KongPeople’s Republic of China Department of Applied Physics The Hong Kong Polytechnic UniversityHong KongPeople’s Republic of China Institute of Nanosurface Science and Engineering Guangdong Provincial Key Laboratory of Micro/Nano Optomechatronics EngineeringShenzhen UniversityShenzhenPeople’s Republic of China School of Physics and technology University of JinanJinanShandongPeople’s Republic of China

Inactive elemental doping is commonly used to improve the structural stability of high-voltage layered transition-metal oxide ***,the one-step co-doping strategy usually results in small grain size since the low diffusivity ions such as ti^(4+)will be concentrated on grain boundaries,which hinders the grain *** order to synthesize large single-crystal layered oxide cathodes,considering the different diffusivities of different dopant ions,we propose a simple two-step multi-element co-doping strategy to fabricate core–shell structured LiCoO_(2)(CS-LCO).In the current work,the high-diffusivity Al^(3+)/Mg^(2+)ions occupy the core of single-crystal grain while the low diffusivity ti^(4+)ions enrich the shell *** ti^(4+)-enriched shell layer(~12 nm)with Co/ti substitution and stronger ti–O bond gives rise to less oxygen ligand ***-situ XRD demonstrates the constrained contraction of c-axis lattice parameter and mitigated structural *** a high upper cut-off voltage of 4.6 V,the single-crystal CS-LCO maintains a reversible capacity of 159.8 mAh g^(−1)with a good retention of~89%after 300 cycles,and reaches a high specific capacity of 163.8 mAh g^(−1)at *** proposed strategy can be extended to other pairs of low-(Zr^(4+),ta^(5+),and W6+,etc.)and high-diffusivity cations(Zn^(2+),Ni^(2+),and Fe^(3+),etc.)for rational design of advanced layered oxide core–shell structured cathodes for lithium-ion batteries.

关键词： Lithium-ion battery LiCoO_(2) Heterogeneous co-doping Core-shell structure High-voltage stability

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BMP9 induces osteogenic differentiation through up-regulating LGR4 via the mtORC1/ Stat3 pathway in mesenchymal stem cells

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Genes & Diseases 2024年第3期11卷 468-483页

作者： Jie Zhang Jinhai Jiang Hang Liu Shiyu Wang Kaixin ke Siyuan Liu Yue Jiang Lu Liu Xiang Gao Baicheng He Yuxi Su Department of Pharmacology School of PharmacyChongqing Medical UniversityChongqing 400016China key Laboratory of Biochemistry and Molecular Pharmacology of Chongqing Chongqing Medical UniversityChongqing 400016China Department of Orthopedics Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China orthopedics Department Children's Hospital of Chongqing Medical UniversityChongqing 400014China China International Science and technology Cooperation Base of Child Development and Critical Disorders Jiangxi Hospital Affiliated Children's Hospital of Chongqing Medical UniversityJiangxi 330000China National Clinical Research Center for Child Health and Disorders China

Bone defects and non-union are prevalent in clinical orthopedy,and the outcomes of current treatments are often *** tissue engineering offers a promising approach to treating these conditions *** morphogenetic protein 9(BMP9)can commit mesenchymal stem cells to osteogenic lineage,and a knowledge of the underlying mechanisms may help advance the field of bone tissue ***-rich repeats con-taining G protein-coupled receptor 4(LGR4),a member of G protein-coupled receptors,is essential for modulating bone *** study is aimed at investigating the impact of LGR4 on BMP9-induced osteogenesis in mesenchymal stem cells as well as the underlying *** marrow stromal cells from BMp9-knockout mice exhibited diminished LGR4 expression,and exogenous LGR4 clearly restored the impaired osteogenic potency of the bone marrow stromal ***,LGR4 expression was increased by BMP9 in C3H10t1/2 ***4 augmented the benefits of BMP9-induced osteogenic markers and bone formation,whereas LGR4 inhibition restricted these ***,the BMP9-induced li-pogenic markers were increased by LGR4 *** protein levels of Raptor and p-Stat3 were elevated by *** knockdown or p-Stat3 suppression attenuated the osteoblastic markers and LGR4 expression brought on by ***4 significantly reversed the blocking ef-fect of Raptor knockdown or p-Stat3 suppression on the BMP9-induced osteoblastic *** interacts with p-Stat3,and p-Stat3 activates the LGR4 promoter *** conclusion,LGR4 boosts BMP9 osteoblastic potency in mesenchymal stem cells,and BMP9 may up-regulate LGR4 via the mtORC1/Stat3 signal activation.

关键词： BMP9 LGR4 mtORC1 Osteogenic differentiation Stat3

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嵌入多阶泰勒微分知识的多尺度注意力循环网络深度时空序列预测方法

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电子与信息学报 2024年第6期46卷 2605-2618页

作者：孙强赵珂西安理工大学自动化与信息工程学院通信工程系西安710048

融合先验物理知识的深度时空序列预测方法通常使用偏微分方程(PDE)进行建模,这种做法通常存在两大问题:(1)偏微分方程的近似精度低;(2)无法在循环网络中有效捕捉多种空间尺度的时空特征和时空序列的边缘相关空间信息。为此,该文提出了... 详细信息

融合先验物理知识的深度时空序列预测方法通常使用偏微分方程(PDE)进行建模,这种做法通常存在两大问题:(1)偏微分方程的近似精度低;(2)无法在循环网络中有效捕捉多种空间尺度的时空特征和时空序列的边缘相关空间信息。为此,该文提出了融合泰勒微分的卷积循环神经网络(tDI-CRNN)。首先,为了提高高阶偏微分方程的近似精度并缓解偏微分方程应用的局限性,设计了一种多阶泰勒近似物理模块。该模块首先使用泰勒展开式对输入序列作微分逼近,再将不同阶数之间的微分卷积层使用微分系数耦合,最后动态调整泰勒展开结果的截断阶数与微分项数。其次,为了捕获循环网络隐藏状态的多种空间尺度特征并更好地捕捉时空序列的边缘相关空间信息,设计了一种多尺度注意力循环模块(MSARM),在该模块的多尺度卷积空间注意力UNet(即MCSA-UNet)的卷积层中使用了多尺度卷积和空间注意力机制,目的是关注时空序列的局部空间区域。在Moving MNISt,KtH以及CIKM数据集上开展了大量实验,Moving MNISt数据集的均方误差(MSE)指标下降到42.7,结构相似性指数(SSIM)提高到0.912;KtH数据集的SSIM和峰值信噪比(PSNR)分别提高到0.882和29.03;CIKM数据集上的临界成功指数(CSI)提高到0.515。最终的可视化和定量预测结果均验证了tDI-CRNN模型的合理性和有效性。

关键词：时空序列预测长短期记忆网络知识引导偏微分方程泰勒展开式

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t2-weighted imaging-based radiomic-clinical machine learning model for predicting the differentiation of colorectal adenocarcinoma

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 819-832页

作者： Hui-Da Zheng Qiao-Yi Huang Qi-Ming Huang Xiao-ting ke Kai Ye Shu Lin Jian-Hua Xu Department of Gastrointestinal Surgery The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina Department of Gynaecology and Obstetrics The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina Department of Computed tomography/Magnetic Resonance Imaging The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina Centre of Neurological and Metabolic Research The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina Group of Neuroendocrinology Garvan Institute of Medical ResearchSydneyNSW 2010Australia

BACKGROUND the study on predicting the differentiation grade of colorectal cancer(CRC)based on magnetic resonance imaging(MRI)has not been reported *** a non-invasive model to predict the differentiation grade of CRC is of great *** to develop and validate machine learning-based models for predicting the differ-entiation grade of CRC based on t2-weighted images(t2WI).MEtHODS We retrospectively collected the preoperative imaging and clinical data of 315 patients with CRC who underwent surgery from March 2018 to July *** were randomly assigned to a training cohort(n=220)or a validation cohort(n=95)at a 7:3 *** were delineated layer by layer on high-resolution *** absolute shrinkage and selection operator regression was applied to screen for radiomic *** and clinical models were constructed using the multilayer perceptron(MLP)*** radiomic features and clinically relevant variables(selected based on a significance level of Pthe training set)were used to construct radiomics-clinical *** performance of the three models(clinical,radiomic,and radiomic-clinical model)were evaluated using the area under the curve(AUC),calibration curve and decision curve analysis(DCA).RESULtS After feature selection,eight radiomic features were retained from the initial 1781 features to construct the radiomic *** different classifiers,including logistic regression,support vector machine,k-nearest neighbours,random forest,extreme trees,extreme gradient boosting,light gradient boosting machine,and MLP,were used to construct the model,with MLP demonstrating the best diagnostic *** AUC of the radiomic-clinical model was 0.862(95%CI:0.796-0.927)in the training cohort and 0.761(95%CI:0.635-0.887)in the validation *** AUC for the radiomic model was 0.796(95%CI:0.723-0.869)in the training cohort and 0.735(95%CI:0.604-0.866)in the validation *** clinical model achieved an AUC of 0.7

关键词： Radiomics Colorectal cancer Differentiation grade Machine learning t2-weighted imaging

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Frequency-Diversified Space-Efficient Radiating Surface Using Convolved Electric and Magnetic Currents for Highly Dense Multiband Antenna-Frontend Integration

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Electromagnetic Science 2024年第1期2卷 63-76页

作者： Amirhossein Askarian Pascal Burasa ke Wu Department of Electrical Engineering Poly-Grames Research CenterPolytechnique MontrealQC H3T1J4Canada

We propose and investigate a methodology based on convolved electric and magnetic currents for the generation of multi-band responses over a space-shared radiating ***,a single wideband antenna operation principle based on inter-leaved dipole and slot modes is studied and analyzed using full-wave simulations followed by a qualitative time domain ***,a 2×2 dual-band radiating unit is conceived and developed by closely arranging single wideband *** this case,multimode resonances are generated in a lower frequency band by a proper convolving and coupling of the magnetic and electric currents realized in the gaps between the antennas and on the surface of the antennas,*** methodology can be deployed repeatedly to build up a self-scalable topology by reusing the electromagnetically(EM)connected radiating surfaces and gaps be-tween the radiating *** to the efficient reuse of the electromagnetic region for the development of multiband radiation,a high aperture-reuse efficiency is ***,as a proof of concept,a 2×4 dual-band array operating in Ku-and Ka-bands is devel-oped and fabricated by a linear arrangement of the two developed radiating *** measurement results show that the proposed antenna array provides impedance and gain bandwidths of 30%and 25.4%in the Ku-band and 10.65%and 8.52%in the Ka-band,respectively.

关键词： Aperture-shared array Aperture-reused efficiency Antenna-frontend integration Dual-band antenna Magneto-electric dipole antenna Multi-mode resonance Multi-band array Multi-functional antenna Wideband antenna array

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