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Advances in oral mesenchymal st.m cell-derived ext.acellular vesicles in healt. and disease

Genes & Diseases 2024年第1期11卷 346-357页

作者： Huanyu Luo Anahid Ahmadi Birjandi feilong Ren t.anmeng Sun Paul t.Sharpe Hongchen Sun Zhengwen An Depart.ent.of Oral Biology Jilin Provincial Key Laboratory of Tooth Development and Bone RemodelingSchool and Hospital of StomatologyJilin UniversityChangchunJilin 130021China facult. of Dent.st.y Oral&Craniofacial SciencesCentre for Craniofacial and Regenerative BiologyKing's College LondonLondonSE19RTUK Depart.ent.of Oral Pat.ology Jilin Provincial Key Laboratory of Tooth Development and Bone RemodelingSchool and Hospital of StomatologyJilin UniversityChangchunJilin 130021China

Ext.acellular vesicles(EVs)are nano-size vesicles secret.d nat.rally by all cells int. t.e ext.acellular space and have been recognized as import.nt.cell-cell mediat.rs in mult.cel-lular *** cont.in nucleic acids,prot.ins,lipids,and ot.er cellular component.,regulat.ng many basic biological processes and playing an import.nt.role in regenerat.ve med-icine and *** can be t.aced t. t.eir cells of origin and exhibit.a similar ***,EVs demonst.at. low immunogenicit.,good biocompat.bilit.,and fewer side ef-fect.,compared t. t.eir parent.*** st.m cells(MsCs)are one of t.e most.import.nt.resource cells for EVs,wit. a great.capacit. for self-renewal and mult.pot.nt.differ-ent.at.on,and play an essent.al role in st.m cell *** mechanism of MsC t.erapy was t.ought.t. be at.ribut.d t. t.e different.at.on of MsCs aft.r t.rget.d migrat.on,as previously ***,emerging evidence shows t.e previously unknown role of MsC-derived para-crine fact.rs in st.m cell *** EVs derived from oral t.ssue MSCs(OMSC-EVs),show more advant.ges t.an t.ose of all ot.er MsCs in t.ssue repair and regenerat.on,due t. t.eir lower invasiveness and easier accessibilit. for sample ***,we syst.mat.cally review t.e biogenesis and biological charact.rist.cs of OMSC-EVs,as well as t.e role of OMsC-EVs in int.rcellular ***,we discuss t.e pot.nt.al t.erapeut.c roles of OMSC-EVs in oral and syst.mic *** highlight.t.e current.challenges and fut.re direct.ons of OMSC-EVs t. focus more at.ent.on on clinical *** aim t. provide valuable insight. for t.e explorat.ve clinical applicat.on of OMSC-EVs.

关键词： Disease Ext.acellular vesicles Oral t.ssue MSC t.erapeut.c applicat.on t.ssue regenerat.on

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Why can some count.ies perform bet.er in resolving some social problems:A comparat.ve st.dy

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Economic and Polit.cal St.dies 2024年第3期12卷 250-266页

作者： Wilson X.B.Li t.na t.He facult. of Business and Management BNU-HKBU United International CollegeZhuhaiChina

t.is st.dy explores t.e rat.onale why some count.ies fare bet.er in resolving social problems such as povert. and t.e COVID-19 *** simple model int.oduces t.e t.rm of resident.viabilit. and point. out.t.at.t.e solut.on t. a social problem wit. a large rat.o of nonviable t. viable resident. requires t.e mobilisat.on of more societ.l resources,and t.e affordable price rat.o of societ.l t. individual resources is det.rmined by count.y charact.rist.cs such as t.e cult.ral background,polit.cal regime,ideology t.wards t.e free-market.mechanism,government.efficiency and social *** st.dy also makes bet.een-count.y comparisons and conduct. preliminary regression analyses wit. cross-count.y dat.,and all t.e result. are consist.nt.wit. t.e model predict.ons on t.e relat.onship bet.een count.y charact.rist.cs and count.y performances in fight.ng povert. and handling t.e COVID-19 pandemic.

关键词： Social problems COVID-19 povert. eradicat.on viabilit. bet.een-count.y comparison

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Life under t.nsion: t.e relevance of force on biological polymers

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Biophysics Report. 2024年第1期10卷 48-56页

作者： Mat.hew t.J.Halma Longfu Xu Depart.ent.of Physics and Ast.onomy and Laser Lab Vrije Universiteit Amsterdam LUMICKS B.V.

Opt.cal t.eezers have elucidat.d numerous biological processes, part.cularly by enabling t.e precise manipulat.on and measurement.of t.nsion. One quest.on concerns t.e biological relevance of t.ese experiment. and t.e generalizabilit. of t.ese experiment. t. wider biological syst.ms. Here, we cat.gorize t.e applicabilit. of t.e informat.on garnered from opt.cal t.eezers in t.o dist.nct.cat.gories: t.e direct.relevance of t.nsion in biological syst.ms, and what.experiment. under t.nsion can t.ll us about.biological syst.ms, while t.ese syst.ms do not.reach t.e same t.nsion as t.e experiment. st.ll, t.ese art.ficial experiment.l syst.ms reveal insight. int. t.e operat.ons of biological machines and life processes.

关键词： t.nsion Opt.cal t.eezers Molecular force

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Imaging and endoscopic t.ols in pediat.ic inflammat.ry bowel disease: What.s new?

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World Journal of Clinical Pediat.ics 2024年第1期13卷 7-13页

作者： Alexandra S Hudson Ghassan t.Wahbeh Hengqi Bet.y Zheng Depart.ent.of Pediat.ics University of WashingtonSeattleWA 98109United States

Pediat.ic inflammat.ry bowel disease(IBD)is a chronic inflammat.ry disorder,wit. increasing incidence and prevalence *** have been recent.advances in imaging and endoscopic t.chnology for disease diagnosis,t.eat.ent.and *** ult.asound,including t.ansabdominal,t.ansperineal,and endoscopic,has been emerging for t.e assessment.of t.ansmural bowel inflammat.on and disease complicat.ons(e.g.,fist.la,abscess).Aside from surgery,IBD-relat.d int.st.nal st.ict.res now have endoscopic t.eat.ent.opt.ons including t.rough-t.e-scope balloon dilat.t.on,inject.on,and needle knife st.ict.rot.my and new evaluat.on t.ols such as endoscopic funct.onal lumen imaging *** t.ansnasal endoscopy may have a role in pat.ent. wit. upper gast.oint.st.nal Crohn’s disease or t.ose wit. IBD wit. new upper gast.oint.st.nal *** t. dysplasia screening in pediat.ic pat.ent. wit. longst.nding colonic disease or primary sclerosing cholangit.s hold promise wit. t.e addit.on of virt.al chromoendoscopy and ongoing research in t.e field of art.ficial int.lligence-assist.d endoscopic *** int.lligence and machine learning is a rapidly evolving field,wit. goals of furt.er personalizing IBD diagnosis and t.eat.ent.select.on as well as *** review summarized t.ese advancement.,focusing on pediat.ic pat.ent. wit. IBD.

关键词： Int.st.nal ult.asound Endoscopy Inflammat.ry bowel disease Pediat.ics Imaging

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Spat.ot.mporal mapping of(ult.a‐)mafic magmat.c mine areas:Implicat.ons of economic and polit.cal realit.es in China

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Deep Underground Science and Engineering 2024年第1期3卷 91-102页

作者： Heling Li Liang t.ng t.m t.Werner Zhengmeng Hou fan Meng Jingjing Li College of Eart. Sciences Chengdu University of TechnologyChengduChina Inst.t.t. of Subsurface Energy Syst.ms Clausthal University of TechnologyClausthal ZellerfeldGermany School of Geography Earth and Atmospheric SciencesFaculty of ScienceThe University of MelbourneMelbourneVictoriaAustralia

t.e spat.ot.mporal ext.nsion/expansion of mine areas is affect.d by mult.ple *** far,very lit.le has been done t. examine t.e int.ract.on bet.een mine areas and polit.cal or economic ***(ult.a‐)mafic magmat.c mines in China played a specific role in support.ng nat.onal development.and providing an ideal research subject.for monit.ring t.eir *** t.is st.dy,remot. sensing and mining‐relat.d GIS dat. were used t. ident.fy and analyze 1233(ult.a‐)mafic magmat.c mine area polygons in China,which covered approximat.ly 322.96 km2 of land and included a V–t.–fe mine,a copper–nickel mine,a chromit. mine,an asbest.s mine,and a diamond *** was found t.at.1)t.e areal expansion of mines is significant.y relat.d t. t.e mine t.pes,perimet.r,t.pography,and populat.on densit..(2)t.e mine area variat.on also reflect. market.and policy *** t.mporal expansion of t.e mine area from 2010 t. 2020 followed an S‐shaped pat.ern(wit. t.e t.rning point.occurring in 2014),closely relat.d t. iron overcapacit. and t.ght.ned mining policies.(3)t.e complexit.(D)of t.e mine area may reflect.mine design and excavat.on *** be specific,lower D indicat.s early‐st.ge or art.sanal/small‐scale mining,whereas higher D represent. large‐scale *** st.dy demonst.at.s t.at.t.e det.iled mapping of mine land can serve as an indicat.r t. implement.miningrelat.d market.and policy ***(ult.a‐)mafic mines area dat. set.can be accessed at.ht.ps://***/record/7636616#.Y-p0uXaZOa0.

关键词： complexit. mine area mining and socioeconomic int.ract.on spat.ot.mporal dist.ibut.on (ult.a‐)mafic magmat.c mine

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Hydrot.ermal t.eat.ent.of pearl millet.grains:Effect. on nut.it.onal composit.on,ant.nut.ient. and flour propert.es

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Grain & Oil Science and t.chnology 2024年第2期7卷 87-95页

作者： P.Prashant. t.Jayasree Joshi Shagolshem Mukt. Singh P.Srinivasa Rao Agricult.ral and food Engineering Depart.ent Indian Institute of Technology KharagpurKharagpurWest Bengal 721302India

Pearl millet.Penniset.m glaucum)is one of t.e major millet. wit. high nut.it.onal *** crop exhibit. except.onal resilience t. drought.and high ***,t.e processing of pearl millet.poses a significant.challenge due t. it. high lipid cont.nt.enzyme act.vit.,and presence of ***,it.becomes imperat.ve t. enhance t.e qualit. and prolong t.e shelf life of pearl millet.flour by employing suit.ble *** t.eat.ent.in t.e food indust.y has long been seen as promising due t. it. pot.nt.al t. reduce microbial load,inact.vat. enzymes,and improve nut.ient.*** st.dy aims t. invest.gat. t.e effect. of hydrot.ermal t.eat.ent.on t.e qualit. charact.rist.cs of pearl *** independent.variables of t.e st.dy were soaking t.mperat.re(35,45,55℃),soaking t.me(2,3,4 h),and st.aming t.me(5,10,15 min).t.eat.ent.condit.ons had a st.t.st.cally significant.effect.on nut.ient.*** ant.nut.ient. like t.nnins and phyt.t.s were reduced by 0.99% t. 5.94% and 0.36% t. 6.00%,respect.vely,aft.r t.e *** act.vit. decreased significant.y up t. 10% wit. t.e t.eat.ent.*** findings of t.is st.dy could pot.nt.ally encourage t.e use of pearl millet.flour in t.e product.on of various food it.ms and promot. t.e applicat.on of hydrot.ermal t.eat.ent.in t.e field of food processing.

关键词： Pearl millet Hydrot.ermal t.eat.ent Nut.it.onal propert.es Ant.nut.ient.

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Edit.rial for Mult.scale&Mult.field Coupling in Geomechanics

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Journal of Rock Mechanics and Geot.chnical Engineering 2024年第6期16卷 1919-1921页

作者： Min Wang Pengzhi Pan Andrew H.C.Chan Y.t.feng t.3 fluid Dynamics and Solid Mechanics Theoretical DivisionLos Alamos National LaboratoryNew MexicoUSA Inst.t.t. of Rock and Soil Mechanics Chinese Academy of SciencesWuhanChina School of Engineering University of TasmaniaTasmaniaAustralia College of Engineering Swansea UniversityWalesUK

We are delight.d t. serve as guest.edit.rs for t.is special issue in t.e Journal of Rock Mechanics and Geot.chnical *** purpose of t.is special issue is dedicat.d t. gat.ering t.e lat.st.research work on Mult.scale&Mult.field Coupling in Geomechanics,where we delve int. t.e int.icat. int.rplay of various fields and scales t.at.govern t.e behavior of *** t.t.l,30 manuscript. from USA,China,UK,Germany,Canada,India and Unit.d Arab Emirat.s are select.d t. be included in t.is issue.

关键词： mat.rials. gat.ering mechanics

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facile synt.esis of int.a-nanogap enhanced Raman t.gs wit. different.shapes

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Nano Research 2024年第9期17卷 8415-8423页

作者： Sanjun fan Brian t.Scarpit.i Zhewen Luo Abigail E.Smit. Jian Ye Zachary D.Schult. Depart.ent.of Chemist.y and Biochemist.y The Ohio State UniversityColumbusOhio 43210USA School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200030China

Hot.spot.engineering in plasmonic nanost.uct.res plays a significant.role in surface-enhanced Raman scat.ering(SERS)for bioanalysis and cell ***,creat.ng st.ble,reproducible,and st.ong SERS signals remains challenging due t. t.e pot.nt.al int.rference from surrounding chemicals and locat.ng SERS-act.ve analyt.s int. hot.spot.***,we developed a st.aight.orward approach t. synt.esize int.a-gap nanopart.cles encapsulat.ng 4-nit.obenzenet.iol(4-NBt.as a report.r molecule wit.in t.ese gaps t. avoid out.ide *** made t.ree kinds of int.a-gap nanopart.cles using nanorods,bipyramids,and nanospheres as cores,in which t.e nanorods based int.a-gap nanopart.cles exhibit.t.e highest.SERS *** advant.ge of our met.od is t.e ease of preparat.on of high-yield and st.ble int.a-gap nanopart.cles charact.rized by a short.incubat.on t.me(10 min)wit. 4-NBt.and quick synt.esis wit.out.requiring an addit.onal st.p t. cent.ifuge for t.e purificat.on of core *** int.nse localized field in t.e synt.esized hot.spot. of t.ese plasmonic gap nanost.uct.res holds great.promise as a SERS subst.at. for a broad range of quant.t.t.ve opt.cal applicat.ons.

关键词： hot.spot.engineering surface enhanced Raman scat.ering int.a-gap nanopart.cles 4-nit.obenzenet.iol

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Opt.mal Design of Hybrid Microgrid in Isolat.d Communit.es of Ecuador

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Journal of Modern Power Syst.ms and Clean Energy 2024年第2期12卷 488-499页

作者： Luis A.Pesant.s Ruben Hidalgo-León Johnny Rengifo Miguel t.rres Jorge Aragundi JoséCordova-Garcia Luis f.Ugart. facult.d de Ingeniería en Elect.icidad y Comput.ción of Escuela Superior Polit.cnica del Lit.ral(ESPOL)Universit. GuayaquilEcuador Depart.ent.of Elect.ical Engineering at.Universidad t.cnica federico Sant. María SantiagoChile IEEE

In rural t.rrit.ries, t.e communit.es use energy sources based on fossil fuels t. supply t.emselves wit. elect.icit., which may address t.o main problems: greenhouse gas emissions and high fuel prices. Hence, t.ere is an opport.nit. t. include renewable resources in t.e energy mix. t.is paper develops an opt.mizat.on model t. det.rmine t.e opt.mal sizing, t.e t.t.l annual invest.ent.cost.in renewable generat.on, and ot.er operat.ng cost. of t.e component. of a hybrid microgrid. By running a k-means clust.ring algorit.m on a met.orological dat.set.of t.e communit. under st.dy, t.e hourly represent.t.ve values become input.paramet.rs in t.e proposed opt.mizat.on model. t.e met.od for t.e opt.mal design of hybrid microgrid is analyzed in six operat.ng scenarios considering:(1) 24-hour cont.nuous power supply;(2) load shedding percent.ge;(3) diesel power generat.r(genset. curt.ilment.(4) t.e worst.met.orological condit.ons;(5) t.e use of renewable energy sources including bat.ery energy st.rage syst.ms(BESSs);and(6) t.e use of genset. A mat.emat.cal programming language(AMPL) t.ol is used t. find solut.ons of t.e proposed opt.mizat.on model. Result. show t.at.t.e t.t.l cost. of microgrid in t.e scenarios t.at.cover 100% of t.e load demand(wit.out.considering t.e scenario wit. 100% renewables) increase by over 16% compared wit. t.e scenario wit. genset.operat.on limit.t.on. for t.e designs wit. power supply rest.ict.ons, t.e t.t.l cost.of microgrid in t.e scenario wit. load shedding is reduced by over 27% compared wit. t.at.wit.out.load shedding.

关键词： Bat.ery energy st.rage syst.m(BESS) isolat.d communit. microgrid renewable energy opt.mizat.on

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Canine on t.e Couch:t.e New Canary in t.e Coal Mine for Environment.l Healt. Research

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Environment.& Healt. 2024年第8期2卷 517-529页

作者： Cat.erine f.Wise Mat.hew Breen Heat.er M.St.plet.n Nicholas School of t.e Environment Duke UniversityDurhamNorth Carolina 27708United States Duke Cancer Inst.t.t. DurhamNorth Carolina 27710United States Depart.ent.of Molecular Biomedical Sciences College of Veterinary MedicineNorth Carolina State University1060 William Moore DriveRaleighNorth Carolina 27607United States Comparat.ve Medicine Inst.t.t. North Carolina State UniversityRaleighNorth Carolina 27607United States Cent.r for Human Healt. and t.e Environment North Carolina State UniversityRaleighNorth Carolina 27607United States

Human healt. is int.mat.ly connect.d and t.ed t. t.e healt. of our environment.and ecosyst.m,wit. only a very small fract.on of t.e risk for chronic diseases explained by genet.cs *** animals are prone t. disease t.pes t.at.are shared wit. people,including cancers and endocrine disorders,reinforcing t.e t.ought.t.at.environment.l fact.rs cont.ibut. t. t.e risks for chronic *** fact.rs include air and wat.r pollut.on and t.e built.*** such,t.ere is increasing int.rest.in pursuing research wit. companion animals,and specifically dogs,as sent.nel species t. inform comparat.ve healt. assessment. and ident.fy risk fact.rs for *** t.e canine diseases for which environment.l exposure research has been published,cancers have received t.e most.*** review summarizes t.o main aspect. of t.is comparat.ve approach:(1)cancers t.at.occur in dogs and which are similar t. humans and(2)research invest.gat.ng environment.l exposures and healt. out.omes in *** goal of t.is review is t. highlight.t.e diverse condit.ons in which pet.dogs may provide unique perspect.ves and advant.ges t. examine relat.onships bet.een environment.l exposures and healt. out.omes,wit. an emphasis on chemical pollut.on and ***,t.is review seeks t. raise awareness and st.mulat. discussion around t.e best.pract.ces for t.e use of companion animals as environment.l healt. sent.nels.

关键词： sent.nels dogs environment.l healt. comparat.ve oncology cancer alt.rnat.ve models environment.l exposure

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