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Improvement.of hist.ne deacet.lase inhibit.r efficacy by SN38 t.rough t.ISt. suppression in synovial sarcoma

Cancer Innovat.on 2024年第2期3卷 80-95页

作者： Sat.ru Sasagawa Jun Kumai t.ru Wakamat.u Yoshihiro yui Molecular Biology Laborat.ry Research InstituteNozaki Tokushukai HospitalDaitoOsakaJapan Sarcoma t.eat.ent.Laborat.ry Research InstituteNozaki Tokushukai HospitalDaitoOsakaJapan Depart.ent.of Musculoskelet.l Oncology Service Osaka International Cancer InstituteOsakaJapan

Background:Synovial sarcoma(SS)is an SS18-SSX fusion gene-driven soft.t.ssue sarcoma wit. mesenchymal charact.rist.cs,associat.d wit. a poor prognosis due t. frequent.met.st.sis t. a dist.nt.organ,such as t.e *** deacet.lase(HDAC)inhibit.rs(HDACis)are arising as pot.nt.molecular t.rget.d drugs,as HDACi t.eat.ent.disrupt. t.e SS oncoprot.in complex,which includes HDACs,in addit.on t. general HDACi *** provide furt.er molecular evidence for t.e advant.ges of HDACi t.eat.ent.and it. limit.t.ons due t. drug resist.nce induced by t.e microenvironment.in SS cells,we examined cellular responses t. HDACi t.eat.ent.in combinat.on wit. t.o-dimensional(2D)and 3D cult.re ***:Using several SS cell lines,biochemical and cell biological assays were performed wit. romidepsin,an HDAC1/2 select.ve ***38 was concomit.nt.y used as an ameliorant.drug wit. romidepsin ***,apopt.sis induct.on,and MHC class I polypept.de-relat.d sequence A/B(MICA/B)induct.on were monit.red t. evaluat. t.e drug *** addit.on t. t.e convent.onal 2D cult.re condit.on,spheroid cult.re was adopt.d t. evaluat. t.e influence of cell-mass microenvironment.on ***:By monit.ring t.e cellular behavior wit. romidepsin and/or SN38 in SS cells,we observed t.at.responsiveness is diverse in each cell *** t.e apopt.t.c inducible cells,co-t.eat.ent.wit. SN38 enhanced cell *** nonapopt.t.c inducible cells,cyt.st.sis and MICA/B induct.on were observed,and SN38 improved MICA/B induct.on *** a novel efficacy of SN38,we revealed t.ISt. suppression in SS *** t.e spheroid(3D)condit.on,romidepsin efficacy was severely rest.ict.d in t.ISt.-posit.ve *** demonst.at.d t.at.t.ISt. downregulat.on rest.red romidepsin efficacy even in spheroid form,and concomit.nt.SN38 t.eat.ent.along wit. romidepsin reproduced t.e ***:t.e current.st.dy demonst.at.d t.e benefit. and concerns of using HDACi for SS t.eat.ent.in 2D and

关键词： HDAC inhibit.r MICA/B SN38 spheroid synovial sarcoma t.ISt.

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台湾北部地下水中氡含量的变化及其与地震活动的相关性

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华北地震科学 1986年第S1期 14-23页

作者： K.-K.Liu t.-f.yui Y.-H.Yeh B.-B.t.ai t.-L.t.ng 王吉易河北省地震局

从1980年7月至1983年12月,每周从台湾北部四个测点取双样测定地下热水和富含CO;的冷泉中的氡(;Rn)浓度。在三个测点上观测到七次脉冲式氡异常（其增长超过均值的2～3倍标准误差）,每次异常（一次除外）后4至51天内均发生M;4.6级以上地... 详细信息

从1980年7月至1983年12月,每周从台湾北部四个测点取双样测定地下热水和富含CO;的冷泉中的氡(;Rn)浓度。在三个测点上观测到七次脉冲式氡异常（其增长超过均值的2～3倍标准误差）,每次异常（一次除外）后4至51天内均发生M;4.6级以上地震。震中距为14到45公里,震源深度小于10公里。具有氡异常前兆的地震分布,偏向于氡测点的某一方向。对其它方向发生的地震,氡测点似乎不敏感。在邻近火山地区的第四个测点上,大量气体（主要是CO;）同热水一起从井孔排出。从排出的气体中检测到的氡浓度很高。因此,水中气体的分离可能导致高的氡含量异常。据有限的测定,水氡浓度相对于气氡似乎没有饱和。这表明热水很容易损失氡。因此,更需要监测气氡。

关键词：地震活动测点点(数学) 边界断层台湾北部氡浓度地热水地下水地下热水

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Inflow and out.low permeabilit. t.st. in a very soft.clay under low st.esses

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Journal of Rock Mechanics and Geot.chnical Engineering 2024年第8期16卷 3270-3283页

作者： J.W.S.Vargas f.A.B.Danziger f.R.Lopes t.Lunne federal Universit. of Rio de Janeiro Rio de JaneiroBrazil Norwegian Geot.chnical Inst.t.t. OsloNorway

In sit. inflow and out.low permeabilit. t.st. wit. t.e BAt.probe at.SarapuíII soft.clay t.st.sit. are present.d.A descript.on of t.e BAt.permeabilit. t.st.is provided,discussing it. advant.ges and short.omings,especially in t.e case of very soft.clays under low *** pressures were monit.red during probe inst.llat.on and were found t. be slight.y lower t.an piezocone u2 pore pressures,consist.nt.wit. t.e posit.on of t.e *** role of filt.r t.p sat.rat.on was invest.gat.d aft.r t.e usual sat.rat.on procedure provided an unsat.sfact.ry pore pressure response during probe *** show t.at.t.e vacuum sat.rat.on procedure provides adequat. response during inst.llat.on and increases t.e reliabilit. of t.e coefficient.of permeabilit. det.rminat.on in early *** inflow and out.low t.st. yielded similar result.,indicat.ng t.at.careful execut.on of t.e t.st.can lead t. good t.st.repeat.bilit. regardless of t.e loading *** sequences of alt.rnat.d inflow and out.low t.st. have yielded similar result.,indicat.ng t.at.soil reconsolidat.on and filt.r clogging were negligible in t.e t.st. *** are present.d concerning t.e relat.onship bet.een index paramet.rs and t.e in sit. coefficient.of permeabilit. for SarapuíII clay,which plot.out.ide t.e range of exist.ng dat.bases.

关键词： Permeabilit. t.st Soft.clay BAt.probe Inflow and out.low t.st.

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t.ermoluminescence charact.rizat.on of nat.ral and synt.et.c irradiat.d Ce-monazit.s

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Journal of Rare Eart.s 2024年第4期42卷 643-650页

作者： V.Correcher C.Boronat.J.Garcia-Guinea J.f.Benavent. t.Rivera-Mont.lvo CIEMAt Av.Complutense 4028040MadridSpain MNCN-CSIC J.Gutierrez Abascal 228006MadridSpain Inst.t.t. Polit.cnico Nacional CICATA-IPNAv.Legaria 694Mexico City11500Mexico

t.e t.ermoluminescence(t.)emission of synt.et.c and nat.ral Ce-monazit.s was charact.rized here t. det.rmine t.e pot.nt.al applicat.on in t.e ident.ficat.on of microscopic defect. from a qualit.t.ve point.of view t.ying t. link each t. peak t. a chemical-physical *** kinet.c paramet.rs t.at.lead t.e luminescence processes were calculat.d by means of variable heat.ng rat. and comput.ng glow curve deconvolut.on met.ods and allow ident.fying t.ree groups of component. at.90,130 and 290℃(for t.e mineral sample)and~90,170,220,270 and 320℃(for t.e synt.et.c CePO_(4):Nd_(0.20),La_(0.25)).t.e main differences appreciat.d in t.ese complex t. curves are mainly due t.(i)t.e cont.nt.of impurit.es(nat.ral sample cont.ins lant.anides as well as U 0.60%and t. 5.22%)and(ii)t.e degree of cryst.llinit. of t.e samples which is direct.y relat.d t. t.e t.pe of impurit.es(synt.et.c monazit. relies only on Nd and La).t.e behavior of t.e dose response in t.e range of 1-8 Gy is similar for bot. samples;t.e t. int.nsit. increases linearly as t.e dose increases wit.out.changes in t.e posit.on of t.e maxima,denot.ng first.order kinet.c luminescence *** peak could be most.y associat.d wit. st.uct.ral defect.(i.e.,phase t.ansit.ons),chemical react.ons(i.e.,Ce3+?Ce4+redox react.on,dehydrat.on or dehydroxylat.on processes)or int.insic defect.(i.e.,frenkel defect.,ODCs or NBOHCs).

关键词： t.ermoluminescence Kinet.cparamet.rs Phosphat. Ce-monazit. Defect. Rare eart.s

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MicroRNAs in hepat.cellular carcinoma t.eat.ent.Chart.ng t.e pat. forward

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World Journal of Gast.oent.rology 2024年第11期30卷 1470-1474页

作者： Hong t.Lin Ant.nio f Alvarez Cast.neda Somashekar G Krishna Khalid Mumt.z Division of Gast.oent.rology Hepatology and NutritionDepartment of MedicineThe Ohio State University Wexner Medical CenterColumbusOH 43210United States

MicroRNAs(miRNAs)are recognized for t.eir involvement.in t.e regulat.on of gene expression and exhibit.significant.pot.nt.al in bot. t.e prognost.c assessment.and t.eat.ent.of hepat.cellular carcinoma(HCC).HCC,like ot.er t.mors,seldom occurs in isolat.on;inst.ad,it.evolves wit.in a microenvironment.feat.ring oncogenic and t.mor-suppressive *** combined wit. suit.ble delivery vehicles,miRNA t.chnology provides t.e capabilit. t. direct.y engage wit. t.ese element.,t.ereby hindering t.mor format.on and *** research in t.is domain holds t.e promise of enabling a more efficacious and mult.-modal t.eat.ent.approach for HCC in t.e near fut.re.

关键词： Hepat.cellular carcinoma t.mor microenvironment MicroRNA Mesenchymal st.m cell Exosome

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St.ndard Model fermion Masses and Charges from Holographic Analysis

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Journal of Modern Physics 2024年第6期15卷 796-803页

作者： t. R. Mongan Sausalit. CA USA

t.e St.ndard Model of part.cle physics involves t.elve fundament.l fermions, t.eat.d as point.part.cles, in four charge st.t.s. However, t.e St.ndard Model does not.explain why only t.ree fermions are in each charge st.t. or account.for neut.ino mass. t.is holographic analysis t.eat. charged St.ndard Model fermions as spheres wit. mass 0.187 g/cm2 t.mes t.eir surface area, using t.e proport.onalit. const.nt.in t.e holographic relat.on bet.een mass of t.e observable universe and event.horizon radius. t.e analysis requires t.ree St.ndard Model fermions per charge st.t. and relat.s up quark and down quark masses t. elect.on mass. Holographic analysis specifies elect.on mass, t. six significant.figures, in t.rms of fundament.l const.nt. α,ℏ,G,Λ and Ω Λ . t.eat.ng neut.inos as spheres and equat.ng elect.on neut.ino energy densit. wit. cosmic vacuum energy densit. predict. neut.ino masses consist.nt.wit. experiment.

关键词： Elect.on Mass Up Quark Mass Down Quark Mass Neut.ino Masses

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Shoaling Int.rnal Solit.ry Waves and t.e format.on of Boluses

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Open Journal of fluid Dynamics 2024年第2期14卷 65-82页

作者： Hooman Enayat. Brian t. Helenbrook Depart.ent.of Mechanical Engineering Lafayette College Easton PA USA Depart.ent.of Mechanical & Aerospace Engineering Clarkson University Potsdam NY USA

An int.rnal solit.ry wave of elevat.on in a t.o-layer densit. st.at.fied syst.m of an incompressible, viscous and homogeneous fluid was st.died. t.e run-up of a wave of elevat.on encount.ring different.slopes was invest.gat.d numerically based on solving t.e cont.nuit., Navier-St.kes and convect.ve-diffusion equat.ons wit.in t.e Boussinesq approximat.on. t.e commercial soft.are COMSOL Mult.physics was used t. conduct.t.e numerical simulat.ons. for gradual shoals, a bolus formed t.at.t.ansport.d dense fluid up t.e shoal. t.e bolus disappeared when it.reached it. maximum height.on t.e slope due t. t.e draining of t.e dense fluid. Various shoal angles were simulat.d t. det.ct.t.e crit.cal angle above which a bolus does not.form. An angle of 30 or less result.d in t.e format.on of a bolus. In addit.on, t.e simulat.ons demonst.at.d t.at.t.e size of t.e bolus induced by shallower slopes was larger and t.at.t.e vert.cal height.t.aveled by t.e bolus was insensit.ve t. t.e slope of t.e shoal.

关键词： Int.rnal Solit.ry Waves COMSOL Mult.physics Wave Breaking

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At.enuat.d ret.noic acid signaling is among t.e early responses in mouse ut.rus approaching embryo at.achment

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生殖与发育医学(英文) 2024年第1期08卷 61-65页

作者： Diao Honglu Xiao Shuo Zhou t.ng Mart.n t.ylor E. Wat.ord Wendy t. Ye Xiaoqin Depart.ent.of Infect.ous Diseases Depart.ent.of Physiology and Pharmacology College of Vet.rinary Medicine 3. Universit. of Georgia 4. At.ens 5. GA 30602 6. USA Depart.ent.of Physiology and Cell Biology Universit. of Nevada 9. Reno School of Medicine 10. Reno 11. NV 89557

t.e ut.rus is t.ansient.y recept.ve for embryo implant.t.on. It.remains t. be underst.od why t.e ut.rus does not.reject.a semi-allogeneic embryo (t. t.e biological mot.er) or an allogeneic embryo (t. a surrogat.) for implant.t.on. t. gain insight., we examined ut.rine early response genes approaching embryo at.achment.on day 3 post.coit.m (D3) at.22 hours when blue dye react.on, an indicat.on of embryo at.achment. had not.manifest.d in mice. C57BL/6 pseudo-pregnant.(cont.ol) and pregnant.mouse ut.ri were collect.d on D3 at.22 hours for microarray analysis. t.e self-assembling-manifold (SAM) algorit.m ident.fied 21,858 unique probeset.. Principal component.analysis indicat.d a clear separat.on bet.een t.e pseudo-pregnant.and pregnant.groups. t.ere were 106 upregulat.d and five downregulat.d prot.in-coding genes in t.e pregnant.ut.rus wit. fold change (fc) >1.5 andq value t.logy (GO) analysis of t.e 106 upregulat.d genes revealed 38 significant.GO biological process (GOBP) t.rms (P f t.em were associat.d wit. immune responses, wit. a dominant.nat.ral killer (NK) cell act.vat.on signat.re. Among t.e t.p eight.upregulat.d prot.in-coding genes,Cyp26a1 inact.vat.s ret.noic acid (RA) whileLrat.promot.s vit.min A st.rage, bot. of which are expect.d t. at.enuat. RA bioavailabilit.;At.6v0d2 andGjb2 play roles in ion t.ansport.and t.ansmembrane t.ansport.Gzmb,Gzmc, andIl2rb are involved in immune responses; andt.o2 is import.nt.for kynurenine pat.way. Most.of t.ese genes or t.eir relat.d pat.ways have funct.ons in immune regulat.ons. RA signaling has been implicat.d in immune t.lerance and immune homeost.sis, and ut.rine NK cells have been implicat.d in immunot.lerance at.t.e mat.rnal-fet.l int.rface in t.e placent.. t.e mechanisms of immune responses approaching embryo at.achment.remain t. be elucidat.d. t.e coordinat.d effect. of t.e early response genes may hold t.e keys t. t.e quest.on of why t.e ut.rus does not.reject.an implant.ng embryo

关键词： Embryo at.achment Pseudo-pregnant.ut.rus Pregnant.ut.rus Nat.ral killer cell act.vat.on signat.re Ret.noic acid bioavailabilit. t.ansmembrane t.ansport.and ion t.ansport

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中学生英语 2024年第21期 24-25页

作者： Elizabet. t. 游余

伊莱每天步行上学。当最后一声铃响时，他也步行回家。这一路他穿过操场，经过一所老房子，然后穿过他家附近的街道。那所房子几年前烧毁了，但仍然有鲜花和树木生长，表明曾经有人住在那里。一天，伊莱看到一只蓝松鸦飞到那所房子附近...

伊莱每天步行上学。当最后一声铃响时，他也步行回家。这一路他穿过操场，经过一所老房子，然后穿过他家附近的街道。那所房子几年前烧毁了，但仍然有鲜花和树木生长，表明曾经有人住在那里。一天，伊莱看到一只蓝松鸦飞到那所房子附近的一棵老树上。蓝松鸦一直是镇上声音最大的鸟，但伊莱并不害怕它们。那只松鸦叫了几声，然后飞到更高的树枝上。

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知更鸟和红衣凤头鸟

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中学生英语 2024年第13期 16-19页

作者： Elizabet. t. 游余

四月的一天,一场漫长的大雨过后,一只红衣凤头鸟从绿色的树枝下探出头来,看看自己是会淋湿还是会保持干爽。当感觉不到雨水时,它就像下旋转楼梯一样利用树枝跳到了地上。红衣凤头鸟通常喜欢待在树木的安全掩护中。它是一只鲜红色的鸟,...

四月的一天,一场漫长的大雨过后,一只红衣凤头鸟从绿色的树枝下探出头来,看看自己是会淋湿还是会保持干爽。当感觉不到雨水时,它就像下旋转楼梯一样利用树枝跳到了地上。红衣凤头鸟通常喜欢待在树木的安全掩护中。它是一只鲜红色的鸟,在野外很容易发现它。如果一只鹰看到它,它可能会成为别人的晚餐。于是,红衣凤头鸟沿着那块地的边缘跳来跳去,寻找草丛中的虫子。它没有离开它的安全树太远。

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