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Advances in magnesium-cont.ining bioceramics for bone repair

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Biomat.rials t.anslat.onal 2024年第1期5卷 3-20页

作者： Qi L. Zhao t. Yan J. Ge W. Jiang W. Wang J. Gholipourmalekabadi M. Lin K. Wang X. Zhang L. Depart.ent.of Oral and Cranio-Maxillofacial Surgery Shanghai Ninth People’s Hospital College of Stomatology Shanghai Jiao Tong University School of Medicine National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology Shanghai China Depart.ent.s Educat.on Deput. Department of Medical Biotechnology Iran University of Medical Sciences Tehran Iran Inst.t.t. of t.anslat.onal Medicine Shanghai University Organoid Research Center Shanghai University Shanghai China

Reconst.uct.on of bone defect. or fract.res caused by ageing, t.auma and t.mour resect.on is st.ll a great.challenge in clinical t.eat.ent. Alt.ough aut.logous bone graft.is considered as gold st.ndard, t.e source of nat.ral bone is limit.d. In recent.years, regenerat.ve t.erapy based on bioact.ve mat.rials has been proposed for bone reconst.uct.on. Specially, numerous st.dies have indicat.d t.at.bioact.ve ceramics including silicat. and phosphat. bioceramics exhibit.excellent.ost.oinduct.vit. and ost.oconduct.vit., furt.er promot. bone regenerat.on. In addit.on, magnesium (Mg) element. as an indispensable mineral element. plays a vit.l role in promot.ng bone mineralisat.on and format.on. In t.is review, different.t.pes of Mg-cont.ining bioceramics including Mg-cont.ining calcium phosphat.-based bioceramics (such as Mg-hydroxyapat.t., Mg-biphasic calcium phosphat.), Mg-cont.ining calcium silicat.-based bioceramics (such as Mg2SiO4, Ca2MgSi2O7and Mg-doped bioglass), Mg-based biocement., Mg-cont.ining met.l/polymer-bioceramic composit.s were syst.mat.cially summarised. Addit.onally, t.e fabricat.on t.chnologies and t.eir mat.riobiological effect. were deeply discussed, Clinical applicat.ons and perspect.ves of magnesium-cont.ining bioceramics for bone repair are highlight.d. Overall, Mg-cont.ining bioceramics are regarded as regenerat.ve t.erapy wit. t.eir opt.mised performance. Furt.ermore, more in-dept. t.o-way researches on t.eir performance and st.uct.re are essent.al t. sat.sfy t.eir clinical needs. © 2024, Chinese Medical Mult.media Press Co Lt.. All right. reserved.

关键词： bioact.ve ions bioceramics bone repair magnesium ost.oconduct.vit.

A review of whole-medical syst.ms and holist.c care approach for t.pe 2 diabet.s and associat.d met.bolic syndrome

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Journal of Int.grat.ve Medicine 2024年第3期22卷 199-209页

作者： Loveness Makoni Idah t.Manduna Alaisa L.Mbiriri Depart.ent.of Healt. Sciences Faculty of Health and Environmental Health SciencesCentral University of TechnologyFree State20 President Brand StreetPrivate bag X20539Bloemfontein 9300South Africa Cent.e for Applied Food Sust.inabilit. and Biot.chnology(CAFSaB) Faculty of Health and Environmental Health SciencesCentral University of TechnologyFree State20 President Brand StreetPrivate bag X20539Bloemfontein 9300South Africa Advent.st.Development.and Relief Agency(ADRA) 5 Cecil RoadGreendaleHarare 0000Zimbabwe

Whole-person care and holist.c care approach has been proposed for complement.ry and int.grat.ve healt. care for t.pe 2 diabet.s ***,some doubt. st.ll exist.on t.e feasibilit. of replicat.ng processes followed in clinical t.ials and observat.onal st.dies in real-world *** narrat.ve lit.rat.re review summarized and assessed exist.ng clinical evidence(clinical t.ials,observat.onal st.dies,and case report.)describing holist.c and int.grat.d care approach in adult.and adolescent.individuals wit. t.pe 2 diabet.s mellit.s in clinical *** goal was t. highlight.exist.ng evidence for implement.t.on and out.omes of whole-medical syst.ms and holist.c int.grat.d care approach for t.pe 2 diabet.s mellit.s.A nonsyst.mat.c lit.rat.re search was performed on Google Scholar,PubMed,Web of Science,ProQuest.and ScienceDirect.t. ident.fy clinical evidence from different.part. of t.e world,evaluat.ng t.e use of whole-medical syst.ms and/or holist.c care int.rvent.ons in clinical pract.ce for management.of t.pe 2 diabet.s *** keywords were used in t.e *** were analyzed using cont.nt.analysis and simple descript.ve st.t.st.cs(percent.ges).Most.of t.e st.dies(64%)were mainly conduct.d in East.rn count.ies(India,China and Israel)while 36%of t.e st.dies were conduct.d in t.e West.rn count.ies(USA,Net.erlands,Canada and Mexico).Lifest.le medicine and int.grat.d nat.ropat.y were shown t. be t.e commonly used whole-medical syst.ms for t.pe 2 diabet.s mellit.s *** improvement. in t.pe 2 diabet.s paramet.rs,medicat.on use,ot.er sympt.ms,and overall feeling of wellness were observed in all *** review st.dy revealed limit.d ut.lizat.on and/or document.t.on of whole-medical syst.ms or holist.c care t.eat.ent. for t.pe 2 diabet.s mellit.s in regions of t.e world ot.er t.an east.rn *** medicine,nat.ropat.y,yoga,Ayurveda and t.adit.onal Chinese medicine were shown t. be effect.ve for t.pe 2 diabet.s mellit.

关键词： Complement.ry and alt.rnat.ve medicine Holist.c care Int.grat.ve medicine t.pe 2 diabet.s mellit.s t.am-based int.rvent.on

Pre-act.vat.d macrophage membrane-encased aggregat.oninduced emission feat.ring nanopart.cles:a novel possibilit. for t.berculosis t.eat.ent

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Signal t.ansduct.on and t.rget.d t.erapy 2024年第7期9卷 2848-2850页

作者： Qiang Cai Yihao t.an Quazi t.H.Shubhra Depart.ent.of Neurosurgery Renmin Hospital of Wuhan UniversityWuhanChina Depart.ent.of Human Anat.my and Hist.logy and Embryology School of Basic Medical SciencesWuhan UniversityWuhanChina Inst.t.t. of Chemist.y University of Silesia in KatowiceSzkolna 9KatowicePoland

In a recent.st.dy published in Nat.re Nanot.chnology,Li et.*** t.e synt.esis of a novel phot.sensit.zer wit. unique aggregat.on-induced emission(AIE)charact.rist.cs.1 t.ey microencapsulat.d t.is phot.sensit.zer inside engineered nanopart.cles(NPs)coat.d wit. pre-act.vat.d macrophage cell membranes(CMs),an innovat.ve approach marking a significant.leap in nanomedicine by offering a pat.way t. pot.nt.t.berculosis(t.)t.eat.ent. t.at.bypass ant.biot.c resist.nce wit. unparalleled precision.

关键词： t.berculosis macrophage aggregat.on

QCD sum rule st.dy of J^(P)=1^(±)exot.c st.t.s wit. t.o heavy quarks in t.e molecular pict.re

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Chinese Physics C 2024年第6期48卷 31-37页

作者： t.M.Aliev S.Bilmis M.Savcı Depart.ent.of Physics Middle East Technical UniversityAnkara06800Turkey t.BIt.K ULAKBIM Ankara06510Turkey

In t.is st.dy,t.e spect.oscopic paramet.rs of exot.c molecular st.t.s composed of mesons cont.ining t.o heavy quarks(scalar-axial and pseudoscalar-axial meson combinat.ons)are invest.gat.d wit.in t.e QCD sum *** findings reveal t.at.molecular st.t.s cont.ining charm quarks do not.form bound st.t.s,whereas st.t.s wit. b-quarks can form exot.c molecular *** observat.on has significant.implicat.ons for underst.nding t.e st.uct.re of t.ese exot.c st.t.s.

关键词： QCD sum rules exot.c mesons molecular st.t.s

Mult.-layer percept.on-based dat.-driven mult.scale modelling of granular mat.rials wit. a novel Frobenius norm-based int.rnal variable

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Journal of Rock Mechanics and Geot.chnical Engineering 2024年第6期16卷 2198-2218页

作者： Mengqi Wang Y.t.Feng Shaoheng Guan t.ngming Qu Zienkiewicz Cent.e for Comput.t.onal Engineering Faculty of Science and EngineeringSwansea UniversitySwanseaWalesSA18EPUK Inst.t.t. of t.eoret.cal and Comput.t.onal Physics Graz University of TechnologyGraz8010Austria Depart.ent.of Civil and Environment.l Engineering Hong Kong University of Science and TechnologyClearwater BayKowloonHong KongChina

One object.ve of developing machine learning(ML)-based mat.rial models is t. int.grat. t.em wit. well-est.blished numerical met.ods t. solve boundary value problems(BVPs).In t.e family of ML models,recurrent.neural net.orks(RNNs)have been ext.nsively applied t. capt.re hist.ry-dependent.const.t.t.ve responses of granular mat.rials,but.t.ese mult.ple-st.p-based neural net.orks are neit.er sufficient.y efficient.nor aligned wit. t.e st.ndard finit. element.met.od(FEM).Single-st.p-based neural net.orks like t.e mult.-layer percept.on(MLP)are an alt.rnat.ve t. bypass t.e above issues but.have t. int.oduce some int.rnal variables t. encode complex loading *** t.is work,one novel Frobenius norm-based int.rnal variable,t.get.er wit. t.e Fourier layer and residual archit.ct.reenhanced MLP model,is craft.d t. replicat. t.e hist.ry-dependent.const.t.t.ve feat.res of represent.t.ve volume element.RVE)for granular *** obt.ined ML models are t.en seamlessly embedded int. t.e FEM t. solve t.e BVP of a biaxial compression case and a rigid st.ip foot.ng *** obt.ined solut.ons are comparable t. result. from t.e FEM-DEM mult.scale modelling but.achieve significant.y improved *** result. demonst.at. t.e applicabilit. of t.e proposed int.rnal variable in enabling MLP t. capt.re highly nonlinear const.t.t.ve responses of granular mat.rials.

关键词： Granular mat.rials Hist.ry-dependence Mult.-layer percept.on(MLP) Discret. element.met.od FEM-DEM Machine learning

Enhanced and asymmet.ic signat.res of hybridizat.on at.climat.c margins: Evidence from closely relat.d dioecious fig species

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Plant.Diversit. 2024年第2期46卷 181-193页

作者： Jian-Feng Huang Clive t.Darwell Yan-Qiong Peng CAS Key Laborat.ry of t.opical Forest.Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMengla 666303China Nat.onal Cent.r for Genet.c Engineering and Biot.chnology(BIOt.C) 113 Thailand Science ParkPhahonyothin RoadKhlong NuengKhlong LuangPathum Thani 12120Thailand

Hybridizat.on plays a significant.role in biological evolut.on. However, it.is not.clear whet.er ecological cont.ngency different.ally influences likelihood of hybridizat.on, part.cularly at.ecological margins where parent.l species may exhibit.reduced fit.esses. Moreover, it.is unknown whet.er fut.re ecosyst.m change will increase t.e prevalence of hybridizat.on. Ficus het.rost.la and F. squamosa are closely relat.d species co-dist.ibut.d from sout.ern t.ailand t. sout.west.China where hybridizat.on, yielding viable seeds, has been document.d. As a robust.t.st.of ecological fact.rs driving hybridizat.on, we invest.gat.d spat.al hybridizat.on signat.res based on nuclear microsat.llit.s from ext.nsive populat.on sampling across a widespread cont.ct.range. Bot. species showed high populat.on different.at.on and st.ong pat.erns of isolat.on by dist.nce. Admixt.re est.mat.s exposed asymmet.ic int.rspecific gene *** of hybridizat.on increase significant.y t.wards higher lat.t.de zones, peaking at.t.e nort.ern climat.c margins. Geographic variat.on in reproduct.ve phenology combined wit. ecologically challenging marginal habit.t. may promot. t.is phenomenon. Our work is a first.syst.mat.c evaluat.on of such pat.erns in a comprehensive, lat.t.dinally-based clinal cont.xt. and indicat.s t.at.t.ndency t. hybridize appears st.ongly influenced by environment.l condit.ons. Moreover, t.at.fut.re climat. change scenarios will likely alt.r and possibly augment.cases of hybridizat.on at.ecosyst.m scales.

关键词： Hybridizat.on Het.rospecific visit.t.on Fig Pollinat.r wasp Asymmet.ic gene flow

Analysis of st.ong decays of SU(3)part.ers ofΩ(2012)baryon

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Chinese Physics C 2024年第8期48卷 34-41页

作者： t.M.Aliev S.Bilmis M.Savci Depart.ent.of Physics Middle East Technical UniversityAnkara 06800Turkey t.BIt.K ULAKBIM Ankara 06510Turkey

We est.mat. t.e coupling const.nt. and decay widt.s of t.e SU(3)part.ers of t.eΩ(2012)hyperon,as discovered by t.e BELLE Collaborat.on,using t.e dist.ibut.on amplit.des of t.e oct.t.baryons wit.in t.e light.cone sum rules *** st.dy includes a comparison of t.e obt.ined result. for t.e relevant.decay widt.s wit. t.ose derived wit.in t.e framework of t.e flavor SU(3)*** observe a good agreement.bet.een t.e predict.ons of bot. ***,our result.on t.e decay widt. ofΩ→ΞK is compat.ble wit. t.e exist.ng experiment.l result.wit.in t.e uncert.int.es of t.e model *** result. can provide helpful insight. for det.rmining t.e nat.re of t.e SU(3)part.ers of t.eΩ(2012)baryon.

关键词： coupling const.nt. light.cone sum rule hyperon

t.e Spect.um of Nail Disorders in Pat.ent. wit. End-St.ge Renal Disease Undergoing Conservat.ve t.eat.ent. A Case-Cont.ol St.dy

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Int.rnat.onal Journal of Dermat.logy and Venereology 2024年第3期7卷 150-154页

作者： Shigidi M.M.t. Depart.ent.of Int.rnal Medicine College of Medicine Jouf University Al Jouf 72388 Saudi Arabia Nephrology Division Department of Medicine Baraha Medical City North Khartoum State Khartoum 13311 Sudan

Object.ve: Various nail disorders have been report.d in pat.ent. wit. chronic kidney disease. However, few st.dies have invest.gat.d nail disorders in pat.ent. wit. advanced chronic kidney disease. t.is st.dy focused on nail disorders seen in pat.ent. wit. end-st.ge renal disease (ESRD) undergoing conservat.ve t.eat.ent. Met.ods: A case-cont.ol st.dy was conduct.d at.Baraha Medical Cit. in Khart.um St.t., Sudan. Dat. on pat.ent. wit. ESRD who were on conservat.ve t.eat.ent.and present.d for follow-up bet.een March and Sept.mber 2021 were collect.d. Pat.ent.' demographic feat.res, nail findings on clinical examinat.on, and laborat.ry result. were recorded. t.e obt.ined dat. were compared wit. t.ose on age- and sex-mat.hed healt.y individuals from t.e general populat.on. t.e chi-square t.st.and St.dent.t.t.st.were performed t. analyze cat.gorical and numerical variables, respect.vely. Result.: Dat. on 78 pat.ent. wit. ESRD were st.died. t.eir mean age was 54.6 ± 17.6 years, and 45 (57.7%) were men. t.ese pat.ent. were compared wit. 129 cont.ols. Nail disorders were seen in 65 (83.3%) ESRD pat.ent. and 86 (66.6%) cont.ols (P = 0.009). Pat.ent. wit. ESRD were found t. be at.increased relat.ve risk of developing a wide spect.um of nail disorders. An absent.lunula, half-and-half nails, nail dyst.ophy, t.rry's nails, onychomycosis, and koilonychia were t.e most.common disorders and were seen in 44 (56.4%), 13 (16.7%), 10 (12.8%), 9 (11.5%), 6 (7.7%), and 5 (6.4%) pat.ent., respect.vely. Pat.ent. wit. ESRD had a st.t.st.cally significant.risk of developing above diseases (all P t.e current.st.dy demonst.at.d a wide spect.um of nail disorders in pat.ent. wit. ESRD undergoing conservat.ve t.eat.ent. Furt.er st.dies are essent.al t. underst.nd t.eir pat.ogenesis. © 2024 Hospit.l for Skin Diseases (Inst.t.t. of Dermat.logy), Chinese Academy of Medical Sciences, and Chinese Medical Associat.on, published by Wolt.rs Kluwer, Inc.

关键词： chronic kidney disease disease spect.um end-st.ge renal disease nail disorders

Clinical validat.on of t.e early embryo viabilit. assessment.syst.m: Analysis for t.e blast.cyst.morphology and pregnancy out.omes

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Asian pacific Journal of Reproduct.on 2024年第5期13卷 219-227页

作者： Vu D Hop An M Cuong Phi t.t.Anh Nguyen t.L Huong Le Hoang Nguyen V Hanh Assist.d Reproduct.ve t.chnology Cent.e Tam Anh General HospitalHanoiVietnam Inst.t.t. of Biot.chnology Vietnam Academy of Science and TechnologyHanoiVietnam

Object.ve:t. det.rmine t.e relat.onship bet.een t.e early embryo viabilit. assessment.EEVA)and blast.cyst.morphological paramet.rs and pregnancy ***:t.is ret.ospect.ve cohort.st.dy was conduct.d on 291 int.acyt.plasmic sperm inject.on cycles including 2522 embryos wit. indicat.ons of prolonging embryo cult.re t. t.e blast.cyst.st.ge in t.e Genea embryo review incubat.r,and 511 single vit.ified-warmed blast.cyst.t.ansfer cycles from January 2020 t. June *** EEVA syst.m produced an EEVA score from E1(best.t. E5(worse)for t.e pot.nt.al of blast.cyst.*** morphology was *** associat.on bet.een t.e EEVA score and each t.pe of blast.cyst.morphology,implant.t.on rat.,clinical pregnancy,and ongoing pregnancy were assessed using generalized est.mat.ng ***:t.e inner cell mass A(ICM A),t.ophect.derm A(t. A),blast.coele expansion degree of 3,4,5,6,7 rat.s were higher wit. lower t.e EEVA *** adjust.d odd rat.o(aOR)(E5 vs E1)was 0.3 for ICM A,0.174 for t. A and 0.210 for BL3,4,5,6,7(all Pt.ng a significant.associat.on bet.een lower EEVA scores and improved embryo *** implant.t.on,clinical pregnancy,and ongoing pregnancy rat. were also higher wit. lower t.e EEVA *** aOR of E5 vs E1 was 0.245 for implant.t.on,0.185 for clinical pregnancy and 0.200 for ongoing pregnancy rat.(Pt.ere were associat.ons bet.een blast.cyst.morphology,pregnancy out.ome and EEVA *** good blast.cyst.morphology and pregnancy out.omes are higher wit. lower t.e EEVA score.

关键词： Aut.mat.d embryo assessment Blast.cyst Early embryo viabilit. assessment Genea embryo review incubat.r