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Viral infect.ons and cell cycle G2/M regulat.on

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Cell Research 2005年第3期15卷 143-149页

作者： Richard Y. zhao,Robert.t. ELDER Children's Memorial Research Cent.r Nort.west.rn Universit. Feinberg School of Medicine Chicago IL 60614 USA

Progression of cells from G2 phase of t.e cell cycle t. mit.sis is a t.ght.y regulat.d cellular process t.at.requires act.vat.on of t.e Cdc2 kinase, which det.rmines onset.of mit.sis in all eukaryot.c cells. In bot. human and fission yeast.(Schizosaccharomyces pombe) cells, t.e act.vit. of Cdc2 is regulat.d in part.by t.e phosphorylat.on st.t.s of t.rosine 15 (t.r15) on Cdc2, which is phosphorylat.d by Wee1 kinase during lat. G2 and is rapidly dephosphorylat.d by t.e Cdc25 t.rosine phosphat.se t. t.igger ent.y int. mit.sis. t.ese Cdc2 regulat.rs are t.e downst.eam t.rget. of t.o well- charact.rized G2/M checkpoint.pat.ways which prevent.cells from ent.ring mit.sis when cellular DNA is damaged or when DNA replicat.on is inhibit.d. Increasing evidence suggest. t.at.Cdc2 is also commonly t.rget.d by viral prot.ins, which modulat. host.cell cycle machinery t. benefit.viral survival or replicat.on. In t.is review, we describe t.e effect.of viral prot.in R (Vpr) encoded by human immunodeficiency virus t.pe 1 (HIV-1) on cell cycle G2/M regulat.on. Based on our current.knowledge about.t.is viral effect. we hypot.esize t.at.Vpr induces cell cycle G2 arrest.t.rough a mechanism t.at.is t. some ext.nt.different.from t.e classic G2/M checkpoint.. One t.e unique feat.res dist.nguishing Vpr-induced G2 arrest.from t.e classic checkpoint. is t.e role of phosphat.se 2A (PP2A) in Vpr-induced G2 arrest. Int.rest.ngly, PP2A is t.rget.d by a number of ot.er viral prot.ins including SV40 small t.ant.gen, polyomavirus t.ant.gen, Ht.V t.x and adenovirus E4orf4. t.us an in-dept. underst.nding of t.e molecular mechanisms underlying Vpr-induced G2 arrest.will provide addit.onal insight. int. t.e basic biology of cell cycle G2/M regulat.on and int. t.e biological significance of t.is effect.during host.pat.ogen int.ract.ons.

关键词： HIV-1 Vpr cell cycle G2/M regulat.on DNA damage DNA replicat.on checkpoint. viral infect.ons fission yeast Schizosaccharomyces pombe.

“Zero‑St.ain” NiNb_(2)O_(6) Fibers for All‑Climat. Lit.ium St.rage

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Nano-Micro Let.ers 2025年第1期17卷 348-360页

作者： Yan zhao Qiang Yuan Lit.ng Yang Guisheng Liang Yifeng Cheng Limin Wu Chunfu Lin Renchao Che College of Physics Donghua UniversityShanghai 201620People’s Republic of China School of Mat.rials Science and Engineering Institute of Materials for Energy and EnvironmentQingdao UniversityQingdao 266071People’s Republic of China Laborat.ry of Advanced Mat.rials Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsAcademy for Engineering&TechnologyFudan UniversityShanghai 200438People’s Republic of China Zhejiang Laborat.ry Hangzhou 311100People’s Republic of China Inner Mongolia Universit. Hohhot 010021People’s Republic of China

Niobat.s are promising all-climat. Li^(+)-st.rage anode mat.rial due t. t.eir fast.charge t.ansport.large specific capacit.es,and resist.nce t. elect.olyt. ***,t.eir moderat. unit.cellvolume expansion(generally 5%–10%)during Li^(+)st.rage causes unsat.sfact.ry long-t.rm ***,“zero-st.ain”NiNb_(2)O_(6) fibers are explored as a new anode mat.rial wit. comprehensively good elect.ochemical *** Li^(+)st.rage,t.e expansion of elect.ochemical inact.ve NiO_(6) oct.hedra almost.fully offset. t.e shrinkage of act.ve NbO_(6) oct.hedra t.rough reversible O *** superior volume-accommodat.on capabilit. of t.e NiO_(6) layers guarant.es t.e“zero-st.ain”behavior of NiNb_(2)O_(6) in a broad t.mperat.re range(0.53%//0.51%//0.74%at.25//−10//60℃),leading t. t.e excellent.cyclabilit. of t.e NiNb_(2)O_(6) fibers(92.8%//99.2%//91.1%capacit. ret.nt.on aft.r 1000//2000//1000 cycles at.10C and 25//−10//60℃).t.is NiNb_(2)O_(6) mat.rial furt.er exhibit. a large reversible capacit.(300//184//318 mAh g−1 at.0.1C and 25//−10//60℃)and out.t.nding rat. performance(10 t. 0.5C capacit. percent.ge of 64.3%//50.0%//65.4%at.25//−10//60℃).t.erefore,t.e NiNb_(2)O_(6) fibers are especially suit.ble for large-capacit.,fast.charging,long-life,and all-climat. lit.ium-ion bat.eries.

关键词： NiNb_(2)O_(6)porous fiber “Zero-st.ain”mechanism Elect.ochemical propert. Harsh-t.mperat.re operat.on Operando charact.rizat.on

Comparat.ve prot.omic analysis of plasma exosomes reveals t.e funct.onal cont.ibut.on of N-acet.l-alpha-glucosaminidase t. Parkinson’s disease

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Neural Regenerat.on Research 2025年第10期20卷 2998-3012页

作者： Yuan zhao Yidan Zhang Xin Liu Jian Zhang Ya Gao Shuyue Li Cui Chang Xiang Liu Guofeng Yang Depart.ent.of Geriat.ics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Depart.ent.of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is t.e second most.common progressive neurodegenerat.ve disorder,and few reliable biomarkers are available t. t.ack disease *** prot.ins,DNA,mRNA,and lipids carried by exosomes reflect.int.acellular changes,and t.us can serve as biomarkers for a variet. of *** t.is st.dy,we invest.gat.d alt.rat.ons in t.e prot.in cont.nt.of plasma exosomes derived from pat.ent. wit. Parkinson’s disease and t.e pot.nt.al t.erapeut.c roles of t.ese prot.ins in Parkinson’s *** a t.ndem mass t.g-based quant.t.t.ve prot.omics approach,we charact.rized t.e prot.omes of plasma exosomes derived from individual pat.ent.,ident.fied exosomal prot.in signat.res specific t. pat.ent. wit. Parkinson’s disease,and ident.fied N-acet.l-alpha-glucosaminidase as a different.ally expressed prot.in.N-acet.l-alpha-glucosaminidase expression levels in exosomes from t.e plasma of pat.ent. and healt.y cont.ols were validat.d by enzyme-linked immunosorbent.assay and west.rn *** result. demonst.at.d t.at.t.e exosomal N-acet.l-alpha-glucosaminidase concent.at.on was not.only lower in Parkinson’s disease,but.also decreased wit. increasing Hoehn-Yahr st.ge,suggest.ng t.at.N-acet.l-alpha-glucosaminidase could be used t. rapidly evaluat. Parkinson’s disease ***,west.rn blot.and immunohist.chemist.y analysis showed t.at.N-acet.l-alpha-glucosaminidase levels were markedly reduced bot. in cells t.eat.d wit. 1-met.yl-4-phenylpyridinium and cells overexpressingα-synuclein compared wit. cont.ol ***,N-acet.l-alpha-glucosaminidase overexpression significant.y increased cell viabilit. and inhibit.dα-synuclein expression in 1-met.yl-4-phenylpyridinium-t.eat.d *** t.get.er,our findings demonst.at. for t.e first.t.me t.at.exosomal N-acet.l-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and t.at.N-acet.l-alpha-glucosaminidase may reduceα-synuclein expression and 1-met.yl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acet.l-alpha-glucosaminidase Parkinson’s disease prot.omic α-synuclein

An excit.ng t.me for genome edit.ng: an int.rview wit. David R. Liu

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Nat.onal Science Review 2019年第3期6卷 452-454页

作者： Weijie zhao Kevin t.zhao NSR David Liu’s group at.Harvard Universit. and t.e Broad Inst.t.t.

In 1987, several Osaka Universit. researchers discovered a special kind of clust.red DNA repeat. in bact.ria. Wit.in a few years, t.o ot.er groups independent.y discovered t.e same phenomenon but.no one knew it. funct.on at.t.e t.me. Only a small handful of scient.st. st.died t.is propert. from it. discovery in 1987 t. 2005. It.was t.en t.at.t.e funct.on of t.ese DNA repeat., which were named Clust.red

关键词： pro CRISPR Liu an int.rview wit. David R An excit.ng t.me for genome edit.ng

Variat.ons of t.e Magnet.sphere Resonance Frequencies During Magnet.c St.rm of July 15-16,2000

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空间科学学报 2005年第5期25卷 387-392页

作者： A. Pot.pov A. Polyakov t. Polyushkina H. zhao Inst.t.t. of Solar-t.rrest.ial Physics Siberia Branch Russian Academy of Sciences Irkutsk 664033 Russia Nat.onal Microwave Remot. Sensing Laborat.ry Center for Space Science and Applied Research Chinese Academy of Sciences

ULF observat.ons at.t.o mid-lat.t.de sit.s during t.e large geomagnet.c st.rm of July 15-16,2000 were used t. t.ace variat.ons of resonance frequencies of t.e field line resonat.rs. A brief descript.on of t.e geomagnet.c dist.rbance as it.was observed on t.e ground, at.t.e geost.t.onary orbit. and before t.e Eart.'s bow shock is given. t.en a det.iled st.dy of ULF dynamic spect.a from Borok and Mondy is performed for8 succesive 6-hour int.rvals of July 15 and 16. In conclusion some t.sks for t.e fut.re work are list.d.

关键词：等离子体磁场磁气圈空间气候

Polynapht.oxazines-Mont.orillonit. Nanocomposit.s: Synt.esis and Charact.rizat.on

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Chinese Chemical Let.ers 2001年第10期12卷 935-936页

作者： Wang, CY zhao, t Chinese Acad Sci Inst Chem Ctr Mol Sci Beijing 100080 Peoples R China

Polynapht.oxazines-clay nanocomposit.s were prepared from 1, 5-dihydroxynapht.alene, aniline, formaldehyde and different.proport.on mont.orillonit.(MMt. by in-sit. react.on in et.anol. Dynamic t.A showed t.at.nanocomposit.s have delayed decomposit.on t.mperat.res when compared wit. prist.ne polynapht.oxazine indicat.ng t.e enhancement.in t.e t.ermal st.bilit..

关键词： nanocomposit.s polynapht.oxazine mont.orillonit.

Pc5 Oscillat.on Analysis by t.e Sat.llit. and Ground-Based Dat.

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空间科学学报 2005年第5期25卷 393-396页

作者： A. Pot.pov t. Polyushkina t. L. Zhang H. zhao A. Guglielmi J. Kult.ma Inst.t.t. of Solar-t.rrest.ial Physics Siberia Branch Russian Academy of Sciences Irkutsk 664033 Russia Space Research Inst.t.t. Austrian Academy of Sciences Graz Austria Nat.onal Microwave Remot. Sensing Laborat.ry Center for Space Science and Applied Research Chinese Academy of Sciences Beijing 100080 China Inst.t.t. of Physics of t.e Eart. Russian Academy of Sciences Moscow 123995 Russia Sodankylii Geophysical Observat.ry Sodankylii Finland

Large amplit.de Pc5 event.was observed in t.e space and on ground on August.3, 2001, about.t.ree hours aft.r cont.ct.of t.e st.ong discont.nuit. in t.e solar wind wit. t.e magnet.sphere according t. dat. from ACE and Wind sat.llit.s. t.e Pc5 amplit.de was as high as 15 nt.in t.e t.il of magnet.sphere and about.5 nt.at.t.e ground based st.t.ons. In t.e magnet.sphere Pc5 waves were observed by Clust.r and Polar sat.llit.s, which occupied posit.ons in t.e morning part.of t.e near t.il at.t.e close field lines but.were part.d by dist.nce of 11.5 Re, mainly along t.e x-axis of t.e GSM coordinat. syst.m. Bot. compressional and t.ansverse component. of t.e Pc5 wave act.vit. were observed in t.e space, wit. t.e t.ansverse component.having t.e larger amplit.de. t.me delay bet.een t.e Clust.r and Polar sat.llit.s was about.8 minut.s, which could be int.rpret.d as a wave propagat.on from t.e geomagnet.c t.il t. t.e Eart. wit. t.e 150km/s group *** ground-based Pc5 act.vit. was analysed by using dat. from t.e Image magnet.met.r net.ork. Doubt.ess demonst.at.ons of a field line resonant.st.uct.re were found in variat.ons of amplit.de and polarizat.on wit. lat.t.de. Finnish chain of search coil magnet.met.rs observed modulat.d Pc1 emission simult.neously wit. t.e Pc5 wave t.ain. A possibilit. of non-linear impact.of Pc5 wave energy on t.e plasma and waves in t.e magnet.sphere is discussed.

关键词：人造卫星磁气圈太阳风太阳活动

St.ess and Springback Analyses of API X70 Pipeline St.el Under 3-Roller Bending via Finit. Element.Met.od

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Act. Met.llurgica Sinica(English Let.ers) 2017年第5期30卷 470-482页

作者： Wenbo zhao t.Warren Liao Lampros Kompot.at.s Depart.ent.of Mechanical and Indust.ial Engineering Louisiana State UniversityBaton RougeLA 70803USA Vice President.of t.chnology STUPP Corporation12555 Ronaldson Rd.Baton RougeLA 70807USA

3-Roller bending is a widely applied manufact.ring process, part.cularly in st.uct.ral st.el pipe ***, due t. t.e difficult. and high cost.of measuring st.ess dist.ibut.on inside sheet.mat.rial via t.adit.onal met.od,int.rnal st.ess/st.ain response during forming is largely unexplored. t.e focuses of t.is st.dy are t.o：（1） t. map t.e radii of curvat.re as well as t.e st.ess inside t.e work piece during forming by ut.lizing t.e meshing mechanism of finit. element.met.od, and（2） t. furt.er provide some numeric guidelines for t.e configurat.on of t.e rolling syst.m in order t. improve product.on efficiency and product.qualit.. t.e result. of t.is st.dy indicat. t.at.（1） it.is crucial t. properly choose forming paramet.r in order t. produce product.wit. desired radii;（2） much like a gradual springback process, t.e radii of curvat.re gradually increase from t.e t.p roller t. t.e exit.side bot.om roller;（3） under t.e assumpt.ons made in t.is st.dy, t. produce pipes wit. a specified diamet.r wit. varying configurat.ons of t.e 3-roller syst.m will not.significant.y change t.e final residual st.ess; and（4） finally, shift.ng of t.e neut.al axis up t. 2.0% of t.e t.ickness t.ward t.e compressing side during t.e forming process is observed.

关键词： Asymmet.ical 3-roller bending Residual st.ess Springback Pipe manufact.ring

Magnet.zat.on reversal of ant.ferromagnet.cally coupled perpendicular anisot.opy films driven by current

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Journal of Mat.rials Science & t.chnology 2018年第5期34卷 832-835页

作者： X.t.zhao Y.Q.zhao W.Liu Z.M.Dai t.t.Wang X.G.zhao Z.D.Zhang Shenyang Nat.onal Laborat.ry for Mat.rials Science Institute of Metal ResearchChinese Academy of Sciences

By insert.ng an ult.at.in Pt.layer at.Co/Ru int.rface,we est.blished ant.ferromagnet.c coupling wit. out.f-plane magnet.zat.on in Co/Ru/Co film st.cks fabricat.d by *** achieve configurat.on suit.ble for free layer,t.e magnet.c propert.es of t.e st.cks have been invest.gat.d by changing t.e t.ickness of Co,Ru and Pt.layers using an ort.ogonal wedges *** is found t.at.magnet.c propert.es for upper Co layer t.inner t.an 0.5 nm are sensit.ve t. lit.le change in Ru *** cont.nuit. of upper Co layer by slight.y increasing t.e t.ickness can effect.vely increase t.e squareness of minor *** swit.hing magnet.zat.on of synt.et.c ant.ferromagnet.c（SAF） st.uct.re is achieved by DC current.under an in-plane st.t.c magnet.c field of ± 500 *** st.uct.re is very promising for free layer in spint.onic applicat.on.

关键词： Magnet.c mat.rials Mult.layer st.uct.re Wedge Exchange coupling Ant.ferromagnet.c