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Evaluat.on of slope st.bilit. t.rough rock mass classificat.on and kinemat.c analysis of some major slopes along NH-1A from Ramban t. Banihal, Nort. West.rn Himalayas

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Journal of Rock Mechanics and Geot.chnical Engineering 2024年第1期16卷 167-182页

作者： Amit.Jaiswal A.K.Verma t.N.Singh Depart.ent.of Civil and Environment.l Engineering Indian Institute of Technology PatnaPatna801106India

t.e net.ork of Himalayan roadways and highways connect. some remot. regions of valleys or hill slopes,which is vit.l for India’s socio-economic *** t. nat.ral and art.ficial fact.rs,frequency of slope inst.bilit.es along t.e net.orks has been increasing over last.few *** of st.bilit. of nat.ral and art.ficial slopes due t. const.uct.on of t.ese connect.ng road net.orks is significant.in safely execut.ng t.ese roads t.roughout.t.e *** rock mass classificat.on met.ods are generally used t. assess t.e st.engt. and deformabilit. of rock *** st.dy assesses slope st.bilit. along t.e NH-1A of Ramban dist.ict.of Nort. West.rn *** st.uct.rally and non-st.uct.rally cont.olled rock mass classificat.on syst.ms have been applied t. assess t.e st.bilit. condit.ons of 14 *** evaluat.ng t.e st.bilit. of t.ese slopes,kinemat.c analysis was performed along wit. geological st.engt. index(GSI),rock mass rat.ng(RMR),cont.nuous slope mass rat.ng(CoSMR),slope mass rat.ng(SMR),and Q-slope in t.e present.*** SMR gives t.ree slopes as complet.ly unst.ble while CoSMR suggest. four slopes as complet.ly *** st.bilit. of all slopes was also analyzed using a design chart.under dynamic and st.t.c condit.ons by slope st.bilit. rat.ng(SSR)for t.e fact.r of safet.(FoS)of 1.2 and 1 respect.vely.Q-slope wit. probabilit. of failure(PoF)1%gives t.o slopes as st.ble *** slope angle has been det.rmined based on t.e Q-slope safe angle equat.on and SSR design chart.based on t.e *** value ranges given by different.empirical classificat.ons were RMR(37-74),GSI(27.3-58.5),SMR(11-59),and CoSMR(3.39-74.56).Good relat.onship was found among RMR&SSR and RMR&GSI wit. correlat.on coefficient.R 2)value of 0.815 and 0.6866,***,a comparat.ve st.bilit. of all t.ese slopes based on t.e above classificat.on has been performed t. ident.fy t.e most.crit.cal slope along t.is road.

关键词： Rock mass classificat.on Kinemat.c analysis Slope st.bilit. Himalayan road St.t.c and dynamic condit.ons

Surface Wat.r Qualit. Profiling Using Physicochemical Paramet.rs in Open Defecat.on Free and Non-Open Defecat.on Free Local Government.Areas in Benue St.t., Nigeria

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Open Journal of Modern Hydrology 2024年第3期14卷 174-191页

作者： Moses t. Asoo Celest.ne U. Aguoru Innocent.O. Ogbonna Hyacint. O.A. Oluma Benue St.t. Minist.y of Healt. Makurdi Nigeria Depart.ent.of Plant.Science and Biot.chnology College of Biological Sciences Joseph Sarwuan Tarka University Makurdi Nigeria Depart.ent.of Microbiology College of Biological Sciences Joseph Sarwuan Tarka University Makurdi Nigeria

Physicochemical paramet.rs of surface wat.r sources in t.e st.dy of local government.areas (LGAs) were assessed using st.ndard procedures. t.e mean physicochemical paramet.rs for pH (5.49), NO2 (0.23 mg/L), SO4 (0.77 mg/L), Na (28.72 mg/L), Ca (28.94 mg/L), Mg (17.50 mg/L), Cl (11.65 mg/L), t.S (6.27 mg/L), t.S (104.23 mg/L), BOD (2.83 mg/L) and F (0.87 mg/L) were below WHO st.ndards irrespect.ve of t.eir defecat.on st.t.s. t.e values for elect.ical conduct.vit. (EC) (2770.50 µs/cm, t.rbidit. (481.24 Nt.), dissolved oxygen (DO) (5.32 mg/L), chemical oxygen demand (COD) (445.50 mg/L), K (125.06 mg/L), PO4 (0.78 mg/L) and Fe (0.57 mg/L) were above t.e WHO limit. for safe wat.r. Higher EC and COD values obt.ined in t.e st.dy is evidence of pollut.on of t.e wat.r sources by organic mat.er.

关键词： Open Defecat.on Surface Wat.r Wat.r Qualit. St.ndard Physicochemical Paramet.rs

HISP-1 Inhibit. HSV-1 Infect.on in Cult.red Vero Cells

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Advances in Bioscience and Biot.chnology 2024年第4期15卷 269-288页

作者： Sandra D. Adams Kevin t. Bilyk Modukuri V. Ramani Got.umukkala V. Subbaraju Depart.ent.of Biology Montclair State University Montclair USA Depart.ent.of Chemist.y Andhara University Visakhapatnam India

Herpes simplex virus-1 (HSV-1) remains a leading cause of viral disease worldwide and is spread by direct.cont.ct.wit. infect.d lesions. t.ere is no vaccine against.HSV-1 infect.ons and t.ere remains a need t. ident.fy t.erapeut.cs t.at.could reduce t.e spread. In t.is st.dy various hispolon compounds were analyzed t. det.rmine t.eir ant.viral pot.nt.al against.HSV-1 infect.ons in cult.red Vero cells. t. det.rmine t.e effect. on infect.vit. and possible mechanisms of inhibit.on, t.e following assays were conduct.d. In vit.o cyt.t.xicit. assays were conduct.d t. det.rmine t.e effect.of t.e compounds on cell viabilit. and t.e maximum non-cyt.t.xic concent.at.ons. Ant.viral assays measured cell viabilit., percent.inhibit.on of infect.on following t.eat.ent.wit. t.e compounds, and t.e effect.on t.e viral infect.on cycle. t.ese effect. were visualized using invert.d light.and fluorescent.microscopy. Of t.e 24 hispolons t.st.d, only hispolon pyrazole-1 (HISP-1) demonst.at.d ant.viral effect.. HISP-1 was demonst.at.d t. effect.early st.ges in HSV-1 infect.on in cult.red Vero cells (at.achment. penet.at.on, and post.penet.at.on). In silico modeling analyses were conduct.d t. analyze t.e int.ract.ons bet.een HISP-1 and viral glycoprot.in D (gD). HISP-1 is safe at.concent.at.ons t.st.d and is effect.ve in inhibit.ng infect.on of HSV-1 in cult.red cells. HISP-1 has pot.nt.al for t.erapeut.c use as an ant.viral against.HSV-1 infect.on, could work in synergy wit. ot.er ant.virals t.at.work be a different.modalit., and could be developed as a component.of a t.pical agent.t. reduce t.e spread of HSV-1 infect.ons.

关键词： Hispolon Herpes Simplex Virus-1 Ant.viral Curcumin

Near resonance vibrat.on isolat.on on a levered-dual response(LEDAR)Coulomb-damped syst.m by different.al preloads/offset. in linear springs

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Applied Mat.emat.cs and Mechanics(English Edit.on) 2024年第6期45卷 1033-1050页

作者： t.I.t.LUWALOJU C.K.t.EIN D.HALIM Depart.ent.of Mechanical Materials and Manufacturing EngineeringUniversity of Nottingham Ningbo ChinaNingbo 315100Zhejiang ProvinceChina Not.ingham Ningbo China Beacons of Excellence Research and Innovat.on Inst.t.t. University of Nottingham Ningbo ChinaNingbo 315048Zhejiang ProvinceChina

t.e levered-dual response(LEDAR)Coulomb-damped syst.m at.ains near resonant.vibrat.on isolat.on by different.al preloads/offset. in linear *** t.kes t.e advant.ges of bot. t.e preloads/offset. in linear springs and t.e guiderail frict.on for realizing different.levels of vibrat.on *** isolat.on capacit.es are invest.gat.d on t.e st.at.gies wit. bot. t.e horizont.l and vert.cal guiderails,wit. t.e horizont.l rail only,and wit.out.*** compressive preloads generally result.in t.e consumpt.on of most.of t.e init.al excit.t.on energy so as t. overcome t.e pot.nt.al *** isolat.on onset. at.t.e frequency rat.o of 1∓0.095 on t.e left.hand side(LHS)and t.e right.hand side(RHS)of t.e lever are relat.ve t. t.e load plat. *** observed near resonant.isolat.on t.us makes t.e LEDAR syst.m a candidat. for t.e isolat.on of t.e mechanical syst.ms about.resonance while opening a pat. for simult.neous harvest.risolat.on funct.ons and passive funct.ons at.ext.eme frequencies.

关键词： lever rat.o Coulomb damping preload t.nsion/compression isolat.on band/dept. offset.pot.nt.al

Development.of endemicit. and conservat.on import.nce indices for t.opical forest. and t.e floral diversit. assessment.of *** in Benguet.Philippines

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Journal of Mount.in Science 2024年第3期21卷 786-804页

作者： Johndale Rein t.BULLONG Jim P.SILVERIO Joanna I.ALAFAG Maricel A.GURON Jones t.NAPALDEt Depart.ent.of Environment.l Science Benguet State UniversityLa Trinidad 2601Philippines Depart.ent.of Biology Benguet State UniversityLa Trinidad 2601Philippines

t.e scient.fic communit. faces t.e challenge of measuring progress t.ward biodiversit. t.rget. and indices have been t.adit.onally ***,recent.invent.ries in secondary t.opical mount.in forest. using t.adit.onal biodiversit. indices have yielded result. t.at.are indist.nct.wit. primary *** shows t.e need t. develop complement.ry indices t.at.goes beyond species count.but.int.grat.s t.e dist.ibut.on and conservat.on st.t.s of t.e *** st.dy developed endemicit. and conservat.on import.nce index for t.opical forest.t.at.incorporat.d t.e dist.ibut.on and conservat.on st.t.s of t.e *** indices were applied t. ***,a remnant.primary mossy forest.in Buguias,Benguet.Philippines,t.at.result.d t. endemicit. index of 81.07 and conservat.on import.nce index of *** t.ese wit. secondary forest.sit.s wit. comparable Shannon-Wiener,Simpson,Evenness and Margalef’s indices,our endemicit. and conservat.on indices clearly different.at.s primary forest.our st.dy sit.)wit. higher values from secondary forest. wit. much lower ***,we are proposing t.ese indices for a direct.but.scient.fically-informed ident.ficat.on of specific sit.s for conservat.on and prot.ct.on in t.opical ***,our st.dy document.d a t.t.l of 168 vascular plant.species(79 endemic and 12 locally t.reat.ned species)in *** are of t.opical element. for bot. generic and species levels wit. some t.mperat. element. t.at.could be at.ribut.d t. t.e sit.'s high elevat.on and semi-t.mperat. *** are import.nt.baseline informat.on for conservat.on plans and monit.ring of t.opical mossy forest..

关键词： Endemicit. index Conservat.on import.nce index Cordillera Cent.al Range Florist.c element Jaccard Index of Similarit.

Macroinvert.brat. Communit. Index (MCI) and Quant.t.t.ve Macroinvert.brat. Communit. Index (QMCI) Analysis: A Comparat.ve St.dy bet.een Le Afe and Mulivaifagat.loa Rivers, Upolu Island, Samoa

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Journal of Geoscience and Environment.Prot.ct.on 2024年第8期12卷 149-167页

作者： S. t.upega-Sat.u P. Amosa A. Leauga J. Nunufolau t. Veni Nun Yan Depart.ent.of Science National University of Samoa Apia Samoa Office of t.e Vice Chancellor National University of Samoa Apia Samoa Depart.ent.of Informat.on t.chnology and Syst.ms National University of Samoa Apia Samoa

t.e diversit. of Samoa’s freshwat.r macroinvert.brat.s remains largely unexplored, wit. past.st.dies focusing on specific species wit.out.comprehensive cat.loguing. t.is research evaluat.d t.e healt. of Upolu Island’s rural rivers t.rough macroinvert.brat. analysis, part.cularly in t.e Le Afe and Mulivaifagat.loa Rivers. Collaborat.ng wit. Samoa’s Wat.r Resources Division in t.e Minist.y of Nat.ral Resources and Environment.(MNRE), t.ree sit.s along each river were sampled, represent.ng a gradient.from prist.ne t. ant.ropogenically impact.d areas. A t.t.l of 2953 macroinvert.brat.s were collect.d and classified int. five cat.gories using est.blished ident.ficat.on keys. t.e Macroinvert.brat. Communit. Index (MCI) and Quant.t.t.ve Macroinvert.brat. Communit. Index (QMCI) were applied for analysis. t.e result. showed no clear pat.ern of pollut.nt.sensit.ve species prevalence or decline in less dist.rbed rivers. High MCI scores wit. low QMCI values indicat.d numerous low-scoring species, while t.e opposit. suggest.d a richness of high-scoring t.xa. Alt.ough MCI and QMCI are t.ols for monit.ring freshwat.r healt., t.is st.dy lays t.e groundwork for fut.re research t. cat.gorize Samoan macroinvert.brat.s and assign t.lerance scores based on t.eir presence in varying river condit.ons. .

关键词： Macroinvert.brat.s Macroinvert.brat. Communit. Index (MCI) Quant.t.t.ve Macroinvert.brat. Communit. Index (QMCI) Wat.r Qualit.

Grazing Pressure and Plant.Funct.onal t.pes in Puna Highlands,Nort.west.rn Argent.na

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Phyt.n-Int.rnat.onal Journal of Experiment.l Bot.ny 2024年第5期93卷 1067-1080页

作者： Quiroga Mendiola Mariana t.lamo Andrés IPAF NOA—INt.(Nat.onal Inst.t.t. for Agricult.ral t.chnology) Posta de HornillosJujuy4622Argentina Facult.d de Ciencias Nat.rales Universidad Nacional de SaltaSalta4400Argentina Inst.t.t. de Bio y Geociencias del NOA(IBIGEO) UNSa-CONICET.Laboratorio de Ecología Aplicada a la Conservación(LEAC)Facultad de Ciencias NaturalesUniversidad Nacional de SaltaSalta4400Argentina Maest.ía en Gest.ón Ambient.l Escuela de NegociosUniversidad Católica de Salta(UCASAL)Salta4400Argentina

t.e Puna grasslands support.grazing syst.ms t.at.produce meat.and wool in mult.-species herds,especially from llama(Lama glama)and ***,it.is yet.unknown whet.er grazing pressure can modify grassland st.uct.re and Plant.Funct.onal t.pes diversit. and cover in Puna *** analyzed t.e relat.onship bet.een grazing pressure and Plant.Funct.onal t.pes by comparing t.ansect. locat.d near st.ckyards(high grazing pressure)and far from t.em(low pressure)and by evaluat.ng t.e relat.onship bet.een t.e Plant.Funct.onal t.pes cover t. a Grazing Pressure Index(GPI).t.is index incorporat.s t.e het.rogeneit. of t.adit.onal past.ral *** t.o ecological sit.s(Ciénego and t.lar),we sampled paired t.ansect.(near-far).Plot. near and far from corrals were similar in all t.e variables measured except.for plot. in t.lar,which t.nd t. have higher t.t.l cover,possibly due t. fecal fert.lizat.on near ***,we recorded an increase in t.t.l cover and grass cover at.higher GPI in Ciénego,while in t.lar we found lower values of t.t.l cover and herbaceous dicot.ledonous cover at.int.rmediat. int.nsit.es of *** only negat.ve relat.onship found was t.e cover of clonal and non-clonal shrubs,possibly explained by t.e great.r use of t.ese shrubs as firewood near *** summary,our st.dy does not.show import.nt.changes in Plant.Funct.onal t.pes as a funct.on of grazing pressure in t.e st.died grasslands probably because grazing pressure is dilut.d or diminished when livest.ck rot.t.s in different.areas and grazing durat.ons ***,t.e long grazing hist.ry wit. which t.e Puna has evolved could also cont.ibut. t. t.e co-st.uct.rat.on bet.een nat.ve veget.t.on and livest.ck farming.

关键词： Nat.ral grasslands Puna herbivory ecological pert.rbat.on

Energy exchange bet.een charged relat.vist.c fluids in f(t. gravit.

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Communicat.ons in t.eoret.cal Physics 2024年第10期76卷 108-120页

作者： Z Yousaf U A Khokhar Nasser Bin t.rki t.Suzuki Depart.ent.of Mat.emat.cs University of the Punjab Quaid-i-Azam Campus Depart.ent.of Mat.emat.cs College of Science King Saud University Depart.ent.of Regional Management Faculty of Management Fukushima College

t.is st.dy focuses on t.e effect. of a polyt.opic fluid on a charged gravit.t.onal source wit.in f(t. gravit., where t.is t.e t.rsion scalar. We invest.gat. how t.e elect.omagnet.c field affect. t.e flow of energy in spherically symmet.ic and st.t.c celest.al object. t.at.cont.in relat.vist.c fluids. By using t.e gravit.t.onal decoupling t.chnique, we analyze t.e effect. of polyt.opic fluid on t.e dynamics of t.e gravit.t.onal source, accompanied by t.e mat.hing of t.e int.rior geomet.y wit. an ext.rior at.t.e hypersurface Σ. Finally, wit. t.e help of t.e t.lman ⅡV solut.on, we observe t.e conduct.of energy condit.ons wit. t.e exist.nce of charge using f(t.field equat.ons and got.t.e int.nded out.omes.

关键词： anisot.opy complexit. energy exchange hydrodynamics self-gravit.t.ng syst.ms

Small act.vat.ng RNA delivery in vivo:Challenges,prospect.,and lessons learned from siRNA delivery

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Nano Research 2024年第10期17卷 8990-9002页

作者： Shalini Pandey Pat.ick t.Bednarz Mat.hias A.Oberli Omid Veiseh Depart.ent.of Bioengineering William Marsh Rice UniversityHouston 77030USA Xibus Syst.ms 199 Dexter AveWatertown 02472USA

Over t.e last.t.o decades,small act.vat.ng RNAs(saRNAs)have quickly moved from discovery t. clinical *** as 20 nucleot.de long,double st.anded RNA,saRNAs have t.e unique abilit. t. increase gene t.anscript.on at.t.e chromat.n *** t.erapeut.c modalit. has great.pot.nt.al as a safe and redosable alt.rnat.ve t. gene t.erapy by increasing t.rget.prot.in expression wit.out.changing t.e genet.c *** describe t.e successful in vivo saRNA delivery vect.rs and found t.at.similar t. small int.rfering RNA(siRNA)and mRNA t.rget.ng t.ssues out.ide t.e liver works best.at.t.e end of a *** highlight.nanopart.cle vect.rs and RNA-conjugat.s,where some success has been report.d for non-hepat.c delivery of saRNAapt.mers.

关键词： small act.vat.ng RNA hepat.c bias lipid nanopart.cles RNA-conjugat.s