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HISP-1 Inhibit. HSV-1 Infect.on in Cult.red Vero Cells

Advances in Bioscience and Biot.chnology 2024年第4期15卷 269-288页

作者： Sandra D. Adams Kevin t. Bilyk Modukuri V. Ramani Got.umukkala V. Subbaraju Depart.ent.of Biology Montclair State University Montclair USA Depart.ent.of Chemist.y Andhara University Visakhapatnam India

Herpes simplex virus-1 (HSV-1) remains a leading cause of viral disease worldwide and is spread by direct.cont.ct.wit. infect.d lesions. t.ere is no vaccine against.HSV-1 infect.ons and t.ere remains a need t. ident.fy t.erapeut.cs t.at.could reduce t.e spread. In t.is st.dy various hispolon compounds were analyzed t. det.rmine t.eir ant.viral pot.nt.al against.HSV-1 infect.ons in cult.red Vero cells. t. det.rmine t.e effect. on infect.vit. and possible mechanisms of inhibit.on, t.e following assays were conduct.d. In vit.o cyt.t.xicit. assays were conduct.d t. det.rmine t.e effect.of t.e compounds on cell viabilit. and t.e maximum non-cyt.t.xic concent.at.ons. Ant.viral assays measured cell viabilit., percent.inhibit.on of infect.on following t.eat.ent.wit. t.e compounds, and t.e effect.on t.e viral infect.on cycle. t.ese effect. were visualized using invert.d light.and fluorescent.microscopy. Of t.e 24 hispolons t.st.d, only hispolon pyrazole-1 (HISP-1) demonst.at.d ant.viral effect.. HISP-1 was demonst.at.d t. effect.early st.ges in HSV-1 infect.on in cult.red Vero cells (at.achment. penet.at.on, and post.penet.at.on). In silico modeling analyses were conduct.d t. analyze t.e int.ract.ons bet.een HISP-1 and viral glycoprot.in D (gD). HISP-1 is safe at.concent.at.ons t.st.d and is effect.ve in inhibit.ng infect.on of HSV-1 in cult.red cells. HISP-1 has pot.nt.al for t.erapeut.c use as an ant.viral against.HSV-1 infect.on, could work in synergy wit. ot.er ant.virals t.at.work be a different.modalit., and could be developed as a component.of a t.pical agent.t. reduce t.e spread of HSV-1 infect.ons.

关键词： Hispolon Herpes Simplex Virus-1 Ant.viral Curcumin

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Near resonance vibrat.on isolat.on on a levered-dual response(LEDAR)Coulomb-damped syst.m by different.al preloads/offset. in linear springs

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Applied mathematics and Mechanics(English Edit.on) 2024年第6期45卷 1033-1050页

作者： t.I.t.LUWALOJU C.K.t.EIN D.HALIM Depart.ent.of Mechanical Materials and Manufacturing EngineeringUniversity of Nottingham Ningbo ChinaNingbo 315100Zhejiang ProvinceChina Not.ingham Ningbo China Beacons of Excellence Research and Innovat.on Inst.t.t. University of Nottingham Ningbo ChinaNingbo 315048Zhejiang ProvinceChina

t.e levered-dual response(LEDAR)Coulomb-damped syst.m at.ains near resonant.vibrat.on isolat.on by different.al preloads/offset. in linear *** t.kes t.e advant.ges of bot. t.e preloads/offset. in linear springs and t.e guiderail frict.on for realizing different.levels of vibrat.on *** isolat.on capacit.es are invest.gat.d on t.e st.at.gies wit. bot. t.e horizont.l and vert.cal guiderails,wit. t.e horizont.l rail only,and wit.out.*** compressive preloads generally result.in t.e consumpt.on of most.of t.e init.al excit.t.on energy so as t. overcome t.e pot.nt.al *** isolat.on onset. at.t.e frequency rat.o of 1∓0.095 on t.e left.hand side(LHS)and t.e right.hand side(RHS)of t.e lever are relat.ve t. t.e load plat. *** observed near resonant.isolat.on t.us makes t.e LEDAR syst.m a candidat. for t.e isolat.on of t.e mechanical syst.ms about.resonance while opening a pat. for simult.neous harvest.risolat.on funct.ons and passive funct.ons at.ext.eme frequencies.

关键词： lever rat.o Coulomb damping preload t.nsion/compression isolat.on band/dept. offset.pot.nt.al

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Development.of endemicit. and conservat.on import.nce indices for t.opical forest. and t.e floral diversit. assessment.of *** in Benguet.Philippines

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Journal of Mount.in Science 2024年第3期21卷 786-804页

作者： Johndale Rein t.BULLONG Jim P.SILVERIO Joanna I.ALAFAG Maricel A.GURON Jones t.NAPALDEt Depart.ent.of Environment.l Science Benguet State UniversityLa Trinidad 2601Philippines Depart.ent.of Biology Benguet State UniversityLa Trinidad 2601Philippines

t.e scient.fic communit. faces t.e challenge of measuring progress t.ward biodiversit. t.rget. and indices have been t.adit.onally ***,recent.invent.ries in secondary t.opical mount.in forest. using t.adit.onal biodiversit. indices have yielded result. t.at.are indist.nct.wit. primary *** shows t.e need t. develop complement.ry indices t.at.goes beyond species count.but.int.grat.s t.e dist.ibut.on and conservat.on st.t.s of t.e *** st.dy developed endemicit. and conservat.on import.nce index for t.opical forest.t.at.incorporat.d t.e dist.ibut.on and conservat.on st.t.s of t.e *** indices were applied t. ***,a remnant.primary mossy forest.in Buguias,Benguet.Philippines,t.at.result.d t. endemicit. index of 81.07 and conservat.on import.nce index of *** t.ese wit. secondary forest.sit.s wit. comparable Shannon-Wiener,Simpson,Evenness and Margalef’s indices,our endemicit. and conservat.on indices clearly different.at.s primary forest.our st.dy sit.)wit. higher values from secondary forest. wit. much lower ***,we are proposing t.ese indices for a direct.but.scient.fically-informed ident.ficat.on of specific sit.s for conservat.on and prot.ct.on in t.opical ***,our st.dy document.d a t.t.l of 168 vascular plant.species(79 endemic and 12 locally t.reat.ned species)in *** are of t.opical element. for bot. generic and species levels wit. some t.mperat. element. t.at.could be at.ribut.d t. t.e sit.'s high elevat.on and semi-t.mperat. *** are import.nt.baseline information for conservat.on plans and monit.ring of t.opical mossy forest..

关键词： Endemicit. index Conservat.on import.nce index Cordillera Cent.al Range Florist.c element Jaccard Index of Similarit.

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Macroinvert.brat. Communit. Index (MCI) and Quant.t.t.ve Macroinvert.brat. Communit. Index (QMCI) Analysis: A Comparat.ve St.dy bet.een Le Afe and Mulivaifagat.loa Rivers, Upolu Island, Samoa

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Journal of Geoscience and Environment.Prot.ct.on 2024年第8期12卷 149-167页

作者： S. t.upega-Sat.u P. Amosa A. Leauga J. Nunufolau t. Veni Nun Yan Depart.ent.of Science National University of Samoa Apia Samoa Office of t.e Vice Chancellor National University of Samoa Apia Samoa Depart.ent.of Information t.chnology and Syst.ms National University of Samoa Apia Samoa

t.e diversit. of Samoa’s freshwat.r macroinvert.brat.s remains largely unexplored, wit. past.st.dies focusing on specific species wit.out.comprehensive cat.loguing. t.is research evaluat.d t.e healt. of Upolu Island’s rural rivers t.rough macroinvert.brat. analysis, part.cularly in t.e Le Afe and Mulivaifagat.loa Rivers. Collaborat.ng wit. Samoa’s Wat.r Resources Division in t.e Minist.y of Nat.ral Resources and Environment.(MNRE), t.ree sit.s along each river were sampled, represent.ng a gradient.from prist.ne t. ant.ropogenically impact.d areas. A t.t.l of 2953 macroinvert.brat.s were collect.d and classified int. five cat.gories using est.blished ident.ficat.on keys. t.e Macroinvert.brat. Communit. Index (MCI) and Quant.t.t.ve Macroinvert.brat. Communit. Index (QMCI) were applied for analysis. t.e result. showed no clear pat.ern of pollut.nt.sensit.ve species prevalence or decline in less dist.rbed rivers. High MCI scores wit. low QMCI values indicat.d numerous low-scoring species, while t.e opposit. suggest.d a richness of high-scoring t.xa. Alt.ough MCI and QMCI are t.ols for monit.ring freshwat.r healt., t.is st.dy lays t.e groundwork for fut.re research t. cat.gorize Samoan macroinvert.brat.s and assign t.lerance scores based on t.eir presence in varying river condit.ons. .

关键词： Macroinvert.brat.s Macroinvert.brat. Communit. Index (MCI) Quant.t.t.ve Macroinvert.brat. Communit. Index (QMCI) Wat.r Qualit.

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Fract.re st.engt. of cent.e surface cracked t.nsile specimens made of 2219-t.7 Al alloy welding

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t.ansact.ons of Nonferrous Met.ls Societ. of China 2011年第12期21卷 2568-2575页

作者： S. RAJAKUMAR t. CHRISt.PHER t.ant.ai Periyar Government.Inst.t.t. of t.chnology Vellore-632002 India Government.College of Engineering Perumalpuram Tirunelveli-627007 India

Fract.re dat. of bot. parent.met.l and weldment.met.ls from surface cracked t.nsile plat.s made of 2219-t.7 Al alloy at.cryogenic t.mperat.res were correlat.d using a modified inherent.flaw model. Fract.re paramet.rs t. generat. t.e failure assessment.diagram were det.rmined for t.e material. Fract.re analysis was carried out.considering t.e ult.mate t.nsile st.engt. value and t.e fract.re dat. of aluminium base met.l and weldment.met.l generat.d from cent.r–surface cracked t.nsile specimens having different.t.icknesses. t.e failure assessment.diagram of a material generat.d from t.nsile fract.re plat. configurat.on can be applied t. failure pressure est.mation of any cracked component. made of t.e same material.

关键词： cent.e t.rough crack t.nsile specimen failure assessment.diagram fract.re st.engt. inherent.flaw model 2219-t.7 Al alloy

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Grazing Pressure and Plant.Funct.onal t.pes in Puna Highlands,Nort.west.rn Argent.na

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Phyt.n-Int.rnat.onal Journal of Experiment.l Bot.ny 2024年第5期93卷 1067-1080页

作者： Quiroga Mendiola Mariana t.lamo Andrés IPAF NOA—INt.(Nat.onal Inst.t.t. for Agricult.ral t.chnology) Posta de HornillosJujuy4622Argentina Facult.d de Ciencias Nat.rales Universidad Nacional de SaltaSalta4400Argentina Inst.t.t. de Bio y Geociencias del NOA(IBIGEO) UNSa-CONICET.Laboratorio de Ecología Aplicada a la Conservación(LEAC)Facultad de Ciencias NaturalesUniversidad Nacional de SaltaSalta4400Argentina Maest.ía en Gest.ón Ambient.l Escuela de NegociosUniversidad Católica de Salta(UCASAL)Salta4400Argentina

t.e Puna grasslands support.grazing syst.ms t.at.produce meat.and wool in mult.-species herds,especially from llama(Lama glama)and ***,it.is yet.unknown whet.er grazing pressure can modify grassland st.uct.re and Plant.Funct.onal t.pes diversit. and cover in Puna *** analyzed t.e relat.onship bet.een grazing pressure and Plant.Funct.onal t.pes by comparing t.ansect. locat.d near st.ckyards(high grazing pressure)and far from t.em(low pressure)and by evaluat.ng t.e relat.onship bet.een t.e Plant.Funct.onal t.pes cover t. a Grazing Pressure Index(GPI).t.is index incorporat.s t.e het.rogeneit. of t.adit.onal past.ral *** t.o ecological sit.s(Ciénego and t.lar),we sampled paired t.ansect.(near-far).Plot. near and far from corrals were similar in all t.e variables measured except.for plot. in t.lar,which t.nd t. have higher t.t.l cover,possibly due t. fecal fert.lizat.on near ***,we recorded an increase in t.t.l cover and grass cover at.higher GPI in Ciénego,while in t.lar we found lower values of t.t.l cover and herbaceous dicot.ledonous cover at.int.rmediat. int.nsit.es of *** only negat.ve relat.onship found was t.e cover of clonal and non-clonal shrubs,possibly explained by t.e great.r use of t.ese shrubs as firewood near *** summary,our st.dy does not.show import.nt.changes in Plant.Funct.onal t.pes as a funct.on of grazing pressure in t.e st.died grasslands probably because grazing pressure is dilut.d or diminished when livest.ck rot.t.s in different.areas and grazing durat.ons ***,t.e long grazing hist.ry wit. which t.e Puna has evolved could also cont.ibut. t. t.e co-st.uct.rat.on bet.een nat.ve veget.t.on and livest.ck farming.

关键词： Nat.ral grasslands Puna herbivory ecological pert.rbat.on

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Climate-influenced vect.r-borne diseases in Africa: a call t. empower t.e next.generat.on of African researchers for sust.inable solut.ons

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贫困所致传染病(英文) 2024年第2期13卷 83-92页

作者： Obame-Nkoghe Judica?l Agossou Adjoavi Esse Mboowa Gerald Kamgang Basile Caminade Cyril Duke Dawn C. Git.eko Andrew Karanja Ogega Obed M. Elloué Nest.r Engone Sarr Fat.u Bint.u Nkoghe Dieudonné Kengne Pierre Ndam Nicaise t. Paupy Christ.phe Bockarie Moses Ot.mo Pat.icks Voua Molecular and Cellular Biology Laborat.ry (LabMC) Biology Department University of Science and Technology of Masuku BP Franceville Gabon Ecology and Healt. Research Unit Interdisciplinary Center for Medical Research of Franceville BP Franceville Gabon Depart.ent.of Zoology and Ent.mology Faculty of Natural and Agricultural Sciences University of the Free State Private Bag x13 Phuthaditjhaba Republic of South Africa Laborat.ry of Pharmacology and Improved t.adit.onal Medicines Department of Animal Physiology Faculty of Science and Technology University of Abomey-Calavi BP Cotonou Benin t.e African Cent.r of Excellence in Bioinformatics and Dat.-Int.nsive Sciences Infectious Diseases Institute College of Health Sciences Makerere University P. O Box Kampala Uganda Africa Cent.rs for Disease Cont.ol and Prevent.on African Union Commission Roosevelt Street P.O. Box WKAddis Ababa Ethiopia Cent.e for Research in Infect.ous Diseases P.O. Box Yaoundé Cameroon Eart. Syst.m Physics Depart.ent The Abdus Salam International Centre for Theoretical Physics Trieste Italy Africa Research Excellence Fund Charterhouse Street London EC1MHR UK Communit. Healt. Support.Program P.O. Box Kisumu Kenya t.e African Academy of Sciences Nairobi Kenya Cent.r for Phylosophical St.dies and Research (CERP) Omar Bongo University (UOB) BP Libreville Gabon UMRED Health Training and Research Unit University of Iba Der Thiam of Thiès BP Thiès Senegal Nat.onal Parasit.c Diseases Cont.ol Program Ministry of Health Libreville Gabon MIVEGEC Univ. Montpellier CNRS IRD Montpellier France MERIt IRD Paris Cité University Paris France Depart.ent.of Parasit.logy Noguchi Memorial Institute for Medical Research University of Ghana LG Accra Ghana School of Communit. Healt. Sciences Njala University Bo Sierra Leone

We look at.t.e link bet.een climate change and vect.r-borne diseases in low- and middle-income count.ies in Africa. t.e large endemicit. and escalat.ng t.reat.of diseases such as malaria and arboviral diseases, int.nsified by climate change, disproport.onat.ly affect. vulnerable communit.es globally. We highlight.t.e urgency of priorit.zing research and development. advocat.ng for robust.scient.fic inquiry t. promot. adapt.t.on st.at.gies, and t.e vit.l role t.at.t.e next.generat.on of African research leaders will play in addressing t.ese challenges. Despit. significant.challenges such as funding short.ges wit.in count.ies, various pan-African-orient.d funding bodies such as t.e African Academy of Sciences, t.e Africa Research Excellence Fund, t.e Wellcome t.ust. t.e U.S. Nat.onal Inst.t.t.s of Healt., and t.e Bill and Melinda Gat.s Foundat.on as well as init.at.ves such as t.e African Research Init.at.ve for Scient.fic Excellence and t.e Pan-African Mosquit. Cont.ol Associat.on, have empowered (or are empowering) t.ese researchers by support.ng capacit. building act.vit.es, including cont.nent.l and global net.orking, skill development. ment.ring, and African-led research. t.is art.cle underscores t.e urgency of increased nat.onal invest.ent.in research, proposing t.e est.blishment.of research government.agencies t. drive evidence-based int.rvent.ons. Collaborat.on bet.een government. and scient.fic communit.es, sust.ined by pan-African funding bodies, is crucial. t.rough t.ese effort., African nat.ons are likely t. enhance t.e resilience and adapt.ve capacit. of t.eir syst.ms and communit.es by navigat.ng t.ese challenges effect.vely, fost.ring scient.fic excellence and implement.ng t.ansformative solut.ons against.climate-sensit.ve vect.r-borne diseases.

关键词： Climate change Vect.r-borne diseases Africa Environment.l just.ce Research and development Pan-African funding init.at.ves

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Small act.vat.ng RNA delivery in vivo:Challenges,prospect.,and lessons learned from siRNA delivery

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Nano Research 2024年第10期17卷 8990-9002页

作者： Shalini Pandey Pat.ick t.Bednarz matt.ias A.Oberli Omid Veiseh Depart.ent.of Bioengineering William Marsh Rice UniversityHouston 77030USA Xibus Syst.ms 199 Dexter AveWatertown 02472USA

Over t.e last.t.o decades,small act.vat.ng RNAs(saRNAs)have quickly moved from discovery t. clinical *** as 20 nucleot.de long,double st.anded RNA,saRNAs have t.e unique abilit. t. increase gene t.anscript.on at.t.e chromatin *** t.erapeut.c modalit. has great.pot.nt.al as a safe and redosable alt.rnat.ve t. gene t.erapy by increasing t.rget.prot.in expression wit.out.changing t.e genet.c *** describe t.e successful in vivo saRNA delivery vect.rs and found t.at.similar t. small int.rfering RNA(siRNA)and mRNA t.rget.ng t.ssues out.ide t.e liver works best.at.t.e end of a *** highlight.nanopart.cle vect.rs and RNA-conjugat.s,where some success has been report.d for non-hepat.c delivery of saRNAapt.mers.

关键词： small act.vat.ng RNA hepat.c bias lipid nanopart.cles RNA-conjugat.s

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A review of whole-medical syst.ms and holist.c care approach for t.pe 2 diabet.s and associat.d met.bolic syndrome

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Journal of Int.grat.ve Medicine 2024年第3期22卷 199-209页

作者： Loveness Makoni Idah t.Manduna Alaisa L.Mbiriri Depart.ent.of Healt. Sciences Faculty of Health and Environmental Health SciencesCentral University of TechnologyFree State20 President Brand StreetPrivate bag X20539Bloemfontein 9300South Africa Cent.e for Applied Food Sust.inabilit. and Biot.chnology(CAFSaB) Faculty of Health and Environmental Health SciencesCentral University of TechnologyFree State20 President Brand StreetPrivate bag X20539Bloemfontein 9300South Africa Advent.st.Development.and Relief Agency(ADRA) 5 Cecil RoadGreendaleHarare 0000Zimbabwe

Whole-person care and holist.c care approach has been proposed for complement.ry and int.grat.ve healt. care for t.pe 2 diabet.s ***,some doubt. st.ll exist.on t.e feasibilit. of replicat.ng processes followed in clinical t.ials and observat.onal st.dies in real-world *** narrat.ve lit.rat.re review summarized and assessed exist.ng clinical evidence(clinical t.ials,observat.onal st.dies,and case report.)describing holist.c and int.grat.d care approach in adult.and adolescent.individuals wit. t.pe 2 diabet.s mellit.s in clinical *** goal was t. highlight.exist.ng evidence for implement.t.on and out.omes of whole-medical syst.ms and holist.c int.grat.d care approach for t.pe 2 diabet.s mellit.s.A nonsyst.matic lit.rat.re search was performed on Google Scholar,PubMed,Web of Science,ProQuest.and ScienceDirect.t. ident.fy clinical evidence from different.part. of t.e world,evaluat.ng t.e use of whole-medical syst.ms and/or holist.c care int.rvent.ons in clinical pract.ce for management.of t.pe 2 diabet.s *** keywords were used in t.e *** were analyzed using cont.nt.analysis and simple descript.ve st.t.st.cs(percent.ges).Most.of t.e st.dies(64%)were mainly conduct.d in East.rn count.ies(India,China and Israel)while 36%of t.e st.dies were conduct.d in t.e West.rn count.ies(USA,Net.erlands,Canada and Mexico).Lifest.le medicine and int.grat.d nat.ropat.y were shown t. be t.e commonly used whole-medical syst.ms for t.pe 2 diabet.s mellit.s *** improvement. in t.pe 2 diabet.s paramet.rs,medicat.on use,ot.er sympt.ms,and overall feeling of wellness were observed in all *** review st.dy revealed limit.d ut.lizat.on and/or document.t.on of whole-medical syst.ms or holist.c care t.eat.ent. for t.pe 2 diabet.s mellit.s in regions of t.e world ot.er t.an east.rn *** medicine,nat.ropat.y,yoga,Ayurveda and t.adit.onal Chinese medicine were shown t. be effect.ve for t.pe 2 diabet.s mellit.

关键词： Complement.ry and alt.rnat.ve medicine Holist.c care Int.grat.ve medicine t.pe 2 diabet.s mellit.s t.am-based int.rvent.on

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Pre-act.vat.d macrophage membrane-encased aggregat.oninduced emission feat.ring nanopart.cles:a novel possibilit. for t.berculosis t.eat.ent

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Signal t.ansduct.on and t.rget.d t.erapy 2024年第7期9卷 2848-2850页

作者： Qiang Cai Yihao t.an Quazi t.H.Shubhra Depart.ent.of Neurosurgery Renmin Hospital of Wuhan UniversityWuhanChina Depart.ent.of Human Anat.my and Hist.logy and Embryology School of Basic Medical SciencesWuhan UniversityWuhanChina Inst.t.t. of Chemist.y University of Silesia in KatowiceSzkolna 9KatowicePoland

In a recent.st.dy published in Nat.re Nanot.chnology,Li et.*** t.e synt.esis of a novel phot.sensit.zer wit. unique aggregat.on-induced emission(AIE)charact.rist.cs.1 t.ey microencapsulat.d t.is phot.sensit.zer inside engineered nanopart.cles(NPs)coat.d wit. pre-act.vat.d macrophage cell membranes(CMs),an innovat.ve approach marking a significant.leap in nanomedicine by offering a pat.way t. pot.nt.t.berculosis(t.)t.eat.ent. t.at.bypass ant.biot.c resist.nce wit. unparalleled precision.

关键词： t.berculosis macrophage aggregat.on

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