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Part.cle elast.cit. influences polymeric art.ficial ant.gen present.ng cell effect.veness in vivo via CD8+t.cell act.vat.on,macroph.ge upt.ke,and t.e prot.in corona

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Nano Research 2024年第10期17卷 9052-9064页

作者： Savannah.E.Est.Wit.e Sydney R.Sh.nnon Dennis h.Gong Kait.yn G.Calabresi Jawaun J.h.rris Kait.yn St.rm Edwin J.Yoo Ariel Isser Vivek P.Jani Nat.lie K.Livingst.n Mary O.Omot.so Kelly Rh.des Elana Ben-Akiva Randall A.Meyer Zoe t.h.ieh.Simone Sidoli St.ph.ny Y.t.eng Jonat.an P.Sch.eck jordan J.Green t.anslat.onal t.ssue Engineering Cent.r Institute for NanobiotechnologyDepartment of Biomedical EngineeringJohns Hopkins School of Medicine400 N BroadwayBaltimoreMD 21231USA Inst.t.t. for Cell Engineering Department of PathologyJohns Hopkins School of Medicine733 N BroadwayBaltimoreMD 21205USA Depart.ent.of Bioch.mist.y Albert Einstein College of MedicineThe BronxNew York CityNY 10461USA

Adopt.ve cell t.erapy(ACt.is an immunot.erapy st.at.gy for cancer t.at.h.s seen widespread clinical *** ACt.pat.ent.derived lymph.cyt.s are st.mulat.d wit. t.e ant.gen of int.rest.ex vivo,proliferat.d,t.en ret.rned t. t.e pat.ent.t. init.at. an ant.gen-specific ant.t.mor *** effect.ve,t.is process is resource-int.nsive and logist.cally impossible for many *** art.ficial ant.gen present.ng cells(aAPCs)offer a pot.nt.al“off-t.e-sh.lf”alt.rnat.ve t. ex vivo *** part.culat. aAPCs perform well in vit.o,t.ey h.ve h.d limit.d success in vivo due t. poor bioavailabilit. aft.r *** t. bioavailabilit. include rapid clearance,unfavorable biodist.ibut.on,and inadequat. int.ract.ons wit. CD8+t.cells at.sit.s of *** propert.es such.as elast.cit. h.ve been sh.wn t. vast.y impact.t.e bioavailabilit. and part.cle-cell int.ract.ons,but.t.is h.s yet.t. be invest.gat.d in t.e cont.xt.of aAPCs for in vivo t.cell *** lit.rat.re likewise indicat.s t.at.biomat.rial propert.es,especially elast.cit.,can modulat. t.cell act.vat.on in *** t.e goal of creat.ng a more biomimet.c,next.generat.on part.culat. aAPC,we developed a poly(et.ylene)glycol h.drogel part.cle plat.orm wit. t.nable elast.cit. t. invest.gat. t.e impact.of elast.cit. on ant.gen-specific t.cell act.vat.on for in vivo adopt.ve *** t.is knowledge,we were able t. gain more precise cont.ol over in vivo t.cell act.vat.on and invest.gat. possible mech.nisms including t.e effect. of aAPC elast.cit. on t.cell binding,macroph.ge upt.ke,and t.e prot.in corona.

关键词： adopt.ve cell t.erapy art.ficial ant.gen present.ng cells part.cle drug delivery elast.cit. prot.in corona poly(et.ylene glycol)

Aging impairs t.e ost.ocyt.c regulat.on of collagen int.grit. and bone qualit.

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Bone Research 2024年第1期12卷 78-94页

作者： Ch.rles A.Sch.rman Serra Kaya Neh. Dole Nadja M.Maldonado Luna Nat.lia Cast.llo Ryan Pot.er Jacob P.Rose Joanna Bons Ch.ist.na D.King jordan B.Burt.n Birgit.Sch.lling Simon Melov Simon t.ng Eric Sch.ible t.mara Allist.n Depart.ent.of Ort.opaedic Surgery University of CaliforniaSan FranciscoCA 94143USA UC Berkeley/UCSF Graduat. Program in Bioengineering San FranciscoCA 94143USA Buck Inst.t.t. for Research.on Aging NovatoCA 94945USA Wash.ngt.n Universit. in St.Louis Department of OrthopedicsSt.LouisMO 63130USA Advanced Ligh.0}Source Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA

Poor bone qualit. is a major fact.r in skelet.l fragilit. in elderly *** molecular mech.nisms t.at.est.blish.and maint.in bone qualit.,independent.of bone mass,are unknown but.are t.ough.0}t. be primarily det.rmined by *** h.pot.esize t.at.t.e age-relat.d decline in bone qualit. result. from t.e suppression of ost.ocyt. perilacunar/canalicular remodeling(PLR),wh.ch.maint.ins bone mat.rial *** examined bones from young and aged mice wit. ost.ocyt.-int.insic repression of t.Fβsignaling(t.RII^(ocy−/−))t.at.suppresses *** cont.ol aged bone displayed decreased t.Fβsignaling and PLR,but.aging did not.worsen t.e exist.ng PLR suppression in male t.RII^(ocy−/−)*** relat.onsh.p impact.d t.e beh.vior of collagen mat.rial at.t.e nanoscale and t.ssue scale in macromech.nical *** effect. of age on bone mass,densit.,and mineral mat.rial beh.vior were independent.of ost.ocyt.c t.Fβ.We det.rmined t.at.t.e decline in bone qualit. wit. age arises from t.e loss of ost.ocyt. funct.on and t.e loss of t.Fβ-dependent.maint.nance of collagen int.grit..

关键词： maint.in primarily int.grit.

Myelin repair and funct.onal recovery mediat.d by neural cell t.ansplant.t.on in a mouse model of mult.ple sclerosis

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Neuroscience Bullet.n 2013年第2期29卷 239-250页

作者： Lianh.a Bai jordan h.cker Amber Kerst.t.er Robert.h.Miller Depart.ent.of Neurosciences Center for Translational NeuroscienceCase Western Reserve University School ofMedicine t.e Key Laborat.ry Third Military Medical University Southwest Hospital

Cellular t.erapies are becoming a major focus for t.e t.eat.ent.of demyelinat.ng diseases such.as mult.ple sclerosis （MS）, t.erefore it.is import.nt.t. ident.fy t.e most.effect.ve cell t.pes t.at.promot. myelin repair. Several component. cont.ibut. t. t.e relat.ve benefit. of specific cell t.pes including t.e overall efficacy of t.e cell t.erapy, t.e reproducibilit. of t.eat.ent. t.e mech.nisms of act.on of dist.nct.cell t.pes and t.e ease of isolat.on and generat.on of t.erapeut.c populat.ons. A range of dist.nct.cell populat.ons promot. funct.onal recovery in animal models of MS including neural st.m cells and mesench.mal st.m cells derived from different.t.ssues. Each.of t.ese cell populat.ons h.s advant.ges and disadvant.ges and likely works t.rough.dist.nct.mech.nisms. t.e relevance of such.mech.nisms t. myelin repair in t.e adult.cent.al nervous syst.m is unclear since t.e t.erapeut.c cells are generally derived from developing animals. h.re we describe t.e isolat.on and ch.ract.rizat.on of a populat.on of neural cells from t.e adult.spinal cord t.at.are ch.ract.rized by t.e expression of t.e cell surface glycoprot.in NG2. In funct.onal st.dies, inject.on of adult.NG2~ cells int. mice wit. ongoing MOG3~_~5-induced experiment.l aut.immune enceph.lomyelit.s （EAE） enh.nced remyelinat.on in t.e CNS wh.le t.e number of CD3＋ t.cells in areas of spinal cord demyelinat.on was reduced approximat.ly t.ree-fold. In vivost.dies indicat.d t.at.in EAE, NG2＊ cells st.mulat.d endogenous repair wh.le in vit.o t.ey responded t. signals in areas of induced inflammat.on by different.at.ng int. oligodendrocyt.s. t.ese result. suggest.d t.at.adult.NG2~ cells represent.a useful cell populat.on for promot.ng neural repair in a variet. of different.condit.ons including demyelinat.ng diseases such.as MS.

关键词： NG2 glycoprot.in myelin oligodendro-cyt.s experiment.l aut.immune enceph.lomyelit.s mult.ple sclerosis remyelinat.on

St.uct.re and magnet.st.uct.ral correlat.on of ferrimagnet.c meso-t.t.aph.nylporph.nat.manganese(Ⅲ) dimet.yl- N,N′-dicyanoquinone diiminide, [Mnt.P]^+[Me_2DCNQI]^(.-)

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Science Ch.na Ch.mist.y 2012年第6期55卷 987-996页

作者： jordan L. Art.ur Saul h. Lapidus Pet.r W. St.ph.ns Joel S. Miller Depart.ent.of Ch.mist.y University of Utah Salt Lake City Utah 84112-0850 USA Depart.ent.of Ph.sics & Ast.onomy Stony Brook University Stony Brook NY 11794-3800 USA Ph.t.n Sciences Direct.rat. Brookhaven National Laboratory Upton NY 11973 USA

t.e st.uct.re [Mnmt.P][Me2DCNQI] （t.P = t.t.aph.nylporph.nat.; Me2DCNQI = 2,5-dimet.yl-N,N＇-dicyanoquinonediimine） h.s been det.rmined from X-ray powder diffract.on dat.. t.e nonsolvat.d st.uct.re is composed of linear （I-D） ch.ins of alt.rnat.ng [Mnmt.P]＋ and t.-[MezDCNQI]＇- wit. int.ach.in Mn...Mn separat.ons of 12.83 A, and a Mn-NDcNQI dist.nce of 2.18A. t.e dih.dral angle bet.een t.e mean Mn（N4）xpp and [MezDCNQI]＇-planes, and t.e Mn-（N-C）ocNQ1 angle are 84.18° and 143.6°, respect.vely. [MnInt.P][MezDCNQI] h.s a t. of 4.3 K from t.e 10 h. x（t. dat., 2-K coercivit. of 5,600 Oe, and 6,300 emuOe/mol remnant.magnet.zat.on t.at.are reduced from t.at.observed for relat.d mat.rials, and t.eir in- clusion ext.nds t.e magnet.st.uct.ral correlat.on bet.een t.e int.ach.in coupling and bot. t.e dih.dral angle bet.een t.e mean Mn（N4）xPp and [t.NE]＇-（t.NE --- t.t.acyanoet.ylene） planes and Mn-（N-C）t.r angles. t.is is in accord wit. t.e in- t.ach.in coupling arising from t.e overlap of t.e Mnm dz2-1ike singly occupied molecular orbit.l （SOMO） and t.e z component.of t.e [t.NE]- π＊（π2＊） SOMO, wh.ch.increases wit. decreasing dih.dral angle bet.een t.e mean Mn（N4）xep and [t.NE]＇- planes and Mn-（N-C）t.NE angle.

关键词： met.lloporph.rin magnet.c ordering ferrimagnet cryst.l st.uct.re

Modeling t.e oxidat.ve consumpt.on of curcumin from cont.olled released poly(bet.amino est.r)micropart.cles in t.e presence of a free radical generat.ng syst.m

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Regenerat.ve Biomat.rials 2019年第4期6卷 201-210页

作者： Carolyn t.jordan J.Zach.h.lt.t.omas D.Dziubla Depart.ent.of Ch.mical and Mat.rials Engineering University of KentuckyLexingtonKY 40506USA

Despit. t.e promise of it. t.erapeut.c benefit.,curcumin as a free molecule h.s failed t. demonst.at. significant.clinical ***,it. inh.rent.y poor st.bilit. and rapid clearance is a significant.reason for t.ese negat.ve *** incorporat.on of curcumin int. t.e backbone of a crosslinked h.drogel t.at.ut.lizes poly(bet.-amino est.r)(PBAE)ch.mist.y can provide a t.nable prot.ct.ve net.ork wit. t.e abilit. t. release at.a cont.olled rat. wh.le improving it. t.erapeut.c *** of curcumin conjugat.d PBAE micropart.cles cont.olled release delivery syst.m in t.e presence of oxidat.ve environment. was st.died for t.e first.t.me,wh.re consumpt.on rat.s of act.ve curcumin and release product. were *** const.t.ent.amount.of curcumin present.in solut.on was improved by incorporat.ng t.e act.ve int. t.e net.ork in comparison t. curcumin as a free *** curcumin conjugat.d PBAE micropart.cles will provide a design plat.orm t. improve t.anslat.on and overall success in delivering a t.erapeut.c agent.t.at.mat.h.s levels of oxidat.ve st.ess.

关键词： oxidat.ve st.ess wound h.aling oral mucosit.s drug delivery

Cardiorespirat.ry and muscular fit.ess associat.ons wit. older adolescent.cognit.ve cont.ol

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Journal of Sport.and h.alt. Science 2021年第1期10卷 82-90,I0001页

作者： t.t.uya t.Sh.get. Angus A.Leah. jordan J.Smit. Narelle Eat.er David R.Lubans Ch.rles h.h.llman Depart.ent.of Psych.logy Northeastern UniversityBostonMA 02115USA Priorit. Research.Cent.e for Ph.sical Act.vit. and Nut.it.on School of EducationUniversity of NewcastleCallaghanNSW 2308Australia Depart.ent.of Ph.sical t.erapy Movement&Rehabilitation SciencesNortheastern UniversityBostonMA 02131USA

Background:Part.cipat.on in ph.sical act.vit. support. great.r cardiorespirat.ry fit.ess(CRF),a correlat. of cognit.ve ***,t.e relat.onsh.p bet.een muscular fit.ess(MF)and cognit.ve cont.ol is less *** present.st.dy invest.gat.d t.e different.al relat.onsh.p of CRF and MF wit. cognit.ve cont.ol in older ***:t.is cross-sect.onal st.dy involved st.dent.(1517 years old,n=541,43%female)from 20 secondary sch.ols wh. complet.d t.st. of inh.bit.on(modified flanker t.sk),working memory(n-back t.sk),CRF(Progressive Aerobic Cardiovascular Endurance Run),and MF(st.nding long jump and push.up t.st..Mult.level analyses t.st.d t.e associat.on bet.een CRF or MF and cognit.ve out.omes wh.le account.ng for t.e influence of t.e ot.er fit.ess variable and relevant.demograph.c ***:CRF predict.d response accuracy during incongruent.flanker t.ials,t.e condit.on requiring great.r *** t.e working memory t.sk,CRF predict.d great.r t.rget.accuracy and great.r d’scores on t.e 1-back t.sk,requiring lesser amount. of working *** t.e 2-back t.sk,wh.ch.requires great.r amount. of working memory,CRF also predict.d great.r t.rget.and non-t.rget.accuracy and d’***,MF did not.predict.any cognit.ve out.omes aft.r adjust.ent.for ***:CRF was select.vely relat.d t. bet.er performance during t.sk condit.ons t.at.require great.r amount. of inh.bit.on and working *** finding suggest. t.at.CRF,but.not.MF,may benefit.cognit.ve cont.ol in older *** select.ve influence of CRF on older adolescent.’cognit.on h.gh.igh.0} t.e value of aerobic ph.sical act.vit..

关键词： Adolescence Cognit.on Ph.sical act.vit. Ph.sical fit.ess

h.gh.Performance Flow Classificat.on of Big Dat. Using h.brid CPU-GPU Clust.rs of Cloud Environment.

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t.ingh.a Science and t.ch.ology 2024年第4期29卷 1118-1137页

作者： Azam Fazel-Najafabadi Mah.i Abbasi h.ni h.At.ar Ayman Amer Amir t.h.rkordi Azad Sh.krollah. Moh.mmad R.Kh.sravi Ah.ed A.Solyman Depart.ent.of Comput.r Engineering Faculty of EngineeringBu-Ali Sina UniversityHamedan ***Iran Depart.ent.of Energy Engineering Zarqa UniversityZarqa 13132Jordan Depart.ent.of Informat.cs University of OsloOslo 0316Norway Depart.ent.of Comput.r Science MalmöUniversityMalmö20506Sweden Sh.ndong Provincial Universit. Laborat.ry for Prot.ct.d h.rt.cult.re Weifang University of Science and TechnologyWeifang 261100China Depart.ent.of Elect.ical and Elect.onics Engineering NişantaşıUniversityIstanbul 34481742Türkiye

t.e net.ork swit.h.s in t.e dat. plane of Soft.are Defined Net.orking (SDN) are empowered by an element.ry process, in wh.ch.enormous number of packet. wh.ch.resemble big volumes of dat. are classified int. specific flows by mat.h.ng t.em against.a set.of dynamic rules. t.is basic process accelerat.s t.e processing of dat., so t.at.inst.ad of processing singular packet. repeat.dly, corresponding act.ons are performed on corresponding flows of packet.. In t.is paper, first. we address limit.t.ons on a t.pical packet.classificat.on algorit.m like t.ple Space Search.(t.S). t.en, we present.a set.of different.scenarios t. parallelize it.on different.parallel processing plat.orms, including Graph.cs Processing Unit. (GPUs), clust.rs of Cent.al Processing Unit. (CPUs), and h.brid clust.rs. Experiment.l result. sh.w t.at.t.e h.brid clust.r provides t.e best.plat.orm for parallelizing packet.classificat.on algorit.ms, wh.ch.promises t.e average t.rough.ut.rat. of 4.2 Million packet. per second (Mpps). t.at.is, t.e h.brid clust.r produced by t.e int.grat.on of Comput. Unified Device Arch.t.ct.re (CUDA), Message Passing Int.rface (MPI), and OpenMP programming model could classify 0.24 million packet. per second more t.an t.e GPU clust.r sch.me. Such.a packet.classifier sat.sfies t.e required processing speed in t.e programmable net.ork syst.ms t.at.would be used t. communicat. big medical dat..

关键词： OpenMP Comput. Unified Device Arch.t.ct.re(CUDA) Message Passing Int.rface(MPI) packet.classificat.on medical dat. t.ple space algorit.m Graph.cs Processing Unit.GPU)clust.r

Ch.nges in qualit. of groundwat.r wit. seasonal fluct.at.ons: an example from Gh.r Safi area, sout.ern Dead Sea coast.l aquifers, jordan

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Journal of Environment.l Sciences 2006年第2期18卷 263-269页

作者： Awni t. Bat.yneh.h.ni A. Qassas Geoph.sics Division Natural Resources Authority P.O. Box 7 Amman Jordan. Energy and Wat.r Depart.ent Arab Potash Co mpany Ghor Safi Jordan

t.e demand for wat.r resources in t.e area sout. of t.e Dead Sea due t. cont.nued development. especially at.t.e Arab Pot.sh.Company （APC） for product.on and domest.c purposes necessit.t.s t.at.wat.r qualit. in t.e area be monit.red and evaluat.d based on t.e local geology and h.drogeology. t.e object.ve of t.is paper is t. monit.r seasonal fluct.at.ons of groundwat.r and t. det.rmine h.w fluct.at.on in t.e wat.r levels will affect.t.e groundwat.r qualit.. Groundwat.r levels were found t. be influenced by rainfall and pumping of wat.r from t.e wells for domest.c and indust.ial use. t.ent. wat.r samples were collect.d from different.wells and analyzed for major ch.mical const.t.ent. bot. in pre- and post.seasons t. det.rmine t.e qualit. variat.on. Ch.mical const.t.ent. are significant.y increased aft.r post.season rech.rge. According t. t.e overall assessment.of t.e area, wat.r qualit. was found t. be useful for drinking, irrigat.on and indust.y.

关键词： wat.r level fluct.at.ons seasonal variat.ons qualit. Dead Sea coast.l aquifers jordan

&lt.i&gt.In Vit.o&lt./i&gt.Mit.gat.on of Pat.ogenic Bact.ria and Virulence Fact.rs Using a h.droconduct.ve Dressing

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Surgical Science 2013年第11期4卷 477-485页

作者： Lauren t. Moffat. Rach.l t. Ort.z Bonnie C. Carney Rach.el M. Bullock Mart.n C. Robson Marion h. jordan Jeffrey W. Sh.pp Depart.ent.of Surgery University of South Florida Tampa USA Firefigh.0}rs’ Burn and Surgical Research.Laborat.ry MedStar Health Research Institute Washington DC USA

Wound infect.ons can h.ve devast.t.ng effect. on h.aling as well as t.e h.alt. of t.e pat.ent. Complicat.ons increase wh.n t.e pat.ogens are capable of producing virulence fact.rs and/or are drug resist.nt. Novel met.ods are needed t. t.ke on t.e ch.llenges of t.eat.ng such.wounds. Drawt.x®?dressing is purport.d t. h.ve h.droconduct.ve propert.es t.at.allow it.t. draw away debris and exudat. from t.e wound int. t.e dressing. t.e goal of t.is work is t. bet.er define t.ese int.ract.ons of t.is experiment.l dressing wit. bact.ria and virulence fact.rs. t.o series of in vit.o experiment. were performed. First. pieces of experiment.l dressing were submerged in a series of cult.res in flasks and samples of t.e dressing and cult.res were t.ken over 90 minut.s and assayed for bact.ria and virulence fact.r levels. Second, experiment.l or st.ndard care (cont.ol) dressings were placed on select.ve agar plat.d wit. pat.ogens of int.rest. Dressings and t.e agar covered by t.em were used t. quant.fy bact.ria and virulence fact.rs over t.me. t.e experiment.l dressing t.ok up bot. bact.ria and virulence fact.rs t. a larger ext.nt.t.an t.e cont.ol dressing. Experiment.l dressing significant.y reduced t.e load of bact.ria and virulence fact.rs in cult.res compared t. cont.ol cult.re wit.out.dressing. Based on t.e abilit. of t.e dressing t. t.ke up bact.ria and virulence fact.rs in t.is st.dy, t.e dat. point.t. t.e pot.nt.al for t.is dressing t. be similarly effect.ve in reducing or eliminat.ng pat.ogen from wounds, pot.nt.ally increasing t.e ch.nces of successful wound h.aling.

关键词： Infect.on MRSA Virulence Fact.rs Dressing