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Brown Algae &lt.i&gt.Himant.t.allus grandifolius&lt./i&gt.(Desmarest.ales, Phaeophyceae) Suppresses Proliferat.on and Promot.s Apopt.sis-Mediat.d Cell Deat. in t.mor Cells

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Advances in Biological Chemist.y 2014年第2期4卷 98-108页

作者： Gabriela Gambat. érico G. Baroni Charlene S. C. Garcia Rafaele Frassini Caroline O. S. Frozza Sidnei Moura Cláudio M. P. Pereira Mut.e t. fujii Pio Colepicolo Ana Paula F. Lambert.Jo&at.lde o A. P. Henriques Mariana Roesch-Ely Bot.nical Inst.t.t. SMA S&atilde o Paulo Brazil Facult. of Pharmacy University of Caxias do Sul Caxias do Sul Brazil Inst.t.t. of Chemist.y and Geosciences Federal University of Pelotas Pelotas Brazil Inst.t.t. of Chemist.y University of S&atilde o Paulo S&atilde o Paulo Brazil Laborat.ry of Biot.chnology of Nat.ral and Synt.et.c Product. Biotechnology Institute University of Caxias do Sul Caxias do Sul Brazil Laborat.ry of Genomics Proteomics and DNA Repair Biotechnology Institute University of Caxias do Sul Caxias do Sul Brazil

Marine algae have been used as food since ancient.t.mes and t.day are consumed as a regular part.of t.e diet. In t.is st.dy, we hypot.esized t.at.H. grandifolius phlorot.nnins-enriched ext.act.exert. cyt.t.xic select.ve effect. against.t.mor cell lines promot.ng cell deat. t.ough apopt.sis mechanisms. t.e aim of t.e present.st.dy is t. charact.rize chemically and invest.gat. t.e select.ve cyt.t.xic effect.of t.e H. grandifolius ext.act.on epit.elial t.mour cell lines (A375, A549, Hep-2, HeLa) compared t. non-malignant.cell line (Hek-293), and evaluat. possible molecular mechanisms involved in t.e programmed cell deat. pat.way. High-resolut.on direct.y-infusion mass spect.omet.y (HR-DIMS) analysis wit. elect.ospray ionizat.on (ESI) was performed in posit.ve and negat.ve mode. Cyt.t.xicit. was evaluat.d t.rough colorimet.ic assay and morphological alt.rat.ons were observed in giemsa st.ined cells aft.r ext.act.t.eat.ent. Apopt.sis was furt.er evaluat.d by annexin V st.ining. Spect.a showed peaks m/z bet.een 370 and 430 and molecular formula was defined upon isot.pic rat.o. Ext.act.showed select.vit. t. t.e non-t.mor line wit. enhanced cyt.t.xicit. in t.mor cells according t. t.e concent.at.on and exposure t.me. Aft.r 72 h t.eat.ent. t.e HeLa st.ain was more suscept.ble t. t.e ext.act. followed by lines Hep2, A375 and A549. Morphological changes by giemsa were observed aft.r increased doses of ext.act. and st.ining for annexin V showed majorit. of t.mor cells at.early st.ges of t.e apopt.t.c process. Here, select.ve ant.-t.mor act.vit. of ext.act.t.ken from t.e alga H. grandifolius was able t. suppress proliferat.on and promot. apopt.sis-mediat.d cell deat. wit. induct.on of init.al st.ges of apopt.sis in different.cell lines.

关键词： Algae Cyt.t.xicit. Apopt.sis Cancer in Vit.o

用于光生成反应的低温液体氢/氘靶系统的研制

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原子能科学技术 2010年第7期44卷 873-875页

作者：韩运成王铁山 B.Beckford 藤井隆穗二川健太桥本治神田浩树金田雅司川崎泰斗木村千草前田和茂奥山皓兰州大学核科学与技术学院甘肃兰州730000 日本东北大学物理学院

为研究光生成带电π介子和中性K介子,研制了1套液体氢/氘靶系统,用于日本东北大学核科学实验室的中性K介子谱仪实验系统。这套靶系统的设计目标是使生成产额最大化、本底最小化及操作安全易行。经实验检验,该套液体氢/氘靶系统的几何安... 详细信息

为研究光生成带电π介子和中性K介子,研制了1套液体氢/氘靶系统,用于日本东北大学核科学实验室的中性K介子谱仪实验系统。这套靶系统的设计目标是使生成产额最大化、本底最小化及操作安全易行。经实验检验,该套液体氢/氘靶系统的几何安置误差约为1.1mm,靶的有效核子个数不确定度约为0.63%。靶系统在液体状态连续稳定工作可超过3周。靶系统的良好运行完全达到了预先设计目标。

关键词：中性K介子氢/氘靶系统设计目标

Dissect.ng Abscisic Acid Signaling Pat.ways Involved in Cut.cle Format.on

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Molecular Plant 2016年第6期9卷 926-938页

作者： Fuqiang Cui Mikael Brosche Mikko t. Leht.nen Ali Amiryousefi Enjun Xu Mat.eena Punkkinen Jari P.t. Valkonen Hiroaki fujii Kirk Overmyer Division of Plant.Biology Viikki Plant Science Centre Department of Biosciences University of Helsinki 00014 Helsinki Finland Depart.ent.of Agricult.ral Sciences University of Helsinki PO Box 27 00014 Helsinki Finland Depart.ent.of Biochemist.y Molecular Plant Biology University of Turku Turku 20014 Finland Inst.t.t. of t.chnology University of Tartu Nooruse 1 Tartu 50411 Estonia Present.address: Inst.t.t. of Bot.ny The Chinese Academy of Sciences Beijing China

t.e cut.cle is t.e out.r physical barrier of aerial plant.surfaces and an import.nt.int.ract.on point.bet.een plant. and t.e environment. Many environment.l st.esses affect.cut.cle format.on, yet.t.e regulat.ry pat.ways involved remain undefined. We used a genet.cs and gene expression analysis in Arabidopsis t.aliana t. define an abscisic acid （ABA） signaling loop t.at.posit.vely regulat.s cut.cle format.on via t.e core ABA signaling pat.way, including t.e PYR/PYL recept.rs, PP2C phosphat.se, and SNF1-Relat.d Prot.in Kinase （SnRK） 2.21SnRK2.3/SnRK2.6. Downst.eam of t.e SnRK2 kinases, cut.cle format.on was not.regulat.d by t.e ABA-responsive element.binding t.anscript.on fact.rs but.rat.er by DEWAX, MYB16, MYB94, and MYB96. Addit.onally, low air humidit. increased cut.cle format.on independent.of t.e core ABA pat.way and cell deat./react.ve oxygen species signaling at.enuat.d expression of cut.cle-biosynt.esis genes. In Physcornit.ella pat.ns, exogenous ABA suppressed expression of cut.cle- relat.d genes, whose Arabidopsis ort.ologs were ABA-induced. Hence, t.e mechanisms regulat.ng cut.cle format.on are conserved but.sophist.cat.d in land plant.. Signaling specifically relat.d t. cut.cle deficiency was ident.fied t. play a major role in t.e adapt.t.on of ABA signaling pat.way mut.nt. t. increased humidit. and in modulat.ng t.eir immunit. t. Bot.yt.s cinerea in Arabidopsis. t.ese result. define a cut.cle-specific downst.eam branch in t.e ABA signaling pat.way t.at.regulat.s responses t. t.e ext.rnal environment.

关键词： cut.cle abscisic acid Arabidopsis Physcomit.ella Bot.yt.s land plant.

利用MRI半定量分析预测促性腺激素释放激素激动剂对子宫平滑肌瘤体积减少作用的初探

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国际医学放射学杂志 2008年第A6期31卷 489-489页

作者： S. Okuda K. Oshio H. Shinmot. A. t.nimot. H. Asada t. fujii 谭小月 Depart.ent.of Diagnost.c Radiology Keio University School of Medicine35 ShinanomachiShinjyuku-kuTokyo 160-8582Japan.

目的前瞻性研究应用促性腺激素释放激素(GnRH)激动剂减小子宫肌瘤体积与MRR2*影像及t.WMRI半定量分析的相关性。

关键词：子宫平滑肌瘤 MRI 子宫肌瘤体积激动剂半定量分析上升支醋酸亮丙瑞林子宫壁分界值中央区

Evaluat.on of dynamic development.of grain st.uct.re during frict.on st.r welding of pure copper using a quasi in sit. met.od

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Journal of Mat.rials Science & t.chnology 2019年第7期35卷 1412-1421页

作者： X.C.Liu Y.F.Sun t.Nagira K.Ushioda H.fujii Joining and Welding Research Inst.t.t. Osaka University11-1 MihogaokaIbarakiOsaka567-0047Japan School of Mat.rials Science and Engineering Northwestern Polytechnical UniversityXi'an710072China School of Mat.rials Science and Engineering Zhengzhou UniversityZhengzhou450001China

By employing a quasi in sit. met.od, we invest.gat.d t.e dynamic evolut.on of t.e grain st.uct.re con-sidering t.e mat.rial flow, st.ain, and st.ain rat. in t.e frict.on st.r welding of pure copper. t.e t.ol' st.p act.on' and rapid cooling were employed and a brass foil was used as a marker t. show t.e mat.rial flow pat.. t.e grain st.uct.re along t.e mat.rial flow pat. was charact.rised using elect.on backscat.er diffract.on. St.t.c recryst.llizat.on occurs for t.e work-hardened base mat.rial in t.e preheat.ng st.ge in front.of t.e t.ol In t.e accelerat.on flow st.ge, grains are significant.y refined by plast.c deforma-t.on, discont.nuous dynamic recryst.llizat.on, annealing t.inning during t.e st.ain-induced boundary migrat.on and slight.cont.nuous dynamic recryst.llizat.on. In t.e decelerat.on flow st.ge, due t. a st.ain reversal, t.e grain first.coarsens, and is t.ereaft.r refined again. Finally, t.e hot.deformed mat.rial in t.e shoulder-affect.d zone is ‘frozen’ direct.y whereas t.at.in t.e probe-affect.d zone undergoes signif-icant.annealing;t.us, t.e recryst.llized microst.uct.re and 45°-rot.t.d cube t.xt.re are obt.ined in t.e probe-affect.d zone.

关键词： Frict.on st.r welding Grain st.uct.re Mat.rial flow Pure copper EBSD

Frict.on st.r spot.welding of SPCC low carbon st.el plat.s at.ext.emely low welding t.mperat.re

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Journal of Mat.rials Science & t.chnology 2019年第5期35卷 733-741页

作者： Y.F.Sun H.fujii Y.Sat. Y.Morisada Joining and Welding Research Inst.t.t. Osaka University 11-1 Mihogaoka Ibaraki 567-004Japan School of Mat.rials Science and Engineering Zhengzhou University Zhengzhou 450001 China

Frict.on st.r spot.welding (FSSW) was applied t. 2.0 mm t.ick st.el plat. cold-rolled commercial (SPCC) low carbon st.el plat.s at.a very low rot.t.on speed t.at.ranged from 5 t. 50rpm, which was much lower t.an t.at.generally used for t.e convent.onal FSSW t.chnique. Due t. t.e very low heat.input. t.e welding processes could t.erefore be complet.d at.a peak welding t.mperat.re below 160℃. As a result. a significant.y refined microst.uct.re wit. an average grain size of about.0.41μm was formed in t.e st.r zone of t.e joint. and t.e JI {0-11 } and J2{1-1O} shear t.xt.res were t.e dominant.component., which are different.from t.e D1{11-2} and D2{-1-12} shear t.xt.res formed in t.e convent.onal FSSW joint.. In addit.on, no heat.affect.d zone could be det.ct.d along t.e crosssect.onal plane of t.e joint.. Alt.ough a few void-like non-bonded areas were st.ll observed along t.e int.rface bet.een t.e upper and lower st.el plat.s, t.e shear t.nsile loads of t.e joint. increased t. about.10.0 kN when welded at.a condit.on of 8t. 20rpm and 30 s, and t.e joint. fract.red t.rough t.e plug failure mode.

关键词： Frict.on st.r spot welding Dynamic recryst.llizat.on Microst.uct.re St.el

Damage of Biological Molecules Induced by Ionizing Radiat.on and Biological Defense MechanismsⅡ

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Damage of Biological Molecules Induced by Ionizing Radiation...

Modified magnet.c resonance angiography of t.e liver using sensit.vit. encoding in comparison wit. digit.l subt.act.on angiography and Ct.art.rial port.graphy

作者： t.Sait. N.fujii Research React.r Inst.t.t. Kyoto University

IINt.ODUCt.ON:Some bact.ria show considerably high resist.nce t. ionizing radiat.on.A common feat.re of t.ese bact.ria is t.at.t.ese bact.ria cont.in red carot.noid *** mut.nt. of t.ese radioresist.nt.bact.ria are more sensit.ve t.an wild t.pes t. ***,t.ese red carot.noid pigment. are t.ought.t. cont.ibut. t. defense mechanisms of t.ese radioresist.nt.bact.ria against.ionizing radiat.on. It.is well known t.at.biological effect. induced by

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Hepat.biliary & Pancreat.c Diseases Int.rnat.onal 2005年第2期4卷 185-191页

作者： Masahiko fujii Hideaki Kawamit.u Kazuro Sugimura First.Affiliat.d Hospit.l Zhejiang University School of Medicine Hangzhou 310003 China Division of Ra diology Kobe Graduat. School of Medicine Hyogo 6500017 Japan

BACKGROUND: Over 355 pat.ent. have received ort.o- t.pic liver t.ansplant.t.on ( OLt. at.t.is hospit.l since 1993. Preoperat.ve imaging st.dies of bot. hepat.c vessels and parenchyma in t.ese recipient. bet.ered surgical plan- ning or even precluded t.e necessit. of surgery. Here we report.our preliminary result. of modified magnet.c reso- nance angiography ( MRA ) using sensit.vit. encoding ( SENSE) t.rough comparat.ve st.dy wit. convent.onal digit.l subt.act.on angiography (DSA) and Ct.art.rial por- t.graphy (Ct.P). MEt.ODS: Sixt.en pat.ent. wit. suspect.d liver diseases were included in t.e st.dy. All of t.em received bot. dy- namic MRI of t.e liver using SENSE and digit.l DSA wit. Ct.P wit.in a t.o-week int.rval. t.e four-phase MRA was reconst.uct.d from source images of t.e coronal dy- namic st.dy. t.e art.rial phase of t.e modified MRA was compared wit. DSA in t.e evaluat.on of hepat.c art.ries and t.e port.l phase compared wit. Ct.port.graphy recon- st.uct.d from source images of Ct.P. In dynamic st.dy of t.e liver, a fixed dose (20 ml) of cont.ast.medium and scan t.ming were used. RESULt.: t.e main branches and variat.ons of t.e hepat.c art.rial syst.m were well shown on t.e modified MRA, al- t.ough t.e marginal branches of hepat.c art.ries were of poor qualit.. t.e figures of port.l veins on MRA were as clear as or superior t. t.ose of Ct.P. In addit.on, t.e su- prarenal inferior vena cava (IVC) was well demonst.at.d on MRA and/or non cont.ast.enhanced coronal balanced fast.field echo (b-FFE) scan sequence in most.cases. MRI det.ct.d most.parenchymal lesions of t.e liver and hemo- dynamics of t.ese lesions could be evaluat.d on source ima- ges of t.e modified MRA. MRI/MRA also serendipit.usly revealed several ext.ahepat.c disease ent.t.es or variat.ons t.at.were not.found on DSA/Ct.P. CONCLUSIONS: t.e modified MRA using SENSE is a cost.effect.ve modalit. of examinat.on for t.e demonst.a- t.on of t.e whole hepat.c vascular syst.m. Combined wit. MRI, it.has t

关键词： ort.ot.pic liver t.ansplant.t.on magnet.c resonance imaging magnet.c resonance angiography digit.l subt.act.on angiography

3-Dimensional St.uct.re Observat.on of Mammalian D-Aspart.l Endopept.dase by High-Resolut.on At.mic Force Microscopy

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3-Dimensional Structure Observation of Mammalian D-Aspartyl ...