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Excellent photoluminescence and electrochemical properties of Sm^(3+) doped Ca_(2)MgSi_(2)O_(7) nanophosphor:Display and electrochemical sensor applications

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Journal of Rare Earths 2024年第6期42卷 1046-1055,I0002页

作者： R.B.Basavaraj K.Sureshkumar D.P.Aarti M.B.Madhusuda.a reddy G.Nagaraju t.Ramakrishnappa G.R.Navyashree K.R.Venkatesha Babu K.S.Hemalatha Department of Physics BMS Institute of Technology and ManagementBangalore560064India Department of Chemistry BMS Institute of Technology and ManagementBangalore560064India Department of Chemistry School of Applied SciencesREVA UniversityBangalore560064India Energy Materials ResearchLaboratory Department of ChemistrySiddaganga Institute of TechnologyTumakuru57203KarnatakaIndia School of Physical Sciences REVA UniversityBangalore560057Indi Department of Physics Govt.Science CollegeBengaluru560001India Department of Physics Maharani Science College for WomenMaharani Cluster UniversityBengaluru560001India

A series of orange-red light emitting Ca_(2)MgSi_(2)O_(7):Sm^(3+)nanopowders were fabricated via low-cost ecofriendly green combustion technique using Aloe vera gel as *** phase purity of the samples were confirmed by the powder X-ray diffraction(PXRD)*** single-phase tetragonal structure is observed from the PXRD results with no additional impurity *** band gap energy of the fabricated powders was estimated by diffuse reflectance spectra(DRS)and is found to be in the range of 4.01-5.98 eV.A high resolution scanning electron microscope(SEM)was used to study the morphological behaviour of the ***-like structures are observed from the SEM *** particle size was evaluated by transmission electron microscopy(tEM)and is found to be~50 *** interplanar distance is found to be 0.53 *** properties were systematically studied in *** phosphors are successfully excited at 403 nm NUV light,producing reddish-orange characteristic *** emission peaks are centered at 558(^(4)G_(5/2)→^(6)H_(5/2)),607(^(4)G_(5/2)→^(6)H_(7/2))and 645 nm(^(4)G_(5/2)→^(6)H_(9/2)),*** the observed peaks the red emanation(^(4)G_(5/2)→^(6)H_(7/2))is stronger than the orange emission(^(4)G_(5/2)→^(6)H_(5/2))in the current *** photoluminescent concentration quenching is noticed above 5 mol%Sm^(3+)ion doping *** dipole-dipole interaction resulting in cross relaxation is found to be the principal cause of concentration quenching *** color features such as Commission Internationale de I’Eclairage(CIE)and correlated color temperature(CCt)were studied in *** optimized chromaticity coordinates were estimated to be(0.6363,0.3632),which fall in the reddish-orange *** average CCt value obtained is 3362 *** average color purity is found to be~82%.Sm^(3+)incorporated Ca_(2)MgSi_(2)O_(7) samples are possible contender for single white light generation commercial candidates owing to

关键词： Green combustion Photoluminescence Orange-red emission Color purity Sensors Rare earths

Serum tumor markers:Can they clinically implicate in type 2 diabetes mellitus?

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World Journal of Diabetes 2024年第7期15卷 1648-1650页

作者： Kotha Sugunakar reddy Ilakkiya Priya Pandiaraj Archana Gaur Sakthivadivel Varatharajan Department of General Medicine All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Physiology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia

“Serum tumor markers expression(CA19-9,CA242,and CEA)and its clinical implications in type 2 diabetes mellitus”authored by Meng and Shi presents an observational case-control study investigating the correlation between tumor markers and type 2 diabetes mellitus(t2DM).the study explores the diagnostic accuracy of tumor markers,particularly cancer antigen 19-9(CA19-9),CA242,and carcinoembryonic antigen,in poorly controlled t2DM patients with hemoglobin A1c levels exceeding 9%,employing receiver operating characteristic curve *** study offers valuable insights into the potential utility of tumor markers in clinical practice,caution is advised regarding routine tumor marker testing due to challenges such as limited availability and ***,the study overlooks potential confounding factors like smoking and alcohol *** in CA19-9 and CA242 expression underscore the complex interplay between tumor markers and systemic diseases,warranting further investigation into their diagnostic and prognostic *** Meng and Shi represent a significant contribution to the field,more extensive research is needed to fully elucidate the role of tumor markers in diabetes management and beyond.

关键词： Cancer antigen 19-9 Cancer antigen 242 Carcinoembryonic antigen tumor markers type 2 diabetes mellitus

Dual inhibition of sirtuins 1 and 2:reprogramming metabolic energy dynamics in chronicmyeloid leukemia as an immunogenic anticancer strategy

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Cancer Communications 2024年第8期44卷 921-925页

作者： Michael Schnekenburger Anne Lorant Sruthi reddy Gajulapalli Ridhika Rajora Jin-Young Lee Aloran Mazumder Haeun Yang Christo Christov Hyoung Jin Kang Bernard Pirotte Marc Diederich Laboratoire de Biologie Moleculaire et Cellulaire du Cancer LuxembourgLuxembourg Research Institute of Pharmaceutical Sciences&Natural Products Research Institute College of PharmacySeoul National UniversitySeoulRepublic of Korea Faculte de Medecine Universite de LorraineVandoeuvre-les-NancyFrance Department of Pediatrics Seoul National University College of MedicineSeoul National University Cancer Research InstituteSeoul National University Children’s HospitalSeoulRepublic of Korea Laboratory of Medicinal Chemistry Center for Interdisciplinary Research on Medicines(CIRM)University of LiegeLiegeBelgium

Chronicmyeloid leukemia(CML)is a lethal hematopoietic malignancy with a global incidence primarily attributed to the breakpoint cluster region-Abelson(BCR-ABL1)fusion oncogene in over 95%of *** introduction of tyrosine kinase inhibitors(tKIs)has revolutionized CML management;however,a subset of patients encounters challenges such as resistance and relapse,hindering the achievement of complete *** these challenges in CML also requires addressing persistent leukemia stem cells(LSCs)with inherent resistance *** regulators of LSC metabolism,proliferation,and survival,as well as genetic and epigenetic alterations,provide potential targets[1].

关键词： metabolism myeloid alterations

Cancer immunotherapy with envelopedself-amplifying mRNA CARG-2020 thatmodulates IL-12,IL-17 and PD-L1 pathways toprevent tumor recurrence

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Acta Pharmaceutica Sinica B 2024年第1期14卷 335-349页

作者： Ju Chen Bhaskara reddy Madina Elham Ahmadi timur Olegovich Yarovinsky Marie Marthe Krady Eileen Victoria Meehan Isabella China Wang Xiaoyang Ye Elise Pitmon Xian-Yong Ma Bijan Almassian Valerian Nakaar Kepeng Wang Department of Immunology School of MedicineUniversity of Connecticut Health CenterFarmingtonCT 06030USA CaroGen Corporation FarmingtonCT 06030USA the Eighth Clinical Medical College of Guangzhou University of Chinese Medicine Foshan Hospital of Traditional Chinese MedicineFoshan 528000China the Loomis Chaffee School WindsorCT 06095USA

targeting multiple immune mechanisms may overcome therapy resistance and further improve cancer immunotherapy for ***,we describe the application of virus-like vesicles(VLV)for delivery of three immunomodulators alone and in combination,as a promising approach for cancer *** vectors were designed to deliver single chain interleukin(IL)-12,shorthairpin RNA(shRNA)targeting programmed death ligand 1(PD-L1),and a dominant-negative form of IL-17 receptor A(dn-IL17RA)as a single payload or as a combination *** delivery of the VLV vector expressing IL-12 alone,as well as the trivalent vector(designated CARG-2020)eradicated large established ***,only CARG-2020 prevented tumor recurrence and provided long-term survival benefit to the tumor-bearing mice,indicating a benefit of the combined *** abscopal effects of CARG-2020 on the non-injected contralateral tumors,as well as protection from the tumor cell re-challenge,suggest immune-mediated mechanism of protection and establishment of immunological ***,CARG-2020 potently activates th1 immune mechanisms and inhibits expression of genes related to t cell exhaustion and cancer-promoting *** ability of CARG-2020 to prevent tumor recurrence and to provide survival benefit makes it a promising candidate for its development for human cancer immunotherapy.

关键词： Virus-like vesicles Oncolytic virus IL-12 IL-17 PD-L1 t cell exhaustion Combination therapy Cancer immunotherapy

Predicting the strength properties of slurry infiltrated fibrous concrete using artificial neural network

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Frontiers of Structural and Civil Engineering 2018年第4期12卷 490-503页

作者： t.Chandra Sekhara reddy Civil Engineering G.P.R.Engineering CollegeKurnool 518002Andhra PradeshIndia

this paper is aimed at adapting Artificial Neural Networks (ANN) to predict the strength properties of SIFCON containing different minerals admixture. the investigations were done on 84 SIFCON mixes, and specimens were cast and tested after 28 days curing. the obtained experimental data are trained using ANN which consists of 4 input parameters like Percentage of fiber (PF), Aspect Ratio (AR), type of admixture (tA) and Percentage of admixture (PA). the corresponding output parameters are compressive strength, tensile strength and flexural strength. the predicted values obtained using ANN show a good correlation between the experimental data. the performance of the 4-14-3 architecture was better than other architectures. It is concluded that ANN is a highly powerful tool suitable for assessing the strength characteristics of SIFCON.

关键词： artificial neural networks root mean square error SIFCON silica fume metakaolin steel fiber

Low velocity impact studies of E-glass/epoxy composite laminates at different thicknesses and temperatures

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Defence technology（防务技术） 2019年第6期15卷 897-904页

作者： t.Sreekantha reddy P.Rama Subba reddy Vemuri Madhu Defence Metallurgical Research Laboratory

Low velocity impact experiments were carried out on E-glass/epoxy composite laminates having varying thicknesses at sub zero and elevated temperatures using hemi spherical steel impactor of 16 mm diameter with impact energies in the rage of 50-150 *** performance of the laminates was assessed in terms of energy absorption,maximum displacement,peak force and failure *** indicated that the effect of temperature on energy absorption of the laminate is negligible although the laminates are embrittling at sub zero *** it has influence on failure behaviour and *** force has increased linearly with increase in laminate thickness from 5 to 10 *** it got reduced by 25% when temperature was increased from-20℃ to 100℃,Based on experimental results,laminate perforation energies were predicted using curve fitting *** analysis was carried out using taguchi method to identify the global effects of various parameters on laminate performance and confirmed that the laminate thickness has significant influence as compared to temperature,for the studied range.

关键词： Laminates Glass fibres Impact behaviour Delamination

Improvising the Self-Healing Capabilities of Concrete Using Different Pozzolanic Materials and Crystalline Admixtures

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Journal of Wuhan University of technology(Materials Science) 2022年第3期37卷 429-439页

作者： A Ravitheja t Chandra Sekhara reddy C Sashidhar SVR Engineering College AyyalurNandyalKurnoolAndhra PradeshIndia Civil Engineering G Pulla Reddy Engineering CollegeKurnoolAPIndia Jawaharlal Nehru technological University AnantapurIndia

to analyse the self-healing capacities in terms of mechanical performance of the pozzolanic materials,such as,fly ash,metakaolin and silica fume and crystalline ***-cracked concrete cubes with about 0.05 mm width were exposed to four different environmental conditions at different exposure times in order to determine the effect of temperature and water availability on the self-healing *** the exposure,the control and tested concrete cubes were evaluated for regained strength,void reduction,corrosion inhibition,damp proofing,relative impermeability and *** samples with SF10CA have better cementitious filling and low percentage of voids and water absorption.

关键词： crystalline admixtures pozzolanic materials self-healing

Effect of Diffuser Vane Shape on the Performance of a Centrifugal Compressor Stage

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Journal of thermal Science 2014年第2期23卷 127-132页

作者： t Ch Siva reddy GV Ramana Murty MVSSSM Prasad Sreenidhi Institute of Science and technology GhatkesarHyderabadA.P.India Vasavi College of Engineering Hhyderabad

the present paper reports the results of experimental investigations on the effect of diffuser vane shape on the performance of a centrifugal compressor stage. these studies were conducted on the chosen stage having a back- ward curved impeller of 500 turn tip diameter and 24.5 mm width and its design flow coefficient is Фd=0.0535. three different low solidity diffuser vane shapes namely uncarnbered aerofoil, constant thickness flat plate and circular arc cambered constant thickness plate were chosen as the variants for diffuser vane shape and all the three shapes have the same thickness to chord ratio （t/c=0.1）. Flow coefficient, polytropic efficiency, total head coeffi- cient, power coefficient and static pressure recovery coefficient were chosen as the parameters for evaluating the effect of diffuser vane shape on the stage performance. the results show that there is reasonable improvement in stage efficiency and total head coefficient with the use of the chosen diffuser vane shapes as compared to conven- tional vaneless diffuser. It is also noticed that the aero foil shaped LSD has shown better performance when com- pared to flat plate and circular arc profiles. the aerofoil vane shape of the diffuser blade is seen to be tolerant over a considerable range of incidence.

关键词： Centrifugal compressor Vaneless diffuser Low solidity diffuser

Development of cost effective personnel armour through structural hybridization

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Defence technology（防务技术） 2020年第6期16卷 1089-1097页

作者： P.Rama Subba reddy t.Sreekantha reddy I.Srikanth Juhi Kushwaha V.Madhu Defence Metallurgical Research Laboratory Hyderabad500058India Advanced Systems Laboratory Hyderabad500058India

the objective of the present study is to develop cost effective thermoplastic hybrid laminate using Dyneema®HB50 and tensylon®HSBD 30A through structural hybridization *** having 20 mm thickness were fabricated and subjected to 7.6239 mm mild steel core projectile with an impact velocity of 730±10 ms*** such as energy absorption,back face deformation and rate of back face deformation were measured as a function of hybridization *** was observed that hybrid laminate with 50:50 ratio(w/w)of tensylon®and Dyneema®with tensylon®as front face showed 200%more energy absorption when compared to 100%tensylon®laminate and showed equal energy absorption as that of expensive 100%Dyneema®***,hybrid laminate with tD50:50 ratio showed 40%lower in terms of final back face deformation than Dyneema®*** of back face deformation was also found to be slow for hybrid laminate as compared to Dyneema®*** mechanical analysis showed that,tensylon®laminate has got higher stiffness and lower damping factor than Dyneema®and hybrid *** interface between tensylon®and Dyneema®layers was found to be separating during the penetration process due to the poor interfacial *** behaviour of laminates for different hybridization ratios were studied by sectioning the impacted *** was observed that,the tensylon®laminate has undergone shear cutting of fibers as major failure mode whereas the hybrid laminate showed shear cutting followed by tensile stretching,fiber pull out and *** inputs are highly useful for body armour applications to design cost effective armour with enhanced performance.

关键词： Dyneema® tensylon® Hybrid laminate Ballistic impact Energy absorption Back face signature