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Effects of gamma-ray irradiation on electronic and non-electronic equipment of Large Helical Device

Plasma Science and technology 2017年第2期19卷 95-100页

作者： K OGAWA t NISHItANI M ISOBE M SAtO M YOKOtA H HAYASHI t kobuchi t NISHIMURA National Institute for Fusion Science National Institutes of Natural Sciences322-6 0roshi-choToki 509-5292Japan SOKENDAI(the Graduate University for Advanced Studies) School of Physical Sciences322-6 Oroshi-choTold 509-5292Japan

In a deuterium operation on the Large Helical Device, the measurement and control equipment placed in the toms hall must survive under an environment of radiation, to study the effects of gamma-ray irradiation on the equipment, an irradiation experiment is performed at the Cobalt-60 irradiation facility of Nagoya University. transient and permanent effects on a personal computer, media converters, programmable logic controllers, isolation amplifiers, a web camera, optical flow meters, and water sealing gaskets are experimentally surveyed. transient noise appears on the web camera. Offset of the signal increases with an increase of the integrated dose on the programmable logic controller. the DeviceNet module on the programmable logic controller is broken at the integrated dose of 72 Gy, which is the expected range of the integrated dose of the toms hall. the other equipment can survive under the gamma-ray field in the toms hall.

关键词： large helical device gamma-ray irradiation radiation effect

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Effects of Cholestasis on Whole Blood Concentration of tacrolimus, an Immunosuppressant, in Living-Related Liver transplant Recipients

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International Journal of Clinical Medicine 2013年第10期4卷 432-439页

作者： Shinji kobuchi Keizo Fukushima Yuta Maeda takatoshi Kokuhu Hidetaka Ushigome Norio Yoshimura Nobuyuki Sugioka Kanji takada 4Department of transplantation and Regenerative Surgery Kyoto Prefectural University of Medicine Kyoto Japan. Department of Clinical Pharmacokinetics Fac- ulty of Pharmaceutical Sciences Kobe Gakuin University Kobe Japan Department of Clinical Pharmacokinetics Fac- ulty of Pharmaceutical Sciences Kobe Gakuin University Kobe Japan Department of Hospital Pharmacy Kyoto Prefectural Uni- versity of Medicine Kyoto Japan Department of Pharmacokinetics Kyoto Pharmaceutical University Kyoto Japan Department of Pharmacokinetics Kyoto Pharmaceutical University Kyoto Japan

Background: to explore the effects of cholestasis on whole blood concentration of tacrolimus (tAC), an immunosup-pressant, we investigated the relationship among blood tAC concentration, bile flow, and tAC metabolites in bile, as well as the relationship between total bilirubin (t-Bil), an index of cholestasis, and blood tAC concentration, in liver transplant recipients. Methods: Data were collected retrospectively from 16 male and 19 female patients (mean age: 38 years;range: 12 -59 years) who had undergone a living-related liver transplantation at Kyoto Prefectural University of Medicine from 2004 through 2008. Analysis of tAC, demethyl-tAC, and hydroxy-tAC in bile was performed by LC-MS/MS. Results: there was no correlation between the ratio of tAC metabolite to tAC in bile (M/P) of demethyl-tAC and post operation days (POD), whereas a weak linear correlation was demonstrated between M/P of hydroxy-tAC and POD (r = -0.345). Moreover, linear correlations were not observed between M/P and the tAC trough level normalized dose (tLtAC/dose), and between tLtAC/dose and POD. A negative linear correlation was demonstrated between bile flow and t-Bil in blood (r = -0.495). Furthermore, a positive linear correlation was observed between tLtAC/dose and t-Bil (r = 0.598), whereas there was no correlation between bile flow and tLtAC/dose. Conclusions: Improvement of hepatic function and the increase of tAC clearance after postoperative day 7 did not significantly contribute to hepatic tAC metabolism, bile excretion, and tLtAC/dose. Postoperative biliary stricture from liver transplantation with/without biliary drainage caused inter-and intra-patient variability in tLtAC/dose after liver transplantation, which could be assessed by t-Bil. t-Bil in blood might be a predictive biomarker for determining the degree of bile duct stricture and tAC dose in liver transplantation patients. Along with an appropriate dosing regimen, therapeutic drug monitoring including t-Bil would be ben

关键词： Pharmacokinetics Bile Duct Stricture tacrolimus Drug Metabolism total Bilirubin therapeutic Drug Monitoring

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