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Physiology of in-situ arterial revascularization in coronary artery bypass grafting: Preoperative,intraoperative and postoperative factors and influences

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World Journal of Cardiology 2016年第11期8卷 623-637页

作者： t bruce ferguson jr CV Sciences East Carolina Heart InstituteEast Carolina Diabetes and Obesity InstituteBrody School of Medicine at East Carolina University

Surgical revascularization with coronary artery bypass grafting(CABG) has become established as the most effective interventional therapy for patients with moderately severe and severe stable ischemic heart disease(SIHD). this recommendation is based on traditional 5-year outcomes of mortality and avoidance of myocardial infarction leading to reintervention and/or cardiac death. However, these results are confounded in that they challenge the traditional CABG surgical tenets of completeness of anatomic revascularization, the impact of arterial revascularization on late survival, and the lesser impact of secondary prevention following CABG on late outcomes. Moreover, the emergence of physiologic-based revascularization with percutaneous cardiovascular intervention as an alternative strategy for revascularization in SIHD raises the question of whether there are similar physiologic effects in CABG. Finally, the ongoing ISCHEMIA trial is specifically addressing the importance of the physiology of moderate or severe ischemia in optimizing therapeutic interventions in SIHD. So it is time to address the role that physiology plays in surgical revascularization. the long-standing anatomic framework for surgical revascularization is no longer sufficient to explain the mechanisms for short-term and long-term outcomes in CABG. Novel intraoperative imaging technologies have generated important new data on the physiologic blood flow and myocardial perfusion responses to revascularization on an individual graft and global basis. Long-standing assumptions about technical issues such as competitive flow are brought into question by real-time visualization of the physiology of revascularization. Our underestimation of the impact of Guideline Directed Medical therapy, or Optimal Medical therapy, on the physiology of preoperative SIHD, and the full impact of secondary prevention on post-intervention SIHD, must be better understood. In this review, these issues are addressed through the

关键词：冠的动脉绕过 grafting 动脉的 revascularization 心肌的灌注外科的结果 Intraoperative 成像

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Architectural and personal influences on neishborin8 behaviors;

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Frontiers of Architectural Research 2016年第2期5卷 194-201页

作者： bruce K. Fersuson Derek E. ferguson 1027 Parkview Bird Pittsburgh PA 15217 USA Virginia Commonwealth University Richmond VA 23284 USA

Architectural and personal influences on neighboring behaviors were studied in a residential neighborhood using both qualitative informal conversations, and systematic recording of activity in the neighborhood＇s social space. this dual approach produced new insights into neighboring behaviors and social networks. It was discovered that the residents who participated in the social space were only a portion of the resident population. there was an additional neighborhood-based network whose neighboring was not conducted in the social space; instead it was maintained by direct house-to-house contact. It was also found that some individuals chose not to participate in any neighborhood social network. the social space was an effective neighboring venue for those residents who chose to use it, but did not attract commingling of groups. Contrary to an assumption in previous neighboring research, there are social groups which develop and maintain themselves without participation in a social space.

关键词： Neighborhood Social network Community Residential design Shared space

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Selectively breeding for high voluntary physical activity in female mice does not bestow inherent characteristics that resemble eccentric remodeling of the heart,but the mini-muscle phenotype does

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Sports Medicine and Health Science 2023年第3期5卷 205-212页

作者： Eric C.Leszczynski Nicole E.Schwartz Ashley C.McPeek Katharine D.Currie David P.ferguson theodore Garland jr. Department of Kinesiology Michigan State UniversityEast LansingMIUSA Department of Evolution Ecologyand Organismal BiologyUniversity of California RiversideRiversideCAUSA

Physical activity engagement results in a variety of positive health outcomes,including a reduction in cardiovascular disease risk partially due to eccentric remodeling of the *** purpose of this investigation was to determine if four replicate lines of High Runner mice that have been selectively bred for voluntary exercise on wheels have a cardiac phenotype that resembles the outcome of eccentric *** females(average age 55 days)from the 4 High Runner and 4 non-selected control lines were anaesthetized via vaporized isoflurane,then echocardiographic images were collected and analyzed for structural and functional *** Runner mice in general had lower ejection fractions compared to control mice lines(2-tailed p=0.0236)and tended to have thicker walls of the anterior portion of the left ventricle(p=0.065).However,a subset of the High Runner individuals,termed mini-muscle mice,had greater ejection fraction(p=0.0006),fractional shortening percentage(ptricular mass at dissection(pth body mass as a covariate)compared to non-mini muscle *** from replicate lines bred for high voluntary exercise did not all have inherent positive cardiac functional or structural characteristics,although a genetically unique subset of mini-muscle individuals did have greater functional cardiac characteristics,which in conjunction with their previously described peripheral aerobic enhancements(e.g.,increased capillarity)would partially account for their increased VO2max.

关键词： Echocardiography Heart Voluntary physical activity Cardiovascular disease Wheel running

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Case Series of 10 Drug-Refractory IBS Patients Who Respond to Oral Serum-Derived Bovine Immunoglobulin/Protein Isolate (SBI)

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Open Journal of Gastroenterology 2014年第10期4卷 321-328页

作者： Raouf Hilal Patricia Mitchell Ernesto Guerra jr. bruce P. Burnett Center for Advanced Gastroenterology Maitland USA San Antonio Gastroenterology Associates San Antonio USA Department of Medical Affairs Entera Health Inc. Cary USA

Aim: the responses of 10 patients with long-standing, symptomatic, intractable drug-refractory histories of irritable bowel syndrome with diarrhea (IBS-D) and with abdominal pain, gas/bloating and distention, termed IBS undefined (IBS-U), were evaluated when administering a medical food product containing serum-derived bovine immunoglobulin/protein isolate (SBI). Methods: Patients in this case series were chosen based on their lack of satisfactory response to a variety of drugs, including antidiarrheal and antispasmodic medications, serotonin 5-Ht3 receptor antagonists, selective serotonin re-uptake inhibitors (SSRIs), proton pump inhibitors (PPIs), antibiotics, and antidepressive drugs. Patients met Rome III criteria and were administered 5 g/day of SBI as standard-of-care nutritional support. A scale of 0% - 25%, 25% - 50%, 50% - 75%, 75% - 100% response to SBI was used for patient-reported improvement in overall IBS symptoms following administration for one month. Exact methods for calculating confidence intervals and p-values were used to assess complete management of symptoms and response to therapy. Adverse events were also monitored for this nutritional product. Results: the onset of gastrointestinal (GI) symptom reduction utilizing nutritional management with SBI occurred within an average time of 2-4 weeks with improved or near complete management in all 10 patients who were refractory to previous drug therapies by 4 weeks. When prompted, patients reported significant IBS symptom improvement which averaged between 50% - 100% (p = 0.002) with an average for complete management in all patients of 69%. No side effects were reported after SBI administration even when taken for up to 28 weeks. Conclusion: Based on the safety profile and reported outcomes in this case report, SBI should be considered as a nutritional option for management in IBS-D and IBS-U.

关键词： Irritable Bowel Syndrome Diarrhea Gas Bloating Distention Serum-Derived Bovine Immunoglobulins

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选育期望的木材

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林业与环境科学 1987年第2期 39-46页

作者： bruce Zobel Edgard Campinhos jr Yara Ikemori 霍应强

工业上一个主要的要求就是木材要具有较大的均匀性。由于树种、地理来源、不同树木个体以及在一株树木之内所出现的木材差异,造成加工上较大的困难。通过营林管理和直接的遗传处理来控制树形和生长率,有可能获得比较均一的木材。在巴西... 详细信息

工业上一个主要的要求就是木材要具有较大的均匀性。由于树种、地理来源、不同树木个体以及在一株树木之内所出现的木材差异,造成加工上较大的困难。通过营林管理和直接的遗传处理来控制树形和生长率,有可能获得比较均一的木材。在巴西阿拉克鲁兹林业公司(Aracruz Forestal)土地上的桉树,通过利用无性繁殖,达到了木材产量增加并具有均匀性,可说明这个问题。

关键词：林业遗传学变异性密度环境

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Specifc inflammatory osteoclast precursors induced during chronic inflammation give rise to highly active osteoclasts associated with inflammatory bone loss

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Bone Research 2022年第3期10卷 548-564页

作者： Yaron Meirow Milena Jovanovic Yuval Zur Juliana Habib Daniele Filippo Colombo Nira twaik Hadas Ashkenazi-Preiser Kerem Ben-Meir Ivan Mikula jr. Or Reuven Guy Kariv Leonor Daniel Saja Baraghithy Yehuda Klein Jeroen Krijgsveld Noam Levaot Michal Baniyash the Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research Israel-Canada Medical Research InstituteFaculty of MedicineThe Hebrew UniversityJerusalemIsrael Department of Physiology and Cell Biology Ben-Gurion University of the NegevBeer-ShevaIsrael Division of Proteomics of Stem Cells and Cancer German Cancer Research Center(DKFZ)HeidelbergGermany Institute for Drug Research Faculty of MedicineThe Hebrew UniversityJerusalemIsrael Hebrew University-Hadassah School of Dental Medicine JerusalemIsrael Heidelberg University Medical FacultyHeidelbergGermany

Elevated osteoclast(OC)activity is a major contributor to inflammatory bone loss(IBL)during chronic inflammatory ***,the specific OC precursors(OCPs)responding to inflammatory cues and the underlying mechanisms leading to IBL are poorly *** identified two distinct OCP subsets:Ly6C^(hi)CD11b^(hi) inflammatory OCPs(iOCPs)induced during chronic inflammation,and homeostatic Ly6C^(hi)CD11b^(lo)OCPs(hOCPs)which remained *** and proteomic characterization revealed that while iOCPs were rare and displayed low osteoclastogenic potential under normal conditions,they expanded during chronic inflammation and generated OCs with enhanced *** contrast,hOCPs were abundant and manifested high osteoclastogenic potential under normal conditions but generated OCs with low activity and were unresponsive to the inflammatory *** derived from iOCPs expressed higher levels of resorptive and metabolic proteins than those generated from hOCPs,highlighting that different osteoclast populations are formed by distinct *** further identified the tNF-αand S100A8/A9 proteins as key regulators that control the iOCP response during chronic ***,we demonstrated that the response of iOCPs but not that of hOCPs was abrogated in tnf-α^(-/-)mice,in correlation with attenuated *** findings suggest a central role for iOCPs in IBL *** can serve as potential biomarkers for IBL detection and possibly as new therapeutic targets to combat IBL in a wide range of inflammatory conditions.

关键词： inflammation inflammatory osteoclast

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肩难产

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中国实用妇科与产科杂志 1986年第3期 159-161页

作者： bruce A. Harris jr. 林其相 the University of Alabama in Birmingham 成都科技大学医院妇产科 Birmingham AlabamaMD

肩难产常常是在意想不到时突然发生,典型情况是在困难地分娩出一个大胎头之后,医生惊奇地发现他无法牵引下胎儿双肩、胎儿颈部阻于阴道口,不能见到儿颈,孩子不能呼吸,牵引胎儿和压迫宫底都没有用,情况很快变得紧急。Wood等曾报告,在婴... 详细信息

肩难产常常是在意想不到时突然发生,典型情况是在困难地分娩出一个大胎头之后,医生惊奇地发现他无法牵引下胎儿双肩、胎儿颈部阻于阴道口,不能见到儿颈,孩子不能呼吸,牵引胎儿和压迫宫底都没有用,情况很快变得紧急。Wood等曾报告,在婴儿头娩出和其躯干娩出的间隔时间内,脐动脉血的pH值每分钟下降0.04。肩难产需

关键词：肩难产发病率中位产钳第二产程分娩胎儿体重臂丛麻痹

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YPED: An Integrated Bioinformatics Suite and Database for Mass Spectrometry-based Proteomics Research

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Genomics, Proteomics & Bioinformatics 2015年第1期13卷 25-35页

作者： Christopher M.Colangelo Mark Shifman Kei-Hoi Cheung Kathryn L.Stone Nicholas J.Carriero Erol E.Gulcicek tuKiet t.Lam terence Wu Robert D.Bjornson Can bruce Angus C.Nairn Jesse Rinehart Perry L.Miller Kenneth R.Williams W.M.Keck Foundation Biotechnology Resource Laboratory School of Medicine Yale University Department of Molecular Biophysics & Biochemistry Yale University Yale Center for Medical Informatics School of Medicine Yale University Department of Anesthesiology School of Medicine Yale University Department of Emergency Medicine School of Medicine Yale University VA Connecticut Healthcare System W.M. Keck Foundation Biotechnology Resource Laboratory School of Medicine Yale University Department of Computer Science Yale University Yale Center for Genome Analysis West Campus Yale University Yale West Campus Analytical Core West Campus Yale University Yale Bioinformatics Resource School of Medicine Yale University Department of Psychiatry School of Medicine Yale University Department of Cellular & Molecular Physiology School of Medicine Yale University Systems Biology Institute Yale University

We report a significantly-enhanced bioinformatics suite and database for proteomics research called Yale Protein Expression Database（YPED） that is used by investigators at more than 300 institutions worldwide. YPED meets the data management, archival, and analysis needs of a high-throughput mass spectrometry-based proteomics research ranging from a singlelaboratory, group of laboratories within and beyond an institution, to the entire proteomics community. the current version is a significant improvement over the first version in that it contains new modules for liquid chromatography–tandem mass spectrometry（LC–MS/MS） database search results, label and label-free quantitative proteomic analysis, and several scoring outputs for phosphopeptide site localization. In addition, we have added both peptide and protein comparative analysis tools to enable pairwise analysis of distinct peptides/proteins in each sample and of overlapping peptides/proteins between all samples in multiple datasets. We have also implemented a targeted proteomics module for automated multiple reaction monitoring（MRM）/selective reaction monitoring（SRM） assay development. We have linked YPED＇s database search results and both label-based and label-free fold-change analysis to the Skyline Panorama repository for online spectra visualization. In addition, we have built enhanced functionality to curate peptide identifications into an MS/MS peptide spectral library for all of our protein database search identification results.

关键词： Proteomics Database Bioinformatics Mass spectrometry Repository Spectral library

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Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 teV with the AtLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.J. Addison J. Adelman A. Adiguzel t. Adye A.A. Affolder Y. Afik M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik t.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa t. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos t. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.t. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki t. Aoki J.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.t.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.J. Bailey V.R. Bailey J.t. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends t. Barillari M-S. Barisits t. Barklow P. Baron D.A. Baron Mo the AtLAS Collaboration

the identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the AtLAS Collaboration,using √s=13 teV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the AtLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 teV and for multiple tagger working points.

关键词： AtLAS JEt QUARK GLUON tAGGING

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CHEMIStRY tHE CENtRAL SCIENCE

CHEMISTRY THE CENTRAL SCIENCE

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2006年

作者： theodore L. Brown H. Eugene LeMay jr. bruce E. Bursten contributing author Catherine J. Murphy.

来源：畅想之星图书光盘版（南... 评论

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