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Long-term safety follow-up of children from a randomized-controlled phase Ⅱb proof-of-concept efficacy study of the live,attenuated,tetravalent dengue vaccine (CYD-tDV) in thailand

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Asian Pacific Journal of tropical Medicine 2019年第9期12卷 396-403页

作者： Kriengsak Limkittikul Weerawan Hattasingh Danaya Chansinghakul Arunee Sabchareon Wut Dulyachai Carina Frago t anh wartel Edith Langevin Sophia Gailhardou Alain Bouckenooghe Department of tropical Peditrics Faculty of Tropical MedicineManidol Unizersiy420/6 Ratchawithi RoodBanghqk10400Thailand Sonofi Pastewr Clirical Sciences 872 CRC Tover 23nd FloorAll Seasons PlaceWireless RodLumpiniPathumwanBanghokThoiland Ratchaburi Hospital 77/4Kathatorm RoadTambon Na MuangAmphoe Muang RatchaburiThailand Sanofi Pasteur Clinical Sciences 38 Beach Roud#18-11 South Beach TowerSingapore 189767 Sanofi Pasteur Clinical Programs Marcy L EioileFrance Sanofi Pusteur Globol Purrmcorigiane Lyon France

Objective:to investigate the long-term safety of a tetravalent dengue vaccine(CYD-tDV)in children in a phase Ⅱ b follow-up study in ***:In the phase Ⅱb study,children aged 4-11 years were randomized(2:1)to receive three injections of CYD-tDV or serve as control at 6-month intervals,with 25 months’ active follow-up(active phase).this study was an additional four-year passive surveillance for hospitalized virologically-confirmed dengue(VCD;hospital phase).Cases of hospitalized VCD,severe hospitalized VCD,vaccine-related serious adverse events,and deaths were reported for the total population,with post-hoc analyses by enrollment age(ts:Of 3 997 participants receiving≥1 injection,80.1% were recruited to the hospital phase[2 131(CYD-tDV);1 072(control)].Eighty-five hospitalized VCD cases were reported in the CYD-tDV group and 46 in the control group during the four-year hospital phase[relative risk(RR):0.93,95% confidence interval(Cl):0.64-1.36].the RR over six years of follow-up was 0.77(95% CI:0.57-1.05).In those aged≥9 years,the cumulative RRs in the active phase,hospital phase,and entire six years were 0.28(95% CI:0.08-0.81),0.51(95% CI:0.25-1.05),and 0.42(95% CI:0.24-0.75),*** the overall population,there were ten severe hospitalized VCD cases in the CYD-tDV group and five in the control group over six years(RR:1.00,95% CI:0.31-3.75).Conclusions:Over six years of follow-up,in children aged ≥9 years,CYD-tDV administration is associated with a reduced risk of hospitalized VCD.

关键词： CYD-tDV Dengue vaccine Hospitalized dengue Severe dengue Virologtically confirmed dengue

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Mapping the high burden areas of cholera in Nepal for potential use of oral cholera vaccine: An analysis of data from publications and routine surveillance systems

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Asian Pacific Journal of tropical Medicine 2020年第3期13卷 107-114页

作者： Chulwoo Rhee Birendra Prasad Gupta Bibek Kumar Lal Jacqueline Kyungah Lim tanh wartel JuliaLynch Sushant Sahastrabuddhe International Vaccine Institute(IVI) SeoulRepublic of Korea Epidemiology and Disease Control Division Department of Health ServicesMinistry of Health and PopulationKathmanduNepal

Objective:to assess the extent of existing published evidence on cholera and to characterize the epidemiologic data of cholera in ***:We conducted a literature scoping review by summarizing published literature reporting on cholera in Nepal from January 1946 to March 2019 in online databases:MEDLINE,Embase,Cochrane,and Global ***,we reviewed national surveillance data on clinically diagnosed and laboratory confirmed cholera reported by the Ministry of Health and ***:Most of the published studies were conducted predominantly in Kathmandu Valley during the rainy season;however,outbreaks have been reported in other parts of Nepal including terai,Hilly and Mountain *** literature review exhibited that all age groups were affected by cholera,but particularly children and young adults were at-risk age groups in *** cholerae serogroup O1,biotype El tor,serotype Ogawa has been predominantly isolated with an emergence of resistant strains since *** mass vaccination campaigns using oral cholera vaccines were conducted:Rautahat district in 2014 and Banke district in ***:Capacity building for a nation wide systematic cholera surveillance with rapid and reliable diagnosis is needed to better estimate the burden of cholera and identify geographically at-risk areas associated with the disease in *** is essential for developing an adequate policy on oral cholera vaccine introduction and effective water,sanitation and hygiene interventions.

关键词： Cholera Outbreak Oral cholera vaccine Surveillance Nepal

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Quantifying the impacts of the COVID-19 pandemic lockdown and the armed conflict with Russia on Sentinel 5P tROPOMI NO_(2)changes in Ukraine

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Big Earth Data 2024年第1期8卷 58-81页

作者： anh Phan Hiromichi Fukui Graduate School of Engineering Chubu UniversityKasugaiJapan Chubu Institute for Advanced Studies and International Digital Earth Applied Science Research Center(IDEAS) Chubu UniversityKasugaiJapan

this study investigated variations in nitrogen dioxide(NO_(2))levels in Ukraine during two significant periods:the COVID-19 pandemic lockdown in 2020 and the armed conflict with Russia in *** and reprocessed Sentinel 5P data products were utilized for the analysis.A machine learning model was employed to generate a business-as-usual NO_(2)time series that accounted for meteorological *** the nine most populous cities in Ukraine,during the lockdown in 2020 we observed a moderation of increases in NO_(2)levels during the lockdown compared to the pre-lockdown *** at the same months during the conflict period in 2022,we identified much more significant reductions in NO_(2)level in these cities,averaging 12.1%for original and 18.1%for reprocessed *** our examination of major urban areas,we observed reductions in NO_(2)levels in areas surrounding coal power plants damaged or destroyed by the *** the major urban areas in Ukraine,we conclude that changes in daily anthropogenic activities due to the conflict-related events had more substantial impacts on NO_(2)levels than did COVID-19 lockdown.

关键词： NO_(2) COVID-19 Russia-Ukraine armed conflict weather-normalization

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EP Aquarii:A New Picture of the Circumstellar Envelope

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Research in Astronomy and Astrophysics 2024年第3期24卷 83-105页

作者： Pham t.Nhung Do t.Hoai Pierre Darriulat Pham tuan-anh Pham N.Diep Nguyen B.Ngoc tran t.thai Department of Astrophysics Vietnam National Space CenterVietnam Academy of Science and Technology18Hoang Quoc VietNghia DoCau GiayHa Noivietnam

New analyses of earlier ALMA observations of oxygen-rich AGB star EP Aquarii are presented,which complete a previously published analysis and offer a different interpretation of the morpho-kinematics of the circumstellar *** birth of the equatorial density enhancement(EDE)is shown to occur very close to the star where evidence for rotation has been *** to the star and where outflows have been observed:their interaction with the gas of the nascent EDE is seen to play an important role in the development of the wind and the evolution of its radial velocity from 8 to 10 km s^(-1) on the polar symmetry axis to~2 km s^(-1) at the *** implies complex morpho-kinematics:making reliable interpretations with reasonable confidence is *** particular,it questions an earlier interpretation implying the presence of a white dwarf companion orbiting the star at an angular distance of -0″4 from its *** proposes instead an interpretation in terms of a standard mass ejection associated with a shock wave leaving a void of emission in its *** Doppler velocity wings are seen to consist of two components,the upper velocity end of the global wind,reaching above±12 km s^(-1),and an effective line broadening,confined within 200 mas from the center of the star,reaching above±20 km s^(-1) and interpreted as caused by the pattern of shock waves resulting from the interaction between stellar pulsation and convective cell partition.

关键词： stars AGB and post-AGB-(stars) circumstellar matter-radio lines stars

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Autohydrolysis treatment of bamboo and potassium oxalate(K_(2)C_(2)O_(4))activation of bamboo product for CO_(2) capture utilization

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Frontiers of Chemical Science and Engineering 2024年第4期18卷 63-72页

作者： Dang Duc Viet Doan thi thao Khuong Duy anh toshiki tsubota Department of Materials Science Faculty of EngineeringKyushu Institute of TechnologyFukuoka 804-8550Japan Vietnamese Academy of Forest Sciences Hanoi 10000Vietnam Collaborative Research Centre for Green Materials on Environmental technology Kyushu Institute of TechnologyFukuoka 808-0196Japan

typically,the hydroxide agents,such as sodium hydroxide and potassium hydroxide,which have corrosive properties,are used in the carbon activation *** this study,potassium oxalate(K_(2)C_(2)O_(4)),a less toxic and non-corrosive activating reagent,was used to synthesize activated carbon from the solid residue after autohydrolysis *** effect of the autohydrolysis treatment and the ratio of the K_(2)C_(2)O_(4)/solid residue are presented in this ***,the comparison between the activated carbon from bamboo and biochar from the solid residue are also *** resulting activated carbon from the solid residue exhibited a high surface area of up to 1432 m^(2)·g^(-1) and a total pore volume of up to 0.88 cm^(3)·g^(-1).the autohydrolysis treatment enhanced the microporosity properties compared to those without pretreatment of the activated *** microporosity of the activated carbon from the solid residue was dominated by the pore width at 0.7 nm,which is excellent for CO_(2) *** 25℃ and 1.013×10^(5) Pa,the CO_(2) captured reached up to 4.1 mmol·g^(-1).On the other hand,the ratio between K_(2)C_(2)O_(4) and the solid residue has not played a critical role in determining the porosity *** ratio of the K_(2)C_(2)O_(4)/solid residue of 2 could help the carbon material reach a highly microporous textural property that produces a high carbon capture *** finding proved the benefit of using the solid residue from the autohydrolysis treatment as a precursor material and offering a more friendly and sustainable activation carbon process.

关键词： activated carbon bamboo biochar CO_(2)capture potassium oxalate

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Clinical validation of the early embryo viability assessment system: Analysis for the blastocyst morphology and pregnancy outcomes

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Asian pacific Journal of Reproduction 2024年第5期13卷 219-227页

作者： Vu D Hop An M Cuong Phi t t anh Nguyen t L Huong Le Hoang Nguyen V Hanh Assisted Reproductive technology Centre Tam Anh General HospitalHanoiVietnam Institute of Biotechnology Vietnam Academy of Science and TechnologyHanoiVietnam

Objective:to determine the relationship between the early embryo viability assessment(EEVA)and blastocyst morphological parameters and pregnancy ***:this retrospective cohort study was conducted on 291 intracytoplasmic sperm injection cycles including 2522 embryos with indications of prolonging embryo culture to the blastocyst stage in the Genea embryo review incubator,and 511 single vitrified-warmed blastocyst transfer cycles from January 2020 to June *** EEVA system produced an EEVA score from E1(best)to E5(worse)for the potential of blastocyst *** morphology was *** association between the EEVA score and each type of blastocyst morphology,implantation rate,clinical pregnancy,and ongoing pregnancy were assessed using generalized estimating ***:the inner cell mass A(ICM A),trophectoderm A(tE A),blastocoele expansion degree of 3,4,5,6,7 rates were higher with lower the EEVA *** adjusted odd ratio(aOR)(E5 vs E1)was 0.3 for ICM A,0.174 for tE A and 0.210 for BL3,4,5,6,7(all Pting a significant association between lower EEVA scores and improved embryo *** implantation,clinical pregnancy,and ongoing pregnancy rate were also higher with lower the EEVA *** aOR of E5 vs E1 was 0.245 for implantation,0.185 for clinical pregnancy and 0.200 for ongoing pregnancy rate(Pthere were associations between blastocyst morphology,pregnancy outcome and EEVA *** good blastocyst morphology and pregnancy outcomes are higher with lower the EEVA score.

关键词： Automated embryo assessment Blastocyst Early embryo viability assessment Genea embryo review incubator

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transient response of doubly-curved bio-inspired composite shells resting on viscoelastic foundation subject to blast load using improved first-order shear theory and isogeometric approach

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Defence technology（防务技术） 2024年第8期38卷 171-193页

作者： thuy tran thi thu tu Nguyen anh Hue Nguyen thi Hong Nguyen thi School of Mechanical and Automotive Engineering Hanoi University of IndustryHanoiViet Nam Faculty of technical Fundamental University of Transport TechnologyHanoiViet Nam Faculty of Mechanical Engineering Thuyloi University175 Tay SonDong DaHanoiViet Nam

Investigating natural-inspired applications is a perennially appealing subject for scientists. the current increase in the speed of natural-origin structure growth may be linked to their superior mechanical properties and environmental resilience. Biological composite structures with helicoidal schemes and designs have remarkable capacities to absorb impact energy and withstand damage. However, there is a dearth of extensive study on the influence of fiber redirection and reorientation inside the matrix of a helicoid structure on its mechanical performance and reactivity. the present study aimed to explore the static and transient responses of a bio-inspired helicoid laminated composite(B-iHLC) shell under the influence of an explosive load using an isomorphic method. the structural integrity of the shell is maintained by a viscoelastic basis known as the Pasternak foundation, which encompasses two coefficients of stiffness and one coefficient of damping. the equilibrium equations governing shell dynamics are obtained by using Hamilton's principle and including the modified first-order shear theory,therefore obviating the need to employ a shear correction factor. the paper's model and approach are validated by doing numerical comparisons with respected publications. the findings of this study may be used in the construction of military and civilian infrastructure in situations when the structure is subjected to severe stresses that might potentially result in catastrophic collapse. the findings of this paper serve as the foundation for several other issues, including geometric optimization and the dynamic response of similar mechanical structures.

关键词： Blast load Modified first-order shear theory Biological composite structures

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An exploration of meteorological effects on PM2.5 air quality in several provinces and cities in Vietnam

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Journal of Environmental Sciences 2024年第11期145卷 139-151页

作者： Giang tran Huong Nguyen Luan thien La Huy Hoang-Cong anh Hoang Le Faculty of Chemistry and Environment Dalat UniversityLam Dong ProvinceVietnam Environmental Protection Agency Lam Dong Province Department of Natural Resources and EnvironmentLam Dong ProvinceVietnam Northern Center for Environmental Monitoring Environmental Pollution Control DepartmentHa Noi CityVietnam Faculty of Environment University of ScienceHo Chi Minh CityVietnam Vietnam National University Ho Chi Minh CityVietnam

Linking meteorology and air pollutants is a key *** study investigated meteorological effects on PM_(2.5)concentration using the advanced convergent cross mapping method,utilizing hourly PM_(2.5)concentration and six meteorological factors across eight provinces and cities in *** demonstrated that temperature(ρ=0.30)and radiation(ρ=0.30)produced the highest effects,followed by humidity(ρ=0.28)and wind speed(ρ=0.24),while pressure(ρ=0.22)and wind direction(ρ=0.17)produced the weakest effects on PM_(2.5)*** theρvalues showed that temperature,wind speed,and wind direction had greater impacts on PM_(2.5)concentration during the dry season whereas radiation had a more influence during the wet season;Southern stations experienced larger meteorological ***,humidity,pressure,and wind direction had both positive and negative influences on PM_(2.5)concentration,while radiation and wind speed mostly had negative *** PM_(2.5)pollution episodes,there wasmore contribution ofmeteorological effects on PM_(2.5)concentration indicated byρ*** contaminated levels,humidity(ρ=0.45)was the most dominant factor affecting PM_(2.5)concentration,followed by temperature(ρ=0.41)and radiation(ρ=0.40).Pollution episodes were pointed out to be more prevalent under higher humidity,higher pressure,lower temperature,lower radiation,and lower wind ***ρcalculation also revealed that lower temperature,lower radiation,and higher humidity greatly accelerated each other under pollution episodes,further enhancing PM_(2.5)*** findings contributed to the literature on meteorology and air pollution interaction.

关键词： Fine particulate matter Air pollution Meteorological effect Convergent cross mapping Causality analysis Vietnam

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A concise review on surface and structural modification of porous zeolite scaffold for enhanced hydrogen storage

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Chinese Journal of Chemical Engineering 2024年第6期70卷 33-53页

作者： B.A.Abdulkadir R.S.R.Mohd Zaki A.t.Abd Wahab S.N.Miskan anh-tam Nguyen Dai-Viet N.Vo H.D.Setiabudi Centre for Research in Advanced Fluid&Processes Universiti Malaysia Pahang Al-Sultan AbdullahLebuh Persiaran Tun Khalil YaakobGambangPahang 26300Malaysia Faculty of Chemical&Process Engineering technology Universiti Malaysia Pahang Al-Sultan AbdullahLebuh Persiaran Tun Khalil YaakobGambangPahang 26300Malaysia Center of Excellence for Green Energy and Environmental Nanomaterials(CE@GrEEN) Nguyen Tat Thanh University300A Nguyen Tat ThanhDistrict 4Ho Chi Minh City 755414Viet Nam

Investigating zeolites as hydrogen storage scaffolds is imperative due to their porous nature and favorable physicochemical ***,the storage capacity of the unmodified zeolites has been rather unsatisfactory(0.224%-1.082%(mass))compared to its modified ***,the contemporary focus on enhancing hydrogen storage capacities has led to significant attention towards the utilization of modified zeolites,with studies exploring surface modifications through physical and chemical treatments,as well as the integration of various active *** enhanced hydrogen storage properties of zeolites are attributed to the presence of aluminosilicates from alkaline and alkaline-earth metals,resulting in increased storage capacity through interactions with the charge density of these ***,there is a great demand to critically review their role such as well-defined topology,pore structure,good thermal stability,and tunable hydrophilicity in enhanced hydrogen *** article aimed to critically review the recent research findings based on modified zeolite performance for enhanced hydrogen *** of the factors affecting the hydrogen storage capacities of zeolites that can affect the rate of reaction and the stability of the adsorbent,like pressure,structure,and morphology were studied,and ***,future perspectives,recommendations,and directions for modified zeolites were discussed.

关键词： Zeolites Hydrogen storage Surface modification Adsorption Active metal

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Study on the tunnel shape and soil-lining interaction influencing the lining behavior under seismic loading

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Earthquake Engineering and Engineering Vibration 2024年第4期23卷 845-862页

作者： Van Vi Pham Ngoc anh Do Piotr Osinski Ngoc thai Do Daniel Dias Sustainable Development in Underground Engineering Research team Hanoi University of Mining and GeologyHanoiVietnam Department of Underground and Mining Construction Faculty of Civil EngineeringHanoi University of Mining and GeologyHanoiVietnam Department of Geotechnical Engineering Institute of Civil EngineeringWarsaw University of Life Sciences-SGGWWarszawaPoland Laboratory 3SR Grenoble Alpes UniversityGrenoble 38400France

the response of tunnels subjected to seismic loading is a complex mechanism and depends not only on the seismic nature but also on tunnel structure and surrounding soil *** individual behavior of circular,rectangular,and sub-rectangular tunnels subjected to seismic loadings has already been studied in the *** the present research,two case scenarios of circular,rectangular tunnels and four sub-rectangular shaped tunnels,with similar cross-section areas,were adopted to perform a comprehensive numerical *** purpose of the study was to determine the mechanical behavior of tunnels of different shapes,depending upon seismic *** were performed by considering the influence of soil-lining interaction,soil parameters,and lining thickness,as well as lining *** were performed for no-slip and full-slip *** results indicate that the tunnel shape design is of great importance when regarding the mechanical behavior of the surrounding *** concerns no-slip as well as full-slip soil-lining interaction,especially when the lining is subjected to seismic ***,it is shown that changes in incremental bending moments for circular,rectangular and sub-rectangular tunnels that depend upon the soil-lining interaction conditions differ significantly.

关键词： tunnel shape soil-lining interaction seismic loading internal forces numerical analysis

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