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Molecular Mechanisms Contributing to Resistance to tyrosine Kinase-targeted therapy for Non-Small Cell Lung Cancer

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Clinical oncology and cancer researeh 2012年第1期9卷 18-22页

作者： Fariz Nurwidya Akiko Murakami Fumiyuki takahashi Kazuhisa takahashi Department of Respiratory Medicine Juntendo University School of Medicine

One of the most important pathways in non-small cell lung cancer(NSCLC) is the epidermal growth factor receptor(EGFR) pathway. this pathway affects several crucial processes in tumor development and progression,including tumor cell proliferation,apoptosis regulation,angiogenesis,and metastatic *** EGFR is currently being intensely *** are witnessing the development of a number of potential molecular-inhibiting treatments for application in clinical *** the last decade,the tyrosine kinase(tK) domain of the EGFR was identified in NSCLC patients,and it has responded very well with a dramatic clinical improvement to tK inhibitors such are gefitinib and ***,there were primary and/or secondary resistance to these treatments,as shown by clinical *** molecular biology studies provided some explanations for the drug resistance *** molecular mechanisms of resistance need to be *** in-depth understanding of these targeted-therapy resistance may help us explore new strategies for overcoming or reversing the resistance to these inhibitors for the future of NSCLC treatment.

关键词： carcinoma non-small-cell lung mutation drug resistance

Fluid-induced high-temperature metasomatism at Rundv?gshetta in the Lützow-Holm Complex, East Antarctica: implications for the role of brine during granulite formation

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Geoscience Frontiers 2018年第5期9卷 1309-1323页

作者： Kazuki takahashi toshiaki tsunogae Emmanuel Nwachukwu Ugwuonah Graduate School of Life and Environmental Sciences University of TsukubaIbaraki 305-8572Japan Department of Geology University of JohannesburgAuckland Park 2006South Africa Department of Geology Chukwuemeka Odumegwu Ojukwu UniversityUliNigeria

We report new petrological, phase equilibria modeling, and fluid inclusion data for pelitic and mafic granulites from Rundv?gshetta in the highest-grade region of the Neoproterozoic Lützow-Holm Complex(LHC),East Antarctica, and provide unequivocal evidence for fluid-rock interaction and high-temperature metasomatism in the presence of brine fluid. the studied locality is composed dominantly of well-foliated pelitic granulite(K-feldspar+quartz+sillimanite+garnet+ilmenite) with foliation-parallel bands and/or layers of mafic granulite(plagioclase+orthopyroxene+garnet+ilmenite+quartz+biotite). the boundary between the two lithologies is defined by thin(about 1 -20 cm in thick) garnet-rich layers with a common mineral assemblage of garnet+plagioclase+quartz+ilmenite+biotite ? orthopyroxene. Systematic increase of grossular and decrease of pyrope contents in garnet as well as decreasing Mg/(Fe+Mg) ratio of biotite from the pelitic granulite to garnet-rich rock and mafic granulite suggest that the garnet-rich layer was formed by metasomatic interaction between the two granulite lithologies. Phase equilibria modeling in the system NCKFMASHtO demonstrates that the metasomatism took place at 850 -860℃, which is slightly lower than the peak metamorphism of this region, and the modal abundance of garnet is the highest along the metapeliteemetabasite boundary(up to 40%), which is consistent with the field and thin section observations. the occurrence of brine(7.0 -10.9 wt.% Na Cleqfor ice melting or 25.1 -25.5 wt.% NaC leqfor hydrohalite melting) fluid inclusions as a primary phase trapped within plagioclase in the garnet-rich layer and the occurrence of Cl-rich biotite(Cl = 0.22 -0.60 wt.%) in the metasomatic rock compared to that in pelitic(0.15 -0.24 wt.%) and mafic(0.06-0.13 wt.%) granulites suggest infiltration of brine fluid could have given rise to the high-temperature metasomatism. the fluid might have been derived from external sources possibly related to the formation

关键词： High-temperature metasomatism Brine Phase equilibrium modeling Fluid inclusion Gondwana Lützow-Holm Complex

Dibaryon resonances and short-range NN interaction

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Chinese Physics C 2022年第11期46卷 238-261页

作者： V.i.Kukulin V.N.Pomerantsev O.A.Rubtsova M.N.Platonova i.t.Obukhovsky Skobeltsyn institute of Nuclear Physics Lomonosov Moscow State UniversityLeninskie Gory 1/2119991 MoscowRussia

the dibaryon concept for nuclear force is presented,assuming that the attraction between nucleons at medium distances is mainly due to the s-channel exchange of an intermediate six-quark(dibaryon)*** construct the respective NN interaction model,a microscopic six-quark description of the NN system is used,in which symmetry aspects play a special *** is shown that the NN interaction in all important partial waves can be described by the superposition of long-range t-channel one-pion exchange and s-channel exchange by an intermediate *** model developed in this study provides a good description of both elastic phase shifts and inelasticities of NN scattering in all S,P,D,and F partial waves at energies from zero to 600-800 MeV and even *** parameters of the intermediate six-quark states,corresponding to the best fit of NN scattering data,are found to be consistent with the parameters of the known dibaryon resonances in those NN partial configurations,where their existence has been experimentally *** for new dibaryon states are given as well.

关键词： nucleon-nucleon interaction dibaryon resonances short-range nuclear force

Separation of spermatozoa fromerythrocytes using their tumblingmechanism in a pinch flow fractionationdevice

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Microsystems & Nanoengineering 2019年第1期5卷 474-480页

作者： Johanna t.W.Berendsen Jan C.t.Eijkel Alex M.Wetzels Loes i.Segerink BiOS Lab on a Chip Group MESA+Institute for NanotechnologyTechnical Medical CentreUniversity of TwenteEnschedeThe Netherlands Department of Obstetrics and Gynaecology Radboud University Nijmegen Medical CentreNijmegenThe Netherlands

Men suffering from azoospermia can father a child,by extracting spermatozoa from a testicular biopsy *** main complication in this procedure is the presence of an abundance of ***,the isolation of the few spermatozoa from the sample is manually performed due to ineffectiveness of filtering methods,making it time consuming and labor *** spermatozoa are smaller in both width and height than any other cell type found in the sample,with a very small difference compared with the erythrocyte for the smallest,making this not the feature to base the extraction ***,the length of the spermatozoon is 5×larger than the diameter of an erythrocyte and can be *** we propose a microfluidic chip,in which the tumbling behavior of spermatozoa in pinched flow fractionation is utilized to separate them from the *** show that we can extract 95%of the spermatozoa from a sample containing 2.5%spermatozoa,while removing around 90%of the *** adjusting the flow rates,we are able to increase the collection efficiency while slightly sacrificing the purity,tuning the solution for the available sample in the clinic.

关键词： erythrocytes flow utilized

Lipophilic extractives of the inner and outer barks from six different Pinus species grown in indonesia

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Journal of Forestry Research 2018年第5期29卷 1329-1336页

作者： Masendra tatsuya Ashitani Koetsu takahashi Ganis Lukmandaru Department of Forest Product technology Faculty of ForestryUniversitas Gadjah Mada Faculty of Agriculture Yamagata University

the chemical compositions of the dichloromethane extracts of inner and outer barks from six Pinus species（***,***,***,***,***,and ***） grown in indonesia were investigated by GC and GC–***,the amounts of extractive contents were higher in the inner bark than in the outer bark except for *** acids,monoterpenes,sesquiterpenes,resin acids,triterpenoids,and steroids were detected and *** and outer barks differed not only in content of these compounds but also in their *** acids and alcohols were the major classes of lipophilic compounds in the outer bark of ***, ***,and *** and triterpenoids were the dominant compounds identified in the inner bark of ***,***,and *** acids were the most abundant group in the inner bark of *** whereas monoterpenes and sesquiterpenes were recorded in minor quantities in both bark layers of all species.

关键词： Bark extractive Lipophilic inner bark Outer bark Pinus spp

Screening the insecticidal Efficacy of Nano ZnO Synthesized via in-situ Polymerization of Crosslinked Polyacrylic Acid as a template

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Journal of Materials Science & technology 2012年第11期28卷 961-968页

作者： M. Mekewi Ahmed Shebl A.i. imam M.S. Amin t. Albert Chemistry Department Faculty of Science Ain Shams University Plants Protection Department Desert Research Center

Nano zinc oxide （ZnO） is a very useful and important material in many industrial and biological applications. in the present work, ZnO was synthesized by post thermal degradation of the precursor ＂zinc acetate di-hydrate＂ templated in crosslinked polyacrylic acid （PAA）. the crosslinked PAA template was prepared through an in-situ polymerization process adopted in presence of ammonium per sulphate, as an initiator, and N, Nt- methylene bis-acrylamide as the crosslinker. Variation of preparation parameters and their impact on the oxide stoichiometry, crystal structure, crystallite size and surface texture of the oxide were investigated. Energy dispersive X-ray technique （EDX）, X-ray diffraction （XRD） and scanning electron microscopy （SEM） were convincingly used to reveal the oxide structural features and characteristics. the performed bioassay tests indicated the efficacy of this method of preparation to produce nano ZnO with novel insecticidal activity against the greater wax moth, Galleria rnellonella.

关键词： Nano ZnO in-situ polymerization Polymer template insecticide Bioassay Galleria mellonella

Structure and Bonding in Some Gd(Ⅲ) Metal Complexes Studied by three-Dimensional X-Ray Analysis and ^(155)Gd Mssbauer Spectroscopy

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Journal of Rare Earths 2007年第6期25卷 647-653页

作者：王军虎 takahashi Masashi Kitazawa takafumi takeda Masuo Dalian institute of Chemical Physics Chinese Academy of Sciences Department of Chemistry Faculty of Science Toho University 2-2-1 Miyama Funabashi Chiba 274-8510 Japan

Some functional lanthanide metal complexes, such as acetylacetonato complexes, ethylenediaminetetraacetato complexes, were successfully applied for diagnostic technique. the authors are interested in investigating the structure and bonding in lanthanide and actinide metal complexes using 166Er, t55Gd, and 237Np Mtissbauer spectroscopies in connection with single-crystal and/or powder X-ray diffraction, making clear the differences on their structures as well as the differences in the participation of 4f and 5f orbitals in the chemical bonds. in this article, the crystal structures of two novel Gd（Ⅲ） acetylacetonato complexes, Gd（pta）3 · 2H2O （pta = 1,1,1 -trifluoro-5,5-dimethy 1-2,4-hexanedione） and Gd（bfa）3 · 2H2O （bfa = 1, 1, 1 -trifluoro-4-phenyl-2-4-butanedione） were reported. though both of them were dihydrate and had distorted square antiprismatical structure, Gd（pta）3 · 2H2O crystallizes in the P 2 1/n （#14） monoclinic space group and its lattice parameters are a = 1.4141（6） nm, b = 1.0708（3） nm, c =2.2344（4） nm, β =952.4（2）°, and Gd（bfa）3· 2H2O crystallizes in P 212121 orthorhombic space group and its lattice parameters were a = 1.322 （1） nm, b = 2.295 （1） nm, c = 1. 0786（8） nm. in the meantime, the authors had finished a systematic investigation on the ^155Gd Mossbauer isomer shift （δ） of various Gd（Ⅲ） metal complexes having a different coordination number （C.N.） and different ratios coordinating oxygen to nitrogen. A tendency for the 6 value to decrease with an increase in the C.N, and the number of the nitrogen atom coordinating to Gd was confirmed. this indicated that the Gd-O and/or Gd-N bond in the investigated Gd（Ⅲ） metal complexes had a small covalent contribution, which was possible to be deduced from the O and/or N atoms of the lisands donating electrons to 6s, 5d, and 4f orbitals of Gd.

关键词： Gd(Ⅲ) metal complex crystal structure bonding ^155Gd Mossbauer spectroscopy three-dimensional X-ray analysis covalent contribution rare earths

Metastable noble gas atoms in strong-field ionization experiments

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High Power Laser Science and Engineering 2016年第3期4卷 74-100页

作者： J.E.Calvert A.J.Palmer i.V.Litvinyuk R.t.Sang Australian Attosecond Science Facility Center for Quantum Dynamics School of Natural Sciences Griffith University

the interactions of strong-field few-cycle laser pulses with metastable states of noble gas atoms are examined. Metastable noble gas atoms offer a combination of low ionization potential and a relatively simple atomic structure, making them excellent targets for examining ionization dynamics in varying experimental conditions. A review of the current work performed on metastable noble gas atoms is presented.

关键词： COLtRiMS electron holography high power lasers ionization regime metastable atoms spin polarized targets

Design of bridges against large tectonic deformation

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Earthquake Engineering and Engineering Vibration 2008年第4期7卷 345-368页

作者： i.Anastasopoulos G.Gazetas V.Drosos t.Georgarakos R.Kourkoulis National technical University

the engineering community has devoted much effort to understanding the response of soil-structure systems to seismic ground motions, but little attention to the effects of an outcropping fault offset. the 1999 earthquakes of turkey and taiwan, offering a variety of case histories of structural damage due to faulting, have （re）fueled the interest on the subject. this paper presents a methodology for design of bridges against tectonic deformation. the problem is decoupled in two analysis steps： the first （at the local level） deals with the response of a single pier and its foundation to fault rupture propagating through the soil, and the superstructure is modeled in a simplified manner; and the second （at the global level） investigates detailed models of the superstructure subjected to the support （differential） displacements of Step 1. A parametric study investigates typical models of viaduct and overpass bridges, founded on piles or caissons. Fixed-head piled foundations are shown to be rather vulnerable to faulting-dnduced deformation. End-bearing piles in particular are unable to survive bedrock offsets exceeding 10 cm. Floating piles perform better, and if combined with hinged pile-to-cap connections, they could survive much larger offsets. Soil resilience is beneficial in reducing pile distress. Caisson foundations are almost invariably successful. Statically-indeterminate superstructures are quite vulnerable, while statically-determinate are insensitive （allowing differential displacements and rotations without suffering any distress）. For large-span cantilever-construction bridges, where a statically determinate system is hardly an option, inserting resilient seismic isolation bearings is advantageous as long as ample seating can prevent the deck from falling off the supports. An actual application of the developed method is presented for a major bridge, demonstrating the feasibility of design against tectonic deformation.

关键词： fault rupture earthquake soil-structure interaction bridge viaduct pile group caisson foundation finite elements