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Open Journal of Anesthesiology 2018年第3期8卷 66-79页

作者： Jieyin Xing sze ying thong Department of Anaesthesia Singapore General Hospital Singapore

Swyer-James-MacLeod Syndrome is a rare acquired pulmonary disorder that develops secondary to infectious etiologies in early childhood. Patients who are affected have the potential of developing perioperative respiratory complications. While regional anaesthetic techniques are often performed as adjuncts to general anaesthesia, there is less data on breast operations being done solely under regional anaesthesia. We herein describe a patient with Swyer-James-MacLeod Syndrome who underwent breast lesion wide excision under combined paravertebral and pectoral nerves block, supplemented with propofol infusion for sedation. Choice of blocks was decided upon based on knowledge on the anatomy. Sole regional anaesthetic techniques have been the safest approach in some circumstances and should always be considered in patients who are of high risk under general anaesthesia.

关键词： Breast Surgery Regional Anaesthesia Paravertebral Nerve Block Pecs Block Swyer-James-MacLeod Syndrome

Analysis of Critical Incidents during Anesthesia in a Tertiary Hospital

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International Journal of Clinical Medicine 2016年第5期7卷 320-333页

作者： Ling Antonia Zeng Shin Yi Ng sze ying thong Department of Anaesthesia Singapore General Hospital Singapore City Singapore

Introduction: Critical incident monitoring is important in quality improvement as it identifies potential risks to patients by analyzing adverse events or near-misses. Methods: This study analyses the reported incidents in a tertiary hospital over a 4-year period. Results: A total of 441 incidents were reported out of 98,502 anesthetics performed during the study period. Of these incidents, 67 resulted in no harm caused, 116 with unanticipated ICU admissions and 20 mortalities. The odds of having a critical incident increased with ASA status: from an odds ratio of 2.08 (95% CI: 1.58 to 2.74) for ASA 2 patients compared to ASA1, to OR of 13.70 (5.91 to 31.74) in ASA 5 compared to ASA 1. Critical incidents also have higher odds occurring out of hours (OR 1.7 (1.45 to 2.23) compared to daytime hours (08:00-17:00). They occurred most commonly in maintenance phase (142, 32.7%), followed by induction (120, 27.6%). The most common types of incidents include airway and respiratory (110, 24.9%) followed by drug related incidents (67, 15.2%). Human error was attributed as a significant contributing factor in 276 incidents (61.5%) followed by patient factors in 112 incidents (25.4%). Mitigating factors such as vigilance by staff involved were significant in 136 incidents (30.3%). Conclusion: Higher ASA status appears to be the most important factor associated with actual or potential patient harm in our study. Also significant, was time of incident, with incidents more likely out of hours. Critical incident reporting is a valuable part of quality assurance. We should continue to invest in incident reporting, incident analysis and improvement plans.

关键词： Critical Incidents Anaesthesia Patient Safety Human Error Complications

Quantification of Carpaine and Antioxidant Properties of Extracts from Carica Papaya Plant Leaves and Stalks

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Journal of Bioresources and Bioproducts 2021年第4期6卷 350-358页

作者： Jing ying Yap Ching Lik Hii sze Pheng Ong Kuan Hon Lim Faridah Abas Kar Yong Pin Future Food Malaysia Department of Chemical and Environmental EngineeringFaculty of Science and EngineeringUniversity of Nottingham MalaysiaJalan Broga43500 SemenyihSelangor Darul EhsanMalaysia School of Pharmacy Faculty of Science and Engineering University of Nottingham MalaysiaJalan Broga43500 SemenyihSelangor Darul EhsanMalaysia Department of Food Science Universiti Putra Malaysia43400 SerdangSelangor Darul EhsanMalaysia Forest Research Institute Malaysia 52109 Kuala LumpurSelangor Darul EhsanMalaysia

Significance increase in dengue cases have been recorded worldwide every year and South East Asian countries have been badly ***,antiviral drug to treat dengue is still not available but papaya leaves extract(PLE)have been successfully used in treating dengue *** in PLE is the major active compounds that contributes to the anti-thrombocytopenic activity(raising platelet count in patient’s blood).The PLE also contains polyphenols that contribute to antioxidant *** were carried out to extract and quantify carpaine from young leaves,old leaves and stalks of papaya *** crystalline powders were successfully purified and confirmed by ^(1)H and ^(13)C NMR(Nuclear Magnetic Resonance).Young papaya leaves recorded significantly higher amount of carpaine(P<0.05)as compared with old leaves and *** treatment showed significant effect(P<0.05)on the amount of carpaine extracted from the young and old leaves and blended young leaves showed significantly much higher amount of carpaine as compared with the unblended samples(P<0.05).In terms of total polyphenols content(TPC),young leaves(both unblended and blended samples)contained significantly higher amount of TPC(P<0.05)followed by the old leaves and *** also showed relationship between the TPC and the 1,1-diphenyl-2-picrylhydrazyl(DPPH)assay scavenging activities namely IC_(50)(R^(2)=0.9743)and acid equivalent antioxidant capacity(AEAC)(R^(2)=0.9581).Both young and old leaves also showed significantly higher(P<0.05)DPPH scavenging activities as compared with the stalks in both unblended and blended *** papaya leaves were recommended as source of material to extract carpaine for future development of drug in dengue treatment.

关键词： Antioxidants Carica papaya Carpaine Dengue Total polyphenols

Safety control of waste cooking oil:transforming hazard into multifarious products with available pre-treatment processes

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Food Materials Research 2022年第1期2卷 1-11页

作者： Wei Han Foo Sherlyn sze Ning Koay Doris ying ying Tang Wen Yi Chia Kit Wayne Chew Pau Loke Show School of Energy and Chemical Engineering Xiamen University MalaysiaJalan SunsuriaBandar Sunsuria43900 SepangSelangorMalaysia Department of Chemical and Environmental Engineering Faculty of Science and EngineeringUniversity of Nottingham MalaysiaJalan Broga43500 SemenyihSelangor Darul EhsanMalaysia College of Chemistry and Chemical Engineering Xiamen UniversityXiamen 361005FujianChina

The increase in worldwide vegetable oil consumption has produced a large increase in hazardous waste cooking oil(WCO)*** improper disposal of WCO has been a significant problem from both an environmental and economic ***,it is advantageous to transform WCOs into valuable products efficiently and effectively in order to contribute towards the establishment of a circular *** this review,the current state of WCO is discussed in relation to WCO production and *** valorisation rate of each country can be categorised into three groups related to the consumption of vegetable oil,production and valorisation of WCO,as well as the production,conversion and valorisation *** any valorisation and processing of WCO can be carried out,pretreatments are crucially needed in refining and upgrading WCOs,specifically to reduce their free fatty acid(FFA)*** could help to produce refined WCOs with appropriate feedstock properties suitable for value-added applications in oleochemical ***,several pretreatment methods(e.g.,solid impurities removal,FFA reduction,moisture removal)have been summarized and evaluated in *** transformation of WCO into valuable products including alkyd resin,green solvent,soap,plastics and plasticizer are also *** technological advances have made WCO feasible as sustainable feedstocks for oleochemical production,but not limited to biofuel production which in turn maximizes the value of this hazardous waste and turns WCO into a sustainable source.

关键词： cooking moisture refined

Purple acid phosphatase promoted hydrolysis of organophosphate pesticides in microalgae

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Environmental Science and Ecotechnology 2024年第2期18卷 137-149页

作者： Xiang Wang Guo-Hui He Zhen-Yao Wang Hui-ying Xu Jin-Hua Mou Zi-Hao Qin Carol sze Ki Lin Wei-Dong Yang Yalei Zhang Hong-Ye Li Key Laboratory of Eutrophication and Red Tide Prevention of Guangdong Higher Education Institutes College of Life Science and TechnologyJinan UniversityGuangzhou510632China School of Energy and Environment City University of Hong KongTat Chee AvenueKowloonHong Kong Centre for Technology in Water and Wastewater School of Civil and Environmental EngineeringUniversity of Technology SydneyUltimoNSW2007Australia Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou510000China State Key Laboratory of Pollution Control and Resources Reuse College of Environmental Science and EngineeringTongji UniversityShanghai200092China

When organophosphate pesticides(OPs)are not used and handled in accordance with the current rules and standards,it results in serious threats to the aquatic environment and human *** tricornutum is a prospective microalgae-based system for pollutant removal and carbon *** engineered ***,designated as the OE line(endogenously expressing purple acid phosphatase 1[PAP1]),can utilize organic phosphorus for cellular ***,the competencies and mechanisms of the microalgae-based system(namely the OE line of ***)for metabolizing OPs remain to be *** this study,the OE line exhibited the effective biodegradation competencies of 72.12%and 68.2%for 30 mg L^(-1)of dichlorvos and 50 mg L^(-1)of glyphosate,accompanied by synergistic accumulations of biomass(0.91 and 0.95 g L^(-1))and lipids(32.71%and 32.08%),***,the biodiesel properties of the lipids from the OE line manifested a high potential as an alternative feedstock for microalgae-based biofuel production.A plausible mechanism of OPs biodegraded by overexpressed PAP1 is that sufficient inorganic P for adenosine triphosphate and concurrent carbon flux for the reduced form of nicotinamide adenine dinucleotide phosphate biosynthesis,which improved the OP tolerance and biodegradation competencies by regulating the antioxidant system,delaying programmed cell death and accumulating lipids via the upregulation of related *** sum up,this study demonstrates a potential strategy using a genetically engineered strain of *** to remove high concentrations of OPs with the simultaneous production of biomass and biofuels,which might provide novel insights for microalgae-based pollutant biodegradation.

关键词： Biodegradation Lipid accumulation Organophosphate pesticide Phaeodactylum tricornutum Purple acid phosphatase

Perceptions of non-alcoholic fatty liver disease–an Asian community-based study

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Gastroenterology Report 2016年第2期4卷 131-135,I0002页

作者： George B.B.Goh Clarence Kwan sze ying Lim Nanda KK Venkatanarasimha Rafidah Abu-Bakar Thinesh L Krishnamoorthy Hang Hock Shim Kiang Hiong Tay Wan Cheng Chow Department of Gastroenterology&Hepatology Singapore General HospitalSingapore Duke-NUS Graduate Medical School Singapore Department of Diagnostic Radiology Singapore General HospitalSingapore

Background and Aims:Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease and is closely related to metabolic syndrome and its risk ***,epidemiological studies have reported NAFLD prevalence rates of 5%to 30%depending on geographical *** epidemiological data suggest a progressively increasing prevalence of metabolic risk factors in Singapore,there are limited data about NAFLD per se in the *** aim to explore the prevalence and perceptions of NAFLD in ***:Attendees at a gastroenterology public forum were enrolled in a cross-sectional observational study evaluating demographic,anthropometric and clinical *** diagnosis of NAFLD was based on sonographic *** syndrome was defined according to International Diabetes Federation *** of NAFLD were explored using a self-administered survey ***:A total of 227 subjects were recruited,with NAFLD being diagnosed in 40%of the *** to those without NAFLD,subjects with NAFLD had higher male preponderance,older age,higher body mass index,waist circumference and more metabolic syndrome(all P0.05).Of note,75.6%of subjects with one or more metabolic risk factors did not think that they were at risk of ***:Our study suggests a significant local prevalence of NAFLD in the community including non-obese *** the tendency to underestimate risk of NAFLD,enhanced public education about NAFLD is warranted to improve understanding.

关键词： non-alcoholic fatty liver disease epidemiology perceptions Singapore

Role of ion channels in maintaining the characteristics of embryonic stem cells

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Role of ion channels in maintaining the characteristics of e...

Genome sequencing reveals the role of rare genomic variants in Chinese patients with symptomatic intracranial atherosclerotic disease

第七届海峡两岸心血管科学研讨会

作者： sze-ying Ng Yuen-Ting Lau Chi-Hou Chin Chun-Kit Wong Suk-ying Tsang Department of Biochemistry Chinese University of Hong Kong

Embryonic stem cells(ESCs)are derived from the inner cell mass of *** can self-renew and are pluripotent,meaning that they can proliferate indefinitely and have the ability to differentiate into all cells in our *** may therefore act as a source of different cell types for future regenerative *** the present study,the role of voltage-gated K(Kv)channels in maintaining the self-renewal and pluripotent characteristics of undifferentiated mouse(m)ESCs was *** channel blocker tetraethylammonium(TEA)was shown to decrease mESC proliferation without affecting cell *** of Kv channels resulted in cell cycle arrest at the G/G *** addition,decreased expression of pluripotent markers such as Oct-4 was detected in Kv channel -blocked *** Kv blockade led to depolarization,and Kv channel-blocked ESCs failed to progress through the cell cycle and had a loss of pluripotency,the present results suggested a possible relationship between the Kv channel functions,membrane potential,cell cycle progression and differentiation potential in *** study shall provide new information about the basic biology of ESCs and provide insights into the possible strategies of controlling ESC self-renewal and differentiation.

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Stroke & Vascular Neurology 2022年第3期7卷 182-189页

作者： Mengmeng Shi Xinyi Leng ying Li Zihan Chen Ye Cao Tiffany Chung Bonaventure YM Ip Vincent HL Ip Yannie OY Soo Florence SY Fan sze Ho Ma Karen Ma Anne Y Y Chan Lisa WC Au Howan Leung Alexander Y Lau Vincent CT Mok Kwong Wai Choy Zirui Dong Thomas W Leung Department of Obstetrics and Gynaecology The Chinese University of Hong KongHong KongChina Key Laboratory for Regenerative Medicine Ministry of Education(Shenzhen Base)Shenzhen Research InstituteThe Chinese University of Hong KongShenzhenChina Hong Kong Hub of Paediatric Excellence The Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics The Chinese University of Hong KongPrince of Wales HospitalHong KongChina Department of Paediatrics The Chinese University of Hong KongHong KongChina The Chinese University of Hong Kong-Baylor College of Medicine Joint Center For Medical Genetics The Chinese University of Hong KongHong KongChina

Objectives The predisposition of intracranial atherosclerotic disease(ICAD)to East Asians over Caucasians infers a genetic basis which,however,remains largely *** prevalence of vascular risk factors(VRFs)in Chinese over Caucasian patients who had a stroke,and shared risk factors of ICAD with other stroke subtypes indicate genes related to VRFs and/or other stroke subtypes may also contribute to *** Unrelated symptomatic patients with ICAD were recruited for genome sequencing(GS,60-fold).Rare and potentially deleterious single-nucleotide variants(SNVs)and small insertions/deletions(InDels)were detected in genome-wide and correlated to genes related to VRFs and/or other stroke *** aneuploidies,copy number variants(CNVs)and chromosomal structural rearrangements were also ***,candidate genes were used for pathway and gene ontology enrichment *** Among 92 patients(mean age at stroke onset 61.0±9.3 years),GS identified likely ICAD-associated rare genomic variants in 54.3%(50/92)of ***-eight patients(52.2%,48/92)had 59 rare SNVs/InDels reported or predicted to be deleterious in genes related to VRFs and/or other stroke *** of the 59 rare variants were identified in local subjects without ICAD(n=126).31 SNVs/InDels were related to conventional VRFs,and 28 were discovered in genes related to other stroke *** study also showed that rare CNVs(n=7)and structural rearrangement(a balanced translocation)were potentially related to ICAD in 8.7%(8/92)of ***,candidate genes were significantly enriched in pathways related to lipoprotein metabolism and cellular lipid catabolic *** Our GS study suggests a role of rare genomic variants with various variant types contributing to the development of ICAD in Chinese patients.

关键词： patients metabolism intracranial

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具有区间峰值的曲面伸缩因子及其实验

计算机工程与应用 2009年第7期45卷 187-189,198页

作者：宋来忠彭刚杨文颖三峡大学理学院湖北宜昌443002 三峡大学土木水电学院湖北宜昌443002

为了改进参数曲面自由变形方法,构造了一种新的伸缩因子函数,它不仅具有以往文献所引入的伸缩因子的特性,还可以在区域上达到峰值,从而克服现有的伸缩因子仅在一点达到峰值的不足。使用新的伸缩因子去作用待变形的曲面方程,从而使曲面... 详细信息

为了改进参数曲面自由变形方法,构造了一种新的伸缩因子函数,它不仅具有以往文献所引入的伸缩因子的特性,还可以在区域上达到峰值,从而克服现有的伸缩因子仅在一点达到峰值的不足。使用新的伸缩因子去作用待变形的曲面方程,从而使曲面发生形变,通过交互改变控制参数来控制曲面的形状,使其能够更好地表示一些实体的外型。实验表明,该方法数学背景简单,易于控制,重复使用可获得丰富的变形效果。适用于几何造型、计算机动画、CAD/CAM等领域。

关键词：参数曲线伸缩因子自由变形

Mechanistic study on the effect of cytokine-induced cardiogenesis in embryonic stem cells

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Mechanistic study on the effect of cytokine-induced cardioge...