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Anticancer Activities and QsAR study of Novel Agents with a Chemical Profile of Benzimidazolyl-Retrochalcone

Open Journal of Medicinal Chemistry 2020年第3期10卷 113-127页

作者： Ouattara Mahama Koné Aboudramane Koné soleymane Collet sylvain Diomandé sekou sissouma Drissa Department of Therapeutic Chemistry and Organic Chemistry UFR SPB FHB University Abidjan C&#244 te d’Ivoire Department of Chemistry UFR Environment Jean LorougnonGuédé University Daloa C&#244 te d’Ivoire Laboratory of Organic Chemistry and Natural substances UFR SSMT FHB University Abidjan C&#244 te d’Ivoire Chemistry and Interdisciplinarity: synthesis Analysis Modelling (CEISAM) University of Nantes Nantes France

The present pharmacochemical and modelling work focused on a benzimidazolyl-chalcone series. These previously synthesized compounds were evaluated in vitro for their anticancer activities against a panel of seven human cancer cell lines and normal fibroblasts. Among the new benzimidazole-supported chalcones, nine (9) compounds (compoundsstrong> 1 - 4, 6 - 8 strong>and compounds strong>10strong> and strong>11strong>) showed promising anticancer activities with ICsub>50sub>s ranging from 0.83 to 2.58 μM. Compounds strong>2 strong>and strong>6strong> with ICsub>50sub>s of 0.83 and 0.86 μM, respectively, were shown to be potent inhibitors of HCT-116 colon cancer cell proliferation. It was therefore necessary, for a development of this new series of chalcones, to establish through a QsAR study, their quantum descriptors according to the DFT calculation method and following the B3LYP/6-31+G (d,p) theory. These descriptive and predictive studies focused on the colon HCT 116 cell line which was found to be more sensitive to the anticancer action of our benzimidazolyl-retrochalcones. QsAR study showed that the electronic energy (Esub>elecsub>), lipophilicity (logP), chemical softness (s) and chemical hardness (η) of benzimidazolyl-retrochalcones play an important role in inhibiting cancer cell proliferation.

关键词： Retrochalcone Benzimidazole Anticancer Agents QsAR Quantum Descriptors DFT Method

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Experimental verification of ill-defined topologies and energy sinks in electromagnetic continua

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Advanced Photonics 2022年第3期4卷 97-104页

作者： David E.Fernandes Ricardo A.M.Pereira sylvain Lannebère Tiago A.Morgado Mário G.silveirinha University of Coimbra Instituto de Telecomunicações and Department of Electrical EngineeringCoimbraPortugal University of Aveiro Instituto de TelecomunicaçõesDepartment of ElectronicsTelecommunications and InformaticsAveiroPortugal University of Lisbon Instituto Superior Técnico and Instituto de TelecomunicaçõesDepartment of Electrical EngineeringLisboaPortugal

.It is experimentally verified that nonreciprocal photonic systems with continuous translation symmetry may have an ill-defined *** topological classification of such systems is only feasible when the material response is regularized with a spatial-frequency *** experimentally demonstrate that adjoining a small air layer to the relevant material interface may effectively imitate an idealized spatial cutoff that suppresses the nonreciprocal response for short wavelengths and regularizes the ***,it is experimentally verified that nonreciprocal systems with an ill-defined topology may be used to abruptly halt the energy flow in a unidirectional waveguide due to the violation of the bulk-edge *** particular,we report the formation of an energy sink that absorbs the incoming electromagnetic waves with a large field enhancement at the singularity.

关键词： topological photonics nonreciprocity topological singularities bulk edge correspondence.

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追逐我们的梦想

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中国葡萄酒 2022年第1期 12-13,8,10页

作者： sylvain Ouchik 不详

品尝2021年的期酒是我们被疫情所颠覆的生活中珍贵而快乐的一刻,葡萄酒告诉我们绝不能放弃对未来的期盼,无论如何我们都应该满怀希望,不地努力。爱迪生(Thomas Edison)曾说实现梦想的最重要的三个元素分别是:努力的工作、坚韧不拔的意... 详细信息

品尝2021年的期酒是我们被疫情所颠覆的生活中珍贵而快乐的一刻,葡萄酒告诉我们绝不能放弃对未来的期盼,无论如何我们都应该满怀希望,不地努力。爱迪生(Thomas Edison)曾说实现梦想的最重要的三个元素分别是:努力的工作、坚韧不拔的意志和常识。今天我们可以肯定,波尔多城堡酒庄的所有者们和他们的酿造团队将这些品质都结合在了2021年期酒的酿造中。

关键词：波尔多满怀希望实现梦想爱迪生坚韧不拔葡萄酒

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Humoral Response to Toxoplasma gondii in Pregnant Women in Bangui Central African Republic

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Open Journal of Immunology 2022年第4期12卷 122-129页

作者： Wilfrid sylvain Nambei Junior Ouefio Nguerenam Edwige Régina Kodia-Lenguetama Arsène Gbamonza Department of science Biomedical Faculty of Health Science University of Bangui Bangui Central African Republic National Center of Blood Donor’s Ministry of Public Health Bangui Central African Republic Community Hospital of Bangui Bangui Central African Republic

Toxoplasmosis is a cosmopolitan antrhropozoonosis widespread in mammals and birds. Normally asymptomatic in the subject health, it can have serious consequences for the fetus in the first trimester of pregnancy in the pregnant woman. It is in this context that we propose to assess the immune response to T. gondii in pregnant women in Bangui. This was a retrospective analytical study that consulted the records of pregnant women received in prenatal consultations at the Bangui Community Hospital Maternity ward from January 2019 to December 2019. socio-demographic and laboratory data (IgM, IgG response to T. gondii) and results of HIV serology were collected from January to June 2021. Chisup>2sup> test was used. A total of 307 pregnant women were analyzed. The average age of the women included was 28 (±6) years. The average parity of the entire sample was 2.18 (±1.93). Toxoplasmosis infectious was 14.65%. Women with a positive IgM response accounted for 17.58% and those with an IgG-positive response for 42.99%. Patients with a positive HIV were 5.86%. Patients aged 20 - 29 had a serological profile suggesting a probable ongoing infection (p = 0.010). The paucipares were more represented with no statistically significant difference (p = 0.23). Pregnant women were not significantly exposed to toxoplasmosis infectious (p = 0.96). Immunized and non-immunized subjects were similarly exposed [OR = 0.97;CI 95% 0.4 = 6 - 2.05]. Toxoplasmosis remains particularly serious during pregnancy. seroprevalence was significantly higher in the 20 - 24 year age group. Women were similarly exposed depending on whether they were immunized or not. This requires the establishment of a specific prevention program against this disease.

关键词： T. gondii Humoral Response HIV Pregnant Women Central African Republic

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打开波尔多酒庄的大门品尝2019年份葡萄酒

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中国葡萄酒 2020年第1期 12-13,8页

作者： sylvain Ouchikh 不详

2020年这个特殊的年份将被我们永记,这一年,我们日常生活的方方面面都被颠覆了。幸运的是,生活依旧继续,一切都将恢复正常。波尔多酒庄的大门正在打开,得益于严格的卫生防护措施,葡萄酒爰好者和顾客们可以再度拜访这些美丽的酒庄,此外,... 详细信息

2020年这个特殊的年份将被我们永记,这一年,我们日常生活的方方面面都被颠覆了。幸运的是,生活依旧继续,一切都将恢复正常。波尔多酒庄的大门正在打开,得益于严格的卫生防护措施,葡萄酒爰好者和顾客们可以再度拜访这些美丽的酒庄,此外,何不借机品尝下2019年份葡萄酒呢?

关键词：波尔多酒庄葡萄酒品尝年份日常生活大门打开

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Decoupling between Plant Productivity and Growing season Length under a Warming Climate in Canada’s Arctic

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American Journal of Climate Change 2016年第3期5卷 334-359页

作者： Wenjun Chen Paul Zorn Lori White Ian Olthof Yu Zhang Robert Fraser sylvain Leblanc Canada Centre for Remote sensing Natural Resources Canada Ottawa Canada Parks Canada Agency Gatineau Canada Wildlife Landscape science Directorate Environment Canada Ottawa Canada

Given the short duration of growing season in the Arctic, a strong correlation between plant productivity and growing season length (GsL) is conventionally assumed. Will this assumption hold true under a warming climate? In this study, we addressed the question by investigating the relationship between net primary productivity of leaves (NPPsub>leafsub>) and GsL for various tundra ecosystems. We quantified NPPsub>leafsub> and GsL using long-term satellite data and field measurements. Our results indicated that the relationship was not significant (i.e., decoupled) for 44% to 64% of tundra classes in the southern Canadian Arctic, but significant for all classes in the northern Canadian Arctic. To better understand the causes of the decoupling, we further decomposed the relationship into two components: the correspondence of interannual variations and the agreement of long- term trends. We found that the longer the mean GsL for a tundra class, the poorer the correspondence between their interannual variations. soil moisture limitation further decoupled the relationship by deteriorating the agreement of long-term trends. Consequently, the decoupling between NPPsub>leafsub> and GsL would be more likely to occur under a warming climate if the tundra class had a mean GsL > 116 (or 123) days with a dry (or moist) soil moisture regime.

关键词： Net Primary Productivity Growing season Length Arctic Tundra Decoupling Remote sensing soil Moisture Regime

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Broadband supercontinuum generation in nitrogen-rich silicon nitride waveguides using a 300 mm industrial platform

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Photonics Research 2020年第3期8卷 352-358页

作者： CHRIsTIAN LAFFORGUE sylvain GUERBER JOAN MANEL RAMIREZ GUILLAUME MARCAUD CARLOs ALONsO-RAMOs XAVIER LE ROUX DELPHINE MARRIs-MORINI ERIC CAssAN CHARLEs BAUDOT FRéDéRIC BOEUF séBAsTIEN CREMER sTéPHANE MONFRAY LAURENT VIVIEN Centre for Nanoscience and Nanotechnology(C2N) CNRSUniversitéParis-SudUniversitéParis-SaclayUMR 900191405 Orsay CedexFrance Technologie R&D STMicroelectronicsSAS850 rue Jean Monnet38920 CrollesFrance III-V lab a joint venture from Nokia Bell LabsThales and CEA1 Avenue Augustin Fresnel91767 Palaiseau CedexFrance

We report supercontinuum generation in nitrogen-rich(N-rich)silicon nitride waveguides fabricated through back-end complementary-metal-oxide-semiconductor(CMOs)-compatible processes on a 300 mm *** pumping in the anomalous dispersion regime at a wavelength of 1200 nm,two-octave spanning spectra covering the visible and near-infrared ranges,including the O band,were *** calculations showed that the nonlinear index of N-rich silicon nitride is within the same order of magnitude as that of stoichiometric silicon nitride,despite the lower silicon content.N-rich silicon nitride then appears to be a promising candidate for nonlinear devices compatible with back-end CMOs processes.

关键词： waveguides pumping nitride

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葡萄酒,人们之间的永恒联系

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中国葡萄酒 2020年第2期 10-11,8页

作者： sylvain Ouchikh 不详

今天,Covid-19疫情在全世界橫行。我们不得不承认,所有人都是相互联系和相互依存的。这是一件好事吗?我个人真诚地认为是的。在当今这个每个人都紧密联系在起的世界,人们分享着彼此的悲伤与欢喜。每一天,我们都能从生活中学习到更多,我... 详细信息

今天,Covid-19疫情在全世界橫行。我们不得不承认,所有人都是相互联系和相互依存的。这是一件好事吗?我个人真诚地认为是的。在当今这个每个人都紧密联系在起的世界,人们分享着彼此的悲伤与欢喜。每一天,我们都能从生活中学习到更多,我们不应该忘记这点。葡萄酒正是这种分享精神的象征,她是为人们带来了欢乐的美酒。我们喜欢为人们推荐适合简单地与亲朋好友们一起享用的葡萄美酒。

关键词：葡萄美酒葡萄酒分享相互依存所有人相互联系

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Reassessment of historical sections from the Paleogene marine margin of the Congo Basin reveals an almost complete absence of Danian deposits

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Geoscience Frontiers 2019年第3期10卷 1039-1063页

作者： Floréal solé Corentin Noiret Delphine Desmares sylvain Adnet Louis Taverne Thierry De Putter Florias Mees Johan Yans Thomas steeman stephen Louwye Annelise Folie Nancy J.stevens Gregg F.Gunnell Daniel Baudet Nicole Kitambala Yaya Thierry smith Royal Belgian Institute of Natural sciences (RBINs) Operational Directorate Earth and History of Life University of Namur (UNamur) Department of Geology Rue de Bruxelles 61 sorbonne Université UPMC Paris 06 UMR 7207 (CR2P) UMR 5554-Institut des sciences de l'Evolution Université Montpellier Place E.Bataillon Royal Museum for Central Africa (RMCA) Geodynamics and Mineral Resources Leuvensesteenweg 13 Ghent University (UGent) Department of Geology Royal Belgian Institute of Natural sciences (RBINs) Heritage Scientific Survey Ohio University Department of Biomedical Sciences Heritage College of Osteopathic Medicine Duke University Lemur Center Division of Fossil Primates (DFP) Centre de Recherches Géologiques et Minières (CRGM) 44 av.de la Démocratie Kinshasa Gombe

The early Paleogene is critical for understanding global biodiversity patterns in modern ecosystems. During this interval, southern Hemisphere continents were largely characterized by isolation and faunal endemism following the breakup of Gondwana. Africa has been proposed as an important source area for the origin of several marine vertebrate groups but its Paleogene record is poorly sampled, especially from sub-saharan Africa. To document the early Paleogene marine ecosystems of Central Africa, we revised the stratigraphic context of sedimentary deposits from three fossil-rich vertebrate localities: the Landana section in the Cabinda exclave(Angola), and the Manzadi and Bololo localities in western Democratic Republic of *** provide more refined age constraints for these three localities based on invertebrate and vertebrate faunas, foraminiferal and dinoflagellate cyst assemblages, and carbon isotope records. We find an almost complete absence of Danian-aged rocks in the Landana section, contrary to prevailing interpretations over the last half a century(only the layer 1, at the base of the section, seems to be Danian). Refining the age of these Paleocene layers is crucial for analyzing fish evolution in a global framework, with implications for the early appearance of scombridae(tunas and mackerels) and Tetraodontiformes(puffer fishes). The combination of vertebrate fossil records from Manzadi and Landana sections suggests important environmental changes around the K/Pg transition characterized by an important modification of the ichthyofauna. A small faunal shift may have occurred during the selandian. More dramatic is the distinct decrease in overall richness that lasts from the selandian to the Ypresian. The Lutetian of West Central Africa is characterized by the first appearance of numerous cartilaginous and bony fishes. Our analysis of the ichthyofauna moreover indicates two periods of faunal exchanges: one during the Paleocene, where Central Africa app

关键词： Central Africa Paleogene stratigraphy Carbon isotope Planktonic foraminifera Vertebrates

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Detection and quantifi cation of extracellular microRNAs in medulloblastoma

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Journal of Cancer Metastasis and Treatment 2015年第1期1卷 67-75页

作者： Tarek shalaby Giulio Fiaschetti sylvain Baulande Nicolas U.Gerber Martin Baumgartner Michael A.Grotzer Department of Oncology University Children’s Hospital Zurich8032 ZurichSwitzerland Department of Biology PartnerChip CEAGénopole Campus 291000ÉvryFrance.

Aim:Medu lloblastoma(MB)is the most common malignant brain tumor in *** crucial role of extracellular-microRNAs(ex-miRNAs)in cancer has been widely recognized;however,their role in MB remains *** study aimed to investigate MB-driven ***:Microarray analysis was used to disclose the identity and quantity of key miRNAs excreted in culture-medium(CM)of 3 human MB cell lines and cere brospinal fl uid(CsF)of brain tumors(including MB)and leukemia *** expression was validated by quantitative reverse transcription polymerase chain ***:We have demonstrated that the 3 MB cell lines tested commonly expressed 1,083 miRNAs in their spent *** them,57 miRNAs were specifi c to the CM of metastasis-related cell lines which represents the aggressive group 3 and group 4 MB subtypes.A signifi cant number(1,254)of ex-miRNAs were identifi ed in the CsF of a MB ***-six of these miRNAs were found to be differentially expressed in this patient’s CsF compared with ***,3 metastasis-associated miRNAs over-represented in CM of metastasis-related MB cell lines were found to be significantly enriched in the CsF of the MB ***:Although more samples are required to fully verify these results,our work provides the first evidence for the presence of a signifi cant amount of miRNAs excreted extracellularly by MB cells and raises the possibility that,in the near future,miRNAs could be probed in CsF of MB patients and serve as novel biological markers.

关键词： Medulloblastoma extracellular-microRNA pediatric cancer

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