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Survival of Antiretroviral Therapy Patients at the Outpatient Treatment Centre of the Community University Hospital of Bangui from 2015 to 2020

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Advances in Infectious Diseases 2023年第3期13卷 389-406页

作者： sylvain honore woromogo Paulette Rose Josephat Mbay Yamotende Jesse Saint Saba Antaon Derguedbé Nebardoum Hermann Ngouakam Pierre Marie Tebeu Inter-State Centre for Higher Education in Public Health of Central Africa Brazzaville Republic of Congo Unit for Research and Intervention in Public Health Department of Public Health Faculty of Health Sciences Bangui Central African Republic Faculty of Medicine and Biomedical Sciences University of Yaounde 1 Yaounde Cameroon

Background: The advent of antiretroviral treatment has considerably increased the life expectancy of people living with HIV in recent years. The Central African Republic, despite challenges related to the socio-political context, is committed to achieving the UNAIDS 90-90-90 targets and to the elimination of AIDS by 2030 advocated by the WHO. Objective: To analyze survival among HIV-positive adult patients on antiretroviral therapy from 2015 to 2020. Methods: This was a history-based cohort study of patients started on ART. The main variable was survival. The Kaplan-Meier method was used to describe the survival curve since inclusion in the cohort and a multivariate Cox model was used to investigate factors associated with mortality on ART. Results: A total of 145 naive patients started ART at the Outpatient Treatment Centre (OTC) in 2015. A female predominance was observed in our study with 78.08% of cases. The analysis of the patients’ fate at the time of point of treatment showed that 58.62% of them were still in active care and 13.10% died. The probability of survival at 5 years was 0.82 and mortality was significantly associated with very advanced disease (WHO stage IV) (p = 0.047) and anemia (p = 0.039). Conclusion: The majority of patients were still in care at the endpoint and mortality was significantly related to advanced disease and anemia. Early management of people living with HIV combined with better quality of care would improve their survival.

关键词： Survival Patients Antiretroviral Treatment Bangui

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