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Isolation and Identification of Multi-Drug Resistant Strains of Non-Lactose Fermenting Bacteria from Clinical Isolates

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Open Journal of Medical Microbiology 2014年第2期4卷 115-123页

作者： Minhas Akbar Muhammad Zahid Pir Asmat Ali Aftab Alam Sthanadar Mudassir Shah Iram Alam Sthanadar Muhammad Kaleem Muhammad Aslam Khayyam Zahirullah Syeda Mahreen ul hassan Noor Jehan Muhammad Ismail Khan Department of Microbiology Shaheed Benazir Bhutto Women University Peshawar Pakistan Department of Zoology Islamia College University Peshawar Pakistan Department of Zoology Islamia College University Peshawar Pakistan Department of Zoology and Animal Sciences Post Graduate College Dargai Malakand Pakistan Department of Zoology Islamia College UniversityPeshawar Pakistan Government Degree College Dara Adam Kheil FR Kohat Pakistan Lady Reading Hospital Peshawar Pakistan

Purpose: We studied the drug resistance of different microbes from clinical isolates. The morphological characteristics of bacteria were observed through culture characteristics and by carrying out gram staining techniques while the biochemical characteristics of bacteria were carried out by biochemical test. Methods: A total of 324 samples were collected from suspected patients visiting different hospitals at district Peshawar. For morphological identification, samples of clinical isolates were analyzed by blood agar, MacConkey agar and Eosine Methylene Blue, identified by gram staining and characterized by different biochemical tests. Antibiotic Sensitivity test by Modified Kirby-Bauer Disc diffusion method was used to test the in-vitro susceptibility of the identified isolates to different antibiotics such as Ceftazidime, Ceftazidime, Ceftriaxone, Cefepime and Imipenem. Results: These resistant non-lactose fermenting gram negative bacteria were isolated from samples of pus/wound (33.30%, n = 108/324), blood (33.30%, n = 108/324), urine (23.30%, n = 75/324) and from ascetic/pleural fluids (10.20%, n = 33/324). The study revealed that the percentage of non-fermenting bacterial infection was higher in females (53%) as compared to males (47%) along with higher infection observed in the age group of 11 - 30 years. Pseudomonas aeroginosa showed high resistance against Cefepime (88.80%), followed by Cefoperazone (55.50%), Ceftazidime (48.10%), Ceftriaxone (33.30%). Imipenem was active with low resistance (7.40%). More resistance was seen in Morganella morganii against Imipenem (66.70%) followed by Cefoperazone (55.50%), Ceftriaxone (55.50%). Cefepime showed low resistance (11%). Multi-drug resistant Proteus mirabillis was highly resistance to Ceftriaxone (74.07%), followed by Cefepime (59.20%), Cefoperazone (44.40%) and low resistance for Imipenem (25.90%). Salmonella typhi demonstrated high resistance against Imipenem (74.07%), followed by Ceftriaxone (40.70%), Ceftazi

关键词： Multidrug Resistant Non-Lactose Fermenting Gram Negative Bacteria Disc Diffusion Technique

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振幅整合脑电图对心肺复苏患儿脑功能早期预后的价值

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齐齐哈尔医学院学报 2020年第10期41卷 1210-1213页

作者：刘义王文辉潘慧茹 SYED IKRAM-ul-hassan 高科赵武蚌埠医学院第一附属医院儿科安徽蚌埠233004 阜南县人民医院儿科安徽阜南236300 灵璧县人民医院儿科安徽灵璧234200

目的探讨振幅整合脑电图(aEEG)在心肺复苏(CPR)患儿早期预后评估中的价值。方法选择2017年3月—2019年5月本院儿童重症监护室(PICU)收治的CPR患儿32例进行aEEG及同步视频脑电图(vEEG)监测,包括患儿复苏时长、住院时间及儿童改良格拉斯... 详细信息

目的探讨振幅整合脑电图(aEEG)在心肺复苏(CPR)患儿早期预后评估中的价值。方法选择2017年3月—2019年5月本院儿童重症监护室(PICU)收治的CPR患儿32例进行aEEG及同步视频脑电图(vEEG)监测,包括患儿复苏时长、住院时间及儿童改良格拉斯哥昏迷评分(GCS)。根据发病后3个月脑功能评分量表(PCPC)分为预后良好组(1~3分)和预后不良组(4~6分)。用Spearman秩相关分析aEEG与vEEG及改良GCS评分的相关性;用受试者工作特征曲线(ROC)评价aEEG、vEEG及改良GCS对脑功能早期预后的价值。结果两组不同预后患儿之间年龄、性别、住院时间差异均无统计学意义(P>0.05),复苏时长、aEEG分级、vEEG分级与改良GCS评分差异有统计学意义(P<0.05);Spearman秩相关分析显示aEEG与vEEG及改良GCS均呈正相关(r值分别为0.630及0.576,均P<0.001);ROC曲线分析显示aEEG预测CPR患儿脑功能预后的ROC曲线下面积(AUC)=0.901,最佳截断值为1.5时,灵敏度为0.958,特异度为0.625,vEEG的AUC=0.880,最佳截断值为3.5时,灵敏度为0.833,特异度为0.875;改良GCS的AUC=0.779,最佳截断值为2.5时,灵敏度为0.833,特异度为0.625。结论 aEEG不仅能用于CPR患儿早期预后评估,而且比vEEG和改良GCS预测价值更高。

关键词：振幅整合脑电图心肺复苏预后

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旁遮普天津技术大学机械工程专业应用型人才培养体系研究

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天津职业技术师范大学学报 2018年第3期28卷 71-74页

作者：徐超辉赵巍 RAMMIZ ul-hassan ASMA Bakht MUHAMMAD Farhan-ejaz 天津职业技术师范大学机械工程学院天津300222 旁遮普天津技术大学机电工程学院拉合尔999010

针对巴基斯坦教育现状,结合本地经济与人才需求的相互关系,介绍了旁遮普天津技术大学的培养理念与目标,并以机械工程专业为例,从课程体系制定、教学组织实施、评价反馈机制等环节入手,阐述在OBE教育理念的指导下,如何有效构建完整的应... 详细信息

针对巴基斯坦教育现状,结合本地经济与人才需求的相互关系,介绍了旁遮普天津技术大学的培养理念与目标,并以机械工程专业为例,从课程体系制定、教学组织实施、评价反馈机制等环节入手,阐述在OBE教育理念的指导下,如何有效构建完整的应用型人才培养体系,旨在为国内外同类院校和专业的建立提供参考。

关键词：旁遮普天津技术大学人才培养体系 OBE

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Efficiency of combining pomegranate juice with low-doses of cisplatin and taxotere on A549 human lung adenocarcinoma cells

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Asian Pacific Journal of Tropical Biomedicine 2018年第1期8卷 19-24页

作者： Nasser Mohamad Hijazi Akram Sayed Ahmad Bouchra Jamal Eddine Zeinab Ibrahim Sajida Rammal hassan Al Rekaby Abd-El-Ameer Nasser Mouhamad Doctoral School of Science and Technology Research Platform for Environmental Science (PRASE) Lebanese University Université Fédérale de Toulouse Midi-Pyrénées INP-ENSIACET Laboratoire de Chimie Agro-industrielle Al Mustansiriya University College of Science Department of Biology American University of Beirut

Objective: To test the coalescence effect of two chemotherapy drugs at low effective dose(cisplatin and taxotere) combined with pomegranate juice on A549 cancer cells. Methods: Infrared spectroscopy method is a qualitative test that was performed to ensure the existence of the phytochemicals providing the antioxidant activity through the presence of the hydroxyl group(-OH). The viability of A549 cell line and normal MCs was tested using the neutral red uptake, Clonogenic survival, XTT and Cell migration assays. Results: Our results showed that this combination firstly led to a greater decrease in the viability of cells comparing to those treated with chemotherapy drugs alone, and secondly led to a significant reduction in cell migration. Conclusions: These data suggest a synergistic effect between the pomegranate and cisplatin which makes probably this combination a powerful option for treating lung adenocarcinoma and in parallel minimizing the systemic side effects.

关键词： Lung cancer Chemotherapy Cisplatin Taxotere Pomegranate A549 cells

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Chemical composition and antioxidant activity of a Lebanese plant Euphorbia macroclada schyzoceras

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Asian Pacific Journal of Tropical Biomedicine 2013年第7期3卷 542-548页

作者： Hussein Farhan hassan Rammal Akram Hijazi Ahmad Daher Mohamad Reda Hussein Annan Ali Chokr Ali Bassal Bassam Badran Doctoral School of Science and Technology Research Platform for Environmental Science Lebanese UniversityLebanon Faculty of Agricultural and Veterinary Sciences Lebanese UniversityLebanon Faculty of Sciences-1- Lebanese UniversityLebanon

Objective:To determine the chemical composition,total phenolic and total flavonoid contents ofthe crude extracts from leaves and stems of a Lebanese plantEuphorbia macroclada schyzoceras(***),and to evaluate their antioxidant potential using DPPH,H2O2,and chelating offerrous ions ***:Quantification of the total phenolic and total flavonoid contents ofthe crude extracts from leaves and stems and the antioxidant activities were evaluated usingspectrophotometric *** chemical composition has been estimated using differenttechniques such as IR,LC/MS and ***:Ethanolic extract from leaves *** was better than aqueous extract and showed higher content in total phenolic and total flavonoidthan found in the *** the other hand,using DPPH and H2O2tests,this extract from leavesshowed higher antioxidant capacity than aqueous ***,using the chelating of ferrousions test,the antioxidant activity of the aqueous extract of both stems and leaves was strongerthan that of ethanolic *** chemical composition of the whole plant showed the presence ofsome aromatic compounds and fatty ***:Both ethanolic and water extracts fromboth parts of this plant are effective and have good antioxidant ***,this plant can be usedin the prevention of a number of diseases related to oxidative stress.

关键词： Euphorbia macroclada schyzoceras Total phenolic Total flavonoid Antioxidant potential Chemical composition

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Prevalence and features of colorectal lesions among Hispanics: A hospital-based study

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World Journal of Gastroenterology 2015年第46期21卷 13095-13100页

作者： hassan Ashktorab Adeyinka O Laiyemo Edward Lee Marcia Cruz-Correa Amita Ghuman Mehdi Nouraie hassan Brim Gastroenterology Division and Cancer Center Pathology DepartmentHoward University College of Medicine

AIM: To evaluate the prevalence and characteristics of colorectal adenoma and carcinoma in an inner city Hispanic ***: We reviewed the reports of 1628 Hispanic patients who underwent colonoscopy at Howard University from 2000 to 2010. Advanced adenoma was defined as adenoma ≥ 1 cm in size,adenomas with villous histology,high grade dysplasia and/or invasive cancer. Statistical analysis was performed using χ2 statistics and ***: The median age of the patients was 54 years,64.2% were females. Polyps were observed in 489(30.0%) of patients. Adenoma prevalence was 16.8%(n = 273),advanced adenoma 2.4%(n = 39),and colorectal cancer 0.4%(n = 7). Hyperplastic polyps were seen in 6.6% of the cohort(n = 107). Adenomas predominantly exhibited a proximal colonic distribution(53.7%,n = 144); while hyperplastic polyps were mostly located in the distal colon(70%,n = 75). Among 11.7%(n = 191) patients who underwent screening colonoscopy,the prevalence of colorectal lesions was 21.4% adenoma,2.6% advanced adenoma; and 8.3% hyperplastic ***: Our data showed low colorectal cancer prevalence among Hispanics in the Washington DC area. However,the pre-neoplastic pattern of colonic lesions in Hispanics likely points toward a shift in this population that needs to be monitored closely through large epidemiological studies.

关键词： Colon Rectum Adenoma Carcinoma Hispanics

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Sphingomyelin phosphodiesterase acid like 3B(SMPDL3b)regulates Perilipin5(PLIN5)expression and mediates lipid droplet formation

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Genes & Diseases 2022年第6期9卷 1397-1400页

作者： Shamroop Kumar Mallela Mengyuan Ge Judith Molina Javier Varona Santos Jin-Ju Kim Alla Mitrofanova hassan Al-Ali Brian Marples Sandra Merscher Alessia Fornoni Katz Family Division of Nephrology and Hypertension Department of MedicineUniversity of MiamiMiller School of MedicineMiamiFL 33136USA Peggy and Harold Katz Family Drug Discovery Center University of MiamiMiller School of MedicineMiamiFL 33136USA Department of Radiation Oncology University of RochesterRochesterNY 14627USA

Lipid droplets(LDs)are lipid storage organelles with a central hydrophobic core of neutral lipids that is enclosed in a monolayer of *** the storage of lipids,mainly cholesterol and triglycerides,was thought to be the primary function of LDs,studies have shown that they have important functions in maintaining lipid homeostasis and modulating various signaling *** lipid accumulation has been recognized as a key feature in several human diseases such as obesity,diabetes,cancer,neurological diseases,cardiovascular diseases,insulin resistance,liver diseases and kidney *** play an important role in innate immunity,in the fight against infections,and in the replication of *** a tight regulation of LD metabolism is essential for proper functioning of a cell.

关键词： metabolism immunity Lipid

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Upper Gastrointestinal Endoscopic Outcomes in Patients with Gastrointestinal Symptoms: Retrospective Analysis at a Tertiary Care Hospital

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Open Journal of Gastroenterology 2019年第8期9卷 141-157页

作者： Iftikhar Haider Naqvi Abu Talib Muqadus Tabraze Omer Mustafa Siddiqui Maheen Fatima Hussaini Neha Saleem Paryani Rida Effendi Samrah lnam Siddiqui Syeda Zuhaa hassan Maham Munawar Zaiya Waseem Ameer Ahmed Khan Zafir Zohab Hussain Khan S. Zain Naeem rizvi Sofia Fatima Farooqui Misbah Munaf Hasan Obaid Faryal Khan Dow University of Health Sciences Department of Medicine Karachi Pakistan

Background: Endoscopic procedures are frequently performed to rule out any disease process which eventuates with either a positive or negative outcome. Association of patient demographics, clinical features with endoscopic outcomes are of paramount importance for better understanding and practice of endoscopy. Objectives: This study aimed to determine the frequency of positive endoscopic findings in patients with gastrointestinal symptoms compared to those with negative findings. As a secondary objective, the association between relevant demographics, symptoms, laboratory investigations and procedural outcomes of the participants and positive endoscopic findings were also assessed. Methods: A retrospective analysis of all the patients who underwent esophagogastroduodenoscopy from January 2017 to December 2017 was conducted. A total of 1066 endoscopy records were retrieved and using a convenience sampling technique, relevant data were manually entered to the questionnaires. Records with incomplete or inconsistent data were disregarded as per the exclusion criteria, resulting in 1011 patient records ultimately utilized for the study. All data were entered and analyzed using IBM SPSS 23.0. Results: The study comprised a total of 1011 patients where 52.2% were females and 47.8% males while the mean age of patients was 42.16 ± 15.45. Positive endoscopic findings were observed in 88.1%, where the most common finding was gastritis (49.1%). Approximately 14.5% had positive investigation findings for HBsAg and 23.1% were seropositive for anti-HCV antibody. P-values statistically significant were for age (p = 0.044), hematemesis (p = 0.002), betel quid addiction (p = 0.044), anti-HCV antibody (p = 0.043), HCV-RNA (p = 0.041) and “H. pylori” antigen (p = 0.032). Conclusion: Both genders were almost equally included where most patients presented between the 3rd and 5th decades of life. A high incidence of gastritis was noted. Positive endoscopic findings were associated with be

关键词： Esophagogastroduodenoscopy Endoscopy Gastritis Esophageal Varices

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Effect of Plumeria alba＇s Bioactive Extract against Colletotrichum gleosporoides in Vitro and in Vivo

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Journal of Agricultural Science and Technology(B) 2014年第3期4卷 195-199页

作者： Maryana Mohamad Nor Husna Hawa Mohd. hassan Nik Hairiah Nik Mohamad Ravi Muhammad Nor Omar Department of Biotechnology International Islamic University Malaysia (IIUM) Kuantan 25200 Pahang Malaysia Department of Food Technology Polytechnic of Sultan Haji Ahmad Shah (POLISAS) Kuantan 25352 Pahang Malaysia

Plant species in the genus Plumeria of Apocynaceae family are well known for their uses in traditional medicine antimicrobial activity. Plant materials from P. alba were extracted using Soxhlet apparatus and screened for the control of anthracnose disease caused by Colletotrichum gleosporoides on fruit during post harvest storage. For in vitro, the crude extract of P. alba （stem bark and leaves） were completely inhibited conidial germination （sporulation test method） of Colletotrichum gleosporoides at all concentration tested except the lowest concentration （4.4 ul）. In vivo studies show that percentage of infection on fruit after treated with both stem bark （11.11 ± 3.8） and leaves （15.55 ± 3.8） part, at 32,000 mg/L have no significant differences during seven days of storage at ambient temperatures. These results proved that P. alba extracted （stem bark and leaves） were found to be promising as an antifungal agent and to control anthracnose disease in fruits tested.

关键词： P. alba Colletotrichum gleosporoides post harvest.

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儿童青少年新诊断糖尿病酮症酸中毒临床、遗传学及随访分析

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蚌埠医学院学报 2023年第3期48卷 311-313,318页

作者：赵武马里奥孙琦杭航高科刘义蚌埠医学院第一附属医院儿科安徽蚌埠233004

目的:分析儿童青少年新诊断糖尿病酮症酸中毒(DKA)的临床表现、遗传学及随访结局。方法:回顾分析23例DKA患儿的临床和随访资料,自愿接受基因检查者给予二代测序。结果:男6例,女17例,中位年龄10.1岁。1型糖尿病(T1DM)22例,2型糖尿病(T2D... 详细信息

目的:分析儿童青少年新诊断糖尿病酮症酸中毒(DKA)的临床表现、遗传学及随访结局。方法:回顾分析23例DKA患儿的临床和随访资料,自愿接受基因检查者给予二代测序。结果:男6例,女17例,中位年龄10.1岁。1型糖尿病(T1DM)22例,2型糖尿病(T2DM)1例。烦渴多饮多尿22例,呼吸深长16例,腹痛恶心呕吐12例,发热5例,意识障碍12例,休克15例。中位随机血糖25.0 mmol/L(11.48~34.72 mmol/L),平均糖化血红蛋白13.62%(9.80%~17.40%),C肽降低22例,平均0.18 ng/mL(0.05~0.37 ng/mL),平均静脉pH 7.06(6.80~7.23),糖尿病自身抗体阳性10例。所有患儿给予补液、小剂量胰岛素持续静脉泵入治疗,1例转院,22例抢救成功。DKA纠正后T1DM患儿给予胰岛素治疗,T2DM患儿口服二甲双胍。随访18例,平均随访26.5月(5~57个月),1例T2DM患儿HbA1c 6.8%,17例T1DM患儿平均HbA1c 8.79%(5.5%~14.4%),中位C肽0.09 ng/mL(0.05~0.50 ng/mL),3例T1DM患儿糖尿病自身抗体转阳性。2例T1DM患儿接受二代测序,其中1例PDE11A外显子2存在c.20_21delGA杂合缺失变异,导致阅读框改变,蛋白质截短(***7ThrfsTer30),父亲为野生型,母亲为杂合携带。结论:儿童青少年新诊断DKA多见于T1DM,临床表现多样,HbA1c达标率低,PDE11A基因突变可能与T1DM有关。

关键词：糖尿病酮症酸中毒基因儿童青少年

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