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Decoding molecular mechanisms:brain aging and Alzheimer's disease

Neural Regeneration Research 2025年第8期20卷 2279-2299页

作者： Mahnoor Hayat Rafay ali syed Hammad Qaiser Mohammad Uzair Khalid Al-Regaiey Roaa Khallaf Lubna Abdullah Mohammed Albassam Imdad Kaleem Xueyi Wang Ran Wang Mehwish SBhatti shahid Bashir Atta-ur-Rahman School of Applied Biosciences(ASAB) National University of Sciences and Technology(NUST)IslamabadPakistan Department of Biotechnology Quaid-i-Azam UniversityIslamabadPakistan Department of Biological Sciences Faculty of Basic&Applied SciencesInternational Islamic University Islamabad(IIUI)IslamabadPakistan Department of Bioengineering King Fahd University of Petroleum and MineralsDhahranSaudi Arabia Department of Physiology College of MedicineKing Saud UniversityRiyadhSaudi Arabia Department of Neurology Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Department of Mental Health Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Department of Biosciences Commission on Science and Technology for Sustainable Development in the South(COMSATS University)IslamabadPakistan Department of Psychiatry The First Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Mental Health Institute of Hebei Medical University ShijiazhuangHebei ProvinceChina Department of Neurobiology and Behavior University of CaliforniaIrvineCAUSA Neuroscience Center King Fahad Specialist Hospital DammamDammamSaudi Arabia

The complex morphological,anatomical,physiological,and chemical mechanisms within the aging brain have been the hot topic of research for *** aging process alters the brain structure that affects functions and cognitions,but the worsening of such processes contributes to the pathogenesis of neurodegenerative disorders,such as Alzheimer's *** these observable,mild morphological shifts,significant functional modifications in neurotransmission and neuronal activity critically influence the aging *** these changes is important for maintaining cognitive health,especially given the increasing prevalence of age-related conditions that affect *** review aims to explore the age-induced changes in brain plasticity and molecular processes,differentiating normal aging from the pathogenesis of Alzheimer's disease,thereby providing insights into predicting the risk of dementia,particularly Alzheimer's disease.

关键词： Alzheimer’s disease brain aging cognitive health dementia molecular mechanisms neuronal activity neuroplasticity neurotransmission

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TiC-Maraging stainless steel composite:microstructure, mechanical and wear properties

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Rare Metals 2006年第6期25卷 630-635页

作者： Akhtar Farid Khadijah ali shah syed Javid Askari School of Material Science and Engineering University of Science and Technology Beijing Beijing 100083 China

Particulate TiC reinforced 17-4PH and 465 maraging stainless steel matrix composites were processed by conventional powder metallurgy （P/M）. TiC-maraging stainless steel composites with theoretical density 〉97% were produced using conventional P/M. The microstructure, and mechanical and wear properties of the composites were evaluated. The microstructure of the composites consisted of （core-rim structure） spherical and semi-spherical TiC particles depending on the wettability of the matrix with TiC particles. In TiC-maraging stainless steel composites, 465 stainless steel binder phase showed good wettability with TiC particles. Some microcracks appeared in the composites, indicating the presence of tensile stresses in the composites produced during sintering. The typical properties, hardness, and bend strength were reported for the composites. After heat treatment and aging, an increase in hardness was observed. The increase in hardness was at- tributed to the aging reaction in maraging stainless steel. The specific wear behavior of the composites strongly depends on the content of TiC particles and their interparticle spacing, and on the heat treatment of the maraging stainless steel.

关键词： TiC-maraging stainless steel composites aging wear powder metallurgy microcracks

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Sepsis during short bowel syndrome hospitalizations:Identifying trends,disparities,and clinical outcomes in the United States

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World Journal of Gastrointestinal Pathophysiology 2024年第1期15卷 26-36页

作者： Dushyant Singh Dahiya Jennifer Wachala Shantanu Solanki Dhanshree Solanki Asim Kichloo Samantha Holcomb Uvesh Mansuri Khwaja Saad Haq Hassam ali Manesh Kumar Gangwani Yash R shah Teresa Varghese Hafiz Muzaffar Akbar Khan Simon Peter Horslen Thomas D Schiano syed-Mohammed Jafri Division of Gastroenterology Hepatology&MotilityThe University of Kansas School of MedicineKansas CityKS 66160United States Department of Internal Medicine Samaritan Medical CenterWatertownNY 13601United States Division of Gastroenterology Hepatology&Nutrition The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Medicine Institute for Foreign Medical Graduate EducationHoustonTX 77030United States Department of Internal Medicine MedStar Harbor HospitalBaltimoreMD 21225United States Department of Internal Medicine WellStar Spalding Regional HospitalGriffinGA 30224United States Division of Gastroenterology Hepatology and NutritionEast Carolina University/Brody School of MedicineGreenvilleNC 27858United States Department of Gastroenterology and Hepatology University of Arkansas for Medical SciencesLittle RockAR 72205United States Department of Internal Medicine Trinity Health Oakland/Wayne State UniversityPontiacMI 48341United States Division of Gastroenterology and Hepatology SUNY Upstate Medical UniversitySyracuseNY 13210United States Department of Pediatrics School of Medicine and UPMC Children’s Hospital of PittsburghUniversity of PittsburghPittsburghPA 15219United States Division of Liver Diseases Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Division of Gastroenterology and Hepatology Henry Ford HospitalDetroitMI 48202United States

BACKGROUND Short bowel syndrome(SBS)hospitalizations are often complicated with *** is a significant paucity of data on adult SBS hospitalizations in the United States and across the *** To assess trends and outcomes of SBS hospitalizations complicated by sepsis in the United *** The National Inpatient Sample was utilized to identify all adult SBS hospitalizations between *** study cohort was further divided based on the presence or absence of *** were identified,and hospitalization characteristics and clinical outcomes were *** of mortality for SBS hospitalizations complicated with sepsis were *** Of 247097 SBS hospitalizations,21.7%were complicated by *** SBS hospitalizations had a rising trend of hospitalizations from 20.8%in 2005 to 23.5%in 2014(P trendalizations,septic SBS hospitalizations had a higher proportion of males(32.8%vs 29.3%,Palizations had a higher proportion of patients with intestinal transplantation(0.33%vs 0.22%,Pality(8.5%vs 1.4%,Pality for septic SBS *** Septic SBS hospitalizations had a rising trend between 2005-2014 and were associated with higher inpatient mortality compared to non-septic SBS hospitalizations.

关键词： Short bowel syndrome Sepsis Outcomes Mortality Trends

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An Energy-Efficient 12b 2.56 MS/s SAR ADC Using Successive Scaling of Reference Voltages

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Computers, Materials & Continua 2022年第7期72卷 2127-2139页

作者： Hojin Kang syed Asmat ali shah HyungWon Kim Department of Electronics Engineering College of Electrical and Computer EngineeringChungbuk National UniversityCheongju28644Korea Department of Electrical and Computer Engineering COMSATS University IslamabadAbbottabad CampusAbbottabad22060Pakistan

This paper presents an energy efficient architecture for successive approximation register(SAR)analog to digital converter(ADC).SAR ADCs with a capacitor array structure have been widely used because of its simple architecture and relatively high ***,conventional SAR ADCs consume relatively high energy due to the large number of capacitors used in the capacitor array and their sizes scaled up along with the number of *** proposed architecture reduces the energy consumption as well as the capacitor size by employing a new array architecture that scales down the reference voltages instead of scaling up the capacitor *** proposed 12-bit SAR ADC is implemented in Complementary Metal Oxide Semiconductor(CMOS)0.13 um library using Cadence Virtuoso design *** results and mathematical model demonstrate the overall energy savings of up to 97.3%compared with conventional SAR ADC,67%compared with the SAR ADC with split capacitor,and 35%compared with the resistor and capacitor(R&C)Hybrid SAR *** ADC achieves an effective number of bits(ENOB)of 11.27 bits and consumes 61.7 uW at sampling rate of 2.56 MS/s,offering an energy consumption of 9.8 fJ per conversion *** proposed SAR ADC offers 95.5%reduction in chip core area compared to conventional architecture,while occupying an active area of 0.088 mm2.

关键词： Low voltage low power successive approximation register analog to digital converter switching energy

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Fractional Analysis of Thin Film Flow of Non-Newtonian Fluid

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Computer Modeling in Engineering & Sciences 2020年第9期124卷 825-845页

作者： Farnaz Ismail Mubashir Qayyum syed Inayat ali shah Department of Mathematics Islamia College UniversityPeshawarPakistan Department of Sciences and Humanities National University of Computer&Emerging Sciences FASTLahorePakistan

Modeling and analysis of thin film flow with respect to magneto hydro dynamical effect has been an important theme in the field of fluid dynamics,due to its vast industrial *** analysis involves studying the behavior and response of governing equations on the basis of various parameters such as thickness of the film,film surface profile,shear stress,liquid velocity,volumetric flux,vorticity,gravity,viscosity among others,along with different boundary *** this article,we extend this analysis in fractional space using a homotopy based scheme,considering the case of a Non-Newtonian Pseudo-Plastic fluid for lifting and drainage on a vertical *** applying similarity transformations,the given problems are reduced to highly non-linear and inhomogeneous ordinary differential ***,fractional differential equations are obtained using basic definitions of fractional *** Homotopy Perturbation Method(HPM),along with fractional calculus is used for obtaining approximate *** quantities such as the velocity profile,volume flux and average velocity respectively for lift and drainage cases have been *** the best of our knowledge,the given problems have not been attempted before in fractional *** and convergence of the obtained solutions are confirmed by finding residual *** a physical perspective,a comprehensive study of the effects of various parameters on the velocity profile is also *** reveals that Stokes number St,non-Newtonian parameterand magnetic parameter M have inverse relationship with fluid velocity in lifting *** the drainage case,Stokes number St and non-Newtonian parameterhave direct relationship with fluid velocity,but magnetic parameter M shows inverse relationship with *** investigation also shows that the fractional parameterhas direct relationship with the fluid velocity in lifting case,while it has inverse relationship with velocity in the

关键词： Pseudo-plastic fluid magneto hydro dynamic fractional differential equation homotopy perturbation method

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RBF Based Localized Method for Solving Nonlinear Partial Integro-Differential Equations

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Computer Modeling in Engineering & Sciences 2020年第6期123卷 957-972页

作者： Marjan Uddin Najeeb Ullah syed Inayat ali shah University of Engineering and Technology PeshawarPakistan Islamia College University PeshawarPakistan

In this work,a numerical scheme is constructed for solving nonlinear parabolictype partial-integro differential *** proposed numerical scheme is based on radial basis functions which are local in nature like finite difference numerical *** radial basis functions are used to approximate the derivatives involved and the integral is approximated by equal width integration *** resultant differentiation matrices are sparse in *** spatial approximation using RBF the partial integro-differential equations reduce to the system of *** ODEs system can be solved by various types of ODE *** proposed numerical scheme is tested and compared with other methods available in literature for different test *** stability and convergence of the present numerical scheme are discussed.

关键词： RBFs integral equations local method

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Unraveling the therapeutic mechanisms of myristic acid and luteolin 7-rutinoside in oral cancer: insights from network pharmacology and molecular docking analysis

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Pharmacology Discovery 2024年第2期4卷 1-9页

作者： Ansari Vikhar Danish Ahmad Misba Ruhi syed Ayaz ali Qazi Yasar Mohd.Mukhtar Khan Subur W Khan Mohammed Imran Anees Y.B.Chavan College of Pharmacy Dr.Babasaheb Ambedkar Marathwada UniversityAurangabad 431001India Maulana Azad College Dr.Babasaheb Ambedkar Marathwada UniversityAurangabad 431001India

Background:The compound Luteolin-7-rutinoside(L7R)is a flavone derivative of luteolin,predominantly identified in plant species belonging to the families ***,Myristic acid is characterized by its structure as a 14-carbon,unsaturated fatty *** this investigation,we endeavor to elucidate the putative mechanisms underlying the therapeutic effects of Myristic Acid and Luteolin 7-rutinoside in the context of oral cancer treatment,employing network pharmacology coupled with molecular docking ***:The protein targets of Myristic Acid and Luteolin 7-rutinoside were identified through a search on the Swiss Target ***,a compound-target network was constructed using Cytoscape *** associated with OC were retrieved from the OMIM and GeneCards *** overlap between compound targets and OC-related targets was determined,and the resulting shared targets were subjected to protein-protein interaction(PPI)network analysis using the STRING ***,gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses were conducted on the identified *** docking were performed to investigate the interactions between the core target and the active ***:The component target network comprises 103 nodes and 102 *** the proteins in the protein-protein interaction(PPI)network,those with higher degrees are TNF,PPARG,and *** through Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathways indicates that the treatment of OC with Myristic Acid and Luteolin 7-rutinoside primarily involves the regulation of miRNA transcription and inflammatory *** identified signaling pathways include Pathways in cancer,PPAR signaling pathway,EGFR signaling pathway,and TNF signaling *** docking studies reveal that Luteolin 7-rutinoside and Myristic acid exhibit higher affinity towards TNF,PPARG,TP53,and ***:This study

关键词： myristic acid luteolin 7-rutinoside network pharmacology oral cancer molecular docking

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Recent advances and emerging trends of rare-earth-ion doped spectral conversion nanomaterials in perovskite solar cells

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Journal of Rare Earths 2022年第11期40卷 1651-1667,I0001页

作者： syed Afaq ali shah Muhammad Hassan Sayyad Jinghua Sun Zhongyi Guo School of Electrical Engineering&Intelligentization Dongguan University of TechnologyDongguan 523808China Advanced Photovoltaic Research Labs(APRL) Faculty of Engineering SciencesGhulam Ishaq Khan Institute of Engineering Sciences and TechnologyTopiDistrictSwabiKhyberPakhtunkhwa23640Pakistan School of Computer and Information Hefei University of TechnologyHefei 2300o9China

Organic-inorganic lead halide based perovskite solar cells(PSCs)have attracted unprecedented research interest over last *** high performance,combined with merits of low fabrication costs and ease of synthesis make PSCs promising alternate to state of the art silicon(Si)based solar *** r,some inherent shortcomings of PSCs are hindering their market dominance over conventional photovoltaic technologies such as transmission loss of sub-bandgap photons,poor stability and hysteresis ***,use of rare earth(RE)ions doped nanomaterials in PSCs,has been identified as an effective means to address the aforementioned issues by expanding the range of absorption spectra minimizing the non-absorption loss of solar photons,enhancing light scattering and improving operational *** article reviews the recent progress in doping rare-earth(RE)ions in the building blocks of PSCs such as semiconductor electrodes and photoactive perovskite layers,and its use as a separate spectral conversion layer in *** effect of size,shape,constitution and concentration of RE-nanoparticles on the overall performance and device stability will be analyzed in ***,we provide an outlook on the opportunities this newly developed field offers and the critical challenges faced in rationally and effectively using RE-ion-doped nanomaterials in PSCs for better operational stability and enhanced performance.

关键词： Efficiency Electron transport layer Photovoltaics Rare-earth(RE) Perovskite solar cells Up/down conversion

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Machine learning empowered COVID-19 patient monitoring using non-contact sensing:An extensive review

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Journal of Pharmaceutical Analysis 2022年第2期12卷 193-204页

作者： Umer Saeed syed Yaseen shah Jawad Ahmad Muhammad ali Imran Qammer H.Abbasi syed Aziz shah Research Centre for Intelligent Healthcare Coventry UniversityCoventryCV15FBUK School of Computing Engineering and Built EnvironmentGlasgow Caledonian UniversityGlasgowG40BAUK School of Computing Edinburgh Napier UniversityEdinburghEH114BNUK James Watt School of Engineering University of GlasgowGlasgowG128QQUK

The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which caused the coronavirus disease 2019(COVID-19)pandemic,has affected more than 400 million people *** the recent rise of new Delta and Omicron variants,the efficacy of the vaccines has become an important *** goal of various studies has been to limit the spread of the virus by utilizing wireless sensing technologies to prevent human-to-human interactions,particularly for healthcare *** this paper,we discuss the current literature on invasive/contact and non-invasive/noncontact technologies(including Wi-Fi,radar,and software-defined radio)that have been effectively used to detect,diagnose,and monitor human activities and COVID-19 related symptoms,such as irregular *** addition,we focused on cutting-edge machine learning algorithms(such as generative adversarial networks,random forest,multilayer perceptron,support vector machine,extremely randomized trees,and k-nearest neighbors)and their essential role in intelligent healthcare ***,this study highlights the limitations related to non-invasive techniques and prospective research directions.

关键词： Artificial intelligence Non-invasive healthcare Machine learning Non-contact sensing COVID-19

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Fractional Processing Based Adaptive Beamforming Algorithm

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Computers, Materials & Continua 2023年第7期76卷 1065-1084页

作者： syed Asghar ali shah Tariqullah Jan syed Muslim shah Ruhul Amin Khalil Ahmad Sawalmeh Muhammad Anan Department of Electrical Engineering University of Engineering and TechnologyPeshawar25120Pakistan Department of Electrical Engineering Capital University of Science and TechnologyIslamabad44000Pakistan Department of Computer Science Northern Border UniversityArar91431Saudi Arabia Department of Software Engineering Alfaisal UniversityRiyadh11533Saudi Arabia

Fractional order algorithms have shown promising results in various signal processing applications due to their ability to improve performance without significantly increasing *** goal of this work is to inves-tigate the use of fractional order algorithm in the field of adaptive beam-forming,with a focus on improving performance while keeping complexity *** effectiveness of the algorithm will be studied and evaluated in this *** this paper,a fractional order least mean square(FLMS)algorithm is proposed for adaptive beamforming in wireless applications for effective utilization of *** algorithm aims to improve upon existing beam-forming algorithms,which are inefficient in performance,by offering faster convergence,better accuracy,and comparable computational *** FLMS algorithm uses fractional order gradient in addition to the standard ordered gradient in weight *** derivation of the algorithm is provided and supported by mathematical convergence *** is evaluated through simulations using mean square error(MSE)minimization as a metric and compared with the standard LMS algorithm for various *** results,obtained through Matlab simulations,show that the FLMS algorithm outperforms the standard LMS in terms of convergence speed,beampattern accuracy and scatter *** outperforms LMS in terms of convergence speed by 34%.From this,it can be concluded that FLMS is a better candidate for adaptive beamforming and other signal processing applications.

关键词： Adaptive beamforming adaptive array fractional processing least mean square fractional least mean square

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