检索结果-南通市图书馆

Biogenic Amines as Biomarkers for Neurotoxicity

Biomedical and Environmental Sciences 1991年第Z1期 207-216页

作者： syed f.ali,louis w.chang,william slikker,jr Division of Reproductive and Developmental Toxicology National Center for Toxicological Research Jefferson Department of Pharmacology and Toxicology Department of Biochemistry and Molecular Biology Division of Reproductive and Developmental Toxicology National Center for Toxicological Research Jefferson Division of Reproductive and Developmental Toxicology National Center for Toxicological Research Jefferson Arkansas 72079-9502 Department of Pharmacology and Toxicology Department of Biochemistry and Molecular Biology Department of Pharmacology University of Arkansas for Medical Sciences Little Rock Arkansas 72205 Arkansas 72079-9502 Department of Pharmacology and Toxicology Department of Pediatrics Universtiy of Arkansas for Medical Sciences and Arkansas Children's Hospital Little Rock Arkansas 72205 Arkansas 72079-9502 Department of Pharmacology and Toxicology Department of Pediatrics Universtiy of Arkansas for Medical Sciences and Arkansas Children's Hospital Little Rock Arkansas 72205

There has been a surge of interest over the past several years in the use of neurochemical endpoints to contribute to our understanding of the mechanism of action of neurotoxicants. In our present presentation, two biogenic amine systems were selected as examples of biomarkers for neurotoxicity. To investigate these neurochemical endpoints, two prototype neurotoxicants were evaluated in experimental animals. One agent, reserpine, was used to assess developmental neurotoxicity and administered prenatally, while the other, MDMA, was used in the adult animal. The neurochemical biomarkers measured were dopamine, serotonin, and their metabolite (DOPAC and 5-HIAA) concentrations by HPLC/EC and dopamine receptor binding by radioligand receptor techniques. A review of the background, experimental design, and results are presented in this article. Our findings indicate that components of the biogenic amine systems can be used as sensitive neurochemical biomarkers of neurotoxicity. These neurochemical biomarkers

关键词： MDMA Biogenic Amines as Biomarkers for Neurotoxicity oral DOPAC

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Biogenic Amines as Biomarkers for Neurotoxicity

引用

Biomedical and Environmental Sciences 1991年第1期4卷 207-216页

作者： syed f.ali louis w.chang william slikker jr Division of Reproductive and Developmental Toxicology National Center for Toxicological Research JeffersonDepartment of Pharmacology and Toxicology Department of Biochemistry and Molecular BiologyDivision of Reproductive and Developmental Toxicology National Center for Toxicological Research JeffersonDivision of Reproductive and Developmental Toxicology National Center for Toxicological Research Jefferson Arkansas 72079-9502 Department of Pharmacology and Toxicology Department of Biochemistry and Molecular BiologyDepartment of Pharmacology University of Arkansas for Medical Sciences Little Rock Arkansas 72205Arkansas 72079-9502 Department of Pharmacology and Toxicology Department of Pediatrics Universtiy of Arkansas for Medical Sciences and Arkansas Children's Hospital Little Rock Arkansas 72205 Arkansas 72079-9502 Department of Pharmacology and Toxicology Department of Pediatrics Universtiy of Arkansas for Medical Sciences and Arkansas Children's Hospital Little Rock Arkansas 72205

关键词： MDMA Biogenic Amines as Biomarkers for Neurotoxicity oral DOPAC

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Meta-Learning Approach for Aircraft Trajectory Prediction

引用

Communications and Network 2023年第2期15卷 43-64页

作者： syed Ibtehaj Raza Rizvi Jamal Habibi Markani René jr. Landry É cole de technologies supérieure (&#201TS) Montréal Canada

The aviation industry has seen significant advancements in safety procedures over the past few decades, resulting in a steady decline in aviation deaths worldwide. However, the safety standards in General Aviation (GA) are still lower compared to those in commercial aviation. with the anticipated growth in air travel, there is an imminent need to improve operational safety in GA. One way to improve aircraft and operational safety is through trajectory prediction. Trajectory prediction plays a key role in optimizing air traffic control and improving overall flight safety. This paper proposes a meta-learning approach to predict short- to mid-term trajectories of aircraft using historical real flight data collected from multiple GA aircraft. The proposed solution brings together multiple models to improve prediction accuracy. In this paper, we are combining two models, Random forest Regression (RfR) and Long Short-term Memory (LSTM), using k-Nearest Neighbors (k-NN), to output the final prediction based on the combined output of the individual models. This approach gives our model an edge over single-model predictions. we present the results of our meta-learner and evaluate its performance against individual models using the Mean Absolute Error (MAE), Absolute Altitude Error (AAE), and Root Mean Squared Error (RMSE) evaluation metrics. The proposed methodology for aircraft trajectory forecasting is discussed in detail, accompanied by a literature review and an overview of the data preprocessing techniques used. The results demonstrate that the proposed meta-learner outperforms individual models in terms of accuracy, providing a more robust and proactive approach to improve operational safety in GA.

关键词： Trajectory Prediction General Aviation Safety Meta-Learning Random forest Regression Long Short-Term Memory Short to Mid-Term Trajectory Prediction Operational Safety

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Near-infrared electroluminescence of AlGaN capped InGaN quantum dots formed by controlled growth on photoelectrochemical etched quantum dot templates

引用

Photonics Research 2022年第1期10卷 33-40页

作者： XIONGLIANG wEI syed AHMED AL MUYEED HAOTIAN XUE ELIA PALMESE RENBO SONG NELSON TANSU JONATHAN J.wIERER,jr. Center for Photonics and Nanoelectronics Department of Electrical and Computer EngineeringLehigh UniversityBethlehemPennsylvania 18015USA School of Electrical and Electronic Engineering The University of AdelaideAdelaideSA 5005Australia Institute for Photonics and Advanced Sensing The University of AdelaideAdelaideSA 5005Australia

Near-infrared electroluminescence of InGaN quantum dots(QDs)formed by controlled growth on photoelectrochemical(PEC)etched QD templates is *** QD template consists of PEC InGaN QDs with high density and controlled sizes,an AlGaN capping layer to protect the QDs,and a GaN barrier layer to planarize the *** transmission electron microscopy(STEM)of Stranski-Krastanov(SK)growth on the QD template shows high-In-content InGaN QDs that align vertically to the PEC QDs due to localized strain.A highAl-content A1_(0.9)Ga_(0.1)N capping layer prevents the collapse of the SK QDs due to intermixing or decomposition during higher temperature GaN growth as verified by *** of low-temperature(830℃)p-type layers is used to complete the p-n junction and further ensure QD ***,electroluminescence shows a significant wavelength shift(800 nm to 500 nm),caused by the SK QDs’tall height,high In content,and strong polarization-induced electric fields.

关键词： AlGaN polarization template

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

ADS-B Reception Error Correction Based on the LSTM Neural-Network Model

引用

Communications and Network 2023年第2期15卷 25-42页

作者： Jamal Habibi Markani syed Ibtehaj Raza Rizvi Abdessamad Amrhar Jean-Marc Gagné René jr. Landry Lassena Laboratory Department of Electrical Engineering école de Technologie Supérieure (éTS) Montreal Canada

Standard automatic dependent surveillance broadcast (ADS-B) reception algorithms offer considerable performance at high signal-to-noise ratios (SNRs). However, the performance of ADS-B algorithms in applications can be problematic at low SNRs and in high interference situations, as detecting and decoding techniques may not perform correctly in such circumstances. In addition, conventional error correction algorithms have limitations in their ability to correct errors in ADS-B messages, as the bit and confidence values may be declared inaccurately in the event of low SNRs and high interference. The principal goal of this paper is to deploy a Long Short-Term Memory (LSTM) recurrent neural network model for error correction in conjunction with a conventional algorithm. The data of various flights are collected and cleaned in an initial stage. The clean data is divided randomly into training and test sets. Next, the LSTM model is trained based on the training dataset, and then the model is evaluated based on the test dataset. The proposed model not only improves the ADS-B In packet error correction rate (PECR), but it also enhances the ADS-B In terms of sensitivity. The performance evaluation results reveal that the proposed scheme is achievable and efficient for the avionics industry. It is worth noting that the proposed algorithm is not dependent on conventional algorithms’ prerequisites.

关键词： ADS-B Long Short-Term Memory Packet Error Correction Rate Error Correction Bit Error Rate

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clinical,pathological,and adjuvant chemotherapy use differences among microsatellite unstable and microsatellite stable colon cancers

引用

Journal of the National Cancer Center 2024年第2期4卷 169-175页

作者： Baqir Hasan Jafry Munir Hassan Buhaya Allante Milsap Amy Little Jones Suleyman Yasin Goksu Nilesh Verma Timothy JBrown Amy Hughes Rasmi Nair Nina Sanford Joseph Su Emina Huang syed Mohammad ali Kazmi Department of Hematology and Oncology University of Texas Southwestern Medical CenterDallasUSA Department of Surgery University of Texas Southwestern Medical CenterDallasUSA west Suburban Medical University ChicagoUSA Peter O’Donnell jr.School of Public Health University of Texas Southwestern Medical CenterDallasUSA Department of Radiation Oncology University of Texas Southwestern Medical CenterDallasUSA

Background:Colon cancers are categorized into mismatch repair deficient/microsatellite unstable(MSI-H)and mismatch repair proficient/microsatellite stable(MSS)*** study aims to compare the disease char-acteristics and trends in the utilization of cancer therapies across different age groups and stages in these two ***:MSI-H and MSS colon adenocarcinomas from 2010 to 2016 were identified using the National Can-cer *** compared patient and disease characteristics between the two groups and evaluated the use of adjuvant chemotherapy across age groups and cancer *** MSI-H and MSS groups,we conducted a land-mark analysis after propensity score matching for adjuvant chemotherapy versus no chemotherapy to determine its effect on ***:Of the 542,368 patients that met inclusion criteria,120,751(22%)had mismatch repair results avail-able-out of these 96,928(80%)had MSS colon cancers while 23,823(19.7%)had MSI-H ***-H disease had a bimodal age distribution(was frequent among females(22%)and non-Hispanic whites(20%).Among thosef low-risk stage 2 MSI-H patients and 40%of high-risk stage 2 MSI-H patients received adjuvant *** than two-thirds of stage 3 patientsfor age,gender,and co-morbidities,we found that adjuvant chemotherapy use had a trend towards lower overall survival(OS)in low-risk stage 2 MSI-H(HR=1.8[95%CI,0.8-4.02])and high-risk stage 2 MSI-H(HR=1.42[95%CI,0.96-2.12])*** chemotherapy significantly improved OS in stage 3 colon cancer patients irrespective of microsatellite status or risk category of ***:MSI-H colon cancer had bimodal age *** stage 2 MSI-H patientswas associated with lower survival wh

关键词： Adjuvant chemotherapy MSI-H MSS NCDB Overall survival

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：