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Shifting balance from neurodegeneration to regeneration of the brain: a novel therapeutic approach to Alzheimer's disease and related neurodegenerative conditions

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Neural Regeneration Research 2014年第16期9卷 1518-1519页

作者： Khalid Iqbal syed faraz kazim Silvia Bolognin Julie Blanchard Department of Neurochemistry Inge Grundke-Iqbal Research Floor New York State Institute for Basic Research in Developmental DisabilitiesStaten Island NY USA

Neurodegeneration is one of the biggest public health problems in modern society. Age-associated neurodegeneration, which is accelerated several-fold in Alzheimer＇s disease （AD） alone, is not only an enormous social and economic burden to the affected in- dividuals and their families, but is also a great scientific challenge. Currently 25-35 million people worldwide suffer from AD, the single largest cause of dementia in middle- to old-aged individuals. These numbers are projected to triple by 2050 if no treatment to prevent or reverse AD is developed.

关键词： a novel therapeutic approach to Alzheimer’s disease and related neurodegenerative conditions Shifting balance from neurodegeneration to regeneration of the brain AD

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槟榔子中抗血小板聚集及抑制乙酰胆碱酯酶活性的有效成分(英文)

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中西医结合学报 2011年第6期9卷 619-625页

作者： Muhammad Nabeel Ghayur syed faraz kazim Huma Rasheed Asaad Khalid Maliha Iqbal Jumani Muhammad Iqbal Choudhary Anwarul Hassan Gilani Department of Biological and Biomedical Sciences Aga Khan UniversityKarachiPakistan Department of Medicine St.Joseph's Healthcare HamiltonMcMaster UniversityHamiltonCanada Dr.Panjwani Center for Molecular Medicine and Drug Research University of KarachiKarachiPakistan Medicinal and Aromatic Plants Research Institute National Center for ResearchKhartoumSudan

目的:研究槟榔子(Areca catechu)粗提取物中所含的抗血小板聚集及抑制乙酰胆碱酯酶活性的有效成分及其作用机制。方法:使用70%甲醇水溶液对槟榔子进行粗提取。使用生物发光血小板凝集仪在富血小板血浆中测定槟榔子粗提取物的抗血小板聚... 详细信息

目的:研究槟榔子(Areca catechu)粗提取物中所含的抗血小板聚集及抑制乙酰胆碱酯酶活性的有效成分及其作用机制。方法:使用70%甲醇水溶液对槟榔子进行粗提取。使用生物发光血小板凝集仪在富血小板血浆中测定槟榔子粗提取物的抗血小板聚集作用,使用分光光度计在试管内测定槟榔子粗提取物对乙酰胆碱酯酶活性的抑制作用。检测槟榔子中的多种化合物以测定槟榔子中抗血小板聚集及抑制乙酰胆碱酯酶活性的有效成分。结果:槟榔子粗提取物能够抑制花生四烯酸、二磷酸腺苷、血小板活化因子、肾上腺素及钙离子载体引起的血小板聚集,尤其对二磷酸腺苷及钙离子载体引起的血小板聚集的抑制最为明显;槟榔子粗提取物能够显著抑制乙酰胆碱酯酶的活性。在所检测的槟榔子所含化合物中,只有儿茶素对肾上腺素引起的血小板聚集有显著的抑制作用,而这种抑制作用显著弱于槟榔子粗提取物,提示槟榔子中的其他成分参与了这种抑制作用;鞣酸、没食子酸、薯蓣皂苷元和异去甲槟榔次碱能够抑制乙酰胆碱酯酶的活性,其中鞣酸的抑制作用强于槟榔子粗提取物。结论:槟榔子中含有抗血小板聚集及抑制乙酰胆碱酯酶活性的有效成分,而发挥这些功效的确切成分有待进一步的研究证实。

关键词：槟榔植物提取物血小板聚集抑制剂胆碱酯酶抑制剂儿茶素鞣酸

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Hypothyroidism—A Question towards Quality and Patient Centricity

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Open Journal of Endocrine and Metabolic Diseases 2015年第2期5卷 19-27页

作者： Hina Rehman syed Junaid Rehan Humera Ishaq Sadia Shakeel faraz Hashmi Safila Naveed Faculty of Pharmacy Jinnah University for Women Karachi Pakistan Faculty of Pharmacy Hamdard University Karachi Pakistan Jinnah Sindh Medical University Karachi Pakistan

The metabolic and endocrine disorders are either increasing across the globe or may have been observed with more focus in recent years. It is not uncommon now to find out neither patients of endocrine and metabolic disorders nor a physician of the associated diseases. There were 42 million people who had thyroid disorders including hypothyroidism according to the survey of endocrine society of India. Hypothyroidism is said when less activity of thyroid glands is observed then the normal. So, to evaluate the quality standard, empowerment and patient centricity in Pakistan with present prevalence of hypothyroidism in different age groups, gender along with the prescribed medication against pre diagnosed disease and associated co-morbidities, the study is designed with a questionnaire development including both qualitative and quantitative variables. Study was conducted on various OPD’s, profit and not for profit secondary and tertiary care hospitals and consultant clinics during July 2013 to Jan 2014 and it was given consideration to include people from all areas of life with minimization of any unforeseen biasness and comprehensive data. After full filling the inclusion criteria, 102 patients were selected as study participants. After completion and reviewing the questionnaire, data were analyzed by 21.00 SPSS version. Chi square/ fisher test, spearmen’s rank correlation were applied for categorical quantitative variable. Paired t test before and after were applied for qualitative variable. Highly significant reliability of items in the questionnaire was found along with inter item correlation (P < 0.05). Out of 102 patients of the study, 80 patients fell into the inclusion criteria, while 22 were excluded. A total of 80 patients were registered in the incorporate duration. Among the total samples 36 (42.9%) were males and 44 (52.4%) were females. Mean age males and females included in the study were 34.89 ± 17.73 and 33.36 ± 13.73 years respectively. The systolic an

关键词： Hypothyroidism Quality Patient Centricity Empowerment

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Performance, Immune, and Carcass Characteristics of Broiler Chickens as Affected by Thyme and Licorice or Enzyme Supplemented Diets

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Open Journal of Animal Sciences 2017年第2期7卷 105-109页

作者： Majid Kalantar Seyed Mahdi Hosseini Liguo Yang Sayed Haider Abbas Raza Linsheng Gui Mostafa Rezaie Mahdi Khojastekey Dawei Wei Rajwali Khan Sulthattin Yasar Shahid faraz syed Allah Bux Kachiwal Mohamed Elkhairey Qijing Lei Rameez Raja Kaleri Ayman Hassan Abd El-Aziz Animal Science Department Agricultural Research Center of Qom Qom Iran The Key Lab of Agricultural Animal Genetics Breeding and Reproduction of the Ministry of Education College of Animal Science and Technology Huazhong Agricultural University Wuhan China College of Animal Science and Technology Northwest A&F University Yangling China Department of Animal Science Saveh Branch Islamic Azad University of Saveh Saveh Iran College of Animal Science Süleyman Demirel University Isparta Turkey College of Veterinary Medicine Northwest A&F University Yangling China Faculty of Animal Husbandry & Veterinary Sciences Sindh Agriculture University Tandojam Pakistan Faculty of Veterinary Medicine Damanhour University Damanhūr Egypt

Numbers of 300 day-old broiler chickens through a CRD design with 5 treatments, 3 replicates and 20 chicks in each pen were used to evaluate the effect of thyme (T), licorice (L), thyme + licorice (TL), and enzyme supplemented (E) diets on performance, immune and carcass characteristics. According to the results, performance traits, immune indices, and carcass traits in herbal medicine and enzyme supplemented diets were improved significantly than control diet (P < 0.05). Weight gain and FCR in T and E groups were significantly higher and lower than other groups respectively (P < 0.05). Internal organs such as abdominal fat and liver weight as indicators of lipogenesis rate were decreased in T, L, and TL diets than control or E diet significantly (P < 0.05). Immune organs such as burse and spleen weight as indicators of immune situation were increased in TL diet than other treatments significantly (P < 0.05). These findings indicated that thyme and licorice singly or in combination as organic herbal medicine can affect performance, carcass and immune characteristics. Also an improved immune organ such as burse or spleen in this study indicates that this herbal medicine can promote the immune situation and efficacy of health and livability.

关键词： Broiler Enzyme Licorice Thyme

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