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Physico-Chemical and Microbiological Study for the Stability of Phenytoin Sodium Extemporaneously Compounded Suspension in Saudi Arabia Hospitals

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Pharmacology & Pharmacy 2021年第1期12卷 1-9页

作者： syed ata ur rahman Abdullah Alsaedi Abdulelah Alhusayni Abdulmalik Alqurshi Sameh Ahmed Yaser M. Alahmadi Alaa Omer M. Abdullaal Badr Ahmed A. Taher El-Sayed E. Habib Department of Pharmaceutics and Pharmaceutical Technology College of Pharmacy Taibah University Madinah Munawwarah Kingdom of Saudi Arabia Department of Pharmacy College of Health Sciences and Nursing AlRayan College Madinah Munawwarah Kingdom of Saudi Arabia Department of Pharmacognosy and Pharmaceutical Chemistry College of Pharmacy Taibah University Madinah Munawwarah Kingdom of Saudi Arabia Department of Clinical and Hospital Pharmacy College of Pharmacy Taibah University Madinah Munawwarah Kingdom of Saudi Arabia Pharmacy Department Madinah Maternity and Children Hospital Madinah Munawwarah Kingdom of Saudi Arabia Department of Microbiology and Immunology Faculty of Pharmacy Mansoura University Mansoura Egypt

Epilepsy is a chronic and the fourth most common neurological disorder which affects people of all age groups. Recently research and awareness on epilepsy-related deaths have rapidly grown over the past two decades. Many previous studies are attributed to the guidelines that apprise health care professionals in handling these deaths, but there is a relative scarcity of information accessible for clinicians and pharmacists who are responsible for manufacturing or preparing the extemporaneous anti-epileptic suspensions in the hospitals. Mostly in partial seizures, phenytoin is one of the first-choice drugs. In Saudi Arabian hospitals, the extemporaneous preparation of phenytoin suspension is common, but the hot climatic weather in Saudi Arabia possesses stability problems that should be tackled as the prepared suspension should pass all the stability tests to ensure uniform dosage of the extemporaneous formulation. In the current study, the commercial capsules were used to prepare the oral phenytoin sodium extemporaneous suspension. The physical, chemical and microbiological stability of phenytoin sodium suspension is analyzed at various temperatures.

关键词： Physical Stability Phenytoin Extemporaneous Preparation Chemical Stability Epilepsy

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Comprehensive analysis of the role of ubiquitin-specific peptidases in colorectal cancer:A systematic review

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 197-213页

作者： Eman Al-Balushi Amina Al Marzouqi Shima Tavoosi Amir Hossein Baghsheikhi Arash Sadri Leyla Sharifi Aliabadi Mohammad-Mahdi Salarabedi syed Azizur rahman Nabeel Al-Yateem Alireza Mosavi Jarrahi Aram Halimi Mohammad Ahmadvand Wael M Abdel-rahman College of Health Sciences University of SharjahSharjah 27272United Arab Emirates Department of Biology Faculty of SciencesUniversity of IsfahanIsfahan 81746-73441Iran Department of Biology Science and Research BranchIslamic Azad UniversityTehran 11365/4435Iran Students’Scientific Research Center Tehran University of Medical SciencesTehran ***Iran Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center Research Institute for OncologyHematologyand Cell TherapyTehran University of Medical SciencesTehran ***Iran Student Research Committee School of MedicineShahid Beheshti University of Medical SciencesTehran ***Iran Department of Nursing University of SharjahSharjah 27272United Arab Emirates Cancer Research Centre Shahid Beheshti University of Medical SciencesTehran ***Iran Department of Medical Laboratory Sciences University of SharjahSharjah 27272United Arab Emirates

BACKGROUND Colorectal cancer(CRC)is the third most frequent and the second most fatal *** search for more effective drugs to treat this disease is ongoing.A better understanding of the mechanisms of CRC development and progression may reveal new therapeutic ***-specific peptidases(USPs),the largest group of the deubiquitinase protein family,have long been implicated in various *** have been numerous studies on the role of USPs in CRC;however,a comprehensive view of this role is *** To provide a systematic review of the studies investigating the roles and functions of USPs in *** We systematically queried the MEDLINE(via PubMed),Scopus,and Web of Science *** Our study highlights the pivotal role of various USPs in several processes implicated in CRC:Regulation of the cell cycle,apoptosis,cancer stemness,epithelial–mesenchymal transition,metastasis,DNA repair,and drug *** findings of this study suggest that USPs have great potential as drug targets and noninvasive biomarkers in *** dysregulation of USPs in CRC contributes to drug resistance through multiple *** Targeting specific USPs involved in drug resistance pathways could provide a novel therapeutic strategy for overcoming resistance to current treatment regimens in CRC.

关键词： Ubiquitin-specific peptidases Colorectal cancer Deubiquitinase protein family Drug target discovery Biomarker discovery

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Experimental investigation of multiphase flow behavior in drilling annuli using high speed visualization technique

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Frontiers in Energy 2020年第3期14卷 635-643页

作者： Alap Ali ZAHID syed Raza ur REHMAN S.RUSHD Anwarul HASAN Mohammad Azizur rahman Department of Mechanical Engineering College of EngineeringQatar UniversityDoha 2713Qatar Petroleum Engineering Program Texas A&M University at QatarDoha 23874Qatar

Imaging with high definition video camera is an important technique to visualize the drilling conditions and to study the physics of complex multiphase flow associated with the hole cleaning *** main advantage of visualizing multiphase flow in a drilling annulus is that the viewer can easily distinguish fluid phases,flow patterns and thicknesses of cutting *** this paper the hole cleaning process which involves the transportation of cuttings through a horizontal annulus was *** two-phase(solid-liquid)and the three-phase(solid-liquid-gas)flow conditions involved in this kind of annular transportation were experimentally simulated and images were taken using a high definition *** the captured images,a number of important parameters like velocities of different phases,heights of solid beds and sizes of gas bubbles were *** different techniques based on an image analysis software and MATLAB coding were used for the *** results were compared to validate the image analyzing *** visualization technique developed in this paper has a direct application in investigating the critical conditions required for efficient hole cleaning as well as in optimizing the mud program during both planning and operational phases of ***,it would be useful in predicting the cuttings transport performance,estimating solid bed height,gas bubble size,and mean velocities of bubbles/particles.

关键词： visualization horizontal annulus hole cleaning multiphase flow image analysis flow regime

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Effective Video Summarization Approach Based on Visual Attention

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Computers, Materials & Continua 2022年第4期71卷 1427-1442页

作者： Hilal Ahmad Habib Ullah Khan Sikandar Ali syed Ijaz ur rahman Fazli Wahid Hizbullah Khattak Department of Computer Sciences Islamia College Peshawar KhyberPakhtunkhwaPakistan Department of Accounting and Information Systems College of Business and EconomicsQatar UniversityDoha2713Qatar Department of Information Technology The University of HaripurKhyber PakhtunkhwaPakistan Department of Information Technology Hazara University MansehraKhyber PakhtunkhwaPakistan

Video summarization is applied to reduce redundancy and developa concise representation of key frames in the video, more recently, video summaries have been used through visual attention modeling. In these schemes,the frames that stand out visually are extracted as key frames based on humanattention modeling theories. The schemes for modeling visual attention haveproven to be effective for video summaries. Nevertheless, the high cost ofcomputing in such techniques restricts their usability in everyday *** this context, we propose a method based on KFE (key frame extraction)technique, which is recommended based on an efficient and accurate visualattention model. The calculation effort is minimized by utilizing dynamicvisual highlighting based on the temporal gradient instead of the traditionaloptical flow techniques. In addition, an efficient technique using a discretecosine transformation is utilized for the static visual salience. The dynamic andstatic visual attention metrics are merged by means of a non-linear weightedfusion technique. Results of the system are compared with some existing stateof-the-art techniques for the betterment of accuracy. The experimental resultsof our proposed model indicate the efficiency and high standard in terms ofthe key frames extraction as output.

关键词： KFE video summarization visual saliency visual attention model

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Automated File Labeling for Heterogeneous Files Organization Using Machine Learning

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Computers, Materials & Continua 2023年第2期74卷 3263-3278页

作者： Sagheer Abbas syed Ali Raza MAKhan Muhammad Adnan Khan Atta-ur-rahman Kiran Sultan Amir Mosavi School of Computer Science National College of Business Administration&EconomicsLahore54000Pakistan Department of Computer Science GC University LahorePakistan Riphah School of Computing&Innovation Faculty of ComputingRiphah International UniversityLahore CampusLahore54000Pakistan Department of Software Pattern Recognition and Machine Learning LabGachon UniversitySeongnam13120Korea Department of Computer Science College of Computer Science and Information Technology(CCSIT)Imam Abdulrahman Bin Faisal University(IAU)P.O.Box 1982Dammam31441Saudi Arabia Department of CIT The Applied CollegeKing Abdulaziz UniversityJeddah31261Saudi Arabia John von Neumann Faculty of Informatics Obuda UniversityBudapest1034Hungary Institute of Information Engineering Automation and MathematicsSlovak University of Technology in BratislavaBratislava81107Slovakia Faculty of Civil Engineering TU-DresdenDresden01062Germany

File labeling techniques have a long history in analyzing the anthological trends in computational *** situation becomes worse in the case of files downloaded into systems from the ***,most users either have to change file names manually or leave a meaningless name of the files,which increases the time to search required files and results in redundancy and duplications of user ***,no significant work is done on automated file labeling during the organization of heterogeneous user files.A few attempts have been made in topic ***,one major drawback of current topic modeling approaches is better *** rely on specific language types and domain similarity of the *** this research,machine learning approaches have been employed to analyze and extract the information from heterogeneous corpus.A different file labeling technique has also been used to get the meaningful and`cohesive topic of the *** results show that the proposed methodology can generate relevant and context-sensitive names for heterogeneous data files and provide additional insight into automated file labeling in operating systems.

关键词： Automated file labeling file organization machine learning topic modeling

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Physico-Chemical and Microbiological Study for the Stability of Phenytoin Sodium Extemporaneously Compounded Suspension in Saudi Arabia Hospitals

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Pharmacology & Pharmacy（药理与制药） 2021年第1期

作者： syed ata ur rahman Abdullah Alsaedi Abdulelah Alhusayni Abdulmalik Alqurshi Sameh Ahmed Yaser M. Alahmadi Alaa Omer M. Abdullaal Badr Ahmed A. Taher El-Sayed E. Habib

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Mechanisms and molecular approaches for heat tolerance in rice (Oryza sativa L.) under climate change scenario

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Journal of Integrative Agriculture 2018年第4期17卷 726-738页

作者： syed Adeel Zafar Amjad Hameed Muhammad Amjad Nawaz MA Wei Mehmood All Noor Muzammil Hussain Mehboob-ur-rahman National Key Facility for Crop Gene Resources and Genetic Improvement/Institute of Crop Sciences Chinese Academy of Agricultural Sciences Beijing 100081 P.R.China Nuclear Institute for Agriculture and Biology (NIAB) Faisalabad 38000 Pakistan Department of Biotechnology College of Engineering Science Chonnam National University Chonnam 59626 Republic of Korea Institute of Crop Sciences Chinese Academy of Agricultural Sciences~Key Laboratory of Crop Physiology and Ecology Ministryof Agriculture Beijing 100081 P.R.China State Key Laboratory of Mycology/Institute of Microbiology Chinese Academy of Sciences Beijing 100101 P.R. China Plant Genomics & Molecular Breeding Laboratories National Institute for Biotechnology and Genetic Engineering (NIBGE)Faisalabad 38000 Pakistan

Rice, a staple cereal crop in many parts of the world, has been confronted with multiple environmental stresses including high temperature, negatively impacts the booting as well as anthesis growth stages. The situation is further complicated by the changing climatic conditions, resulting in gradual escalation of temperature as well as changing the rainfall pattern and frequency, thus raising a concern of food security worldwide. The situation can be combat by developing rice varieties with excellent genetics with improved morpho-physiological, biochemical, and molecular mechanisms, together can minimize the adverse effects of heat stress. Here, several strategies(encompassing genetic and genomic, and mechanisms involved) for mitigating the impact of high temperature on rice have been discussed. Finally, the utilization of genomic knowledge in augmenting the conventional breeding approaches have been comprehensively elaborated to develop heat tolerant germplasm.

关键词： heat stress rice climate change molecular markers heat stress responses

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Multi-Scale Network with Integrated Attention Unit for Crowd Counting

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Computers, Materials & Continua 2022年第11期73卷 3879-3903页

作者： Adel Hafeezallah Ahlam Al-Dhamari syed Abd rahman Abu-Bakar Department of Electrical Engineering Taibah UniversityMadinahSaudi Arabia Department of Electronics and Computer Engineering School of Electrical EngineeringFaculty of EngineeringUniversiti Teknologi Malaysia81310JohorMalaysia Department of Computer Engineering Hodeidah UniversityHodeidahYemen

Estimating the crowd count and density of highly dense scenes witnessed in Muslim gatherings at religious sites in Makkah and Madinah is critical for developing control strategies and organizing such a large ***,since the crowd images in this case can range from low density to high density,detection-based approaches are hard to apply for crowd ***,deep learning-based regression has become the prominent approach for crowd counting problems,where a density-map is estimated,and its integral is further computed to acquire the final count *** this paper,we put forward a novel multi-scale network(named 2U-Net)for crowd counting in sparse and dense *** proposed framework,which employs the U-Net architecture,is straightforward to implement,computationally efficient,and has single-step *** layers are used to retrieve the pooling layers’erased information and learn hierarchically pixelwise spatial *** helps in obtaining feature values,retaining spatial locations,and maximizing data integrity to avoid data *** addition,a modified attention unit is introduced and integrated into the proposed 2UNet model to focus on specific crowd *** proposed model concentrates on balancing the number of model parameters,model size,computational cost,and counting accuracy compared with other works,which may involve acquiring one criterion at the expense of other *** on five challenging datasets for density estimation and crowd counting have shown that the proposed model is very effective and outperforms comparable mainstream ***,it counts very well in both sparse and congested crowd *** 2U-Net model has the lowest MAE in both parts(Part A and Part B)of the ShanghaiTech,UCSD,and Mall benchmarks,with 63.3,7.4,1.5,and 1.6,***,it obtains the lowest MSE in the ShanghaiTech-Part B,UCSD,and Mall benchmarks with 12.0,1.9,and 2.1,respectively.

关键词： Computer vision crowd analysis crowd counting U-Net max-pooling index unpooling attention units

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State of Health Estimation of LiFePO_(4) Batteries for Battery Management Systems

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Computers, Materials & Continua 2022年第11期73卷 3149-3164页

作者： Areeb Khalid syed Abdul rahman Kashif Noor Ul Ain Ali Nasir Department of Electrical Engineering University of Engineering and TechnologyLahorePakistan Department of Electrical Engineering University of Central PunjabLahorePakistan

When considering the mechanism of the batteries,the capacity reduction at storage(when not in use)and cycling(during use)and increase of internal resistance is because of degradation in the chemical composition inside the *** optimize battery usage,a battery management system(BMS)is used to estimate possible aging effects while different load profiles are requested from the *** is specifically seen in a case when the vehicle is connected to the net(online through BMS).During this process,the BMS chooses the optimized load profiles based on the least aging effects on the battery *** major focus of this paper is to design an algorithm/model for lithium iron phosphate(LiFePO4)*** model of the batteries is based on the accelerated aging test data(data from the beginning of life till the end of life).The objective is to develop an algorithm based on the actual battery trend during the whole life of the *** the analysis of the test data,the complete trend of the battery aging and the factors on which the aging is depending on is identified,the aging model can then be recalibrated to avoid any differences in the production process during cell *** validation of the model was carried out at the end by utilizing different driving profiles at different C-rates and different ambient temperatures.A Linear and non-linear model-based approach is used based on statistical *** parameterization was carried out by dividing the data into small chunks and estimating the parameters for the individual ***-adaptive characteristic map using a lookup table was also *** nonlinear model was chosen as the best candidate among all other approaches for longer validation of 8-month data with real driving data set.

关键词： Aging model state of health lithium-ion cells battery management system state of charge battery modeling

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Geospatial and clinical analyses on pediatric related road traffic injury in Malaysia

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World Journal of Emergency Medicine 2016年第3期7卷 213-220页

作者： Nik Hisamuddin rahman Ruslan Rainis syed Hatim Noor Sharifah Mastura syed Mohamad Department of Emergency Medicine School of Medical Sciences USM Kota Bharu 16150 Malaysia School of Humanity USM Penang Malaysia Unit of Biostatistics School of Medical Sciences USM Kota Bharu 16150 Malaysia Unit of Health Informatics School of Health Sciences USM Kota Bharu 16150 Malaysia

BACKGROUND: The main aim of this study is to utilize the geographical information system(GIS) software and perform the spatial analysis in relation to clinical data for road traffi c injury(RTI) pediatric cases attending the emergency ***: The study sample included pediatric patients(age less than 18 years) with roadrelated injuries within a district in Malaysia who attended emergency departments of two tertiary hospitals within the district. In addition to injury, pre-hospital care and outcome data, the coordinate of the locations were obtained by the ambulance paramedics by using portable handheld GPS unit brand Garmin? model GPS 72 H. The data was transferred into the excel format which in turn underwent GIS analysis by using ARCGIS?(by ESRI) software version 10.1 licensed to the study ***: A total of 102(24.8%) of all motor vehicle crash(MVC) victims involved the pediatric age group(age 18 years and below). The mean(SD) age of the pediatric victims was 14.30 years(SD 3.830). Male comprised of 68(66.7%) of the cases. Motorcyclists [88(88.0%)] were the most common type of victims involved. Interestingly, the majority of the severely injured victims [75(73%)] sustained the RTI on roads with maximum speed limit of 60 km/hour. The mean(SD) length of hospital stay was 7.83 days(5.59).CONCLUSION: The pediatric related road traffic injury in Malaysia causes significant health and social burden in the country. This study showed both important clinical and geographical factors that need to be taken into consideration for future preventive action.

关键词： Pediatric Injury Road safety Geospatial Geographical information system

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