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Safety of tranexamic acid in surgically treated isolated spine trauma

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World Journal of Orthopedics 2024年第4期15卷 346-354页

作者： Wajiha Zahra Sandeep Krishan Nayar Ashwin Bhadresha Vinay Jasani syed aftab Trauma and Orthopedics Department University Hospital of North Midlands NHS TrustStoke-on-Trent ST46QGUnited Kingdom Trauma and Orthopedics Department Royal London HospitalBarts Health InstituteLondon E11BBUnited Kingdom Craniospinal Services University Hospital of North Midlands NHS TrustStokeon-Trent ST46QGUnited Kingdom Spine Department Royal London HospitalBarts Health InstituteLondon E11BBUnited Kingdom

BACKGROUND Tranexamic acid(TXA),a synthetic antifibrinolytic drug,effectively reduces blood loss by inhibiting plasmin-induced fibrin *** is the first study in the United Kingdom to investigate the effectiveness of TXA in the surgical management of isolated spine *** To assess the safety of TXA in isolated spine *** primary and secondary outcomes are to assess the rate of thromboembolic events and to evaluate blood loss and the incidence of blood transfusion,*** This prospective observational study included patients aged≥17 years with isolated spine trauma requiring surgical intervention over a 6-month period at two major trauma centers in the United *** We identified 67 patients:26(39%)and 41(61%)received and did not receive TXA,*** groups were matched in terms of age,gender,American Society of Anesthesiologists grade,and mechanism of injury.A higher proportion of patients who received TXA had a subaxial cervical spine injury classification or thoracolumbar injury classification score>4(74%vs 56%).All patients in the TXA group underwent an open approach with a mean of 5 spinal levels involved and an average operative time of 203 min,compared with 24 patients(58%)in the non TXA group who underwent an open approach with an average of 3 spinal levels involved and a mean operative time of 159 *** patients who received TXA,blood loss was<150 and 150–300 mL in 8(31%)and 15(58%)patients,*** were no cases of thromboembolic events in any patient who received *** Our study demonstrated that TXA is safe for isolated spine *** is challenging to determine whether TXA effectively reduces blood loss because most surgeons prefer TXA for open or multilevel ***,larger studies are necessary to explore the rate,dosage,and mode of administration of TXA.

关键词： Tranexamic acid Infection Trauma Thromboembolic disease Minimally invasive Percutaneous

AMachine Learning Approach to User Profiling for Data Annotation of Online Behavior

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Computers, Materials & Continua 2024年第2期78卷 2419-2440页

作者： Moona Kanwal Najeed AKhan aftab A.Khan Computer Science and Information Technology Department NED University of Engineering and TechnologyKarachiPakistan Computer Engineering Department Sir Syed University of Engineering and TechnologyKarachiPakistan College of Education Health and Human ServicesLongwood UniversityFarmvilleVAUSA

The user’s intent to seek online information has been an active area of research in user *** profiling considers user characteristics,behaviors,activities,and preferences to sketch user intentions,interests,and *** user characteristics can help capture implicit and explicit preferences and intentions for effective user-centric and customized content *** user’s complete online experience in seeking information is a blend of activities such as searching,verifying,and sharing it on social ***,a combination of multiple behaviors in profiling users has yet to be *** research takes a novel approach and explores user intent types based on multidimensional online behavior in information *** research explores information search,verification,and dissemination behavior and identifies diverse types of users based on their online engagement using machine *** research proposes a generic user profile template that explains the user characteristics based on the internet experience and uses it as ground truth for data *** feedback is based on online behavior and practices collected by using a survey *** participants include both males and females from different occupation sectors and different *** data collected is subject to feature engineering,and the significant features are presented to unsupervised machine learning methods to identify user intent classes or profiles and their *** techniques are evaluated,and the K-Mean clustering method successfully generates five user groups observing different user characteristics with an average silhouette of 0.36 and a distortion score of *** average is computed to identify user intent type *** user intent classes are then further generalized to create a user intent template with an Inter-Rater Reliability of 75%.This research successfully extracts different user types based on th

关键词： User intent cluster user profile online search information sharing user behavior search reasons

Chemical modification of acetaminophen：PASS assisted in vivo antiinflammatory activity of chalcones,flavanones and Schiff bases

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Journal of Chinese Pharmaceutical Sciences 2017年第8期26卷 611-620页

作者： syed Misbahul Hasan Shah Alam Khan Kavita Golani Jaswinder Lamba aftab Ahmad Asif Husain Department of Pharmaceutical Chemistry School of Pharmaceutical Education and Research Jamia Hamdard (Hamdard University)New Delhi 110062 India Faculty of Pharmacy Integral University Lucknow UP 226026 India Department of Pharmacy Oman Medical College PO Box 620 Postal code-130 Muscat Sultanate of Oman Health Information Technology Department Jeddah Community College King Abdulaziz University deddah Kingdom of Saudi Arabia

In the present study,synthetic chalcones,flavanones and Schiff bases were prepared starting from paraceamol,and evaluated their anticipated anti-inflammatory *** were synthesized by reacting 3-acetyl-4-hydroxy acetanilide and aromatic aldehydes in alcoholic potassium hydroxide(KOH) solution under Claisen-Schmidt condensation *** chalcones were cyclized in the presence of piperidine in isoamyl alcohol to obtain flavonone *** bases were synthesized by condensing 3-acetyl-4-hydroxy anilines with aromatic aldehydes in the presence of *** Schiff bases were further reacted with other aromatic aldehydes in alcoholic KOH *** cheminformatics software was used to predict the anti-inflammatory activity of synthesized *** software predicted that chalcone-based Schiff bases 6a–d contained structural features that can exhibit anti-inflammatory *** the prepared derivatives of acetaminophen exhibited moderate to excellent in vivo anti-inflammatory activity in carrageenan-induced edema in rat *** the Schiff bases coupled chalcones showed good anti-inflammatory activity compared with the reference drug,*** evaluation of their therapeutic potential and safety profile is required in the future study.

关键词： p-Acetaminophen Anti-inflammatory Chalcone Flavanone

Facile NiCo_(2)S_(4)/C nanocomposite: an efficient material for water oxidation

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Tungsten 2020年第4期2卷 403-410页

作者： Umair aftab Aneela Tahira Raffaello Mazzaro Vittorio Morandi Muhammad Ishaq Abro Muhammad Moazam Baloch Junaid Ali syed Ayman Nafady Zafar Hussain Ibupoto Mehran University of Engineering and Technology Jamshoro 76080Pakistan Department of Science and Technology Linköping University60174 NorrköpingSweden Institute for Microelectronics and Microsystems Italian National Research CouncilSection of Bologna40129 BolognaItaly College of Science King Saud UniversityRiyadh 11451Saudi Arabia Dr.M.A Kazi Institute of Chemistry University of SindhJamshoro 76080Pakistan

The water oxidation in alkaline media is a kinetically sluggish process and it requires an active electrocatalyst for overall water splitting which is a challenging task to ***,we formulate a platform for the design of efficient NiCo_(2)S_(4)/C nanocomposite using earth abundant and nonprecious *** nanocomposites are prepared by scale up hydrothermal method using different carbon contents from acid dehydrated *** are structurally and morphologically character-ized by various analytic *** scanning electron microscopy has shown few microns flower-like morphology of nanocomposite and hexagonal crystalline phase is identified by X-ray diffraction(XRD).Further,high-resolution transmission electron microscopy supported the XRD results,and C,Ni,Co and O elements were found in the composition nanocomposite as investigated by energy-dispersive *** most active nanocomposite reaches a current density of 20 mA·cm^(−2) at potential of 285 mV vs reversible hydrogen *** nanocomposite is kinetically supported by 61 mV·dec^(−1) as small Tafel *** nanocomposite is stable and durable for 40 *** electrochemical impedance spectroscopy described a small charge transfer resistance of 188.4Ω.These findings suggest that the NiCo_(2)S_(4)/C nanocomposite could be used as a promising material for an extended range of applications particularly in energy technology.

关键词： NiCo_(2)S_(4)/C Water oxidation Alkaline media Stable and durable

Fascial space odontogenic infections: Ultrasonography as an alternative to magnetic resonance imaging

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World Journal of Clinical Cases 2021年第3期9卷 573-580页

作者： Sreenivasarao Ghali Girish Katti syed Shahbaz Parita K Chitroda Anukriti V Darshan Devang Divakar aftab Ahmed Khan Sachin Naik Abdulaziz A Al-Kheraif Chitra Jhugroo Department of Oral Medicine and Radiology Nanded Rural Dental College and Research CenterNanded 431606MaharashtraIndia Department of Oral Medicine and Radiology Al-Badar Dental College and HospitalKalaburagi 585102KarnatakaIndia Department of Dental Health College of Applied Medical SciencesKing Saud UniversityRiyadh 11433Saudi Arabia

BACKGROUND The introduction of modern diagnostic tools has transformed the field of maxillofacial *** infection and fascial space involvement have been evaluated with many diagnostic tools,including ultrasonography(USG)and magnetic resonance imaging(MRI).AIM To explore USG as an alternative model to MRI in the detection of fascial space spread of odontogenic *** Among 20 patients,50 fascial spaces were clinically diagnosed with odontogenic infection and included in this prospective *** space infection involvement was examined by USG and *** were compared for both and confirmed by microbiological *** Ultrasonography identified 42(84%)of 50 involved fascial *** MRI identified all 50(100%).USG could stage the infections from edematous change to cellulitis to complete abscess *** MRI was superior in recognizing deep fascial space infections compared to ***, USG is a significant addition and has a definite role in prognosticatingthe stage of infection and exact anatomic location in superficial space infections.

关键词： Abscess Cellulitis Facial space Magnetic resonance imaging Odontogenic infection Ultrasonography

Phytochemical composition, biological potential and enzyme inhibition activity of Scandix pecten-veneris L.

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2018年第2期19卷 120-129页

作者： Abdul WAHAB syed Aleem JAN Abdur RAUF Zia ur REHMAN Zahid KHAN aftab AHMED Fatima syed Sher Zaman SAFI Hamayun KHAN Muhammad IMRAN Department of Chemistry Islamia College University Biochemistry Section Institute of Chemical Sciences University of Peshawar Department of Chemistry University of Swabi Department of Botany Islamia College University State Key Laboratory of Chemical Resource Engineering College of Life Science and TechnologyBeijing University of Chemical Technology Interdisciplinary Research Center in Biomedical Materials COMSATS Institute of Information Technology

Objective： Scandix pecten-veneris L. is a less studied wild edible herb and is considered an extinct plant species in many parts of the world. This study was designed to evaluate its phytochemical composition and biological potential of S. pecten-veneris L. Methods： Phytochemicals including alkaloids, fiavonoids, polyphenols, and tannins were determined in extracts of S. pecten-veneris. Antioxidant activity was determined using 2,2-diphenyl-1- picrylhydrazyl （DPPH）, while reducing power was tested by ferric reducing/antioxidant power （FRAP） assay. Antimi- crobial activity against seven bacterial and four fungal strains was evaluated using agar well diffusion assay. Enzymes inhibition study was performed for urease, phosphodiesterase-I, and catalase-II. Results： S. pecten-veneris showed moderate antiradical activity and reducing potential of hydroxyl radicals to about 20% of the initial value. The antiox- idant activity of various extracts of S. pecten-veneris showed a linear correlation with total phenolic contents in the order of water〉n-butanol〉chloroform〉ethyl acetate〉methanol extracts. S. pecten-veneris leaves showed the highest inhibitory activity against Staphylococcus aureus while the highest antifungal activity was observed against Candida albicans. The plant extract was most potent against urease enzymes but showed moderate activity against phosphodiestrase-I and carbonic anhydrase-II. Conclusions： Our data demonstrate that in addition to its culinary uses, S. pecten-veneris has good medicinal potential and hence could be used for treating some specific health ailments.

关键词： Scandix pecten-veneris L. Phytochemical composition Antioxidant activity Antimicrobial potential Enzyme inhibition

Drug-Drug Interaction Studies of Levocetirizine with Atenolol

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Journal of Pharmacy and Pharmacology 2017年第3期5卷 118-124页

作者： Shafaque Mehboob Muhammad Azhar Mughal Khalid aftab MoonaMehboob Khan Najma Sultana syed Arayne Institute of Pharmaceutical Sciences Jinnah Sindh Medical University Karachi 75510 Pakistan Department of Pharmacology & Therapeutics Jinnah Sindh Medical University Karaehi 75510 Pakistan Department of Pharmacology & Therapeutics Islam Medical & Dental College Sialkot 51311 Pakistan Department of Pharmaceutical Chemistry Dow University of Health Sciences Karachi 74200 Pakistan Department of Pharmaceutical Chemistry Faculty of Pharmacy University of Karachi Karachi 75270 Pakistan

The objective of the study was to evaluate the drug-drug interaction studies of levoceterizine with atenolol. Calibration curve studies of working standard solutions of levocetirizine and atenolol （0.01-0.1 mmol） were scanned. Maxima appeared at 231 nm for levocetirizine and 224 nm for atenolol. The calibration curve obeyed Beer Lambert＇s Law. Lone availabilities of both the drugs were studied in pH 1, pH 4, pH 7.4 and pH 9 at 37℃ on B.P. （British Pharmacopoeia） dissolution apparatus. To study the drug-drug interaction of levocetirizine （5 mg tablet） and atenolol （100 mg tablet）, both the drugs were introduced to the dissolution apparatus in simulated gastric juice （pH 1）, pH 4, pH 7.4 and pH 9 at 37℃ at zero time and measured the absorbance maxima of both the drugs at the corresponding wavelength. Graphs were plotted for availability percentage （%） of drug versus time at each set of experiment. The availability percentage （%） of levocetirizine in the buffers of pH simulated to gastric pH 4, pH 7.4 and pH 9 in the presence of atenolol was 436.78%, 376.90%, 436.78% and 436.78%, respectively, but the availability of atenolol was increased up to 214.80%, 212.96%, 214.93% and 231.51% in simulated to gastric pH and in the buffers ofpH 4, pH 7.4 and pH 9, respectively. On the basis of these studies, it is concluded that levocetirizine forms a charge-complex with atenolol; therefore, co-administration of these drugs should be avoided.

关键词： Levocetirizine atenolol drug-drug interactions absorbance maxima.

Viruses and autism: A Bi-mutual cause and effect

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World Journal of Virology 2023年第3期12卷 172-192页

作者： Mohammed Al-Beltagi Nermin Kamal Saeed Reem Elbeltagi Adel Salah Bediwy syed A Saboor aftab Rawan Alhawamdeh Department of Pediatrics Faculty of MedicineTanta UniversityTanta 31511AlghrabiaEgypt Department of Pediatrics University Medical CenterKing Abdulla Medical CityDr.Sulaiman Al Habib Medical GroupManama 26671Bahrain Medical Microbiology Section Pathology DepartmentSalmaniya Medical ComplexMinistry of HealthKingdom of BahrainManama 12Bahrain Microbiology Section Pathology DepartmentIrish Royal College of SurgeonBusaiteen 15503MuharraqBahrain Department of Medicine The Royal College of Surgeons in Ireland-BahrainBusiateen 15503MuharraqBahrain Department of Pulmonolgy Faculty of MedicineTanta UniversityTanta 31527AlghrabiaEgypt Department of Chest Disease University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityDr.Sulaiman Al Habib Medical GroupManama 26671Bahrain Endocrinology and DM William Harvey Hospital(Paula Carr Centre)Ashford TN240LZKentUnited Kingdom Pediatrics Research and Development Genomics Creativity and Play CenterManama 0000Bahrain

Autism spectrum disorder(ASD)is a group of heterogeneous,multi-factorial,neurodevelopmental disorders resulting from genetic and environmental factors *** is a significant trigger of autism,especially during the critical developmental *** is a strong interplay between the viral infection as a trigger and a result of *** aim to highlight the mutual relationship between autism and *** performed a thorough literature review and included 158 research in this *** of the literature agreed on the possible effects of the viral infection during the critical period of development on the risk of developing autism,especially for specific viral infections such as Rubella,Cytomegalovirus,Herpes Simplex virus,Varicella Zoster Virus,Influenza virus,Zika virus,and severe acute respiratory syndrome coronavirus *** infection directly infects the brain,triggers immune activation,induces epigenetic changes,and raises the risks of having a child with *** the same time,there is some evidence of increased risk of infection,including viral infections in children with autism,due to lots of *** is an increased risk of developing autism with a specific viral infection during the early developmental period and an increased risk of viral infections in children with *** addition,children with autism are at increased risk of infection,including *** effort should be made to prevent maternal and early-life infections and reduce the risk of *** modulation of children with autism should be considered to reduce the risk of infection.

关键词： Autism Children Rubella Cytomegalovirus Herpes simplex virus Influenza virus Zika virus SARS-CoV-2 COVID-19 Viral infection Core Tip:There is a mutual relationship between viral infections and autism.There is an increased risk of developing autism when contracting a viral infection during pregnancy or early postnatal life during the critical period of brain development.At the same time,children with autism have many co-morbidities that expose them to more risk of contracting infections,including viruses.Therefore,every effort should be made to prevent infections,especially during this critical period of neurodevelopment.Parents should also be educated about the importance of vaccination and immune modulation in children with autism to avoid further infections.

A Prospective Study on the Efficiency of Ciprofloxacin in Combination with Chloramphenicol against Multiple Antibiotics Resistant <i>Klebsiella pneumonia</i>

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Advances in Microbiology 2020年第9期10卷 411-421页

作者： Akash Ahmed Ishrat Binte aftab Tonima Fairooz Mouly Sinthia Kabir Mumu Abu syed Md. Mosaddek Mahboob Hossain Microbiology Program Department of Mathematics and Natural Sciences BRAC University Dhaka Bangladesh Department of Pharmacology Uttara Adhunik Medical College Dhaka Bangladesh

Pneumonia is the single largest infectious cause of death in children worldwide and also a form of an acute respiratory infection that affects the lung. The purpose of the study was to develop a new approach to treat antibiotic-resistant K. pneumoniae infection. This study aimed in quest of a drug to combine with ciprofloxacin, a broad spectrum antibiotic frequently used to treat lung infections. Methodology: A total of 23 lung infection bacterial samples were collected and studied against 14 antibiotics of different classes. The disk diffusion method was performed to determine synergy screening, MIC value, and qualitative toxicity analysis of ciprofloxacin and chloramphenicol combination. Results: After primary screening of antibiotic susceptibility, they were categorized into multidrug-resistant (MDR), extensively drug-resistant (XDR) and pan drug-resistant (PDR) pathogens where 9 isolates were MDR, 5 were XDR and 3 isolates were PDR. Furthermore, they were trialed in combination ciprofloxacin along with other 7 drugs in disk diffusion to explore the synergistic effect. The combination of ciprofloxacin and moxifloxacin, ciprofloxacin and chloramphenicol were found to be synergic. Then the MIC test was done for the combination ciprofloxacin and chloramphenicol. When the MIC result was generated, the MIC of the respective combination was analyzed. Furthermore, the fractional inhibitory concentration (FIC) was calculated and in accordance with the results of the FIC index, ciprofloxacin-chloramphenicol combination has shown value 0.4510 which revealed a synergistic effect against multi-drug resistant Klebsiella pneumoniae. Conclusion: Given these points, if the efficiency of this antibiotic can be accelerated from combination with other drugs, it might be lifesaving and cost effective as well.

关键词： Multidrug Resistant Bacteria Klebsiella pneumonia Combination Therapy FIC