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Current perspective on amyloid aggregation accelerating properties of the artificial butter flavoring,diacetyl

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Neural Regeneration Research 2024年第10期19卷 2113-2114页

作者： Ashish P.Vartak swati S.More Center for Drug Design College of PharmacyUniversity of MinnesotaMinneapolisMNUSA

The amyloid—what peptide can resist its entropic bliss?Without kinetic barricades and chaperones,most peptides would simply tumble down that *** amyloid-β(Aβ) peptides are understood to underlie the hallmark pathology of Alzheimer's disease(AD) and are considered one of the causative factors for neurodegeneration and cognitive *** affects critical connected structures within the brain that are responsible for memory,language,and social behavior.

关键词： amyloid Alzheimer Aβ

Sirtuin 1 in regulating the p53/glutathione peroxidase 4/gasdermin D axis in acute liver failure

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World Journal of Gastroenterology 2024年第34期30卷 3850-3855页

作者： swati Katoch Vikram Patial Division of Dietetics and Nutrition Technology Institute of Himalayan Bioresource TechnologyPalampur 176061Himachal PradeshIndia Academy of Scientific and Innovative Research Ghaziabad 201002Uttar PradeshIndia

In this editorial,we comment on the article by Zhou et *** study reveals the connection between ferroptosis and pyroptosis and the effect of silent information regulator sirtuin 1(SIRT1)activation in acute liver failure(ALF).ALF is characterized by a sudden and severe liver injury resulting in significant hepatocyte damage,often posing a high risk of *** predominant form of hepatic cell death in ALF involves apoptosis,ferroptosis,autophagy,pyroptosis,and *** peroxidase 4(GPX4)inhibition sensitizes the cell to ferroptosis and triggers cell death,while Gasdermin D(GSDMD)is a mediator of *** study showed that ferroptosis and pyroptosis in ALF are regulated by blocking the p53/GPX4/GSDMD pathway,bridging the gap between the two *** inhibition of p53 elevates the levels of GPX4,reducing the levels of inflammatory and liver injury markers,ferroptotic events,and GSDMDN protein *** p53 expression and increased GPX4 on deletion of GSDMD indicated ferroptosis and pyroptosis ***1 is a NAD-dependent deacetylase,and its activation attenuates liver injury and inflammation,accompanied by reduced ferroptosis and pyroptosis-related proteins in ***1 activation also inhibits the p53/GPX4/GSDMD axis by inducing p53 acetylation,attenuating LPS/D-GalN-induced ALF.

关键词： Acute liver failure Ferroptosis Gasdermin D Pyroptosis p53 Silent information regulator sirtuin 1

Decoding bovine coronavirus immune targets:an epitope informatics approach

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Animal Diseases 2024年第2期4卷 138-153页

作者： swati Rani Mehnaj Khatoon Jagadish Hiremath Kuralayanapalya Puttahonnappa Suresh Jayashree Anandakumar Nagendra Nath Barman Sheethal Manjunath Yamini Sri S Sharanagouda S.Patil Spatial Epidemiology Lab ICAR-National Institute of Veterinary Epidemiology and Disease InformaticsYelahankaBengaluruKarnataka 560064India College of Veterinary Science Assam Agricultural UniversityGuwahatiAssam 785013India Yuvaraja’s College Mysuru University of MysuruMysuruKarnataka 570005India

Bovine coronavirus(BCoV)poses a significant threat to the global cattle industry,causing both respiratory and gastrointestinal infections in cattle *** necessitates the development of efficacious *** several inactivated and live BCoV vaccines exist,they are predominantly limited to *** immunization of adult cattle is imperative for BCoV infection control,as it curtails viral transmission to calves and ameliorates the impact of enteric and respiratory ailments across all age groups within the *** study presents an in silico methodology for devising a multiepitope vaccine targeting *** spike glycoprotein(S)and nucleocapsid(N)proteins,which are integral elements of the BCoV structure,play pivotal roles in the viral infection cycle and immune *** constructed a remarkably effective multiepitope vaccine candidate specifically designed to combat the BCoV *** immunoinformatics technology,B-cell and T-cell epitopes were predicted and linked together using linkers and adjuvants to efficiently trigger both cellular and humoral immune responses in *** in silico construct was characterized,and assessment of its physicochemical properties revealed the formation of a stable vaccine *** 3D modeling of the vaccine construct,molecular docking revealed a stable interaction with the bovine receptor ***,the viability of the vaccine’s high expression and simple purification was demonstrated by codon optimization and in silico cloning expression into the pET28a(+)*** applying immunoinformatics approaches,researchers aim to better understand the immune response to bovine coronavirus,discover potential targets for intervention,and facilitate the development of diagnostic tools and vaccines to mitigate the impact of this virus on cattle health and the livestock *** anticipate that the design will be useful as a preventive treatment for BCoV sickness in cattle,opening the door for furthe

关键词： Immunoinformatics Bovine coronavirus Multiepitope vaccine Molecular docking In silico cloning

Rice-wheat comparative genomics:Gains and gaps

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The Crop Journal 2024年第3期12卷 656-669页

作者： Akila Wijerathna-Yapa Ruchi Bishnoi Buddhini Ranawaka Manu Maya Magar Hafeez Ur Rehman swati G.Bharad Michal T.Lorenc Vinita Ramtekey Sasha Gohar Charu Lata Md.Harun-Or-Rashid Maryam Razzaq Muhammad Sajjad Bhoja *** School of Agriculture and Food Sustainability The University of QueenslandSt LuciaQLD 4072Australia ARC Centre of Excellence for Plant Success in Nature and Agriculture The University of QueenslandSt LuciaQLD 4072Australia Department of Genetics and Plant Breeding College of AgricultureUmmedganj-KotaAgriculture UniversityKotaRajasthan 324001India Centre for Agriculture and the Bioeconomy Queensland University of Technology(QUT)2 George StreetBrisbaneQLD 4000Australia UWA School of Agriculture and Environment The University of Western Australia35 Stirling HighwayCrawleyWA 6009Australia Nepal Agriculture Research Council KhumaltarLalitpurNepal Department of Agronomy University of AgricultureFaisalabad 38040Pakistan Department of Agricultural Botany Dr Panjabrao Deshmukh Krishi VidyapeethAkola 444104MaharashtraIndia ICAR-Indian Institute of Seed Science MauUttar Pradesh 275103India School of Natural Sciences Macquarie UniversityMacquarie ParkNSW 2109Australia ICAR-Indian Institute of Wheat and Barley Research Flowrdale 54642ShimlaIndia International Maize and Wheat Improvement Center(CIMMYT)Bangladesh Office Gulshan-2Dhaka 1212Bangladesh Center for Seed Science University of AgricultureFaisalabad 38000Pakistan Department of Biosciences COMSATS University IslamabadPark RoadTarlai KalanIslamabad 45550Pakistan CGIAR’s Excellence in Breeding(EiB)Platform/Accelerated Breeding Initiative International Maize and Wheat Improvement Center(CIMMYT)El Batán 56237Mexico

Rice and wheat provide nearly 40%of human calorie and protein *** share a common ancestor and belong to the Poaceae(grass)*** their genetic homology is crucial for developing new cultivars with enhanced *** wheat genes and gene families have been characterized based on their rice ***–wheat orthology can identify genetic regions that regulate similar traits in both ***–wheat comparative genomics can identify candidate wheat genes in a genomic region identified by association or QTL mapping,deduce their putative functions and biochemical pathways,and develop molecular markers for marker-assisted breeding.A knowledge of gene homology facilitates the transfer between crops of genes or genomic regions associated with desirable traits by genetic engineering,gene editing,or wide crossing.

关键词： Comparative genomics Orthologs Genes Synteny Genetic engineering Molecular breeding

Impact of Cumulative Exposure to Circulating Ovarian Sex Hormones on Increasing the Risk of Hormone Receptor-Positive Breast Cancer

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生物组学研究杂志(英文) 2024年第1期07卷 36-43页

作者： Mohanty swati Sucharita Mohanty Sumit Subhadarshi Panda Soumya Surath Sahoo Chita Ranjan Mohanty Prafulla Kumar Padhy Rabindra Nath Siksha O Anusandhan University Institute of Medical Sciences and SUM Hospital Bhubaneswar Odisha India Regional Medical Research Centre Bhubaneswar Bhubaneswar Odisha India Khallikote Unitary University Brahmapur Odisha India

There were 2.3 million new cases of breast cancer registered in 2020, establishing it as the world’s leading cancer. The regular exposure of breast cells to circulating ovarian sex hormones may contribute to cancer growth at all stages. A literature review was performed by downloading research articles from PubMed Central, with keywords such as breast cancer, hormone exposure in breast cancer, estrogen/progesterone exposure in breast cancer, and breast cancer risk factors. Since breast cancer is a hormone-related disease, several factors that influence hormonal conditions or are indicators of alterations in hormonal conditions have been linked with the risk for breast cancer. Likewise, an elevated risk for breast cancer has been related to reproductive history and exogenous estrogen exposure because they may amplify lifetime estrogen exposure. All these factors address the total cumulative exposure to circulating ovarian sex hormones that a female is vulnerable to in her lifetime. A healthy lifestyle, a more extended breastfeeding period, and regular physical activity may help lower one’s risk. This review summarizes the factors that increase the risk of estrogen/progesterone (hormone receptor) receptor-positive breast cancer due to overall cumulative estrogen exposure, with an understanding of estrogen biosynthesis mechanisms and estrogen receptor signaling.

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Effects of thermal radiation on Casson fluid flow and heat transfer over an unsteady stretching surface subjected to suction/blowing

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Chinese Physics B 2013年第11期22卷 362-368页

作者： swati mukhop.dhyay Department of Mathematics The University of Burdwan

The unsteady flow of a Casson fluid and heat transfer over a stretching surface in presence of suction/blowing are investigated. The transformed equations are solved numerically by using the shooting method. The exact solution corre- sponding to the momentum equation for the steady case is obtained. Fluid velocity initially decreases with the increase of unsteadiness parameter. Due to an increasing Casson parameter the velocity field is suppressed. Thermal radiation enhances the effective thermal diffusivity and the temperature rises.

关键词： unsteady flow Casson fluid stretching surface suction/blowing

Heat Transfer in a Moving Fluid over a Moving Non-Isothermal Flat Surface

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Chinese Physics Letters 2011年第12期28卷 183-186页

作者： swati mukhop.dhyay Department of Mathematics The University of BurdwanBurdwan-713104W.B.India

Boundary layer forced convective flow and heat transfer passing a moving flat surface parallel to a moving stream are *** power-law surface temperature of the second degree at the boundary is *** similarity solutions for the problem are obtained and the reduced ordinary differential equations are solved *** numerical results are compared with the known results from the literature for some special cases of the present study to support their *** is found that dual solutions exist when the surface and the fluid move in opposite directions.

关键词： moving ordinary directions

Heat Transfer Analysis of the Unsteady Flow of a Maxwell Fluid over a Stretching Surface in the Presence of a Heat Source/Sink

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Chinese Physics Letters 2012年第5期29卷 165-168页

作者： swati mukhop.dhyay Department of Mathematics The University of BurdwanBurdwan-713104W.B.India

The unsteady two-dimensional flow of a MHD non-Newtonian Maxwell fluid over a stretching surface with a prescribed surface temperature in the presence of a heat source/sink is *** solutions for the governing equations are *** transformed boundary layer equations are then solved numerically by using the shooting *** velocity initially decreases with the increasing unsteadiness parameter,and temperature decreases significantly due to *** is also found that the fluid velocity decreases with the increasing magnetic *** the Maxwell parameter values has the effect of suppressing the velocity field and increasing the temperature.

关键词： temperature. parameter. method.

Dual solutions in boundary layer flow of a moving fluid over a moving permeable surface in presence of prescribed surface temperature and thermal radiation

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Chinese Physics B 2014年第1期23卷 279-283页

作者： swati mukhop.dhyay Department of Mathematics The University of Burdwan Burdwan-713104 W. B. India

An analysis of the heat transfer for a boundary layer forced convective flow past a moving permeable flat surface parallel to a moving fluid is presented. Prescribed surface temperature at the boundary is considered, A thermal radiation term in the energy equation is considered. The similarity solutions for the problem are obtained and the reduced ordinary differential equations are solved numerically. To support the validity of the numerical results, a comparison is made with the available results for some particular cases of this study. Dual solutions exist when the surface and the fluid move in the opposite directions.

关键词： moving fluid prescribed surface temperature suction thermal radiation