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Current perspective on amyloid aggregation accelerating properties of the artificial butter flavoring,diacetyl

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Neural Regeneration Research 2024年第10期19卷 2113-2114页

作者： Ashish P.Vartak swati S.More Center for Drug Design College of PharmacyUniversity of MinnesotaMinneapolisMNUSA

The amyloid—what peptide can resist its entropic bliss?Without kinetic barricades and chaperones,most peptides would simply tumble down that *** amyloid-β(Aβ) peptides are understood to underlie the hallmark pathology of Alzheimer's disease(AD) and are considered one of the causative factors for neurodegeneration and cognitive *** affects critical connected structures within the brain that are responsible for memory,language,and social behavior.

关键词： amyloid Alzheimer Aβ

Rice-wheat comparative genomics:Gains and gaps

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The Crop Journal 2024年第3期12卷 656-669页

作者： Akila Wijerathna-Yapa Ruchi Bishnoi Buddhini Ranawaka Manu Maya Magar Hafeez Ur Rehman swati G.Bharad Michal T.Lorenc Vinita Ramtekey Sasha Gohar Charu Lata Md.Harun-Or-Rashid Maryam Razzaq Muhammad Sajjad Bhoja *** School of Agriculture and Food Sustainability The University of QueenslandSt LuciaQLD 4072Australia ARC Centre of Excellence for Plant Success in Nature and Agriculture The University of QueenslandSt LuciaQLD 4072Australia Department of Genetics and Plant Breeding College of AgricultureUmmedganj-KotaAgriculture UniversityKotaRajasthan 324001India Centre for Agriculture and the Bioeconomy Queensland University of Technology(QUT)2 George StreetBrisbaneQLD 4000Australia UWA School of Agriculture and Environment The University of Western Australia35 Stirling HighwayCrawleyWA 6009Australia Nepal Agriculture Research Council KhumaltarLalitpurNepal Department of Agronomy University of AgricultureFaisalabad 38040Pakistan Department of Agricultural Botany Dr Panjabrao Deshmukh Krishi VidyapeethAkola 444104MaharashtraIndia ICAR-Indian Institute of Seed Science MauUttar Pradesh 275103India School of Natural Sciences Macquarie UniversityMacquarie ParkNSW 2109Australia ICAR-Indian Institute of Wheat and Barley Research Flowrdale 54642ShimlaIndia International Maize and Wheat Improvement Center(CIMMYT)Bangladesh Office Gulshan-2Dhaka 1212Bangladesh Center for Seed Science University of AgricultureFaisalabad 38000Pakistan Department of Biosciences COMSATS University IslamabadPark RoadTarlai KalanIslamabad 45550Pakistan CGIAR’s Excellence in Breeding(EiB)Platform/Accelerated Breeding Initiative International Maize and Wheat Improvement Center(CIMMYT)El Batán 56237Mexico

Rice and wheat provide nearly 40%of human calorie and protein *** share a common ancestor and belong to the Poaceae(grass)*** their genetic homology is crucial for developing new cultivars with enhanced *** wheat genes and gene families have been characterized based on their rice ***–wheat orthology can identify genetic regions that regulate similar traits in both ***–wheat comparative genomics can identify candidate wheat genes in a genomic region identified by association or QTL mapping,deduce their putative functions and biochemical pathways,and develop molecular markers for marker-assisted breeding.A knowledge of gene homology facilitates the transfer between crops of genes or genomic regions associated with desirable traits by genetic engineering,gene editing,or wide crossing.

关键词： Comparative genomics Orthologs Genes Synteny Genetic engineering Molecular breeding

A Novel Approach for Mitigating Power Quality Issues in a PV Integrated Microgrid System Using an Improved Jelly Fish Algorithm

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Journal of Bionic Engineering 2023年第1期20卷 30-46页

作者： swati Suman Debashis Chatterjee Rupali Mohanty Department of Electrical Engineering Jadavpur UniversityKolkataWest Bengal700032India

A two-step methodology was used to address and improve the power quality concerns for the PV-integrated microgrid system. First, partial shading was included to deal with the real-time issues. The Improved Jelly Fish Algorithm integrated Perturb and Obserb (IJFA-PO) has been proposed to track the Global Maximum Power Point (GMPP). Second, the main unit-powered via DC–AC converter is synchronised with the grid. To cope with the wide voltage variation and harmonic mitigation, an auxiliary unit undergoes a novel series compensation technique. Out of various switching approaches, IJFA-based Selective Harmonic Elimination (SHE) in 120° conduction gives the optimal solution. Three switching angles were obtained using IJFA, whose performance was equivalent to that of nine switching angles. Thus, the system is efficient with minimised higher-order harmonics and lower switching losses. The proposed system outperformed in terms of efficiency, metaheuristics, and convergence. The Total Harmonic Distortion (THD) obtained was 1.32%, which is within the IEEE 1547 and IEC tolerable limits. The model was developed in MATLAB/Simulink 2016b and verified with an experimental prototype of grid-synchronised PV capacity of 260 W tested under various loading conditions. The present model is reliable and features a simple controller that provides more convenient and adequate performance.

关键词： Harmonic mitigation Selective harmonic elimination pulse width modulation inverters Search-based optimization techniques Bionic algorithm Total harmonic distortion Modulation indices

Peroxisome proliferator-activated receptor gamma as a therapeutic target for hepatocellular carcinoma:Experimental and clinical scenarios

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World Journal of Gastroenterology 2022年第28期28卷 3535-3554页

作者： swati Katoch Vinesh Sharma Vikram Patial Division of Dietetics and Nutrition Technology Institute of Himalayan Bioresource TechnologyPalampur 176061Himachal PradeshIndia Academy of Scientific and Innovative Research Ghaziabad 201002UPIndia

Hepatocellular carcinoma(HCC)is the most common type of liver cancer *** hepatitis is a significant risk factor for HCC,although metabolic syndrome and diabetes are more frequently associated with the *** increasing prevalence,there is expected to be>1 million cases annually by ***,there is an urgent need to establish potential therapeutic targets to cure this ***-proliferator-activated receptor gamma(PPARγ)is a ligand-activated transcription factor that plays a crucial role in the pathophysiology of *** synthetic agonists of PPARγsuppress HCC in experimental studies and clinical *** synthetic agonists have shown promising results by inducing cell cycle arrest and apoptosis in HCC cells and preventing the invasion and metastasis of ***,some synthetic agonists also pose severe side effects in addition to their therapeutic *** natural PPARγagonists can be an alternative to exploit this potential target for HCC *** this review,the regulatory role of PPARγin the pathogenesis of HCC is ***,the experimental and clinical scenario of both synthetic and natural PPARγagonists against HCC is *** of the available literature advocates PPARγas a potential therapeutic target for the treatment of HCC.

关键词： Anticancer Hepatocellular carcinoma Natural agonists Peroxisome proliferator-activated receptor-γ Thiazolidinediones

Stability assessment of emulsion of carotenoids extracted from carrot bio-waste in flaxseed oil and its application in food model system

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Food Bioscience 2022年第3期47卷 1016-1022页

作者： swati Tiwari Neelam Upadhyay Ashish Kumar Singh Dairy Technology Division ICAR-National Dairy Research InstituteKarnal132001HaryanaIndia

The research was conducted on the stability assessment of emulsion of carotenoids extracted from carrot-pomace in omega-3 rich flaxseed oil,followed by converting this emulsion into freeze-dried powder,and its application as natural functional colorant in the preparation of flavored *** study indicated that emulsion was stable over a range of pH (5–9),temperature (forewarming to HTST pasteurization) and ionic strength (0.1–0.75 M NaCl) except at pH 4,sterilization temperature and 1.0 M NaCl based on zeta potential and particle size of emulsion analysed at these *** percent (out of 8,10 and 12%) of freeze-dried emulsion was selected for addition as a natural functional ingredient in flavored milk on the basis of organoleptic *** fat,protein,total solids,total carotenoid content and antioxidant value (in terms of ABTS and reducing power assay) of developed product were significantly higher (p < 0.05) than *** whiteness index of control was significantly higher (p < 0.05) than the developed product,while reverse was true for yellowness ***,both the products showed total color difference of *** research concludes that carotenoid-rich emulsion can be efficiently freeze-dried and used as a functional natural colorant in flavored milk for providing it better bio-functional attributes over control.

关键词： Carotenoids Carrot bio-waste Nano-emulsion Stability studies Flavored milk

Role of hormone receptors and HER2 as prospective molecular markers for breast cancer:An update

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Genes & Diseases 2022年第3期9卷 648-658页

作者： swati Sucharita Mohanty Chita Ranjan Sahoo Rabindra Nath Padhy Cytogenetics Laboratory P.G.Department of ZoologyUtkal UniversityBhubaneswarOdisha 751004India Central Research Laboratory Institute of Medical Sciences&SUM HospitalSiksha'O’Anusandhan Deemed to be UniversityBhubaneswarOdisha 751003India

This review provides an updated account on the current methods,principles and mechanism of action of therapies for the detection of molecular markers of therapeutic importance in the prognosis of breast cancer progression and recurrence,which includes estrogen receptor(ER),progesterone receptor(PR)and human epidermal growth factor receptor2(HER2).Indeed,hormone-receptors namely,ER,PR,proto-oncogene HER2 are the basic molecular markers that are recognized and established prognostic factors and predictors of response,for therapeutic *** markers can be detected by using immunohistochemistry(IHC)and fluorescence in situ hybridization(FISH),which are established,faster and cost effective detection *** molecular markers along with clinicopathological prognostic parameters give the best prediction of the prognosis of cancer recurrence and ***,hormone receptors and HER2 as molecular markers are of prime therapeutic importance and have the capability to take part in future drug development techniques.

关键词： Breast cancer Molecular diagnostic Molecular markers Predictive markers Prognostic

Fingerprint analysis for the determination of hand origin(right/left)using the axis slant in whorl patterns

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Forensic Sciences Research 2022年第2期7卷 285-289页

作者： Neeti Kapoor Ashish Badiye swati Dubey Mishra Department of Forensic Science Government Institute of Forensic ScienceNagpurMaharashtraIndia Shri Vaishnav Institute of Forensic Science Shri Vaishnav Vidyapeeth VishwavidyalayaIndoreMadhya PradeshIndia

Fingerprints are frequently encountered during both civil and criminal *** possess numerous characteristics that assist with personal *** the hand of origin(right or left)for an individual fingerprint would help reduce investigation time and potentially eliminate certain *** this study,we collected a total of 2900 single digit fingerprints from 290 individuals,and the whorl axis slant was examined in the 743 whorl pattern fingerprints(385 from the right hand and 358 from the left hand).A slant towards the right side was present in 81.82%of samples from the right hand,while a slant towards the left side was observed in 80.73%of samples from the left *** applying a chi-square test to the dataset,the results were found to be statistically significant for the determination of hand *** results suggest that the whorl axis slant in a fingerprint is indicative of hand origin(right or left).

关键词： Forensic sciences side determination whorl slant fingerprint analysis crime hand

Effects of thermal radiation on Casson fluid flow and heat transfer over an unsteady stretching surface subjected to suction/blowing

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Chinese Physics B 2013年第11期22卷 362-368页

作者： swati Mukhopadhyay Department of Mathematics The University of Burdwan

The unsteady flow of a Casson fluid and heat transfer over a stretching surface in presence of suction/blowing are investigated. The transformed equations are solved numerically by using the shooting method. The exact solution corre- sponding to the momentum equation for the steady case is obtained. Fluid velocity initially decreases with the increase of unsteadiness parameter. Due to an increasing Casson parameter the velocity field is suppressed. Thermal radiation enhances the effective thermal diffusivity and the temperature rises.

关键词： unsteady flow Casson fluid stretching surface suction/blowing

A novel herbal combination ameliorates ovarian dysfunction and regulates altered biochemical parameters in rats with letrozole-induced polycystic ovary syndrome

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Asian pacific Journal of Reproduction 2023年第1期12卷 23-34页

作者： Sunita Shailajan Sasikumar Menon swati Singh Yugandhara Patil Herbal Research Lab(Department of Botany) Ramnarain Ruia Autonomous CollegeMatungaMumbai-400019India Therapeutic Drug Monitoring Laboratory Sion(East)Mumbai-400022India

Objective:To investigate the potential activity of novel herbal combination and novel herbal formulation(syrup)in female Sprague Dawley rats with letrozole-induced polycystic ovary syndrome(PCOS).Methods:Forty-two rats were randomly divided into seven groups with six rats in each *** 1 received 0.5%carboxy methylcellulose orally for 37 days and served as the normal control *** 2 was orally administered with letrozole of 1 mg/kg for 21 days and served as the PCOS induction group without *** 3 to 7 were administered with letrozole of 1 mg/kg for 21 days orally to induce PCOS,and then respectively received clomiphene citrate at 1 mg/kg,100 and 200 mg/kg of novel herbal combination,200 mg/kg of novel herbal formulation(syrup),and 400 mg/kg of marketed formulation of Pushyanuga churna,once daily for 15 *** of the novel herbal combination and its syrup formulation were evaluated on the hormonal profile,the levels of antioxidants,the lipid profile and on the ovarian morphology,using letrozole-induced PCOS model in ***:Letrozole caused alterations in hormonal levels and lipid levels similar to PCOS and ovarian histology showed presence of ovarian cysts confirming the induction of PCOS in *** treatment with the novel herbal combination and its syrup formulation in PCOS-induced rats,the altered hormonal and lipid profiles showed significant recovery to normal *** histology confirmed the restoration of folliculogenesis in the PCOS-induced *** treatment with the syrup formulation of novel herbal combination was found to be more effective than novel herbal combination and showed better recovery in various parameters *** results of the study,however,suggested that treatment with novel herbal combination and its syrup formulation provided minimal protection against oxidative stress caused due to the induction of ***:The integrated approach for management of PCOS is to counterbalance the limita

关键词： Polycystic ovarian syndrome Polyherbal combination Letrozole Pushyanuga churna Clomiphene citrate Histopathology Biochemical Herbal