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Heterogeneity of mature oligodendrocytes in the central nervous system

Neural regeneration research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam M.r.Groh Moein Yaqubi Qiao-Ling Cui Jo Anne Stratton G.r.Wayne Moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by robertson and río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus rNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

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Spastin and alsin protein interactome analyses begin to reveal key canonical pathways and suggest novel druggable targets

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Neural regeneration research 2025年第3期20卷 725-739页

作者： Benjamin r.Helmold Angela Ahrens Zachary Fitzgerald P.Hande Ozdinler Department of Neurology Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Center for Molecular Innovation and Drug Discovery Center for Developmental TherapeuticsChemistry of Life Processes InstituteNorthwestern UniversityEvanstonILUSA Mesulam Center for Cognitive Neurology and Alzheimer’s Disease Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Feinberg School of Medicine Les Turner ALS Center at Northwestern UniversityChicagoILUSA

Developing effective and long-term treatment strategies for rare and complex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among patients. This hinders understanding the underlying disease-causing mechanisms and building solutions that have implications for a broad spectrum of patients. One potential solution is to develop personalized medicine approaches based on strategies that target the most prevalent cellular events that are perturbed in patients. Especially in patients with a known genetic mutation, it may be possible to understand how these mutations contribute to problems that lead to neurodegeneration. Protein–protein interaction analyses offer great advantages for revealing how proteins interact, which cellular events are primarily involved in these interactions, and how they become affected when key genes are mutated in patients. This line of investigation also suggests novel druggable targets for patients with different mutations. Here, we focus on alsin and spastin, two proteins that are identified as “causative” for amyotrophic lateral sclerosis and hereditary spastic paraplegia, respectively, when mutated. Our review analyzes the protein interactome for alsin and spastin, the canonical pathways that are primarily important for each protein domain, as well as compounds that are either Food and Drug Administration–approved or are in active clinical trials concerning the affected cellular pathways. This line of research begins to pave the way for personalized medicine approaches that are desperately needed for rare neurodegenerative diseases that are complex and heterogeneous.

关键词： ALS2 alsin amyotrophic lateral sclerosis hereditary spastic paraplegia neurodegenerative diseases personalized medicine precision medicine protein interactome protein-protein interactions SPAST spastin

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Evaluation of anti-inflammatory and anti-arthritic property of ethanolic extract of Clitoria ternatea

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Chinese Herbal Medicines 2021年第2期13卷 243-249页

作者： K.P.swathi Saravanan Jayaram Deepa Sugumar Emdormi rymbai Department of Pharmacology KMCH College of PharmacyTamil Nadu Dr.M.G.R.Medical UniversityCoimbatore 641048India Department of Pharmacology JSS College of PharmacyJSS Academy of Higher Education and ResearchOoty 643001India

Objective:Clitoria ternatea is a well-known bioactive plant used to treat several inflammatory ailments in Ayurvedic system of medicine in *** present investigation aimed to determine the antiinflammatory and anti-arthritic activity of ethanolic extract of Clitoria ternatea roots(EECT) in animal ***:The anti-inflammatory activity of the EECT was evaluated by carrageenan and histamineinduced paw ***:EECT showed a significant reduction in mean paw edema volume in both carrageenan and histamine-induced *** efficacy of EECT in rheumatoid arthritis was tested against Freund's complete adjuvant(CFA) induced arthritic model in Wistar *** anti-arthritic effect of EECT was determined by systematic scoring of arthritis symptoms and measuring paw edema.A considerable decrease in paw diameter was observed in the EECT(200 and 400 mg/kg) and diclofenac(10 mg/kg) treated groups after day ***(10 mg/kg) and EECT(400 mg/kg) showed a significant reduction in paw diameter from day 14 compared with CFA control(P rthritic activity was also confirmed from the altered biochemical,haematological(Hb,rBC and WBC) and anti-oxidant parameters(SOD,MDA,CAT,and GSH).EECT(400 and 200 mg/kg) also showed a marked inhibition of joint ***:This study provides a pharmacological rationale for the traditional use of *** against inflammation and rheumatoid arthritis in India.

关键词： antioxidants Clitoria ternatea Linn. inflammation rheumatoid arthritis

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Confluence of ZnO and PTFE Binder for Enhancing Performance of Thin-Film Lithium-Ion Batteries

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Energy & Environmental Materials 2024年第5期7卷 48-56页

作者： Subhashree Behera swathi Ippili Venkatraju Jella Na-Yeong Kim Seong Cheol Jang Ji-Won Jung Soon-Gil Yoon Hyun-Suk Kim Department of Materials Science and Engineering Chungnam National UniversityDaejeon 34134South Korea School of Materials Science and Engineering University of UlsanUlsan 44776South Korea Department of Energy and Materials Engineering Dongguk UniversitySeoul 04620South Korea

Developing anode materials with high specific capacity and cycling stability is vital for improving thin-film lithium-ion ***-film zinc oxide(ZnO)holds promise due to its high specific capacity,but it suffers from volume changes and structural stress during cycling,leading to poor battery *** this research,we ingeniously combined polytetrafluoroethylene(PTFE)with ZnO using a radio frequency(rF)magnetron co-sputtering method,ensuring a strong bond in the thin-film composite *** effectively reduced stress on the active material and mitigated volume change effects during Li^(+)ion intercalation and *** composite thin films are thoroughly characterized using advanced techniques such as X-ray diffraction,scanning electron microscopy,and X-ray photoelectron spectroscopy for investigating correlations between material properties and electrochemical ***,the ZnO/PTFE thin-film electrode demonstrated an impressive specific capacity of 1305 mAh g^(-1)(=7116 mAh cm^(-3))at a 0.5C rate and a remarkable capacity retention of 82%from the 1st to the 100th cycle,surpassing the bare ZnO thin film(50%).This study provides valuable insights into using binders to stabilize active materials in thin-film batteries,enhancing battery performance.

关键词： li-ion batteries metal oxides anodes polytetrafluoroethylene(PTFE) thin films

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Suicide trends among patients with cancer in India over the past 24 years

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General Psychiatry 2023年第6期36卷 537-540页

作者： M swathi Shenoy Ashish Wasudeo Khobragade Muthathal Subramanian Department of Community and Family Medicine All India Institute of Medical Sciences Raipur Chhattisgarh India

To the editor:Suicide is a significant global public health concern,claiming over 0.7million lives *** is seen in all age groups and is the fourth leading cause of mortality in the 15-29 year old age ***-quarters of suicides are reported in low-income and middle-income countries.1Notably,India significantly contributes to this global burden,reporting 164000 suicides in 2021.

关键词： mortality income patients

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An IoT-based agriculture maintenance using pervasive computing with machine learning technique

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International Journal of Intelligent Computing and Cybernetics 2022年第2期15卷 201-214页

作者： swathi Kailasam Sampath Dakshina Murthy Achanta P.rama Koteswara rao ramesh Vatambeti Saikumar Kayam CSE Koneru Lakshmaiah Education FoundationGunturIndia ECE Vignan’s Institute of Information TechnologyVisakhapatnamIndia ECE NRI Institute of TechnologyKrishnaIndia CHrIST(Deemed to be University) BengaluruIndia ECE Koneru Lakshmaiah Education FoundationGunturIndia

Purpose-In cultivation,early harvest offers farmers an opportunity to increase production while decreasing the chances of lower crop production rates,ensuring that the economy remains *** significant reason is to predict the disease in plants and distinguish the type of syndrome with the help of segmentation and random forest optimization *** this investigation,the accurate prior phase of crop imagery has been collected from different datasets like cropscience,yesmodes and *** the current study,the real-time earlier state of crop images has been gathered from numerous data sources similar to crop_science,yes_modes,nelson_wisc ***/methodology/approach-In this research work,random forest machine learning-based persuasive plants healthcare computing is *** proper ecological care is not applied to early harvesting,it can cause diseases in plants,decrease the cropping rate and less *** now different methods have been developed for crop analysis at an earlier stage,but it is necessary to implement methods to advanced ***,the detection of plant diseases with the help of threshold segmentation and random forest classification has been involved in this *** implemented design is verified on Python 3.7.8 software for simulation ***-In this work,different methods are developed for crops at an earlier stage,but more methods are needed to implement methods with prior stage crop *** of this,a disease-finding system has been *** methodologies like“Threshold segmentation”and rFO classifier lends 97.8% identification precision with 99.3%real optimistic rate,and 59.823 peak signal-to-noise(PSNr),0.99894 structure similarity index(SSIM),0.00812 machine squared error(MSE)values are ***/value-The implemented machine learning design is outperformance methodology,and they are proving good application detection rate.

关键词： Crop harvesting Detection of plant disease rFO Classification Threshold segmentation

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racial differences in prevalence and severity of non-alcoholic fatty liver disease

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World Journal of Hepatology 2021年第7期13卷 763-773页

作者： Maurizio Bonacini Farah Kassamali swathi Kari Nieves Lopez Barrera Mohamed Kohla Department of Gastroenterology and Hepatology California Pacific Medical CenterCalifornia Pacific Medical CenterSan FranciscoCA 94115United States Department of Gastroenterology and Hepatology California Pacific Medical CenterSan FranciscoCA 94115United States Department of Internal Medicine St.Mary's medical CenterSan FranciscoCA 94117United States Quest Clinical research San FranciscoCA 94115United States Department of Hepatology National Liver InstituteMenoufiya UniversityShibin Al Kom 32511MenoufiyaEgypt

The aim of this review is to assess the evidence regarding racial differences in the prevalence and severity of nonalcoholic fatty liver disease(NAFLD).We reviewed the published literature that reported prevalence,severity,and genetic associations of NAFLD in different ethnic *** metabolic syndrome(MetS)has been associated with NAFLD,but each component of the MetS is present in various races in different percentages and their effect on NAFLD appears to be *** elevated triglyceride(TG)level seems to have the strongest association with *** latter is more prevalent in Hispanic patients;Blacks have lower TG levels and a lower NAFLD prevalence,compared to Caucasians or *** severity of liver fibrosis is lower in some,but not all biopsy-based studies of Black *** study has evaluated the severity of liver disease controlling for the individual components of MetS,especially *** racial differences in the prevalence of selected genetic polymorphisms,particularly PNPLA-3 and MBOAT7 have been documented,together with their effects on the prevalence of liver steatosis and *** on overall and liver mortality have found no significant differences according to race/ethnicity,with the possible exception of one paper reporting lower cirrhosis mortality in Black *** conclude that NAFLD is more prevalent in Hispanics and less in *** is supported by differences in key genetic polymorphisms associated with hepatic fat ***,there is presently insufficient evidence to firmly conclude that race,per se,plays a role in the development of liver fibrosis and its *** studies,appropriately controlled for diet,exercise,and individual MetS parameters are needed.

关键词： race Ethnicity Nonalcoholic fatty liver disease Fatty liver disease Metabolic syndrome

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Structure, photocatalytic and antibacterial activity study of Meso porous Ni and S co-doped TiO2 nano material under visible light irradiation

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Chinese Journal of Chemical Engineering 2019年第7期27卷 1630-1641页

作者： K.V.Divya Lakshmi T.Siva rao J.swathi Padmaja I.Manga raju M.ravi Kumar Department of Inorganic and Analytical Chemistry Andhra University

Undoped and Ni–S co-doped mesoporous TiO2 nano materials were synthesized by using sol–gel *** characteristic features of as prepared catalyst samples were investigated using various advanced spectroscopic and analytical *** characterization results of the samples revealed that all the samples exhibited anatase phase(XrD),decreasing band gap(2.68 eV)(UV–Vis-DrS),small particle size(9.2 nm)(TEM),high surface area(142.156 m^2·g^-1)(BET),particles with spherical shape and smooth morphology(SEM);there is a frequency shift observed for co-doped sample(FT-Ir)and the elemental composition electronic states and position of the doped elements(Ni and S)in the TiO2 lattice analyzed by XPS and *** results supported the photocatalytic degradation of Bismarck Brown red(BBr)achieved with in 110 min and also exhibited the antibacterial activity on Staphylococcus aureus(MTCC-3160),Pseudomonas fluorescence(MTCC-1688)under visible light irradiation.

关键词： Sol–gel Ni–S co-doped TiO2 Photocatalysis under visible light Degradation of Bismarck Brown red Antibacterial activity

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A spotlight on dosage and subject selection for effective neuroprotection: exploring the central role of mitochondria

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Neural regeneration research 2025年第4期20卷 1081-1082页

作者： John Mitrofanis Jonathan Stone Michael r.Hamblin Pierre Magistretti Alim-Louis Benabid Glen Jeffery Fonds Clinatec UniversitéGrenoble AlpesGrenobleFrance School of Medical Science University of SydneySydneyAustralia Faculty of Health Sciences University of JohannesburgJohannesburgSouth Africa King Abdullah University of Science and Technology ThuwalSaudi Arabia Institute of Ophthalmology University College LondonLondonUK

Neurons are notoriously vulnerable cell *** the slightest change in their internal and/or external environments will cause much distress and dysfunction,leading often to their death.A range of pathological conditions,including stroke,head trauma,and neurodegenerative disease,can generate stress in neurons,affecting their survival and proper *** most neural pathologies,mitochondria become dysfunctional and this plays a pivotal role in the process of cell *** challenge over the last few decades has been to develop effective interventions that improve neuronal homeostasis under pathological *** interventions,often referred to as disease-modifying or neuroprotective,have,however,proved frustratingly elusive,at both preclinical and,in particular,clinical *** this perspective,we highlight two factors that we feel are key to the development of effective neuroprotective *** are:firstly,the choice of dose of intervention and method of application,and secondly,the selection of subjects,whether they be patients or the animal model.

关键词： protective dosage distress

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Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural regeneration research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown rafael J.Yáñez-Muñoz Heidi r.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

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