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Evaluation of L-dopa,proximate composition with in vitro anti-inflammatory and antioxidant activity of Mucuna macrocarpa beans:A future drug for Parkinson treatment

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Asian Pacific Journal of Tropical Biomedicine 2017年第12期7卷 1097-1106页

作者： Chetan Aware Ravishankar Patil swaroopsingh gaikwad Shrirang Yadav Vishwas Bapat Jyoti Jadhav Department of Biotechnology Shivaji UniversityVidyanagarKolhapurMaharashtraIndia Department of Biochemistry Shivaji UniversityVidyanagarKolhapurMaharashtraIndia Department of Botany Shivaji UniversityVidyanagarKolhapurMaharashtraIndia

Objective: To investigate L-3, 4-dihydroxyphenylalanine(L-dopa, anti-Parkinson drug),anti-inflammatory activity, proximate nutritional composition and antioxidant potential of Mucuna macrocarpa(M. macrocarpa) ***: L-dopa content was determined and quantified by high performance thin layer chromatography and reversed phase high-performance liquid chromatography(RPHPLC) methods. Anti-inflammatory activity was performed by in vitro protein denaturation inhibition and human red blood cell membrane stabilisation activity. Proximate composition and elemental analysis were also investigated. The antioxidant potential(2,2-diphenyl-1-picrylhydrazyl, N-N-dimethyl-phenylenediamine and ferric-reducing antioxidant power) of M. macrocarpa beans were evaluated by using different extraction solvents. The RP-HPLC analysis also quantified significant phenolics such as gallic acid, tannic acid, p-hydroxybenzoic acid and p-coumaric ***: RP-HPLC quantification revealed that M. macrocarpa beans contain a high level of L-dopa [(115.41 ± 0.985) mg/g] which was the highest among the Mucuna species from Indian sub-continent. Water extract of seed powder showed strong antiinflammatory and antioxidant potential. Proximate composition of M. macrocarpa beans revealed numerous nutritional and anti-nutritional components. RP-HPLC analysis of major phenolics such as tannic acid(43.795 mg/g), gallic acid(0.864 mg/g), p-coumaric acid(0.364 mg/g) and p-hydroxybenzoic acid(0.036 mg/g) quantified successfully from M. macrocarpa beans ***: This study suggests that M. macrocarpa is a potential source of L-dopa with promising anti-inflammatory, antioxidant and nutritional benefits.

关键词： Anti-inflammatory Antioxidants L-dopa Mucuna macrocarpa Oxidative stress Parkinson’s disease

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