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In vivo femtosecond laser nanosurgery of the cell wall enabling patch-clamp measurements on filamentous fungi

Microsystems & Nanoengineering 2024年第2期10卷 251-267页

作者： Tanja Pajić Katarina Stevanović Nataša V.Todorović Aleksandar J.Krmpot Miroslav Živić svetlana savić-šević Steva M.Lević Marina Stanić Dejan Pantelić Brana Jelenković Mihailo D.Rabasović Institute of Physiology and Biochemistry“Ivan Djaja” Faculty of BiologyUniversity of BelgradeStudentski trg 1611158BelgradeSerbia Institute for Biological Research“Siniša Stanković” University of BelgradeNational Institute of the Republic of SerbiaBulevar Despota Stefana 14211000BelgradeSerbia Institute of Physics Belgrade University of BelgradeNational Institute of the Republic of SerbiaPregrevica 11811080BelgradeSerbia University of Belgrade Faculty of AgricultureNemanjina Street 611080BelgradeSerbia Institute for Multidisciplinary Research University of BelgradeKneza Višeslava 111030BelgradeSerbia

Studying the membrane physiology of filamentous fungi is key to understanding their interactions with the environment and crucial for developing new therapeutic strategies for disease-causing ***,their plasma membrane has been inaccessible for a micron-sized patch-clamp pipette for pA current recordings due to the rigid chitinous cell ***,we report the first femtosecond IR laser nanosurgery of the cell wall of the filamentous fungi,which enabled patch-clamp measurements on protoplasts released from hyphae.A reproducible and highly precise(diffraction-limited,submicron resolution)method for obtaining viable released protoplasts was *** release from the nanosurgery-generated incisions in the cell wall was achieved from different regions of the *** plasma membrane of the obtained protoplasts formed tight and high-resistance(GΩ)contacts with the recording *** entire nanosurgical procedure followed by the patch-clamp technique could be completed in less than 1 *** to previous studies using heterologously expressed channels,this technique provides the opportunity to identify new ionic currents and to study the properties of the ion channels in the protoplasts of filamentous fungi in their native environment.

关键词： patch recording laser

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Mechanism of Cu entry into the brain:many unanswered questions

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Neural Regeneration Research 2024年第11期19卷 2421-2429页

作者： Shubhrajit Roy svetlana Lutsenko Department of Physiology Johns Hopkins University School of MedicineBaltimoreMDUSA

Brain tissue requires high amounts of copper(Cu)for its key physiological processes,such as energy production,neurotransmitter synthesis,maturation of neuropeptides,myelination,synaptic plasticity,and radical *** requirements for Cu in the brain vary depending on specific brain regions,cell types,organism age,and nutritional *** imbalances cause or contribute to several life-threatening neurologic disorders including Menkes disease,Wilson disease,Alzheimer’s disease,Parkinson’s disease,and *** the well-established role of Cu homeostasis in brain development and function,the mechanisms that govern Cu delivery to the brain are not well *** review summarizes available information on Cu transfer through the brain barriers and discusses issues that require further research.

关键词： ATOX1 ATP7A ATP7B blood-brain barrier brain choroid plexus copper SLC31A1

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Comparison of extraction abilities of deep eutectic solvents and aqueous acid solutions for extraction of rare earths and transition metals

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Journal of Rare Earths 2024年第6期42卷 1157-1164,I0006页

作者： svetlana Drogobuzhskaya Margarita Frolova Andrey Shishov Nikita Tsvetov Tananaev Institute of Chemistry-Subdivision of the Federal Research Centre《Kola Science Centre of the Russian Academy of Sciences》 18420926a AcademgorodokApatityRussia Murmansk State Technical University 183010Sportivnaja str.13MurmanskRussia Department of Analytical Chemistry Institute of ChemistrySaint Petersburg State UniversitySpbSU.1990347/9 Universitetskaya embSt.Petersburg Russia

In recent years,deep eutectic solvents have attracted increasing interest as effective extractants for the separation of both organic substances and metals from various ***-based deep eutectic solvents are most often used as extractants for the extraction of *** this work,for the first time,the extraction efficiency of transition metals and rare earth elements(Y,Zr,Nb,La,Ce,Pr,Nd,Sm,Eu,Gd,Tb,Dy,Ho,Er,Tm,Yb,Lu,Hf and Ta)from mining tailings and Na,K,Ca,Mg,Cu,Fe,Mn,Pb,Ba,Ni and Sr from biodiesel samples using acidic deep eutectic solvents and saturated aqueous solutions of the same acids(malonic,malic,tartaric and citric)is *** this,deep eutectic solvents based on acids and their aqueous saturated solutions were prepared and *** prepared mixtures were analyzed by IR spectroscopy to confirm the formation of eutectic *** such as the density and viscosity of the resulting mixtures were also investigated,as this can be of key importance for the efficiency of metal *** extraction of rare earth metals from mining tailings took a long time(up to several days),while the extraction of metals from fuel took no more than 30 *** emission spectral methods were used as an analysis *** is shown that the extraction efficiency with aqueous solutions is better than that with eutectic solvents,which casts doubt on the need for deep eutectic solvents use in this area.

关键词： Deepeutectic solvent Metal separation Elemental analysis Rare earth metals Biodiesel

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Cardiovascular disease mortality and air pollution in countries with different socioeconomic status

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Chronic Diseases and Translational Medicine 2024年第3期10卷 247-255页

作者： Nikolai Khaltaev svetlana Axelrod Global Non-Communicable Diseases Platform Global Alliance against Chronic Respiratory DiseasesGenevaSwitzerland Institute for Leadership and Health Management I.M.Sechenov First Moscow State University(Sechenov University)MoscowRussia

Background Cardiovascular diseases(CVDs)account for 17.9 million deaths *** risk factors increase the risk of dying from *** pollution is not included in this risk calculation since the appreciation of air pollution as a modifiable risk factor is still *** purpose of this study was to analyze CVD mortality attributed to air pollution in all World Health Organization WHO member states and demonstrate the association of CVD mortality with air pollution depending on countries'income *** The CVD death rate was calculated by dividing the number of deaths by the total *** proportion of the population with primary reliance on clean fuels and technologies for cooking was calculated as an indicator of household air *** annual mean concentration of fine particulate matter≤2.5µg/m^(3) and≤10.0µg/m^(3) to which the population is exposed was used as an indicator of ambient air *** There is a gradual increase in CVD mortality attributed to air pollution from high-income countries(HICs)to low-income countries(LICs).Household air pollution is the major cause of CVD mortality in *** heart disease mortality attributed to ambient air pollution in all countries is higher than stroke mortality attributed to ambient air *** LIC,mortality from stroke is attributed to household air pollution of 39.27±14.47,which is more than twice the stroke mortality attributed to ambient air pollution at 18.60±5.64,t=7.17,p<*** Air pollution control should be an essential component of the CVD preventive strategy,along with lifestyle modifications and effective disease management.

关键词： ambient air pollution cardiovascular disease household air pollution low-income countries World Health Organization

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Phosphine/Benzocyclone-based Neutral Nickel Catalysts for Ethylene Polymerization and Copolymerization with Polar Monomers

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Chinese Journal of Polymer Science 2024年第2期42卷 202-212,I0007页

作者： Fei Wang Li Pan Vladislav A.Tuskaev svetlana Ch.Gagieva Yue-Sheng Li Tianjin Key Lab of Composite&Functional Materials School of Material Science and EngineeringTianjin UniversityTianjin300072China Department of Chemistry Lomonosov Moscow State UniversityRussian Federation InstitutionLeninskie Gory 1Moscow119991Russian Federation A N Nesmeyanov Institute of Organoelement Compounds Russian Academy of SciencesVavilova st.28Moscow119991Russian Federation

The efficient copolymerization of olefin with polar monomers using nickel-based catalysts presents a longstanding challenge. In this contribution, three phosphine-benzocyclone ligands and corresponding neutral nickel catalysts(Ni1: Ar = Ph;Ni2: Ar = 2-(C_(6)H_(5))C_(6)H_(4);Ni3: Ar = 2-[2',6'-(Me O)_(2)-C_(6)H3]C_(6)H_(4)) were prepared and applied for the ethylene polymerization and copolymerization with polar monomers without any cocatalyst. The bulky substituent groups in complexes Ni2 and Ni3 contributed to high catalytic activities(up to 7.24×10^(6) and 9.04×10^(6)g·mol Ni^(-1)·h^(-1), respectively), and produced high-molecular-weight polyethylene(Mw up to 545.7 k Da). Complex Ni3 exhibited high activities for ethylene polymerization at the level of 10^(6) g·mol Ni^(-1)·h^(-1) across a wide range from 30 ℃ to 120 ℃, exhibiting excellent high temperature tolerance. These nickel complexes were also effectively employed in the copolymerization of ethylene with methyl acrylate, ethyl acrylate, butyl acrylate and lauryl acrylate, producing copolymers with high molecular weights(Mw up to 80.5 k Da) and high polar monomer incorporation(up to 8.2 mol%). Microstructure analyses revealed that the introduction of large sterically hindered substituents facilitated the incorporation of polar functional units into the polymer backbone. This study demonstrates the potential of these nickel-based catalysts for efficient copolymerization of olefin with polar monomers.

关键词： Neutral nickel catalyst Ethylene polymerization Copolymerization Polar acrylate monomers

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Association of ABCB1 gene polymorphisms rs1128503, rs2032582, rs4148738 with anemia in patients receiving dabigatran after total knee arthroplasty

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Chinese Journal of Traumatology 2024年第1期27卷 27-33页

作者： Alina Kasimova Dmitry Labutin Anton Gvozdetsky svetlana Bozhkova Division of Wound Infection Prevention and Treatment Vreden National Medical Research Center of Traumatology and OrthopaedicsSt.PetersburgRussian Federation Department of Clinical Pharmacology and evidence-based Medicine Pavlov First Saint Petersburg State Medical UniversitySt.PetersburgRussian Federation Department of Psychiatry and Addictology North-Western State Medical University named after I.I.MechnikovSt.PetersburgRussian Federation

Purpose:Dabigatran is usually prescribed in recommended doses without monitoring of the blood coagulation for the prevention of venous thromboembolism after joint ***1 is a key gene in the metabolism of dabigatran *** allele variants are likely to play a pivotal role in the occurrence of hemorrhagic ***:The prospective study included 127 patients with primary knee osteoarthritis undergoing total knee *** with anemia and coagulation disorders,elevated transaminase and creatinine levels as well as already receiving anticoagulant and antiplatelet therapy were excluded from the *** association of ABCB1 gene polymorphisms rs1128503,rs2032582,rs4148738 with anemia as the outcome of dabigatran therapy was evaluated by single-nucleotide polymorphism analysis with a realtime polymerase chain reaction assay and laboratory blood *** beta regression model was used to predict the effect of polymorphisms on the studied laboratory *** probability of the type 1 error(p)was less than 0.05 was considered statistically *** was used to correct for significance levels in multiple hypothesis *** calculations were performed using Rprogramming language ***:For all polymorphisms there was no association with the level of platelets,protein,creatinine,alanine transaminase,prothrombin,international normalized ratio,activated partial thromboplastin time and *** of rs1128503(TT)had a significant decrease of hematocrit(p=0.001),red blood count and hemoglobin(p=0.015)while receiving dabigatran therapy during the postoperative period compared to the CC,*** of rs2032582(TT)had a significant decrease of hematocrit(p=0.001),red blood count and hemoglobin(p=0.006)while receiving dabigatran therapy during the postoperative period compared to the GG,GT *** differences were not observed in carriers of ***:It might be necessary to r

关键词： Thromboprophylaxis P-glycoprotein Dabigatran Anemia SNPs

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Peculiarities of Ethylene Polymerization Reactions with Bis(imino)pyridyl Complexes of CoCl_(2) and FeCl_(2)

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Chinese Journal of Polymer Science 2024年第4期42卷 492-500页

作者： Laura A.Rishina Yury V.Kissin svetlana S.Lalayan Artem A.Antonov Vadim G.Krasheninnikov Alexander A.Gulin N.N.Semenov Federal Research Center for Chemical Physics Russian Academy of Sciences4 Kosygin St.Moscow119991Russia Department of Chemistry and Chemical Biology RutgersThe State University of New Jersey123 Bevier Rd.PiscatawayNJ08854USA Boreskov Institute of Catalysis Russian Academy of Sciences5 Lavrentieva Prosp.Novosibirsk630090Russia

The article describes ethylene polymerization reactions with transition metal catalysts based on complexes of CoCl_(2) and FeCl_(2) with an N,N,N-tridentate ligand 2,6-bis[1-(2,6-dimethylphenylimino)ethyl]pyridine. The complexes are converted into polymerization catalysts by reacting them either with polymethylalumoxane (MAO) or with a combination of Al(C2H5)2Cl and Mg(C4H9)2 at an [Al]:[Mg] ratio of ~3. Both MAO-activated complexes readily polymerize ethylene at 35 ℃ with the formation of linear, low molecular weight polymers with a narrow molecular weight distribution. The same complexes, when activated with the Al(C2H5)2Cl-Mg(C4H9)2 combination, form multi-center catalysts and generate polyethylenes with a broad molecular weight distribution.

关键词： Ethylene polymerization Bis(imino)pyridyl complexes of CoCl_(2)and FeCl_(2) Molecular-weight distribution Polymer chain structure

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Individual alcohol consumption by the population of Russia versus regional living conditions

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Global Health Journal 2024年第1期8卷 24-31页

作者： Sergey A.Maksimov svetlana A.Shalnova Galina A.Muromtseva Yuliya A.Balanova svetlana E.Evstifeeva Anna V.Kapustina Oksana M.Drapkina National Medical Research Center for Therapy and Preventive Medicine Moscow 101990Russia

Background:There are substantial regional differences in drinking alcohol in Russia,both at the population and individual ***,the causes of these differences have not been studied ***:The goal of our study was to examine the effect of regional living conditions on individual alcohol consumption by the population of ***:For the analysis,we used data from a cross-sectional epidemiological study conducted in *** final analytical sample included 18,130 people aged 25-64 *** conducted the interviews face to face,based on which any drinking in the last year,as well as alcohol abuse,were considered as a *** abuse was recorded when the respondent consumed 5.75 or more grams of pure ethanol per day(75th percentile of average daily alcohol consumption among alcohol drinkers).The assessment of the regional living conditions was accomplished via integral indexing,which was previously performed based on publicly available data for *** were assessed using generalized scoring equations with unchanging standard *** associations were expressed by odds ratios(OR)and 95%confidence intervals(C).Results:Deterioration of social conditions and increase in demographic depression in the region of residence increased the odds of any drinking(OR 1.51,95%CI:1.33 to 1.72,P<0.001 and OR 1.22,95%CI:1.05 to 1.41,P=***9,respectively).The odds of alcohol abuse increased with the deterioration of social living conditions and the growth of the industrial development in the region:OR 1.35,95%CI:1.14 to 1.59,P<0.001 and OR 1.16,95%CI:1.05 to 1.28,P=0.002,***:Our analysis allowed assessing the impact of the regional living conditions on individual drinking alcohol in the population of Russia.

关键词： Alcohol Living environment Regional features Russia

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A rare case of cardiac and ophthalmic manifestations of meningococcal septicemia

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World Journal of Emergency Medicine 2024年第4期15卷 328-330页

作者： svetlana Rachina Anastasia Shchendrygina Heshan Radeesha de Silva svetlana Tarasenko Nadezhda Mukhina Irina Komarova Ludmila Fedina Elena Burmistrova Elvira Martens Sergey Sidorenko Vladimir Gostev Dmitry Polev Alina Saitova Lyudmila Kraeva Nikita Goncharov Irina Zvetkova Department of Hospital Therapy I M Sechenov First Moscow State Medical UniversityMoscow 119048Russia Outpatient Clinic#64 Moscow 119048Russia Department of Cardiology City Clinical Hospital n.a.S.S.YudinMoscow 119048Russia Department of Medical Microbiology and Molecular Epidemiology Pediatric Research and Clinical Center for InfectiousDiseasesSaint Petersburg 197022Russia Department of Medical Microbiology North-Western State Medical University Named After I.I.MechnikovSaintPetersburg 191015Russia Department of Epidemiology Saint-Petersburg Pasteur InstituteSaint Petersburg 197101Russia

Acute pericarditis is usually a self-limiting disorder that commonly occurs due to viral etiology or unexplained *** pericarditis(MP)is a remarkably uncommon clinical entity that manifests as a complication during the acute or convalescent phase of meningococcal ***,its occurrence within the context of meningococcal septicemia has also been *** report a rare case of a previously healthy male patient who developed both acute pericarditis and uveitis as a presentation of meningococcal septicemia,with no characteristic skin rashes or meningeal signs.

关键词： acute Acute rare

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Functional Dependence of IM and HV Angle in Hallux Valgus Deformity before and after Operative

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Journal of Applied Mathematics and Physics 2024年第5期12卷 1626-1646页

作者： Nenad Stojanović Mirko Sovilj Vesna Ivanišević Department of Mathematics Faculty of Philosophy University of Banja Luka Banja Luka Bosnia and Herzegovina Higher Medical School Prijedor Bosnia and Herzegovina Faculty of Medicine University of Banja Luka Banja Luka Bosnia and Hercegovina

Hallux valgus is a relatively common and multifaceted complex deformity of the front part of the foot. It is the result of multiple effects of innate (endogenous) and exogenous etiological factors with different degrees of influence. The degree of hallux valgus deformity is usually assessed by radiological values of hallux valgus (HV) and intermetatarsal (IM) angles. The aim of the paper is to justify the definition of hallux valgus deformity as a function of one angle, (HVA or IMA), and then to determine the functional connection and the most suitable function equalizing the values of the angles IMA and HVA. As hallux valgus is a double angulation deformity, the analytically determined connection between the HVA and IMA angles reduces the study of the deformity to the study of function with one argument, and makes the analysis of deformity changes before and after operative treatment simpler. For the determined connections between the angles, the values of linear proportionality coefficients and regression coefficients of corresponding linear functions of analytical equalization of the value of the IM angle and the degree of deformity for a given value of the HV angle were experimentally determined. The obtained results were checked on a sample of 396 operatively treated hallux valgus deformities. The presented analytical approach and the obtained functional links of IMA and HVA enable quantitative observation of the change in the degree of deformity based on the radiologically determined value of these angles, and the established nonlinear function will be useful for evaluating the expected value of the IM angle and the degree of deformity based only on the measured value of the HV angle. .

关键词： Functional Connection of Deformity Angles Analytical Equalization of IM Angle Values Hallux Valgus Intermetatarsal Angle Correction of Deformity

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