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Antidiabetic profiling of veramycins,polyketides accessible by biosynthesis,chemical synthesis and precursor-directed modification

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Organic Chemistry Frontiers 2022年第6期9卷 1604-1615页

作者： Denis Dardić Nils Böhringer Alberto Plaza Florian Zubeil Juliane Pohl svenja Sommer Leo Padva Jonathan Becker Maria A.Patras Mona-Katharina Bill Michael Kurz Luigi Toti sven w.görgens Sören M.M.Schuler AndréBillion Oliver Schwengers Paulus wohlfart Alexander goesmann Norbert Tennagels Andreas Vilcinskas Peter E.Hammann Till F.Schäberle Armin Bauer Fraunhofer Institute for Molecular Biology and Applied Ecology(IME) Branch for Bioresources35392 GießenGermany Justus-Liebig-University gießen 35392 GießenGermany Sanofi-Aventis Deutschland gmbH R&D Integrated Drug Discovery65926 Frankfurt am MainGermany Sanofi-Aventis Deutschland gmbH R&D German Hub65926 Frankfurt am MainGermany german Center of Infection Research(DZIF) Partner Site Gießen-Marburg-Langen35392 GießenGermany

Seven new polyketides,termed veramycins,were isolated from a Streptomyces *** the Sanofi microbial strain collection along with their known congeners NFAT-133 and *** A,anα-pyrone congener of TM-123 and NFAT-133 showed an increased baseline deoxy-glucose uptake in the absence of insulin in a modified L6 rat skeletal muscle cell line(L6 gLUT4 AS160-like cells).In addition,both compounds slightly increased the sensitivity to insulin in this cell *** syntheses of NFAT-133,TM-123 and veramycin A were accomplished starting from a central building block,which bears the three contiguous stereogenic centers of this polyketide *** approach enables an efficient,selective and flexible access to all possible isomers of the stereotriad for further exploration of this series as a potential anti-diabetic lead structure as exemplified by the synthesis of an NFAT-133 ***,the corresponding biosynthetic gene cluster(BgC)was identified by genome sequencing and gene *** on feeding experiments,a biosynthetic pathway was proposed,which enabled access to new veramycin A analogs by precursor-directed biosynthesis.

关键词： synthesis directed isomers

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In situ spontaneous emission control of MoSe2-wSe2 interlayer excitons with high quantum yield

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Photonics Research 2025年第1期13卷 210-224页

作者： BO HAN CHIRAg C.PALEKAR FREDERIK LOHOF sven STEPHAN VICTOR N.MITRYAKHIN JENS-CHRISTIAN DRAwER ALEXANDER STEINHOFF LUKAS LACKNER MARTIN SILIES BáRBARA ROSA MARTIN ESMANN FALK EILENBERgER CHRISTOPHER gIES STEPHAN REITZENSTEIN CHRISTIAN SCHNEIDER Institut für Physik Fakult?t VCarl von Ossietzky Universit?t Oldenburg Institut für Festk?rperphysik Technische Universit?t Berlin Institute for Theoretical Physics and Bremen Center for Computational Material Science Universit?t Bremen Institute for Lasers and Optics Hochschule Emden/Leer Fraunhofer-Institute for Applied Optics and Precision Engineering IOF Institute of Applied Physics Abbe Center of PhotonicsFriedrich Schiller Universit?t Jena Max Planck School of Photonics

Optical resonators are a powerful platform to control the spontaneous emission dynamics of excitons in solidstate nanostructures. we study a MoSe2-wSe2heterostructure that is integrated in a cryogenic open optical microcavity to gain insights into fundamental optical properties of the emergent interlayer excitons. First, we utilize a low-quality-factor planar open cavity and investigate the modification of the excitonic lifetime as on-and offresonance conditions are met with consecutive longitudinal modes.

关键词： Cavity quantum electrodynamics Nanostructures Optical properties Optical resonators Quantum fluctuations Zeeman effect

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ROMAN LAw: OPENINg THE SYSTEM

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Journal of Ancient Civilizations 2018年第2期33卷 267-282,284页

作者： sven günther IHAC NENU Changchun

Throughout the 20th century, Roman Law was mainly an enigma for historians and classical philologists alike. Its position in the Faculties of Law as Legal History and a systematic, and sometimes even synchronic, perspective of many researchers on legal sources together with self-referential tendencies made it appear a closed system, even though the nestor of Altertumswissenschaften, Theodor Mommsen had once encompassed the trias history, law and philology, albeit with his own taxonomy and connected with his liberal ideas that can be frequently found in his Romische geschichte and Romisches Staatsrecht.

关键词： ROMAN LAw OPENINg THE SYSTEM classical philologists

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NARRATINg CHECKS AND BALANCES?THE SETUP OF FINANCERELATED ADMINISTRATIVE DOCUMENTS AND INSTITUTIONS IN 5TH AND 4TH CENTURY BC ATHENS

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Journal of Ancient Civilizations 2019年第2期34卷 211-227,328页

作者： sven günther IHAC NENUChangchun

The setup and narratives of finance-related administrative documents and powers tell the story and fate of the Athenian *** the one hand,one can see the permanently repeated and impressive statement of stability that did not only astonish contemporaries,especially critics of the democratic *** was mirrored in the frequent publication of financial *** were more representative in various aspects than informative in the sense of a real transparent ***,the many offices mentioned both in the literary and epigraphic documents reflect the constant mistrust in,and restriction of,the accumulation of power in the democratic *** the other hand,these formalities and standardized formulas do clearly not carry the whole story,and are superseded in the course of the 4th century by informal powerconglomerations.

关键词： SETUP finance statement

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global Value Chains, Horizontal Intra-lndustry Trade and the Heterogeneous Firm

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Frontiers of Economics in China-Selected Publications from Chinese Universities 2018年第1期13卷 68-82页

作者： sven w. Arndt Robert Day School of Economics and Finance Claremont McKenna College Claremont CA91711 USA

This paper examines global value chains at the level of the heterogeneous firm. The context is a world of horizontal intra-industry trade, characterized by imperfect competition and product differentiation at the firm level. Standard microeconomic tools are employed to assess the effects of inter-firm dissimilarities in both demand and supply on firms＇ responses to changes in trade policy. In this set-up, dissimilarities in firm characteristics play roles similar to factor endowments and technology differences in traditional trade models. when cross-border production sharing （＂fragmentation＂） is introduced into this framework, those differences in firm characteristics determine the degree to which individual firms will enter into production networks. In this context, horizontal and vertical intra-industry tradel elements interact in their effects on firm decisions. Traditional comparative advantage considerations still govern the choice of off-shored activities, while direct competition between imports and exports expands the range of possible outcomes. Finally, it is shown that cross-border production sharing reduces the sensitivity of firms to variations in exchange rates, matching a phenomenon that has been observed in traditional country-level models.

关键词： heterogeneous firms global value chains intra-industry trade,intra-product specialization exchange-rate elasticities

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Revised barrier function-based adaptive finite-and fixed-time convergence super-twisting control

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Journal of Systems Engineering and Electronics 2023年第3期34卷 775-782页

作者： LIU Dakai ESCHE sven Department of Mechanical Engineering Stevens Institute of TechnologyHoboken 07030USA

This paper presents an adaptive gain,finite-and fixedtime convergence super-twisting-like algorithm based on a revised barrier function,which is robust to perturbations with unknown *** is shown that this algorithm can ensure a finite-and fixed-time convergence of the sliding variable to the equilibrium,no matter what the initial conditions of the system states are,and maintain it there in a predefined vicinity of the origin without ***,the proposed method avoids the problem of overestimation of the control gain that exists in the current fixed-time adaptive ***,it shows that the revised barrier function can effectively reduce the computation load by obviating the need of increasing the magnitude of sampling step compared with the conventional barrier *** feature will be beneficial when the algorithm is implemented in *** that,the estimation of the fixed convergence time of the proposed method is derived and the impractical requirement of the preceding fixed-time adaptive control that the adaptive gains must be large enough to engender the sliding mode at time t=0 is ***,the outperformance of the proposed method over the existing counterpart method is demonstrated with a numerical simulation.

关键词： super-twisting algorithm barrier function fixed-time sliding mode control adaptive control

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Analysis and Numerical Modeling of a 20 w Microwave Electrothermal Thruster

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Journal of Beijing Institute of Technology 2010年第3期19卷 324-330页

作者：高恩宇 sven g.Bilén 杨树兴 College of Aerospace Engineering Beijing Institute of Technology Department of Electrical Engineering The Pennsylvania State UniversityUniversity ParkPAUS

The microwave electrothermal thruster （MET） is an electric propulsion device that uses an electromagnetic resonant cavity within which free-floating plasma is ignited and sustained in a propellant *** thrust is generated when the heated propellant gas is exhausted out of a gas-dynamic *** an empty cavity without any perturbing regions—e.g.,dielectric regions or antenna regions—it is fairly straightforward to accurately calculate the cavity＇s resonant frequency and describe the electric field intensity distribution within the ***,actual METs do contain perturbing regions,which means that analytical solutions are no longer possible to fully characterize the ***,the numerical methods to simulate the electric field intensity and distribution within the resonant cavity were *** simulation results are that with the cap height increasing,the resonant frequency and electric field strength decrease,also increasing the permittivity of dielectric material causes decreasing the resonant frequency and electric field strength.A decrease in resonant frequency and maximum electric field strength,and an increase in resonant bandwidth,were observed with increasing antenna *** an antenna of a given depth equals decreasing the depth.

关键词： resonant cavity electric propulsion numerical modeling

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Computer vision supported by 3D geometric modelling

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Advances in Manufacturing 2014年第1期2卷 22-31页

作者： sven Fjeldaas Department of Engineering Design and Materials Norwegian University of Science and Technology

This paper suggests four data structures, one based on the other, for a geometric modeller suitable for computer vision. The structures are the key to advance from two-dimensional to three-dimensional automatic picture processing. Three application areas are indicated： one in semisynthetic design of materials, another in measurements of large three-dimensional industrial constructions, and the third one in robotics. There are comments on the software development needed.

关键词： Picture processing 3D geometric modelling Measurements

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Shaping digital earth applications through open innovation - setting the scene for a digital earth living lab

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International Journal of Digital Earth 2014年第7期7卷 594-612页

作者： sven Schade Carlos granell European Commission Joint Research CentreInstitute for Environment and SustainabilityIspraItaly

Science and policy increasingly request for sustainable development and ***,Digital Earth undergoes a paradigm shift to an open platform that actively supports user *** the public becomes able to contribute new content,we recognize a gap in user-driven validation,feedback and requirements capture,and innovative application *** than defining Digital Earth applications top down,we see a need for methods and tools that will help building applications bottom up and driven by community *** should include a technology toolbox of geospatial and environ-mental enablers,which allow to access functional building blocks and content in multiple ways,but-equally important-enable the collaboration within partially unknown stakeholder *** validation and testing in real-life scenarios will be a central requirement when approaching the Digital Earth 2020 goals,which were articulated *** particularly argue to follow a Living Lab approach for co-creation and awareness rising in relation to environmental and geospatial *** explain why and how such a Digital Earth Living Lab could lead to a sustainable approach for developing,deploying,and using Digital Earth applications and suggest a paradigm shift for Virtual globes becoming forums for research and innovation.

关键词： sustainable development open innovation stakeholder engagement living laboratories governance methodologies virtual globes

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Physical activity,COVID-19,and respiratory comorbidities:The good,the bad,and the ugly

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Journal of Sport and Health Science 2023年第2期12卷 216-218页

作者： Anh-Tuan Dinh-Xuan Thõng Hua-Huy sven günther Lung Function&Respiratory Physiology Units Department of Respiratory Physiology and Sleep MedicineAssistance Publique-Hôpitaux de ParisCochin&George Pompidou HospitalsUniversity Paris CitéParis 75006France

Almost 3 years after the outbreak of the novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)responsible for the coronavirus disease 2019(COVID-19)that has caused more than 6 million deaths worldwide,1the pandemic persists and hampers our daily *** are at least 2 main reasons explaining why we still struggle to terminate this ***,novel variants of concern of SARS-CoV-2unceasingly emerge despite almost 12 billion doses of vaccinebeing administered to date.

关键词： respiratory doses acute

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