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Pegylated interferon α/ribavirin therapy enhances bone mineral density in children with chronic genotype 4 HCV infection

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World Journal of Pediatrics 2017年第4期13卷 346-352页

作者： Ahmed Megahed Nanees Salem Abeer Fathy Tarik Barakat Mona abd el Latif Alsayed suzy abd el mabood Khaled R Zalata Ahmed F abdalla Pediatric Gastroenterology and Hepatology Unit Mansoura University Children's HospitalFaculty of MedicineMansoura UniversityEgypt Pediatric Endocrinology Unit Mansoura University Children's HospitalFaculty of MedicineMansoura UniversityEgypt Pediatric Hematology&Oncology Unit Mansoura University Children's HospitalFaculty of MedicineMansoura UniversityEgypt Pathology Department Faculty of MedicineMansoura UniversityEgypt

Background:The impact of chronic hepatitis C (CHC) on bone mineral density (BMD) has been well studied in adults with a relative paucity of data in children,especially concerning effect of treatment with pegylated interferon (PEG-IFN) plus ribavirin (RV).In the current work,we assessed prospectively changes in BMD in children with CHC before,during,and after ***:Forty-six consecutive children with noncirrhotic genotype 4 CHC were subjected to dual-energy X-ray absorptiometry at baseline,24 weeks,48 weeks of therapy and 24 weeks after ***,bone mineral content (BMC),and Z score of lumbar spine (L2-L4) were *** pubertal stage,viral load,liver function tests,serum calcium,phosphorus,alkaline phosphatase,parathyroid hormone,and liver histopathology were assessed in all included ***:Thirty (65.2%) patients had normal BMD,10 (21.7%) were at risk for low BMD,and 6 (13.1%) had low BMD for chronological *** with low BMD were significantly older (P=0.001),with higher frequency of delayed puberty than other groups (P=0.002).Baseline densitometric parameters (BMD & BMC) were significantly positively correlated with patients' age,weight,height,body mass index and hemoglobin level;while they were insignificantly correlated with basal viral load,histopathology activity index and fibrosis *** parameters improved significantly on PEG-IFN plus RV treatment,this improvement was found to be sustainable 24 weeks after ***:Low BMD is detectable in a proportion of CHC *** therapy leads to a sustainable increase in BMD.

关键词： bone mineral density chronic hepatitis C pegylated interferon ribavirin

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