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Long noncoding RNAs:a missing link in osteoporosis

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Bone Research 2019年第1期7卷 25-40页

作者： Andreia Machado Silva Sara Reis Moura JoseHenrique Teixeira Mario Adolfo Barbosa Susana gomes Santos Maria Ines Almeida i3S-Instituto de Investigacao e Inovacao em Sau.de University of PortoPortoPortugal INEB-Instituto de Engenharia Biomedica University of PortoPortoPortugal ICBAS-Instituto de Ciências Biomedicas Abel Salazar University of PortoPortoPortugal

osteoporosis is a systemic disease that results in loss of bone density and increased fracture risk,particularly in the vertebrae and the *** condition and associated morbidity and mortality increase with population *** noncoding(lnc)RNAs are transcripts longer than 200 nucleotides that are not translated into proteins,but play important regulatory roles in transcriptional and post-transcriptional *** contribution to disease onset and development is increasingly ***,we present an integrative revision on the studies that implicate lncRNAs in osteoporosis and that support their potential use as therapeutic ***,current evidence on lncRNAs involvement in cellular and molecular mechanisms linked to osteoporosis and its major complication,fragility fractures,is *** analyze evidence of their roles in osteogenesis,osteoclastogenesis,and bone fracture healing events from human and animal model ***,the potential of lncRNAs alterations at genetic and transcriptomic level are discussed as osteoporosis risk factors and as new circulating biomarkers for ***,we conclude debating the possibilities,persisting difficulties,and future prospects of using lncRNAs in the treatment of osteoporosis.

关键词： osteoporosis density lncRNAs

Nutrient content affecting Spodoptera frugiperda and Dalbulus maidis occurrence in corn

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Insect Science 2007年第2期14卷 117-123页

作者： CRISTINA SCHETINo BASToS JoAo CARLoS CARDoSo GALVAo MARCELo CoUTINHo PICANCo PAULo RoBERTo gomes PEREIRA PAULo RoBERTo CECoN EMBRAPA/Algodao Centenário Campina Grande PB Brazil Departamento de Fitotecnia Universidade Federal de Vicosa (UFV) Vicosa MG Brazil. Departamento de Biologia Animal Universidade Federal de Vicosa (UFV) Vicosa MG Brazil. Departamento de Informática Campus Universitário Universidade Federal de Vicosa (UFV) Vicosa MG Brazil.

This work aims to study the effect of the nutrient contents in the leaves of corn on the incidence of Spodopterafrugiperda （Smith）（Lepidoptera： Noctuidae） and Dalbulus maidis （Delong ＆ Wolcott）（Homoptera： Cicadellidae）. The treatments were represented by unfertilized corn plants and corn plants fertilized with 250 kg of the formulation 4-14-8 （N- P-K）＋ 100 kg of ammonium sulfate （AS）/ha and 500 kg of the formulation 4-14-8 （N-P-K）＋200 kg of AS/ha, arranged in randomized blocks with four replicates. Attacks by S. frugiperda and D. maidis were higher as the nitrogen, sulfur, calcium and copper content in the leaves of corn increased. The effects of calcium and copper found in this study were not consistent with that of lower susceptibility associated with higher levels of these nutrients mentioned in the literature. We believe that there was a cumulative effect of the nutrients altogether, building up a nutritiously better vegetable which in turn had less reserve for defense, or that the content of both nutrients in the leaves were not high enough to induce such effects.

关键词： calcium copper corn cicada fall armyworm fertilization nitrogen sulfur

Punch‑excised explants of bovine mammary gland to model early immune response to infection

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Journal of Animal Science and Biotechnology 2023年第6期14卷 2649-2662页

作者： Pablo gomes Noleto Florence B.Gilbert Christelle Rossignol Patricia Cunha Pierre Germon Pascal Rainard Rodrigo Prado Martins ISP INRAEUniversitéde ToursUMR1282NouzillyFrance

Background Mammary gland(MG)infections(mastitis)are frequent diseases of dairy cows that affect milk quality,animal welfare and farming *** infections are commonly associated with the bacteria Escherichia coli and Staphylococcus *** in vitro models have been used to investigate the early response of the MG to bacteria,but the role of the teat in mastitis pathogenesis has received less *** this study,we used punch-excised teat tissue as an ex vivo model to study the immune mechanisms that arise early during infection when bacteria have entered the *** Cytotoxicity and microscopic analyses showed that bovine teat sinus explants have their morphology and viability preserved after 24 h of culture and respond to ex vivo stimulation with TLR-agonists and *** and *** trigger stronger inflammatory response in teat when compared to LTA and ***,leading to a higher produc-tion of IL-6 and IL-8,as well as to an up-regulation of proinflammatory *** also demonstrated that our ex vivo model can be applied to frozen-stored *** In compliance with the 3Rs principle(replacement,reduction and refinement)in animal experimenta-tion,ex vivo explant analyses proved to be a simple and affordable approach to study MG immune response to *** model,which better reproduces organ complexity than epithelial cell cultures or tissue slices,lends itself particularly well to studying the early phases of the MG immune response to infection.

关键词： Bovine teat Escherichia coli Explant Mastitis Staphylococcus aureus 3Rs

Animal models applied to acute-on-chronic liver failure:Are new models required to understand the human condition?

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World Journal of Clinical Cases 2022年第9期10卷 2687-2699页

作者： Jaciara Fernanda gomes Gama Liana Monteiro da Fonseca Cardoso Jussara Machado Lagrota-Candido LuizAnastacio Alves Laboratory of Cellular Communication Oswaldo Cruz InstituteOswaldo Cruz FoundationRio de Janeiro 21045900Rio de JaneiroBrazil Laboratory of Immunopathology Department of ImmunobiologyFluminense Federal UniversityNiteroi 24210-200Rio de JaneiroBrazil

The liver is a multifaceted organ;its location and detoxifying function expose this organ to countless ***-on-chronic failure liver(ACLF)is a severe syndrome that affects the liver due to acute decompensation in patients with chronic liver *** infection environment,ascites,increased liver enzymes and prothrombin time,encephalopathy and fast-evolving multiorgan failure,leading to death,usually accompany *** pathophysiology remains poorly *** this context,animal models become a very useful tool in this regard,as understanding;the disease may be helpful in developing novel therapeutic methodologies for ***,although animal models display several similarities to the human condition,they do not represent all ACLF manifestations,resulting in significant *** initial liver cirrhosis framework followed by the induction of an acute decompensation by administering lipopolysaccharide and D-Ga IN,potentiating liver damage supports the methodologies applied to induce experimental *** entire methodology has been described mostly for ***,a quick Pub Med database search indicates about 30 studies concerning ACFL models and over 1000 regarding acute liver failure *** findings demonstrate the clear need to establish easily reproducible ACFL models to elucidate questions about this quickly established and often fatal syndrome.

关键词： Liver disease Acute-on-chronic liver failure Cirrhosis Acute decompensate event Translational study Animal models

Validating a dust production model by field experiment in Mu Us Desert, China

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Chinese Science Bulletin 2006年第7期51卷 878-884页

作者： MEI Fanmin J. Rajot S. Alfaro L. gomes ZHANG Xiaoye WANG Tao Key Laboratory of Desert and Desertification Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences Lanzhou 730000 China State Key Laboratory of Loess and Quaternary Geology Institute of Earth Environment Chinese Academy of Sciences Xi'an 710075 China Department of Environmental Science and Technology Xi'an University of Engineering and Technology Xi'an 710048 China Center of Monitoring and Forecasting of Chemical Components of Atmosphere State Key Laboratory of Atmospheric Chemistry Institute of National Meteorology Research Beijing 100081 China Laboratoire lnteruniversitaire des Systemes Atmospheriques Universite de Paris 12 Paris 94010 France

Field experiments of dust production have been seldom performed in Chinese deserts that are identified as one of main dust sources in the world, and such an experiment to validate a dust production model (DPM) has not been made in China until now. Saltation flux, dust emission flux, surface features and meteorological parameters (U*, Z0, Ri, etc.) were investigated in Mu Us Desert of China to verify the DPM model and accumulate dust emission data during the spring of 2002. It indicates that observed saltation fluxes from 0.07 to 8.00 g·m?1·s?1 are in good agreement with the ones predicted by the DPM model when the constant of the saltation flux equation is tuned to about 2.61, which corresponds to wind fric- tion velocities from 0.26 to 0.35 m·s?1. Unfortunately, during three local dust emission events, the observed dust fluxes are from 1 to 3 μg· m?2· s?1, lower than the modeled ones, implying that the model needs to be improved further under lower wind velocity. In comparison with data from a sandy soil with physical crust and a loam soil, saltation fluxes of the loose sandy soil in Mu Us Desert are obviously higher, which suggests that deserts and sandy land with desertification are major dust sources in northern China.

关键词：沙漠尘埃模拟野外试验

Ecophysiology and multivariate analysis for production of Tachigali vulgaris in Brazil:Influence of rainfall seasonality and fertilization

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Journal of Forestry Research 2023年第5期34卷 1289-1305页

作者： Pedro Henrique oliveira Simoes Candido Ferreira de oliveira Neto Manoel Tavares de Paula Dênmora gomes de Araújo Rodrigo Silva do Vale Joao olegário Pereira de Carvalho Universidade Federal de Mato Grosso Campus Universitario de SinopSinop 78550728Mato GrossoBrazil Universidade Federal Rural da Amazonia Campus BelemBelem 66077830ParaBrazil Universidade do Estado do Para Centro de Ciencias Naturais e TecnologiaBelem 66095015ParaBrazil Universidade Federal Rural da Amazonia Campus Capitao-PocoCapitao Poco 68650000ParaBrazil

Studies on fertilization management of species native to the Amazon for energy plantations contribute to the diversity of species use and reduce biological risk due to the excessive use of clones or hybrids of *** study evaluates the effect of precipitation seasonality and phosphorus and potassium fertilization on gas exchange in a Tachigali vulgaris *** levels of P(zero,65.2,130.4 kg ha^(-1))and three of K(zero,100.0,200.0 kg ha^(-1))were applied in a 3×3 factorial randomized block *** exchange measurements were conducted in April and November *** low rainfall,high irradiance period,photo synthetic rates were up to four times higher than in the high rainfall period,reaching 20.3μmol m^(-2)s^(-1)in the treatment with 130.4 g kg^(-1)of P and 100.0 g kg^(-1)of *** analysis and principal component analysis reduced the initial eight gas exchange variables to two and three principal components in periods of high and low rainfall,*** multivariate method used in this study readily identified variations in the variables as a function of rainfall,with high reliability in explaining the data set.

关键词： Photosynthesis rate Stomatal conductance Principal component analysis Factor analysis Tachigali vulgaris

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Assessment of Cancer-Related Fatigue Expression:Comparing the Expression of Fatigue in Patients with a History of Cancer,Patients with other Chronic Diseases,and Healthy Individuals

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Psycho-oncologie 2024年第1期18卷 49-57页

作者： Maria Inês Clara Maria Cristina Canavarro Ana Severina Susana Ramos Carla Rafael Ana Allen gomes Chronopsychology and Cognitive Systems Lab(ChronCog) University of CoimbraCoimbra3000-115Portugal Center for Research in Neuropsychology and Cognitive and Behavioral Intervention(CINEICC) University of CoimbraCoimbra3000-115Portugal Faculty of Psychology and Educational Sciences University of CoimbraCoimbra3000-115Portugal oncology Department Centro Hospitalar do Médio Tejo(CHMT)Torres Novas2350-754Portugal

Aims:We aimed to compare cancer survivors’fatigue expression with that of the general population and examine psychobiological factors associated with ***:In this quantitative,transversal study,we analyzed clinical and sociodemographic indicators of 389 participants(68.38%females):148 cancer survivors on active treatment,55 disease-free survivors,75 patients with another chronic disease,and 111 healthy ***:Fatigue was expressed dissimilarly in patients with a previous history of cancer and participants without a history of *** on active treatment reported significantly higher levels of fatigue than the other clinical status ***,some level of cancer-related fatigue persisted,in a similar pattern,after active treatment into the survivorship ***-free survivors showed significantly lower vigor levels when compared to patients with other chronic *** distress and daytime sleepiness emerged as transdiagnostic factors associated with ***:Cancer-related fatigue may have a unique pattern,characterized by reduced endurance and muscle *** the present study,psychological distress and daytime sleepiness are associated with cancer-related *** findings suggest the pertinence of future studies examining whether interventions targeting those factors may help manage this burdensome complaint.

关键词： Fatigue cancer patients cancer burden psychological distress cancer survivors neoplasms

Cardiovascular risk burden and disability:findings from the International Mobility in Aging Study(IMIAS)

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Journal of Geriatric Cardiology 2024年第3期21卷 331-339页

作者： Juan-David Martinez-Aristizábal Carmen-Lucia Curcio Juliana Fernandes Afshin Vafael Cristiano dos Santos gomes Fernando Gomez Internal Medicine Critical Care DepartmentPablo Tobón Uribe HospitalMedellínColombia Research Group in Geriatrics and Gerontology Faculty of Health SciencesUniversidad de CaldasManizalesColombia Laboratory of Physical Therapy and Collective Health Physical Therapy DepartmentFederal University of PernambucoJornalista Aníbal Fernandes Avenue RecifeBrazil Department of Public Health Sciences Queen’s UniversityKingstonONCanada Department of Physiotherapy University of PernambucoBR 203KmBrazil

BACKGRoUND The association of cardiovascular risk burden with disability is *** examined the association between trajectories of the Framingham general cardiovascular disease risk score(FGCRS)with the trajectories of limitations of physical function in older *** A total of 1219 participants with no disabilities from the International Mobility in Aging Study(IMIAS)study who had up to three repeated measures of FGCRS between 2012–2016 and without a history of stroke or coronary heart disease at baseline and follow-up were *** at baseline was assessed and categorized into *** function was evaluated with the Short Physical Performance Battery(SPPB).The data were analyzed using linear mixed-effects *** At baseline,FGCRS ranged between 3–94(mean score:24±15.8),participants were 32(2.6%),502(41.2%)and 685(56.2%)in lowest,middle,and highest tertiles,*** the trajectories of limitations of physical function,the lowest FGCRS had no differences,while the middle and highest had a decrease in physical performance between 2012–2014(P=0.0001).Age,being female,living in Andes Mountains,having middle and highest FGCRS,higher alcohol consumption,being obese,lack of exercise and cognitive impairment increase the probability of disability(Pore developed regions and having a higher educational level reduced the probability of disability during the follow-up time(PoNCLUSIoNS Higher cardiovascular risk burden is associated with decreased physical performance,especially in *** suggest SPPB may provide a measure of cardiovascular health in older adults.

关键词： finding Battery burden

CoVID-19 in Brazil:Epidemiological update and perspectives

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Asian Pacific Journal of Tropical Medicine 2020年第5期13卷 193-196页

作者： Marli C Cupertino Graziela A Cupertino Andréia P gomes Nicholas AJ Mayers R Siqueira-Batista Medical School Faculdade Dinamica do Vale do PirangaPonte NovaMinas GeraisBrazil Laboratory of Epidemiological and Computational Methods in Health Department of Medicine and NursingUniversidade Federal de VicosaVicosaMinas GeraisBrazil Department of Veterinary Medicine Universidade Federal de VicosaVicosaMinas GeraisBrazil

Coronaviruses are RNA viruses (Family: Coronaviridae) constituents of a significant number of viruses that provoke diseases in animals and human beings. There are four genera of these microorganisms: Alphacoronavirus, Betacoronavirus, Deltacoronavirus and Gammacoronavirus. From this group, the alpha- and beta-coronaviruses are designated as human coronavirus (HCoV) for their propensity to infect human beings[1].

关键词： diseases Corona Brazil