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Emerging role of liquid biopsy in rat sarcoma virus mutated metastatic colorectal cancer:A case report

World Journal of Gastrointestinal oncology 2024年第1期16卷 234-243页

作者： João Gramaça Isabel gomes Fernandes Carolina Trabulo Joana Gonçalves Rita Gameiro dos Santos Adriano Baptista Idília Pina Centro Hospitalar Barreiro Montijo Centro Hospitalar Barreiro MontijoSetúbalBarreiro 2830-003Portugal Medical oncology Unit Centro Hospitalar Barreiro MontijoSetúbalBarreiro 2830-003Portugal

BACKGRoUND In patients with metastatic colorectal cancer(mCRC),the treatment options are limited and have been proved to be affected by rat sarcoma virus(RAS)mutational *** RAS wild-type(wt)patients,the combination of antiepidermal growth factor receptor(EGFR)monoclonal antibodies with chemotherapy(CT)is more effective than CT *** the other hand,RAS-mutated patients are not eligible for treatment with anti-EGFR *** SUMMARY Eleven patients with initially RAS-mutated mCRC were followed from diagnosis to May *** the time of cell-free DNA determination,five patients had undergone one CT line,five patients had undergone two CT lines,and one patient had undergone three CT lines(all in combination with bevacizumab).At the second and third treatment lines[second line(2L),third line(3L)],patients with neo-RAS wt received a combination of CT and *** neo-RAS wt patients treated with anti-EGFR,our findings indicated an increase in progression-free survival for both 2L and 3L(14.5 mo,P=0.119 and 3.9 mo,P=0.882,respectively).Regarding 2L overall survival,we registered a slight increase in neo-RAS wt patients treated with anti-EGFR(33.6 mo vs 32.4 mo,P=0.385).At data cut-off,two patients were still alive:A RAS-mutated patient undergoing 3L treatment and a neo-RAS wt patient who received 2L treatment with anti-EGFR(ongoing).CoNCLUSIoN our case series demonstrated that monitoring RAS mutations in mCRC by liquid biopsy may provide an additional treatment line for neo-RAS wt patients.

关键词： Metastatic colorectal cancer Rat sarcoma virus mutational status Liquid biopsy Rat sarcoma virus wild-type Neo-rat sarcoma virus wild-type Anti-epidermal growth factor receptor therapy Case report

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All-electron basis sets for H to Xe specific for ZoRA calculations:Applications in atoms and molecules

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Chinese Physics B 2024年第8期33卷 238-246页

作者： C.S.gomes F.E.Jorge A.Canal Neto Departamento de Fisica Universidade Federal do Espirito Santo29075-910 VitoriaESBrazil Departamento de Fisica Instituto de Ciencias Exatas e BiologicasUniversidade Federal de Ouro Preto Campus Universitario Morro do Cruzeiro35402-136 Ouro PretoMGBrazil

A segmented basis set of quadruple zeta valence quality plus polarization functions(QZP)for H through Xe was developed to be used in conjunction with the ZoRA *** set was augmented with diffuse functions to describe electrons farther away from the nuclei *** the ZoRA-CCSD(T)/QZP-ZoRA theoretical model,atomic ionization energies and bond lengths,harmonic vibrational frequencies,and atomization energies of some molecules were *** addition of core-valence corrections has been shown to improve the agreement between theoretical and experimental results for molecular *** atomization energies,a similar observation emerges when considering spin-orbit *** the augmented QZP-ZoRA set,static mean dipole polarizabilities of a set of atoms were calculated and compared with previously published recommended and experimental *** evaluations of the ZoRA and Douglas–Kroll–Hess Hamiltonians were made for each property studied.

关键词： QZP-ZoRA and AQZP-ZoRA basis sets elements from H to Xe CCSD(T)method atomic and molecular properties

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Targeting the premetastatic niche:epigenetic therapies in the spotlight

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1871-1872页

作者： Vivien Low John Blenis Ana P.gomes Meyer Cancer Center Weill Cornell MedicineNew YorkNYUSA Department of Pharmacology Weill Cornell MedicineNew YorkNYUSA

The treatment of metastatic cancers remains a challenge in the clinic,with recurrences persisting at high rates even after surgical resection of primary *** the perseverance of circulating tumor cells after resection,this phenomenon is abetted by the formation of the premetastatic niche(PMN),a distant environment ripe for the colonization of new metastases,which is conditioned by factors and extracellular vesicles secreted by the primary *** their recent paper,Lu et *** how such PMNs in the lung can be disrupted by low-dose adjuvant epigenetic therapy,and propose a novel therapeutic avenue to supplement tumor resection.

关键词： metastatic epigenetic al

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MEASUREMENTS oF INDooR AIR PoLLUTANT LEVELS IN A UNIVERSITY oFFICE BUILDING

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Journal of Green Building 2007年第4期2卷 123-129页

作者： João F.P.gomes J.C.M.Bordado Georgina Sarmento JoséDias Departamento de Engenharia Química Instituto Superior de Engenharia de Lisboa11949-014 LisboaPortugal CEBQ-Centro de Engenharia Biológica e Química Departamento de Engenharia QuímicaInstituto Superior TécnicoTorre SulAv.Rovisco Pais11049-001 LisboaPortugal

This work consisted of a series of determinations performed in typical rooms of a building belonging to the Technical University of Lisbon,which is located in a central urban area of *** main objective was to evaluate the Indoor Air Quality(IAQ)of the rooms so that further corrective measures could be taken if unsatisfactory IAQ levels were to be *** were derived,between indoor and outdoor pollutant concentrations,in order to assess the existence of contaminations coming from ***,correlations were derived between total volatile organic compounds(VoC)concentrations and speciﬁc individual organic species measured in the same *** methodology recorded in this paper is effective to assess compliance analysis of total VoCs,however,it seems somewhat limited to determine speciﬁc individual chemical species responsible for obtaining high total VoC concentrations.

关键词： Indoor Air Quality Hazardous Substances Ventilation

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Trial eligibility in advanced hepatocellular carcinoma: Does it support clinical practice in underrepresented subgroups?

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World Journal of Gastroenterology 2021年第24期27卷 3429-3439页

作者： Federico Piñero Leonardo gomes da Fonseca Hepatology and Liver Unit Hospital Universitario AustralSchool of MedicineAustral UniversityBuenos Aires B1629HJArgentina Clinical oncology Insituto do Cancer do Estado de São PauloUniversity of São PauloSão Paulo 05403-000Brazil

Although hepatocellular carcinoma is considered a highly lethal malignancy,recent therapeutic advances have been achieved during the last 10 *** scenario resulted in an unprecedented improvement in survival for patients with advanced hepatocellular carcinoma,almost reaching 20-26 mo of overall survival after first-second line sequential *** advent of the combination of atezolizumab with bevacizumab showed,for the first time,superiority over sorafenib with improvement in overall ***,first and second-line trials were correctly based on the premise that a strict selection of patients enhances the power to capture the positive effect of treatment by excluding competing risks for mortality such as liver failure,decompensated cirrhosis or other underlying medical *** a result,the inclusion criteria used in clinical trials do not support the use of novel therapies in several real-world scenarios involving underrepresented subgroups,such as patients with unpreserved liver function,other comorbid conditions,a history of solid-organ transplantation,autoimmune disorders and those with a high risk of *** present text aims at discussing treatment strategies in these subgroups.

关键词： Eligibility Systemic therapies End-stage Hepatocellular carcinoma

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Changes on Anuran Tadpole Functional Diversity along an Environmental Gradient at the Southernmost Atlantic Rainforest Remnant

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Asian Herpetological Research 2020年第1期11卷 63-70页

作者： Victor Mendes LIPINSKI Andre Passaglia SCHUCH Tia.o.gomes dos SANToS Post Graduation Program of Animal Biodiversity Federal University of Santa MariaLaboratory of HerpetologyDepartment of BiologyAv.Roraima no 1000 building 17room 1140Camobi97105-900Santa MariaRSBrazil Universidade Federal do Pampa Av.Antonio Trilha1847Centro973000000 Sao GabrielRSBrasil Southern Regional Space Research Center CRS/INPE-MCTIP.O.Box 5021room 104197110-970Santa MariaRSBrazil

For decades the ecologists are using the same methods in order to determine the environmental health of a community,however,the crescent need on defining how these processes act,triggered the development of new methods that could classify the organisms and their function at the *** we used the anuran larvae to understand the effects of an environmental gradient on the structure and organization of the anuran assemblages along it,and to access in a realistic form,the actual state of preservation of the la rgest remnant of Atlantic Rainforest on the Southernmost portion of *** found that despite the higher diversity of species and the conservation unit status of the place,the ecosystem itself is still in danger,given the low number of functional groups and thus a higher number of ecosystem services that can be lost.

关键词： Anuran ecosystem function conservation unities tadpoles

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Intimate partner violence against women. Does violence decrease after the entry of the alleged offender into the criminal justice system?

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Forensic Sciences Research 2022年第1期7卷 53-60页

作者： Paulo Vieira-Pinto JoséIgnacio Muñoz-Barús Tiago Taveira-gomes Maria João Vidal-Alves Teresa Magalhães Department of Forensic Sciences PathologyGynaecology and ObstetricsPaediatricsInstitute of Forensic SciencesUniversity of Santiago de CompostelaSantiago de CompostelaSpain IINFAC TS-Institute of Research and Advanced Training in Health Sciences Department of SciencesCESPUUniversity Institute of Health Sciences(IUCS)GandraPortugal cFaculty of Medicine University of PortoPortoPortugal CINTESIS-Centre of Health Technology and Service Research University of PortoPortoPortugal Fernando Pessoa University PortoPortugal

Intimate partner violence(IPV)is simultaneously assumed as a serious crime and a major public health issue,having recurrences as one of its main characteristics and,consequently,re-entries of some alleged offenders in the criminal justice system(CJS).The main goal of this study is to assess if in cases of female victims of IPV,violence decreases after the first entry of the alleged offender in the CJS.A retrospective study was performed based on the analysis of police reports of alleged cases of IPV during a 4-year *** final sample(n=1488)was divided into two groups according to the number of entries in the CJS(single or multiple)followed by a comparative *** suggest that violence decreases after the first entry of alleged offenders in the ***-entries were found in only 15.5%of the cases but they were accountable for 3.3 times more crimes on ***,victims of recidivism presented more injuries and required more medical ***,a small group of alleged offenders seems to be more violent and accountable for most of the IPV crimes registered in the CJS suggesting that regardless of legal sanctions aiming to deter violence,these measures may not be enough for a certain group of *** study sustains the need for a predictive model to quantify the risk of repeated IPV cases within the Portuguese population.

关键词： Forensic sciences intimate partner violence women re-entry recidivism criminal justice system

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Neurogenesis in the hippocampus of adult humans: controversy “fixed” at last

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Neural Regeneration Research 2019年第11期14卷 1917-1918页

作者： Silene M.A. Lima Walace gomes-Leal Laboratory of Neurobiology Institute of Biological SciencesFederal University of ParaBelem-ParaBrazil Laboratory of Experimental Neuroprotection and Neuroregeneration Institute of Biological SciencesFederal University of ParaBelem-ParaBrazil

The presence of adult neurogenesis in the mammalian brain has been a theme of intense controversy for a long time since the original report by Altman and Das (1965). The scientific community, for about 30 years, has difficulties to accept that progenitor cells give rise to new neurons in some specific regions of the mammalian adult brain, the neurogenic niches (Kuhn et al., 1996;Doetsch et al., 1997, 1999).

关键词： Neurogenesis hippocampus mammalian brain

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Combination approaches in hepatocellular carcinoma:How systemic treatment can benefit candidates to locoregional modalities

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World Journal of Gastroenterology 2022年第28期28卷 3573-3585页

作者： Leonardo gomes da Fonseca Raphael L C Araujo Department of Medical oncology Instituto do Cancer do Estado de Sao PauloUniversity of Sao PauloSão Paulo 01246-000São PauloBrazil Hospital e Maternidade Brasil-Rede D'or São Luiz Santo André09030-590São PauloBrazil Department of Digestive Surgery Escola Paulista de Medicina-UNIFESPSão Paulo 04023-062São PauloBrazil

The management of hepatocellular carcinoma(HCC)is challenging because most patients have underlying cirrhosis,and the treatment provides,historically,a limited impact on the natural history of patients with advanced-stage ***,recurrence rates are high for those patients who receive local and locoregional modalities,such as surgical(resection and transplantation)or imageguided(ablation and intra-arterial)*** research has led to new concepts that are reshaping the current clinical *** advancements were achieved in the understanding of the hallmarks that drive *** has primed a successful incorporation of novel agents with different targets,such as anti-angiogenic drugs,targeted-therapies,and immune-checkpoint *** clinical trials have proven efficacy of systemic agents in advanced stage disease,there is no conclusive evidence to support their use in combination with loco-regional *** novel local modalities are being incorporated(e.g.,radioembolization,microwave ablation,and irreversible electroporation),emerging data indicate that locoregional treatments may induce tumor microenvironment changes,such as hyperexpression of growth factors,release of tumor antigens,infiltration of cytotoxic lymphocytes,and modulation of adaptative and innate immune *** trials that evaluated the use of antiangiogenic drugs in the adjuvant setting after ablation or chemoembolization fail to demonstrate a substantial *** efforts are directed to investigate the role of immunotherapy-based regimens in this *** present review aims to describe the current landscape of systemic and locoregional treatments for HCC,present evidence to support combination approaches,and address future perspectives.

关键词： Liver cancer Hepatocellular carcinoma Immunotherapy Systemic therapy Ablation Embolization

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Engineering carbon quantum dots for photomediated theranostics

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Nano Research 2018年第1期11卷 1-41页

作者： Mahbub Hassan Vincent G. gomes Alireza Dehghani Sara M. Ardekani School of Chemical and Biomolecular Engineering The University of Sydney NSW 2006 Australia

Carbon quantum dots （CQDs） have emerged as potential alternatives to classical metal-based semiconductor quantum dots （QDs） due to the abundance of their precursors, their ease of synthesis, high biocompatibility, low cost, and particularly their strong photoresponsiveness, tunability, and stability. Light is a versatile, tunable stimulus that can provide spatiotemporal control. Its interaction with CQDs elicits interesting responses such as wavelength-dependent optical emissions, charge/electron transfer, and heat generation, processes that are suitable for a range of photomediated bioapplications. The carbogenic core and surface characteristics of CQDs can be tuned through versatile engineering strategies to endow specific optical and physicochemical properties, while conjugation with specific moieties can enable the design of targeted probes. Fundamental approaches to tune the responses of CQDs to photo-interactions and the design of bionanoprobes are presented, which enable biomedical applications involving diagnostics and therapeutics. These strategies represent comprehensive platforms for engineering multifunctional probes for nanomedicine, and the design of QD probes with a range of metal-free and emer^in~ 2D materials.

关键词： carbon quantum dots nanobiophotonics therapeutics diagnostics nanomedicine

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