检索结果-南通市图书馆

Ultrastructural and enzymatic alterations in the ovary of Rhodnius prolixus infected with Trypanosoma rangeli

Asian Pacific Journal of Tropical Medicine 2022年第2期15卷 71-78页

作者： Guilherme S.Machado Rosane L.Lopes Simone S.C.oliveira Simone P.C.Freitas Jacenir R.Santos-Mallet AndréL.S.Santos Denise Feder suzete a.o.gomes Programa de Pós-Graduação em Ciências e Biotecnologia Instituto de BiologiaUniversidade Federal FluminenseNiteróiRJBrazil Laboratório de Biodiversidade de Insetos e Patógenos Departamento de Biologia GeralInstituto de BiologiaUniversidade Federal FluminenseNiteróiRJBrazil Laboratório de Estudos Avançados de Microrganismos Emergentes e Resistentes Departamento de Microbiologia GeralInstituto de Microbiologia Paulo de GóesUniversidade Federal do Rio de JaneiroRJBrazil Fundação oswaldo Cruz Piauí TeresinaPIBrazil Laboratório Interdisciplinar de Vigilância Entomológica em Díptera e Hemíptera Instituto Oswaldo CruzFundação Oswaldo CruzRio de JaneiroRJBrazil Universidade Iguaçu Nova IguaçuRJBrazil Laboratório de Biologia de Insetos Departamento de Biologia GeralInstituto de BiologiaUniversidade Federal FluminenseNiteróiRJBrazil

objective:To investigate the morphological structure of ovarian follicular cells and biochemical parameters of both ovaries and fat bodies(sites of vitellogenesis)from Rhodnius(R.)prolixus infected with Trypanosoma(T.)***:Adult virgin females of *** were fed upon a membrane apparatus containing heat-inactivated citrated rabbit blood and a suspension of *** epimastigotes(Macias strain).Females from the control group and all the males received parasite-free *** electron microscopy was used to reveal the morphological aspects of ovarian follicle cells in both control and parasite-infected *** profile,proteolytic activities and Western blotting analyses were performed in either ovary or fat body samples of control and parasite-infected ***:According to the ultrastructural data,*** infection elicited a degeneration process in the ovarian follicular cells of *** assays indicated a reduction in the activity of aspartic peptidases in the ovary and fat body from parasite-infected group,while a significant increase in the cysteine peptidase activity was measured in both insect ***,immunoblotting revealed that vitellogenin was overexpressed in the ovary of parasite-infected ***:*** infection seems to elicit an early programmed cell death in the ovarian follicle cells as well as induces the modulation on the activities of different peptidase classes in either ovaries or fat bodies and the overexpression of the vitellogenin in the ovary of ***.

关键词： Trypanosoma rangeli Rhodnius prolixus ovarian follicle Vitellogenin Aspartic protease Cysteine protease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

optimizing building retrofit through data analytics:A study of multi-objective optimization and surrogate models derived from energy performance certificates

Energy and Built Environment

引用

Energy and Built Environment 2024年第6期5卷 889-899页

作者： G.R.Araújo Ricardo gomes Paulo Ferrão M.Glória gomes IN+ DEMTécnico LisboaUniversidade de lisboaAv Rovisco PaisLisboa1049-001Portugal CERIS DECivilTécnico LisboaUniversidade de LisboaAv Rovisco PaisLisboa1049-001Portugal

The building stock is responsible for a large share of global energy consumption and greenhouse gas emissions,therefore,it is critical to promote building retrofit to achieve the proposed carbon and energy neutrality *** of the policies implemented in recent years was the Energy Performance Certificate(EPC)policy,which proposes building stock benchmarking to identify buildings that require ***,research shows that these mechanisms fail to engage stakeholders in the retrofit process because it is widely seen as a mandatory and complex *** study makes use of an EPC database to integrate machine learning techniques with multi-objective optimization and develop an interface capable of(1)predicting a building’s,or household’s,energy needs;and(2)providing the user with optimum retrofit solutions,costs,and return on *** goal is to provide an open-source,easy-to-use interface that guides the user in the building retrofit *** energy and EPC prediction models show a coefficient of determination(R2)of 0.84 and 0.79,and the optimization results for one case study EPC with a 2000€budget limit inÉvora,Portugal,show decreases of up to 60%in energy needs and return on investments of up to 7 in 3 years.

关键词： Building energy performance Building optimization Multi-objective surrogate models Building retrofitting

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A review on the scale-up of high-shear wet granulation processes and the impact of process parameters

引用

Particuology 2024年第9期92卷 180-195页

作者： Ana Rita Alves Marta Filipe Simões Sérgio Simões João gomes University of Coimbra CERESDepartment of Chemical EngineeringFaculty of Sciences and TechnologyRua Sílvio Lima3030-790CoimbraPortugal Bluepharma-Indústria Farmacêutica São Martinho do BispoCoimbra3045-016Portugal Faculty of Pharmacy University of CoimbraAzinhaga de Santa Comba3000-548CoimbraPortugal

Wet granulation is one of the most important agglomeration processes,and high-shear granulation(HSG)one of the most employed technologies in the pharmaceutical *** most critical process parameters of HSG are discussed in this *** main concern in scaling up the wet granulation process is the differences between scales,which prevent the particles from having the same experience across all *** scale-up of wet granulation processes is commonly divided into two categories:engineering and attribute-based *** engineering-based scale-up approach is a strategy based on dimensional analysis and an attribute-based supported on the principles of“equifinality”,where process variables are adjusted to obtain equivalent granule *** work presents the effect of different HSG process parameters on the scale-up,as well as the use of process analytical tools(PAT)and modelling *** aim is to review applied scale-up approaches in HSG and discuss benefits and *** is proven why the scale-up for oral solid pharmaceutical products is still considered a hot topic and a very challenging task for development and engineering teams.

关键词： High-shear wetgranulation Parametric-based Attribute-based Physics-based modelling Impeller design Scale-up

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Supergiant Barocaloric Effects in Acetoxy Silicone Rubber over a Wide Temperature Range:Great Potential for Solid-state Cooling

引用

Chinese Journal of Polymer Science 2020年第9期38卷 999-1005,I0008页

作者： William Imamura Erik oda Usuda Lucas Soares Paixao Nicolau Molina Bom Angelo Marcio gomes Alexandre Magnus gomes Carvalho Faculdade de Engenharia Mec(a)nica UNICAMPCEP 13083-860CampinasSPBrazil Universidade Federal de Sāo Paulo UNIFESPCEP 09913-030DiademaSPBrazil Instituto de Física Gleb Wataghin UNICAMPCEP 13083-859CampinasSPBrazil Catalan Institute of Nanoscience and Nanotechnology ICN208860 BelaterraBarcelonaSpain The Institute of Photonic Sciences ICFO08193 CastelldefelsBarcelonaSpain Instituto de Física UFRJCEP 21941-972Rio de JaneiroRJBrazil Departamento de Engenharia Mec(a)nica UEMCEP 87020-900MaringáPRBrazil

Solid-state cooling based on caloric effects is considered a viable alternative to replace the conventional vapor-compression refrigeration *** barocaloric materials,recent results show that elastomers are promising candidates for cooling applications around *** the present paper,we report supergiant barocaloric effects observed in acetoxy silicone rubber—a very popular,low-cost and environmentally friendly *** values of adiabatic temperature change and reversible isothermal entropy change were obtained upon moderate applied pressures and relatively low *** huge barocaloric changes are associated both to the polymer chain rearrangements induced by confined compression and to the first-order structural *** results are comparable to the best barocaloric materials reported so far,opening encouraging prospects for the application of elastomers in near future solid-state cooling devices.

关键词： Solid-state cooling Barocaloric effect Elastomer Silicone rubber Crystalline-amorphous transition

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The role of surface functionalization of silica nanoparticles for bioimaging

引用

Journal of Innovative optical Health Sciences 2016年第4期9卷 11-26页

作者： Maria C.gomes Angela Cunha Tito Trindade João P.C.Tome QoPNA University of Aveiro 3810-193 AveiroPortugal CICECo and Department of Chemistry University of Aveiro 3810-193 AveiroPortugal CESAM and Department of Biology University of Aveiro 3810-193 AveiroPortugal Centro de Quimica Estrutural Instituto Superior Tecnico Universidade de LisboaAv.Rovisco Pais1049-001 LisboaPortugal Department of organic and Macromolecular Chemistry Ghent University B-9000 Gent Belgium

Among the several types of inorganic nanoparticles available,silica nanoparticles(SNP)have earned their relevance in biological applications namely,as bioimaging *** fact,uorescent SNP(FSNP)have been explored in this-eld as protective nanocarriers,overcoming some limitations presented by conventional organic dyes such as high photobleaching rates.A crucial aspect on the use of uorescent SNP relates to their surface properties,since it determines the extent of interaction between nanoparticles and biological systems,namely in terms of colloidal stability in water,cellular recognition and internalization,tracking,biodistribution and speci-city,among ***,it is imperative to understand the mechanisms underlying the interaction between biosystems and the SNP surfaces,making surface functionalization a relevant step in order to take full advantage of particle *** versatility of the surface chemistry on silica platforms,together with the intrinsic hydrophilicity and biocompatibility,make these systems suitable for bioimaging applications,such as those mentioned in this review.

关键词： Fluorescent silica nanoparticles bioimaging surface functionalization nanoparticlecell interactions.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Complex Systems in Economics and Where to Find Them

引用

Journal of Systems Science & Complexity 2021年第1期34卷 314-338页

作者： gomes orlando GUBAREVA Mariya ISCAL-Lisbon Accounting and Business School Instituto Politécnico de Lisboaand CEFAGE-ISCAL/IPL Research CenterISCALAv.Miguel Bornbarda 201069-035 LisbonPortugal Accounting and Business School Instituto Politécnico de Lisboa SoCIUS-Research Centre in Economic and organizational Sociology CSG-Research in Social Sciences and Management

The economy as a whole and most of its constituent parts, like markets, government institutions, firms, or households, are inherently complex conceptual constructions. Micro-level diversity,decentralized interaction, self-organization, adaptation and learning, emergence, and evolution, are some of the fundamental features that the above entities share and that allow to classify them as being complex entities. In a complex economic system, existing structures of interaction are in constant mutation as individual agents contact and influence one another and, by doing so, reshape the macro environment in which socio-economic relations unfold. Notwithstanding the observed pervasiveness of complexity in economics, there are a few areas of economic thought where the discussion on the theme has gained an exceptional relevance. In this article, six of such areas are identified and their complex nature is highlighted and scrutinized. These pertain to:(i) Knowledge interactions and technological innovation;(ii) Corporate design and organizational learning;(iii) Public policies directed at market regulation;(iv) Banking and financial markets;(v) Environmental economics, sustainability,and climate change;and(vi) income inequality.

关键词： Agent-based models complex networks complex systems emergent phenomena evolutionary nature market regulation public policies

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Why microglia kill neurons after neural disorders? The friendly fire hypothesis

引用

Neural Regeneration Research 2019年第9期14卷 1499-1502页

作者： Walace gomes-Leal Laboratory of Experimental Neuroprotection and Neuroregeneration Institute of Biological Sciences Federal University of Para-Brazil

Neuroinflammation plays a fundamental role on the pathophysiology of acute and chronic neural *** activation is a major event following central nervous system inflammation displaying different phenotypes with beneficial and detrimental actions(a Janus face).The reason for this apparent duality is *** have previously shown that following experimental middle cerebral artery occlusion in the rat brain,microglia seem to support and impair adult neurogenesis in the same ischemic *** on these results,we raised the hypothesis that in the same pathologic environment,gradients of different ligands distributed over different anatomical niches might contribute to both detrimental and beneficial microglial *** ligands(“danger signals”)are released by dying cells and bind to microglial receptors in their *** of different microglial receptors induces downstream biochemical pathways culminating in a spectrum of microglial phenotypes like M1 and M2 and *** this paper,we first review the immune functions of microglia and the role of toll-like receptors on the fight against *** then briefly revise the dual role of microglia after neural *** then propose a novel hypothesis to explain the Janus face of microglia during the pathophysiology of central nervous system diseases:the“friendly fire hypothesis”.According to this idea“danger signals”or danger associated molecular patterns released by stressed,damaged and/or dying cells during stroke,trauma and other diseases might activate microglial pattern-recognition receptors(i.e.,toll like receptors)or other unidentified receptors normally activated by *** could activate the same genetic and biochemical machinery used by microglia to fight against pathogens even in the absence of *** to this notion,microglia may cause bystander neuronal damage with a kind of blind“friendly fire”,fighting against a non-existing infection during

关键词： stroke trauma Alzheimer’s disease neuroinflammation glial cells phenotypes degeneration neuroprotection

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Experimental evidence of pressure effects on spinel dissolution and peridotite serpentinization kinetics under shallow hydrothermal conditions

引用

Geoscience Frontiers 2024年第2期15卷 236-250页

作者： Yuri de Melo Portella Rommulo Vieira Conceição Tiago Abreu Siqueira Lucas Bonan gomes Rodrigo Sebastian Iglesias Programa de Pós-Graduação em Geociências(PPGGEo) Universidade Federal do Rio Grande do SulPorto AlegreBrazil Petrobras–Petróleo Brasileiro S.A. Avenida Henrique Valadares 28CentroRio de Janeiro(RJ)20231-030Brazil Instituto do Petróleo e dos Recursos Naturais-PUCRS–Pontifícia Universidade Católica do Rio Grande do Sul 90619-900Porto AlegreBrazil Universidade Federal do Rio Grande do Sul Instituto de GeociênciasLaboratório de Difratometria de Raios XPorto AlegreBrazil Escola Politécnica–PUCRS-Pontifícia Universidade Católica do Rio Grande do Sul 90619-900 Porto AlegreBrazil

Serpentinization reactions are paramount to understand hydro-geothermal activity near plate boundaries and mafic–ultramafic massifs,as well as fluid and element transfer between the Earth’s mantle and ***,fluid-rock element exchange and serpentinization kinetics under shallow hydrothermal conditions is still largely *** we present two constant temperature(230℃)time-series of natural peridotite(77.5%olivine;13.7%enstatite;6.8%diopside;2%spinel)serpentinization experiments:at 13.4 MPa;and 20.7 ***-enriched lizardite was the main secondary mineral in all runs after olivine(olv)and orthopyroxene(opx)serpentinization(without any detectable brucite,talc or magnetite),while primary spinel and diopside partially dissolved during the *** serpentinization stages comprises intrinsically coupled reactions between olivine and enstatite,as Al and Si are progressively transferred from orthopyroxene-derived to olivine-derived serpentine,while the opposite is true for Mg and Fe,with homogenization of serpentines compositions after 40 *** Ni/Cr ratios of serpentines,however,remain diagnostic of the respective primary *** average serpentine content indicates fast serpentinization rates of 0.55 wt.%·day^(-1)(0.26 mmol·day^(-1))and 0.26 wt.%·day^(-1)(0.13 mmol·day^(-1))at 13.4 and 20.7 MPa,*** 2x faster serpentinization kinetics at lower pressure is likely linked to enhanced spinel dissolution leading to one order of magnitude higher available Al,which accelerates olivine serpentinization while delays orthopyroxene ***,time-dependent increase in solid products masses suggests rock volume expands linearly 0.37%±0.01%per serpentine wt.%independently of *** balance constrains suggests olv:opx react at~5:2 and~3:2 M ratios,resulting in Si-deficient and Si-saturated serpentines at the end of the low-pressure series(13.4 MPa)and high-pressure series(20.7 MPa),***

关键词： Serpentine Volume expansion Serpentinization fluids Lost City hydrothermal field Serpentinite-hosted hydrothermal systems Hydrogen(H_(2))generation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Doubling down with CAR-T cell cancer immunotherapy:a two-step recognition circuit enables discrimination between target antigen high and low cancer cells

引用

Signal Transduction and Targeted Therapy 2021年第8期6卷 2280-2281页

作者： Jehad Charo Bruno gomes hoffmann-la roche ag pharmaceutical research and early development oncologyroche innovation center zurichzurichswitzerland hoffmann-la roche ag pharmaceutical research and early development oncologyroche innovation center baselbaselswitzerland

In a recent article published in Science by Hernandez-Lopez et *** antigen receptor(CAR)expressing T(CAR-T)cells with a two-step recognition system successfully discriminated between target cells expressing high and l... 详细信息

关键词： CAR cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Novel ecosystems in the restoration of cultural landscapes of Tl’chés,West Chatham Island,British Columbia,Canada

引用

Ecological Processes 2013年第1期2卷 143-155页

作者： Thiago C gomes School of Environmental Studies University of VictoriaPO Box 3060 STN CSCVictoriaBC V8W 3R4Canada

Introduction:The small archipelago of Tl’chés,in coastal British Columbia,has gone through drastic social-ecological change culminating in the decline of traditional management practices,invasion of exotic plant species and,in the early 1960s,land *** is a common trend in cultural landscapes around the *** landscapes have great social-ecological significance,including cultural safeguarding and renewal,as well as maintenance of biodiversity,ecosystem functions and services,making them objects of special attention in conservation and restoration *** study investigates the relationship between the Lekwungen people and heavily altered ecosystems in the context of ecological restoration for the cultural landscapes of Tl’ché***:In order to thoroughly explore the ecological,social and cultural aspects and processes involved in the restoration of Tl’chés,this study combined different environmental sciences methodologies,including historical and archival research,semi-structured interviews and participatory observation with Lekwungen participants,as well as ecological field assessments and an innovative mapping approach termed Terrestrial Cultural Ecosystem Mapping(TCEM).Results:This study generated historical and spatial references for ecosystem and land use change in West Chatham Island,as well as cultural and ecological understandings to support *** important native species such as Camassia *** still thriving,present-day ecosystems on this island are heavily altered from the natural Garry oak ecosystem reference sites and are largely dominated by exotic invasive shrubs and graminoid *** investigation indicates that the Lekwungen value both the historical ecological conditions of the island and particular types of the present-day novel or hybrid ecological states,such as the overgrown heritage orchard and nonnative berries found on the ***:Present-day ecosystems of Tl’chés are a result of

关键词： Ecological restoration Novel ecosystems Cultural landscapes Traditional ecological knowledge and wisdom(TEKW) Historical ecology Garry oak ecosystems Lekwungen

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：