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Typical Aspects of the Granular Cell Tumor of the Oral Cavity

International Journal of Otolaryngology and Head & Neck Surgery 2014年第6期3卷 318-322页

作者： Paula Prieto-Oliveira Sergio Vitorino Cardoso Florence Zumbaio Mistro Sergio Kignel suzana cantanhede orsini machado de sousa Marco Tullio Brazao-Silva Inter-Institutional Grad Program on Bioinformatics University of Sao PauloSao PauloBrazil department of Oral Pathology School of DentistryFederal University of UberlandiaUberlandiaBrazil department of Semiology School of DentistryFundacao Herminio OmettoArarasBrazil department of Oral Pathology School of DentistryUniversity of Sao PauloSao PauloBrazil department of Oral Diagnosis School of DentistrySchool of Health SciencesUniversity of the State of AmazonasManausBrazil

Granular cell tumor (GCT) is a rare neoplasm that can occur in any part of the body, but mostly they are located intraorally. Its histogenetic origin remains controversial, but it probably arises from Schwann cells and is generally benign. The tumor is typically asymptomatic and appears as a nodule, with a relatively high predilection for the tongue. This article reports a case of a 72-year-old woman treated at the Center of Oral Diagnosis of the Fundação Hermínio Ometto dental School. The patient presented with an asymptomatic nodule in the dorsal surface of the tongue for approximately 4 months. The patient was submitted to an excisional biopsy and histopatological examination revealed polyhedral cells with granular aspect. The immunohistochemical staining for S-100 presented strong reactivity, confirming the diagnosis of GCT. Finally, we made a concise discussion about the pathogenesis and fundamental clinico-pathological aspects of GCT making the differential diagnosis.

关键词： Granular Cell Tumor Mouth Diagnosis

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