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Sintilimab(anti-PD-1 antibody)plus chidamide(histone deacetylase inhibitor)in relapsed or refractory extranodal natural killer T-cell lymphoma(SCENT):a phase Ⅰb/Ⅱ study

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2765-2773页

作者： Yan Gao Haixia He Xueping Li Liling Zhang Wei Xu Ru Feng Wenyu Li Yin Xiao Xinxiu Liu Yu Chen Xiaoxiao Wang Bing Bai Huijing Wu Qingqing Cai Zhiming Li Jibin Li suxia lin Yanxia He Liqin Ping Cheng Huang Jiaying Mao Xiujin Chen Baitian Zhao Huiqiang Huang State Key Laboratory of Oncology in South China&Collaborative Innovation Center of Cancer Medicine Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhouChina Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhouChina Department of Radiation Oncology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina Department of Hematology Sun Yat-sen University Cancer CenterGuangzhouChina Cancer Center Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and TechnologyWuhanChina Department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingChina Department of Hematology Nanfang HospitalSouthern Medical UniversityGuangzhouChina Department of Lymphoma Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouChina Department of pathology Guangdong General HospitalGuangdong Academy of Medical SciencesGuangzhouChina Department of Medical Oncology Hubei Cancer CenterWuhanChina Department of Clinical Research Sun Yat-sen University Cancer CenterGuanzhouChina Department of Pathology Sun Yat-sen University Cancer CenterGuangzhouChina

Anti-PD-1 antibodies are a favorable treatment for relapsed or refractory extranodal natural killer T cell lymphoma(RR-ENKTL),however,the complete response(CR)rate and the duration of response(DOR)need to be *** phase 1b/2 study investigated the safety and efficacy of sintilimab,a fully human anti-PD-1 antibody,plus chidamide,an oral subtype-selective histone deacetylase inhibitor in 38 patients with *** objective response rate(ORR)of combination treatment was 80%.Patients received escalating doses of chidamide,administered concomitantly with fixed-dose sintilimab in 21-days cycles up to 12 *** dose-limiting events were observed,RP2D of chidamide was 30 mg twice a ***-nine patients were enrolled in phase *** the intention-to-treat population(n=37),overall response rate was 59.5% with a complete remission rate of 48.6%.The median DOR,progression-free survival(PFS),and overall survival(OS)were 25.3,23.2,and 32.9 months,*** most common grade 3 or higher treatment-emergent adverse events(AEs)were neutropenia(28.9%)and thrombocytopenia(10.5%),immune-related AEs were reported in 18(47.3%)*** biomarker assessment suggested that a combination of dynamic plasma ctDNA and EBV-DNA played a vital prognostic ***3 mutation shows an unfavorable *** outcome of anticipate ORR was not achieved,sintilimab plus chidamide was shown to have a manageable safety profile and yielded encouraging CR rate and DOR in RR-ENKTL for the first *** is a promising therapeutic option for this population.

关键词： killer lymphoma doses

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Inactivation of FOXO1 induces T follicular cell polarization and involves angioimmunoblastic T cell lymphoma

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Cancer Biology & Medicine 2019年第4期16卷 743-755页

作者： Meifang Xu Fei Wang Hong Chen lin Liu Wenwen Liu Yinghong Yang Qiaoling Zheng Lihong Zhang Xiaoxuan Li suxia lin Shengbing Zang Department of Pathology Fujian Medical University Union HospitalFuzhou 350001China Division of Pediatrics University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Pathology The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350004China Department of Pathology Fujian Medical UniversityFuzhou 350004China Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhou 510060China Department of Pathology Sun Yat-sen University Cancer CenterGuangzhou 510060China

Objective:Angioimmunoblastic T cell lymphoma(AITL)is an aggressive form of non-Hodgkin lymphoma derived from mature T ***,the underlying pathogenesis of AITL remains *** aimed to explore the role of FOXO1-mediated signaling in the tumorigenesis and progression of ***:FOXO1 expression was assessed using immunohistochemistry on a total of 46 AITL tissue *** encoding FOXO1 shRNA were used to knockdown FOXO1 expression in CD4^+T *** cytometric assays analyzed the proliferation and survival of FOXO1 knockdown CD4^+T ***,we performed adoptive T-cell transfer experiments to identify whether inactivation of FOXO1 induced neoplastic follicular-helper T(Tfh)cell polarization and ***:Patients with low FOXO1 protein levels were prone to have an advanced tumor stage(P=0.049),higher ECOG ps(P=0.024),the presence of bone marrow invasion(P=0.000),and higher IPI(P=0.035).Additionally,the survival rates of patients in the FOXO1 high-expression group were significantly better than those in the FOXO1 low-expression group(χ^2=5.346,P=0.021).We also observed that inactivation of FOXO1 increased CD4^+T cell proliferation and altered the survival and cell-cycle progression of CD4^+T ***,we confirmed that inactivation of FOXO1 induces Tfh cell programing and ***:Inactivation of FOXO1 in AITL plays a key role in the tumorigenesis and progression of *** propose that FOXO1 expression could be a useful prognostic marker in AITL patients to predict poor survival,and to design appropriate therapeutic strategies.

关键词： Angioimmunoblastic T cell lymphoma FOXO1 inactivation differentiation

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PD0325901, an ERK inhibitor, enhances the efficacy of PD-1 inhibitor in non-small cell lung carcinoma

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Acta Pharmaceutica Sinica B 2021年第10期11卷 3120-3133页

作者： Min Luo Yuhui Xia Fang Wang Hong Zhang Danting Su Chaoyue Su Chuan Yang Shaocong Wu Sainan An suxia lin Liwu Fu State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangdong Esophageal Cancer InstituteSun Yat-sen University Cancer CenterGuangzhou 510060China Pharmacy College Guangzhou Medical UniversityGuangzhou 510182China

ERK pathway regulated the programmed death ligand-1(PD-L1)expression which was linked to the response of programmed death-1(PD-1)/PD-L1 blockade *** it is deducible that ERK inhibitor could enhance the efficacy of PD-1 inhibitor in cancer *** this study,PD0325901,an oral potent ERK inhibitor,strongly enhanced the efficacy of PD-1 antibody in vitro and in vivo models in non-small cell lung carcinoma(NSCLC)***,PD0325901 or shRNA-ERK1/2 significantly downregulated the PD-L1 expression in NSCLC cells and increased the CD3+T cells infiltration and functions in tumor *** was a positive correlation between the p-ERK1/2 expression and PD-L1 expression in patients with *** the patients with low p-ERK1/2 expression were observed a high response rate of PD-1/PD-L1 blockage *** results demonstrate that PD0325901,an ERK inhibitor,can enhance the efficacy of PD-1 blockage against NSCLC in vitro and in vivo *** the combination of ERK inhibitor such as PD0325901 and PD-1/PD-L1 blockage is a promising regimen and encouraged to be further confirmed in the treatment of patients with NSCLC.

关键词： ERK1/2 PD-L1 PD-1 PD0325901 NSCLC Immunotherapy Targeted therapy Combination therapy

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Notch 1 and NF-κB Expression and Clinical Correlation in Chinese Patients with Lymphoblastic Lymphoma

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Journal of Cancer Therapy 2013年第3期4卷 441-447页

作者： lin lin Xiaofei Sun Juan Wang Zijun Zhen suxia lin Gangling Tong Yan Chen Department of Pediatric Oncology Sun Yat-Sen University Cancer Center Guangzhou China State Key Laboratory of Oncology in South China Guangzhou China

T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/T-LBL) is commonly associated with Notch 1 mutations. There is limited data on the relationship between Notch l and NF-κB expression and clinical features in LBL. We evaluated the expression of Notch l and NF-κB in LBL using immunohistochemistry and analyzed their relationship with clinical characteristics, treatment results, and survival. From October 2000 to August 2008, 34 untreated patients with LBL were enrolled in the study. Median age was 11.8 years (range, 1 - 25 years). Twenty-five patients were diagnosed with T-LBL and 9 patients with B-LBL. Most patients received chemotherapy consisting of modified ALL-BFM- 90. Notch l showed high expression in 68% of T-LBL and low expression in 100% of B-LBL (p = 0.015). High expression of Notch l positively correlated with presence of a mediastinal mass but not with 5-year event free survival (EFS) in T-LBL. NF-κB showed high expression in 65% of all patients with LBL, with no difference between T- and B-LBL. NF-κB expression was higher in T-LBL patients with bulky disease and B symptom;it did not correlate with 5-year EFS in T-LBL. Expression of Notch 1 and NF-κB strongly correlated (p = 0.014) in T-LBL. Notch 1 is highly ex- pressed in T-LBL. NF-κB is highly expressed in all patients with LBL with no difference between T-LBL and B-LBL. Notch 1 expression was significantly associated with NF-κB expression in T-LBL. Notch l and NF-κB may play an important role in the development of T-LBL;further investigation is warranted.

关键词： Lymphoblastic Lymphoma Notch l NF-κB

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淋巴瘤化疗后继发感染患者病原菌及耐药性分析

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中国微生态学杂志 2023年第9期35卷 1045-1049页

作者：甘东辉潘志群林君曾锦芳林素霞莆田学院附属医院血液内科福建莆田351100

目的分析淋巴瘤化疗后继发感染患者病原菌分布及病原菌对常见抗菌药物的敏感性,从而为制定患者干预方案、提高患者生活质量提供参考依据。方法以经病理确诊的淋巴瘤化疗后继发感染患者为研究对象,采集患者血液、尿液、痰液和粪便样本。... 详细信息

目的分析淋巴瘤化疗后继发感染患者病原菌分布及病原菌对常见抗菌药物的敏感性,从而为制定患者干预方案、提高患者生活质量提供参考依据。方法以经病理确诊的淋巴瘤化疗后继发感染患者为研究对象,采集患者血液、尿液、痰液和粪便样本。采用VITEK 2 COMPACT全自动微生物鉴定及药敏分析仪鉴定病原菌种类,采用Mueller-Hinton琼脂平板和Kirby-Bauer纸片扩散法测定分离的主要病原菌菌株对常见抗菌药物的敏感性。结果455例淋巴瘤病人,总计住院1776人次,累计有356人次发生化疗后继发感染,发生率为20.1%。累计培养出病原菌106株,以大肠埃希菌和肺炎克雷伯菌为主。大肠埃希菌对头孢替坦、阿米卡星、亚胺培南、美罗培南、厄他培南敏感性均>95%;肺炎克雷伯菌对阿米卡星、头孢替坦、亚胺培南、美罗培南、厄他培南敏感性均>90%;金黄色葡萄球菌对呋喃妥因、利奈唑胺、替加环素、万古霉素、喹奴普汀/达福普汀敏感性均为100%;铜绿假单胞菌对多黏霉素B敏感性为100%,对哌拉西林/他唑巴坦、头孢吡肟、阿米卡星、庆大霉素、妥布霉素、亚胺培南敏感性均达87.5%。结论淋巴瘤住院患者化疗后继发感染发生率较高,大肠埃希菌和肺炎克雷伯菌为主要病原菌,大肠埃希菌和肺炎克雷伯菌对阿米卡星、头孢替坦、亚胺培南、美罗培南、厄他培南敏感性较高。

关键词：病原菌抗生素耐药性继发感染淋巴瘤化疗

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个体与情境因素如何促成员工低频安全违规行为?——基于个体-情境互动理论的组态分析

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系统管理学报 2024年第2期33卷 368-380页

作者：刘林梅强吴金南刘素霞安徽工业大学管理科学与工程学院安徽马鞍山243032 江苏大学管理学院江苏镇江212013 安徽工业大学商学院安徽马鞍山243032

为了揭示社会人口统计学因素和情境因素之间复杂的交互关系如何促成员工低频安全违规行为,结合组态思想和个体-情境互动理论,采用模糊集定性比较分析(fsQCA)方法分析1294份员工调查数据,探究个体(雇佣形式和性别)和情境(同事安全违规频... 详细信息

为了揭示社会人口统计学因素和情境因素之间复杂的交互关系如何促成员工低频安全违规行为,结合组态思想和个体-情境互动理论,采用模糊集定性比较分析(fsQCA)方法分析1294份员工调查数据,探究个体(雇佣形式和性别)和情境(同事安全违规频率、企业安全投入、企业员工规模和行业危险程度)因素构成的不同条件组态对员工低频安全违规行为的影响。研究发现:任何单一因素均不构成员工低频安全违规行为的必要条件。员工低频安全违规行为存在3种不同驱动模式:非高危行业同事低频安全违规模式、高安全投入与同事低频安全违规共驱模式以及非高危行业大型企业高安全投入模式。同事低频安全违规行为在4种组态解中均是实现员工低频安全违规行为的核心条件。本研究引入fsQCA探究个体与情境因素对员工低频安全违规行为的组态效应,不仅拓展了对员工低频安全违规行为驱动模式的理解,还有助于倡导组态方法在行为安全领域的应用。

关键词：安全违规个体-情境互动安全投入雇佣形式模糊集定性比较分析

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体外膜肺氧合患者功能锻炼的最佳证据总结

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护理学杂志 2024年第4期39卷 86-91页

作者：卢梦洁史苏霞曹燕华林嘉鳞同济大学医学院上海200092 无锡市中医医院同济大学附属上海市肺科医院

目的总结体外膜肺氧合患者功能锻炼的最佳证据,为制定科学的体外膜肺氧合患者功能锻炼方案提供参考。方法系统检索国内外相关指南网站、循证数据库、相关协会网站及学术文献数据库等关于体外膜肺氧合患者功能锻炼的相关证据。检索时限... 详细信息

目的总结体外膜肺氧合患者功能锻炼的最佳证据,为制定科学的体外膜肺氧合患者功能锻炼方案提供参考。方法系统检索国内外相关指南网站、循证数据库、相关协会网站及学术文献数据库等关于体外膜肺氧合患者功能锻炼的相关证据。检索时限为建库至2023年6月。由2名经过循证医学方法学培训的研究人员对所纳入的文献进行质量评价。结果共纳入12篇文献,包括指南2篇,系统评价5篇,专家共识3篇,随机对照试验2篇。最终提取出了前期准备、评估、运动方法和安全监测4个方面共35条最佳证据。结论总结的最佳证据可为开展体外膜肺氧合患者功能锻炼提供依据,从而为患者提供个性化的康复训练方案。

关键词：危重症患者体外膜肺氧合功能锻炼运动评估运动安全监测证据总结循证护理

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血浆/血清中EB病毒DNA的检测:一个对诊断鼻咽癌有价值的血清学指标(英文)

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Chinese Medical Journal 2002年第12期115卷 1895-1897,157页

作者：买世娟宗永生张敏钟碧玲林素暇中山大学中山医学院病理学教研室广州510089

目的　比较血浆 /血清中的EB病毒 (Epstein Barrvirus,EBV)DNA检出率在健康成人和鼻咽癌患者之间的差别 ,评价其在鼻咽癌诊断中的意义。方法　从 5 8例健康成人和 66例未经治疗的鼻咽癌患者获取血浆和血清标本 ,用巢式PCR法检测EB病毒W... 详细信息

目的　比较血浆 /血清中的EB病毒 (Epstein Barrvirus,EBV)DNA检出率在健康成人和鼻咽癌患者之间的差别 ,评价其在鼻咽癌诊断中的意义。方法　从 5 8例健康成人和 66例未经治疗的鼻咽癌患者获取血浆和血清标本 ,用巢式PCR法检测EB病毒W片段。用免疫酶标法检测IgA/VCA滴度。结果　鼻咽癌患者血浆 /血清EB病毒DNA检出率为 84 85 % ,明显高于健康人 (10 34% )。血浆 /血清EB病毒DNA检测方法的敏感度 (0 84 85 )高于IgA/VCA(1∶4 0 )检测 (0 80 30 ) ,特异度相同 (均为 0 8966)。血浆 /血清EB病毒DNA和IgA/VCA(1∶4 0 )双阳性的正确率 (0 8387)、阳性实验预测值 (0 9792 )和优势比 (141 0 )比单独血浆 /血清EB病毒DNA阳性 (分别为 0 5 2 4 2 ,0 7333和 1 142 3)或IgA/VCA阳性者 (分别为 0 4 839,0 5 385和 1 0 4 80 )高。结论　用巢式PCR方法检测血浆 /血清中EB病毒DNA是诊断鼻咽癌有价值的指标之一。

关键词：鼻咽癌鼻咽肿瘤血清学检测 DNA检测 Epstein-Barr病毒

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急性白血病早期死亡相关因素分析

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肿瘤 2005年第3期25卷 262-263页

作者：林素霞刘永武严俊福建省莆田学院附属医院莆田351100

目的探讨急性白血病早期死因的相关因素。方法对65例早期死亡的病例进行回顾性总结及相关因素回归分析。结果并发出血、感染是早期死亡的主要原因,而且与就诊时外周白细胞、血小板、年龄、白血病类型、骨髓中幼稚细胞比例及是否合并脏... 详细信息

目的探讨急性白血病早期死因的相关因素。方法对65例早期死亡的病例进行回顾性总结及相关因素回归分析。结果并发出血、感染是早期死亡的主要原因,而且与就诊时外周白细胞、血小板、年龄、白血病类型、骨髓中幼稚细胞比例及是否合并脏器功能衰竭有关。结论针对上述高危因素采取有效的防治,是减少早期死亡的主要措施。

关键词：白血病死亡原因回归分析

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Erratum to Inactivation of FOXO1 induces T follicular cell polarization and involves angioimmunoblastic T cell lymphoma

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Cancer Biology & Medicine 2020年第1期17卷 251-251页

作者： Meifang Xu Fei Wang Hong Chen lin Liu Wenwen Liu Yinghong Yang Qiaoling Zheng Lihong Zhang Xiaoxuan Li suxia lin Shengbing Zang Department of Pathology Fujian Medical University Union HospitalFuzhou B50001China Division of Pediatrics University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Pathology The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350004China Department of Pathology Fujian Medical UniversityFuzhou 350004China Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhou 510060China Department of Pathology Sun Yat-sen University Cancer CenterGuangzhou 510060China

In the published article1,an error appeared in Acknowledgments on page *** omitted Natural Science Foundation of Guangdong Province from Acknowledgments,and we updated it as *** apologize for the errors and for any co... 详细信息

关键词： ledgment Guangdong polarization

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