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Pharmacogenetic studies update in type 2 diabetes mellitus

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World Journal of Diabetes 2016年第15期7卷 302-315页

作者： Shalini Singh Kauser Usman Monisha banerjee Molecular and Human Genetics Laboratory Department of Zoology University of Lucknow Lucknow 226007 India Department of Medicine King George’s Medical University Lucknow 226003 India

Type 2 diabetes mellitus(T2DM) is a silent progressive polygenic metabolic disorder resulting from ineffective insulin cascading in the body. World-wide, about 415 million people are suffering from T2DM with a projected rise to 642 million in 2040. T2DM is treated with several classes of oral antidiabetic drugs(OADs) viz. biguanides, sulfonylureas, thiazolidinediones, meglitinides, etc. Treatment strategies for T2DM are to minimize long-term micro and macro vascular complications by achieving an optimized glycemic control. Genetic variations in the human genome not only disclose the risk of T2DM development but also predict the personalized response to drug therapy. Inter-individual variability in response to OADs is due to polymorphisms in genes encoding drug receptors, transporters, and metabolizing enzymes for example, genetic variants in solute carrier transporters(SLC22A1, SLC22A2, SLC22A3, SLC47A1 and SLC47A2) are actively involved in glycemic/HbA1c management of metformin. In addition, CYP gene encoding Cytochrome P450 enzymes also play a crucial role with respect to metabolism of drugs. Pharmacogenetic studies provide insights on the relationship between individual genetic variants and variable therapeutic outcomes of various OADs. Clinical utility of pharmacogenetic study is to predict the therapeutic dose of various OADs on individual basis. Pharmacogenetics therefore, is a step towards personalized medicine which will greatly improve the efficacy of diabetes treatment.

关键词： Type 2 diabetes mellitus Pharmacogenetics Genetic variants Oral antidiabetic drugs Personalized medicine

Why do young people with chronic kidney disease die early?

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World Journal of Nephrology 2014年第4期3卷 143-155页

作者： Shankar Kumar Richard Bogle Debasish banerjee Medical School St George’sUniversity of London Department of Cardiology St George’s Hospital NHS Trust Department of Cardiology Epsom and St Helier University HospitalsNHS Trust Renal and Transplantation Unit St George’s Hospital NHS Trust

Cardiovascular disease poses the greatest risk of premature death seen among patients with chronic kidney disease(CKD).Up to 50% of mortality risk in the dialysis population is attributable to cardiovascular disease and the largest relative excess mortality is observed in younger *** early CKD,occlusive thrombotic coronary disease is common,but those who survive to reach end-stage renal failure requiring dialysis are more prone to sudden death attributable mostly to sudden arrhythmic events and heart failure related to left ventricular hypertrophy,coronary vascular calcification and electrolyte *** this review,we discuss the basis of the interaction of traditional risk factors for cardiovascular disease with various pathological processes such as endothelial dysfunction,oxidative stress,low grade chronic inflammation,neurohormonal changes and vascular calcification and stiffness which account for the structural and functional cardiac changes that predispose to excess morbidity and mortality in young people with CKD.

关键词：心血管疾病慢性肾病治疗方法临床分析

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动态变压吸附工艺的有效能分析

四川化工 1994年第S2期 56-60页

作者： R.banerjee ,K.G.Narayankhedkar ,S.P.Sukhatme ,李劲松

有效能分析法,可用于选择最佳操作条件和比较不同工艺组合的性能。本文以有效能分析方法为基础,对不同的动态变压吸附工艺进行了分析。变压吸附(PAS)工艺,已成为传统低温蒸馏法分离气体的一种富有活力的取代方法。Ruthven(1984年)曾提... 详细信息

有效能分析法,可用于选择最佳操作条件和比较不同工艺组合的性能。本文以有效能分析方法为基础,对不同的动态变压吸附工艺进行了分析。变压吸附(PAS)工艺,已成为传统低温蒸馏法分离气体的一种富有活力的取代方法。Ruthven(1984年)曾提出了吸附模型的简单原理和假设;Raghavan和Ruthven(1985年)、Shin和Knaebel(1987年)、

关键词：有效能效率回收率产品纯度组合形式均压过程有效能分析法

Cancer and age related colonic crypt deficiencies in cytochrome c oxidase Ⅰ

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World Journal of Gastrointestinal Oncology 2010年第12期2卷 429-442页

作者： Carol Bernstein Alexander Facista Huy Nguyen Beryl Zaitlin Nadia Hassounah Cristy Loustaunau Claire Margaret Payne Bhaskar banerjee Steve Goldschmid V Liana Tsikitis Robert Krouse Harris Bernstein Department of Cell Biology and Anatomy College of MedicineUniversity of ArizonaTucsonAZ 85724United State Schulich School of Civil Engineering University of CalgaryCalgary Alberta T2L 1M3Canada Department of Cell Biology and Anatomy College of MedicineUniversity of ArizonaTucsonAZ 85724United States Biomedical Diagnostics and Research Inc TucsonAZ 85719United States Department of Medicine College of MedicineUniversity of ArizonaTucsonAZ 85724United States Department of Surgery College of MedicineUniversity of ArizonaTucsonAZ 85724United States Southern Arizona Veterans Affairs Health Care System TucsonAZ 85723United States

AIM: To investigate whether defi ciency of expressionof cytochrome c oxidase I (CcOI) in colonic crypts is associated with colon ***: The pattern and level of expression of CcOI in non-neoplastic colonic crypts,and in dysplastic tissues,was assessed using standard immunohis-tochemical *** were obtained from individuals undergoing colonoscopies for screening purposes or for a medically indicated *** samples were also obtained from surgical colonic *** from resections were taken from colonic mucosa 1 and 10 cm from tumors and from the tumors *** were evaluated for frequency of crypts with reduced or absent expression of *** most crypts the loss was apparent throughout the entire crypt,while in a small minority the loss was *** strong immunoreactivity using this monoclonal antibody makes the scoring *** percent of crypts with reduced or absent expression of CcOI or (infrequent) segmented loss of expression was then *** analyses were performed using SPSS statistical package ***: The average frequency of CcOI deficient crypts (CcOI-DC) is low in individuals between 20 and 39 years of age,with 0.48% ± 0.40% CcOI-DC for women and 1.80% ± 0.35% for ***-DC increases after age 40 years,so that between the ages of 40 and 44 years the average frequency of CcOI- DC goes up to 5.89% ± 0.84% in women and 2.15% ± 1.27% in *** 80-84 years of age,the average frequency of CcOI-DC goes up in women to 15.77% ± 0.97% and in men to 22.6% ± 0.65%.The increases in CcOI-DC from ages 40-44 years compared to 80-84 years in women and men are significantly different with P < *** women over age 60 years,deficiency of CcOI expression is greater in those women who have had a cancer in their *** frequency of CcOI-DC,measured in men,increased in tissues adjacent to colon cancer,being 4.03% ± 0.27% in individuals free of neoplasia in the age range 55-64 yearsand 14.13% ± 0.

关键词： Cytochrome c oxidase Aging Colon crypts Colorectal cancer Focal lesions

Cellular oxidative stress stimulates cystathionine γ-lyase derived-H2S synthesis via a disulfide redox switch

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Cellular oxidative stress stimulates cystathionine γ-lyase ...

Overview of the HiLASE project: high average power pulsed DPSSL systems for research and industry

中国生物化学与分子生物学会2020全国学术在线会议

作者： Jun Wang Guanya Jia Heng Li Shasha Yan Jing Qian Xin Guo Ge Li Haizhen Qi Zhilong Zhu Yanjun Wu Weijuan He Ruma banerjee Weining Niu School of Life Sciences Northwestern Polytechnical University Department of Biological Chemistry University of Michigan Medical School

Hydrogen sulfide(H S),which is mainly generated by cystathionine γ-lyase in the cardiovascular system,plays a pivotal role in a wide range of physiological and pathological ***,the regulatory mechanism of CSE/H S system is poorly ***,we show that oxidation induces the disulfide bond formation between Cys and Cys in the CXXC motif,thus stimulating the H S-producing activity of CSE,but not the canonical cystathionine cleavage *** dynamics and molecular docking suggest that the disulfide bond formation increase the affinity of the substrate L-cysteine for enzyme active *** spectrometry and mutagenesis studies further established that Cys is crucial for oxidation ***,we demonstrate that exogenous H O and endogenous H O triggered by vascular endothelial growth factor(VEGF) promote cellular H S production through oxidizing the CSE to form disulfide *** together,we report a new post-translational modification of CSE that provides a molecular mechanism for H S/H O cross-talk in cells.

关键词： Cystathionine γ-lyase Hydrogen sulfide Oxidative stress Disulfide redox switch Allosteric control

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High Power Laser Science and Engineering 2014年第2期2卷 1-10页

作者： M.Divoky M.Smrz M.Chyla P.Sikocinski P.Severova O.Novak J.Huynh S.S.Nagisetty T.Miura J.Pila O.Slezak M.Sawicka V.Jambunathan J.Vanda A.Endo A.Lucianetti D.Rostohar P.D.Mason P.J.Phillips K.Ertel S.banerjee C.Hernandez-Gomez J.L.Collier T.Mocek HiLASE Institute of Physics AS CR v.v.i. Na Slovance 2 182 21 Prague Czech Republic STFC Rutherford Appleton Laboratory Didcot OX11 0QX United Kingdom

An overview of the Czech national R&D project HiLASE(High average power pulsed laser) is presented. The project focuses on the development of advanced high repetition rate, diode pumped solid state laser(DPSSL) systems with energies in the range from mJ to 100 J and repetition rates in the range from 10 Hz to 100 kHz. Some applications of these lasers in research and hi-tech industry are also presented.

关键词： DPSSL Yb3+:YAG thin-disk multi-slab pulsed high average power laser

Antiseptic use in the neonatal intensive care unit-a dilemma in clinical practice: An evidence based review

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World Journal of Clinical Pediatrics 2016年第2期5卷 159-171页

作者： Sundar Sathiyamurthy Jayanta banerjee Sunit V Godambe Children’s Directorate Department of Neonatal Medicine Imperial College Healthcare NHS Trust

Infants in the neonatal intensive care unit are highly susceptible to healthcare associated infections(HAI), with a substantial impact on mortality, morbidity and healthcare costs. Effective skin disinfection with topical antiseptic agents is an important intervention in the prevention or reduction of HAI. A wide array of antiseptic preparations in varying concentrations and combinations has been used in neonatal units worldwide. In this article we have reviewed the current evidence of a preferred antiseptic of choice over other agents for topical skin disinfection in neonates. Chlorhexidine(CHG) appears to be a promising antiseptic agent; however there exists a significant concern regarding the safety of all agents used including CHG especially in preterm and very low birth weight infants. There is substantial evidence to support the use of CHG for umbilical cord cleansing and some evidence to support the use of topical emollients in reducing the mortality in infants born in developing countries. Well-designed large multicentre randomized clinical trials are urgently needed to guide us on the most appropriate and safe antiseptic to use in neonates undergoing intensive care, especially preterm infants.

关键词： Antiseptics Disinfectants Topical Neonate Preterm Very low birth weight infant Chlorhexidine Povidone-iodine Alcohol

Gimbal orientation study and assessment for the autonomous underwater vehicles

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Journal of Ocean Engineering and Science 2020年第2期5卷 101-115页

作者： Sudhir Kumar Chaturvedi Sourav Basu Saikat banerjee Department of Aerospace Engineering UPESDehradun 248007UttarakhandIndia Department of Electrical Engineering Jalpaiguri Government Engineering CollegeJalpaiguri 735102West BengalIndia Department of UAV and Remote Sensing WingboticsKolkata-700086West BengalIndia

Autonomous underwater vehicles are at present being used for scientific,commercial and military submerged *** this paper,a system has been proposed which can be used underwater as remotely operated underwater vehicle for submerged survey for different *** systems require self-sufficient direction and control frameworks so as to perform submerged ***,framework identification and control of these vehicles are as yet real dynamic zones of innovative *** theory is worried about the plan and improvement of an Autonomous Underwater Vehicle(AUV)specifically proposed for passage into global submerged vehicle *** theory comprises of two stages;the first includes the plan and development of the vehicle while the subsequent stage is worried about the demonstrating and framework identification of the vehicle,just as the reproduction of a control *** structure and advancement of the vehicle comprised of actualizing a mechanical and electrical framework,just as the reconciliation of *** framework identification of the vehicle parameters comprised of utilizing locally available sensors to perform static and dynamic *** squares estimation was utilized to gauge the parameters from the pre-researched data obtained.

关键词： IMU sensor Gimbal stabilization Kalman filter MATLAB Simulink Brushless DC motor

Retraction notice to<"Gimbal orientation study and assessment for the autonomous underwater vehicles"><[Journal of Ocean Engineering and Science Volume 5,Issue 2,June 2020,Pages 101-115]>

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Journal of Ocean Engineering and Science 2021年第2期6卷 215-215页

作者： Sudhir Kumar Chaturvedi Sourav Basu Saikat banerjee Department of Aerospace Engineering UPES Dehradun 248007 Uttarakhand India Department of Electrical Engineering Jalpaiguri Government Engineering College Jalpaiguri 735102 West Bengal India Department of UAV and Remote Sensing Wingbotics Kolkata 700086 West Bengal India

Sudhir Kumar Chaturvedi,Sourav Basu,Saikat *** of Aerospace Engineering,UPES,Dehradun 248007,Uttarakhand,*** of Electrical Engineering,Jalpaiguri Government Engineering College,Jalpaiguri 735102,West Bengal,*** of UAV and Remote Sensing,Wingbotics,Kolkata 700086,West Bengal,India This article has been retracted:please see Elsevier Policy on Article Withdrawal(https://***/about/our-business/policies/article-withdrawal).This article has been retracted at the request of *** article duplicates significant parts of a paper that had already appeared in[International Journal of Recent Technology and Engi-neering,volume 8(2019)https://***/wp-content/uploads/papers/v8i1/*** of the conditions of submission of a paper for publication is that authors declare explicitly that the paper has not been previously published and is not under consideration for publication ***-use of any data should be appropriately *** such this article represents a misuse of the scientific pub-lishing *** scientific community takes a very strong view on this matter and apologies are offered to readers of the journal that this was not detected during the submission process.

关键词： please process. journal