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Candida tropicalis infection in a term neonate with gall bladder masses and infective endocarditis

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Asian Pacific Journal of Tropical Medicine 2012年第5期5卷 410-412页

作者： Mamta Jajoo Vishal Kumar Vishnu K.goyal Amit Garg Department of Pediatrics Maulana Azad Medical College & Associated Chacha Nehru Bal Chikitsalaya New Delhi-110031India Department of Radiology Maulana Azad Medical couege & Associated Chacha Nehru Bal ChikisalayaNew pelhi-110031India.

Candida endocarditis is extremely rare in term neonates,and gall bladder involvement due to candidemia has never been reported amongst neonates and infants.A term,appropriate for gestational age neonate developed Candida tropicalis blood stream infection in second week of *** was started on conventional amphotericin ***,he failed to show any clinical improvement,and candidemia keep on *** sanctuary sites screening revealed multiple echogenic masses in heart(vegetations) and gall *** changing the treatment to liposomal amphotericin B and fluconazole,he recovered clinically,echogenic masses in gall bladder disappeared,and intracardiac vegetations decreased in size.

关键词： Candida tropicalis Endocarditis Gall bladder

Quantification of Ride Comfort Using Musculoskeletal Mathematical Model Considering Vehicle Behavior

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Computer Modeling in Engineering & Sciences 2023年第6期135卷 2287-2306页

作者： Junya Tanehashi Szuchi Chang Takahiro Hirosei Masaki Izawa Aman goyal Ayumi Takahashi Kazuhito Misaji Graduate Student Graduate School of Industrial TechnologyNihon UniversityChiba275-8575Japan Hitachi Astemo Ltd.Tochigi321-3325Japan Former Graduate Student Graduate School of Industrial TechnologyNihon UniversityChiba275-8575Japan College of Industrial Technology Nihon UniversityChiba275-8575Japan

This research aims to quantify driver ride comfort due to changes in damper characteristics between comfort mode and sport mode,considering the vehicle’s inertial *** comfort of riding in an automobile has been evaluated in recent years on the basis of a subjective sensory evaluation given by the ***,reflecting driving sensations in design work to improve ride comfort is abstract in nature and difficult to express ***,we evaluated the human body’s effects while driving scientifically by quantifying the driver’s behavior while operating the steering wheel and the behavior of the automobile while in motion using physical *** this end,we collected driver and vehicle data using amotion capture system and vehicle CAN and IMU *** also constructed a three-dimensional musculoskeletal mathematical model to simulate driver movements and calculate the power and amount of energy per unit of time used for driving the joints and muscles of the human ***,we used comfort mode and sport mode to compare damper characteristics in terms of *** comfort mode,damper characteristics are soft and steering stability is mild,but vibration from the road is not easily transmitted to the driver making for a lighter load on the *** sport mode,on the other hand,damper characteristics are hard and steering stability is comparatively ***,vibration from the road is easily transmitted to the driver,whichmakes it easy for a load to be placed on the *** a result of this comparison,it was found that a load was most likely to be applied to the driver’s *** result in relation to the neck joint can therefore be treated as an objective measure for quantifying ride comfort.

关键词： Human engineering biomechanics driver’s sense of fatigue double lane change musculoskeletal mathematical model

Prognostic significance of red blood cell distribution width in gastrointestinal disorders

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World Journal of Gastroenterology 2017年第27期23卷 4879-4891页

作者： Hemant goyal Giuseppe Lippi Altin Gjymishka Bijo John Rajiv Chhabra Elizabeth May Department of Internal Medicine Mercer University School of Medicine Section of Clinical Biochemistry University of Verona Texas Digestive Disease Consultants Department of Gastroenterology Saint Luke’s HospitalSchool of MedicineUniversity of Missouri Kansas City Gastroenterology Attending Mc Laren Northern Hospital

The red blood cell distribution width(RDW) is a routinely measured and automatically reported blood parameter,which reflects the degree of anisocytosis. Recently,the baseline RDW was found to have clinical significance for assessing clinical outcome and severity of various pathological conditions including cardiovascular diseases,sepsis,cancers,leukemia,renal dysfunction and respiratory diseases. A myriad of factors,most of which ill-defined,have an impact on the red cell population dynamics(i.e.,production,maturation and turnover). A delay in the red blood cell clearance in pathological conditions represents one of the leading determinants of increased anisocytosis. Further study of RDW may reveal new insight into inflammation mechanisms. In this review,we specifically discuss the current literature about the association of RDW in various disease conditions involving the gastrointestinal and hepatobiliary systems. We also present some of the related measurements for their value in predicting clinical outcomes in such conditions. According to our data,RDW was found to be a valuable prognostic index in gastrointestinal disorders along with additional inflammatory biomarkers(i.e.,C reactive protein,erythrocyte sedimentation rate,and platelet count) and current disease severity indices used in clinical practice.

关键词： Red blood cell distribution width Hepatitis Pancreatitis Inflammatory bowel diseases Crohn’s disease Ulcerative colitis Colon cancer Hepatocellular carcinoma Acute mesenteric ischemia Gastrointestinal diseases

Swarm-LSTM: Condition Monitoring of Gearbox Fault Diagnosis Based on Hybrid LSTM Deep Neural Network Optimized by Swarm Intelligence Algorithms

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Computers, Materials & Continua 2021年第2期66卷 2041-2059页

作者： Gopi Krishna Durbhaka Barani Selvaraj Mamta Mittal Tanzila Saba Amjad Rehman Lalit Mohan goyal School of Electrical and Electronics Sathyabama Institute of Science and TechnologyChennai600119India Department of Computer Science and Engineering G.B.Pant Government Engineering CollegeNew Delhi110020India Artificial Intelligence and Data Analytics(AIDA)Laboratory CCISPrince Sultan UniversityRiyadh11586Saudi Arabia Department of Computer Engineering J.C.Bose University of Science and TechnologyFaridabad121006India

Nowadays,renewable energy has been emerging as the major source of energy and is driven by its aggressive expansion and falling *** of the renewable energy sources involve turbines and their operation and maintenance are vital and a difficult *** monitoring and fault diagnosis have seen remarkable and revolutionary up-gradation in approaches,practices and technology during the last *** mostly do use a rotating type of machinery and analysis of those signals has been challenging to localize the *** paper proposes a new hybrid model wherein multiple swarm intelligence models have been evaluated to optimize the conventional Long Short-Term Memory(LSTM)model in classifying the faults from the vibration signals data acquired from the *** helps to analyze the performance and behavioral patterns of the system more effectively and efficiently which helps to suggest for replacement of the unit with higher *** results have demonstrated that the proposed hybrid modeling approach is effective in classifying the faults of the gearbox from the time series data and achieve higher diagnostic accuracy in comparison to the conventional LSTM methods.

关键词： Gearbox long short term memory fault classification swarm intelligence optimization condition monitoring

MRMR Based Feature Vector Design for Efficient Citrus Disease Detection

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Computers, Materials & Continua 2022年第9期72卷 4771-4787页

作者： Bobbinpreet Sultan Aljahdali Tripti Sharma Bhawna goyal Ayush Dogra Shubham Mahajan Amit Kant Pandit Department of Electronics&Communication Engineering Chandigarh UniversityMohali140413India Department of Computer Science College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia Ronin Institute Mont ClairNJ07043USA School of Electronics&Communication Engineering Shri Mata Vaishno Devi UniversityKatra182320India

In recent times,the images and videos have emerged as one of the most important information source depicting the real time *** images nowadays serve as input for many applications and replacing the manual methods due to their capabilities of 3D scene representation in 2D *** capabilities of digital images along with utilization of machine learning methodologies are showing promising accuracies in many applications of prediction and pattern *** of the application fields pertains to detection of diseases occurring in the plants,which are destroying the widespread *** the disease detection process was done by a domain expert using manual examination and laboratory *** is a tedious and time consuming process and does not suffice the accuracy *** creates a room for the research in developing automation based methods where the images captured through sensors and cameras will be used for detection of disease and control its *** digital images captured from the field’s forms the dataset which trains the machine learning models to predict the nature of the *** accuracy of these models is greatly affected by the amount of noise and ailments present in the input images,appropriate segmentation methodology,feature vector development and the choice of machine learning *** ensure the high rated performance of the designed system the research is moving in a direction to fine tune each and every stage separately considering their dependencies on subsequent *** the most optimum solution can be obtained by considering the image processing methodologies for improving the quality of image and then applying statistical methods for feature extraction and *** training vector thus developed is capable of presenting the relationship between the feature values and the target *** this article,a highly accurate system model for detecting the diseases occurring in citrus fruits

关键词： Citrus diseases classification feature vector design plant disease detection redundancy reduction

CCR5A32 mutation does not influence the susceptibility to HCV infection, severity of liver disease and response to therapy in patients with chronic hepatitis C

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World Journal of Gastroenterology 2006年第29期12卷 4721-4726页

作者： Ankur goyal PV Suneetha GT Kumar Deepak K Shukla Naveen Arora Shiv K Sarin Department of Gastroenterology G.B.Pant Hospital New DelhiInstitute of Genomic and Integrative Biology(Formerly CBT)Mall RoadDelhiDr.Ambedkar Center for Biomedical ResearchUniversity of DelhiIndia Department of Gastroenterology G.B.Pant Hospital New DelhiIndia Division of Non-communicable Disease Indian Council of Medical Research Ansari NagarNew DelhiIndia Institute of Genomic and Integrative Biology (Formerly CBT) Mall RoadDelhiIndia

AIM： To study whether CCR5△32 mutation was associated with viral infection and severity of liver disease. METHODS： Two hundred and fifty two histologically proven, chronic HCV patients （mean age： 41±14 years; M/F： 164/88） were genotyped. PCR based genotyping of 32 bp deletion at the CCR5 locus was done. Fourhundred and eight matched healthy controls were studied to assess susceptibility to HCV infection. To assess correlation of immune gene polymorphism with severity of HCV related liver disease, patients with chronic HCV infection were divided into those with a fibrosis score of ≤ 2 （mild） or 〉 2 （severe） and histological activity index （HAI） of ≤ 5 or 〉 5. For correlation between CCR5△32 mutations and response to therapy, 129 patients who completed therapy were evaluated. RESULTS： The majority （89.4%） of the patients were infected with genotype 3. The frequency of homozygous CCR5△32 mutants was comparable to HCV patients as compared to the healthy controls （0.7% vs 0%, P = 0.1）. Further more, the frequency of CCR5△32 mutation was comparable in patients with mild or severe liver disease.（P = NS）. There was also no association observed with response to therapy and CCR5△32 mutation. CONCLUSION： CCR5△32 mutation does not have a role in disease susceptibility, severity or response to therapy in patients with chronic hepatitis C infection.

关键词： β-chemokine receptor 32 bp deletion CCchemokine ligand Human leukocyte antigen Histologicalactivity index

Designing a watershed scorecard as a performance evaluation tool for Ur River watershed,Tikamgarh District,Madhya Pradesh

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International Soil and Water Conservation Research 2017年第4期5卷 280-292页

作者： Meeta Gupta V.C.goyal Fawzia Tarannum Jyoti P.Patil National Institute of Hydrology Roorkee 247667India Teri University New Delhi 110070India

The study is an attempt to design a watershed scorecard by identifying and evaluating selected set of indicators,such as surface water quality,ground water quality,soil condition,agriculture condition,and forest condition,which accurately reflect the health of the *** River Watershed in Tikamgarh District,Madhya Pradesh was taken as a case study to assess the watershed *** was done by calculating different indices for the selected set of indicators and comparing them with the National standards and *** on the performance of each indicator,the grades were assigned to the indicators which helped in designing the watershed *** results revealed that within the watershed,the forest and soil conditions need a considerable plan for improvement in order to maintain the ecosystem whereas the surface water quality,groundwater quality and the agricultural conditions requires protection as well as enhancement in certain areas.

关键词： Watershed scorecard Ur River Bundelkhand Water quality Agricultural condition

Endoscopic ultrasound-guided vascular interventions: Current insights and emerging techniques

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World Journal of Gastroenterology 2021年第40期27卷 6874-6887页

作者： Rupinder Mann Hemant goyal Abhilash Perisetti Saurabh Chandan Sumant Inamdar Benjamin Tharian Department of Internal Medicine Saint Agnes Medical CenterFresnoCA 93730United States Department of Internal Medicine The Wright Center for Graduate Medical EducationScrantonPA 18503United States Department of Gastroenterology and Hepatology The University of Arkansas for Medical SciencesLittle RockAR 72205United States Department of Gastroenterology and Hepatology CHI Creighton University Medical CenterOmahaNE 68107United States Department of Internal Medicine Gastroenterology and Hepatology DivisionUniversity of Arkansas for Medical SciencesLittle RockAR 72205United States

Endoscopic ultrasound(EUS)is one of the significant breakthroughs in the field of advanced *** the last two decades,EUS has evolved from a diagnostic tool to a real-time therapeutic *** luminal gastrointestinal(GI)tract provides a unique opportunity to access multiple vascular structures,especially in the mediastinum and abdomen,thus permitting a variety of EUS-guided vascular *** addition of the doppler and contrast-enhanced capability to EUS has further helped provide real-time visualization of blood flow in vessels through the GI ***-guided vascular interventions rely on standard endoscopic accessories and interventional tools such as fine-needle aspiration needles and fine-needle *** allows the visualization of various structures in real-time by differentiating tissue densities and vascularity,thus,avoiding radiation ***-guided techniques also allow real-time microscopic examination after target ***,many necessary interventions can be done during the same procedure after *** article provides an overview of EUS-guided vascular interventions such as variceal,non-variceal bleeding interventions,EUSguided portal vein(PV)access with the formation of an intrahepatic portosystemic shunt,and techniques related to diagnosis of GI ***,we discuss current insights and future outlook of therapeutic modalities like PV embolization,PV sampling,angiography,drug administration,and portal pressure measurement.

关键词： Endoscopic ultrasound Vascular intervention Esophageal varices Gastric varices Portal vein Therapeutic endoscopy

Sarcopenia in hepatocellular carcinoma:Current knowledge and future directions

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World Journal of Gastroenterology 2022年第4期28卷 432-448页

作者： Abhilash Perisetti Hemant goyal Rachana Yendala Saurabh Chandan Benjamin Tharian Ragesh BabuThandassery Department of Internal Medicine Gastroenterology and Hepatology DivisionUniversity of Arkansas for Medical SciencesLittle RockAR 72205United States Department of Interventional Oncology and Surgical Endoscopy Parkview HealthFort WayneIN 46825United States Department of Internal Medicine The Wright Center for Graduate Medical EducationThe Wright Center for Graduate Medical EducationScrantonPA 18501United States Department of Hematology and Oncology Conway Regional Medical CenterConwayAR 72034United States Department of Internal Medicine Gastroenterology and Hepatology DivisionCHI Creighton University Medical CenterOmahaNE 68107United States Department of Medicine Central Arkansas Veterans Healthcare SystemLittle RockAR 72205United States

Liver cancer is the second most occurring cancer worldwide and is one of the leading causes of cancer-related *** carcinoma(HCC)is the most common(80%-90%)type among malignant liver *** occurs very early in HCC and can predict and provide an opportunity to improve muscle health before engaging in the treatment options such as loco-regional,systemic,and transplant *** prognostic stating systems have been developed in HCC,such as Barcelona Clinic Liver Cancer,Child-Pugh score and Albumin-Bilirubin ***,the evaluation of patients’performance status is a major limitation of these scoring *** this review,we aim to summarize the current knowledge and recent advances about the role of sarcopenia in cirrhosis in general,while focusing specifically on ***,the role of sarcopenia in predicting clinical outcomes and prognostication in HCC patients undergoing loco-regional therapies,liver resection,liver transplantation and systematic therapy has been discussed.A literature review was performed using databases PubMed/MEDLINE,EMBASE,Cochrane,Web of Science,and CINAHL on April 1,2021,to identify published reports on sarcopenia in *** can independently predict HCC-related mortality especially in patients undergoing treatments such as loco-regional,surgical liver transplantation and systemic *** research is focused on evaluating a balance of anabolic and catabolic pathways responsible for muscle *** clinical studies have shown promising results in methods to improve sarcopenia in HCC which can potentially increase prognosis in these *** sarcopenia occurs very early in HCC,it can predict and provide an opportunity to improve muscle health before engaging in the treatment options such as loco-regional,systemic,and transplant ***,sarcopenia measurement can obviate the confounding caused by the abdominal ascites in these *** use of sarcopenia can

关键词： Sarcopenia Skeletal muscle Hepatocellular carcinoma Cirrhosis Outcomes Liver cancer