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Nrf2 a.tiva.or corosolic a.id meliora.es a.loxa. induced dia.etic nephropa.hy in mice

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a.ia. Pa.ific Journa. of Tropica. Biomedicine 2017年第9期7卷 797-804页

作者： Priti S.Tidke Cha.dra.ouda.R.patil Depa.tment of Pha.ma.ology R.C.Patel Institute of Pharmaceutical Education and ResearchShirpurDist-DhuleMaharashtraIndia

Objective: To determine whether corosolic a.id(Ca. ta.geting nuclea. protein expression of Nrf2 a.tiva.ion ca. be used to a.tenua.e rena. da.a.e a.d preserve rena. function in a.loxa. dia.etic ***: a.mouse model with dia.etic nephropa.hy wa. esta.lished to exa.ine the Nrf2 expression. Mice were ra.domly divided into control, dia.etic control, a.d Ca.groups trea.ed a. 0.4 mg/kg, 2 mg/kg a.d 10 mg/kg p.o. for 8 weeks. Dia.etes wa. induced in mice by single intra.eritonea. injection of a.loxa. 200 mg/kg in a.l groups except the control. The mice with fa.ting blood glucose level over 200 mg/d L were considered a. dia.etic a.d were employed in the study. a.ter 4 th a.d 8 th weeks, urine sa.ples were collected(using meta.olic ca.es) to mea.ure protein a.d urea. a.ima.s were eutha.ized, a.d serum sa.ples were collected to estima.e the glucose, crea.inine, tota. protein, urea.a.d blood urea.nitrogen. Kidney wa. isola.ed a. the end of experiment for histology to eva.ua.e a.ti-oxida.t pa.a.eters. Immunohistochemistry wa. performed to exa.ine the Nrf2 ***: Ca.trea.ment showed dose dependent reduction in level of biochemica. pa.a.eters in serum a.d urine. Ca.group(10 mg/kg) showed significa.tly higher body weight a.d reduced kidney weight. Histopa.hologica. exa.ina.ion revea.ed reduced infla.ma.ion, colla.en deposition a.d glomerulosclerosis in rena. tissue. Ca.a.tenua.ed rena. dysfunction, oxida.ive stress a.d infla.ma.ory pro-cytokine ***: Ca.trea.ment exhibited a.eliora.ive effect on kidney in mice with its enha.ced Nrf2 expression.

关键词： Corosolic a.id Nrf2 Dia.etic nephropa.hy Oxida.ive stress Infla.ma.ion Penta.yclic triterpenoid

Three-dimensiona. dyna.ic cha.a.teriza.ion of squa.e-nosed slugging phenomena.in a.fluidized bed

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Pa.ticuology 2022年第8期20卷 35-46页

作者： Ya.wa.th Pottimurthy Da.ei Wa.g Cody Pa.k Sha.in patil a.drew Tong Lia.g-Shih Fa. Willa. G.Lowrie Depa.tment of Chermica. a.d Biomolecula. Engineering.The Ohio Sta.e Univrsity ColumbusOH 43210USA

Slugging represents one of the ma.or regimes in fluidiza.ion,which occurs in sma.l dia.eter beds with la.ge bed height-to-dia.eter ra.io or in la.ge dia.eter beds with interna.s tha. resemble multiple sma.l dia.eter fluidized *** types include round-nosed slug,wa.l slug a.d squa.e nosed *** of the slugs ha.e been ma.nly focused on round-nosed or wa.l slugs known a. ha.f *** occurring in Gelda.t group a.pa.ticle *** squa.e-nosed slug typica.ly occurring for Gelda.t group D pa.ticles a.pea.s to be rega.ded a. simple in its *** Electrica. Ca.a.ita.ce Volume Tomogra.phy(ECVT)ima.ing of the squa.e-nosed slugging phenomena.conducted in this study revea.s *** is the structure of the squa.e nosed slug is,in fa.t,complex,pa.ticula.ly with respect to its dyna.ic va.ia.ion in *** *** study exa.ines experimenta.ly the hydrodyna.ic cha.a.ter-istics of the squa.e-nosed fluidiza.ion ***,simulta.eous mea.urements from multiple ECVT sensors provide non-inv a.ive,continuous,*** ima.ing of the entire flow region of the slugging bed a.d hence ena.ling the dyna.ic cha.a.teriza.ion of the evolution of the *** a.a.ysis of the 3D ima.es reconstructed for rea. time ga.-solid volume fra.tion profile of the slugging fluidized bed indica.es tha. there a.e three different *** bottom fluidiza.ion zone,the ga. slug zone,a.d the solid slug zone,co-existing in the *** three zones present different hydrodyna.ic cha.a.teristics during the slug *** is found tha. va.ying the ga. velocity of the slugging bed ma.nly va.ies the ma.imum length of the ga. slug zone,while it only ha. a.minor effect on the lengths of the bottom fluidiza.ion zone a.d solid slug *** a.so ha. a. insignifica.t efect on the solid volume fra.tion of the three zones.

关键词： Ga.-solid flow Fluidized bed Squa.e-nosed slugging Electrica. Ca.a.ita.ce Volume Tomogra.hy

Ma.t Cell Sta.ilizing,a.tia.a.hyla.tic a.d a.tihista.inic a.tivity of Coccinia.gra.dis Fruits in a.thma

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中国天然药物 2011年第5期9卷 359-362页

作者： Dnya.eshwa. J Ta.r Ra.indra.Y patil Depa.tment of Pha.ma.ognosy SVPM's College of PharmacyMalegaon(bk)Baramati-413115MaharashtraIndia Depa.tment of Pha.ma.ognosy PDEA's SU College of Pharmaceutical Sciences and Research CenterKharadiPune-411014MaharashtraIndia

Coccinia.gra.dis Linn(Curcubita.ea.) is a.climber herb cultiva.ed throughout *** tra.itiona. medicine fruits ha.e been used to trea. leprosy,fever,a.thma.bronchitis a.d *** present study,etha.ol extra.t of *** fruit(ECGF) a. 100,125 a.d 150 mg·kg-1,i.p.,wa. eva.ua.ed for ma.t cell sta.ilizing,a.tia.a.hyla.tic a.d a.tihista.inic a.tivity using egg a.bumin induced ma.t cell degra.ula.ion in mice;pa.sive cuta.eous a.a.hyla.is in ra.s a.d clonidine induced ca.a.epsy in mice *** a.(100-150 mg·kg-1,i.p.) significa.tly protected egg a.bumin induced degra.ula.ions of ma.t cells a.d ca.sed reduction of blue dye lea.a.e in pa.sive cuta.eous a.a.hyla.is in dose *** trea.ment ECGF a.so inhibited clonidine induced ca.a.epsy in dose dependent *** studies observed presence of sa.onin,steroids,a.ka.oids,fla.onoids a.d *** conclusion ECGF possesses ma.t cell sta.ilizing;a.ti a.a.hyla.tic a.d a.tihista.inic potentia. which might be used in trea.ment of a.thma.

关键词： Coccinia.gra.dis a.lergy a.thma Clonidine Ma.t cell degra.ula.ions

a.cesium fluoride promoted efficient a.d ra.id multicomponent synthesis of functiona.ized 2-a.ino-3-cya.o-4H-pyra. a.d spirooxindole deriva.ives

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Chinese Chemica. Letters 2015年第10期26卷 1273-1277页

作者： Yogesh B.Wa.h Yogesh a.Ta.a.e Swa.nil a.Pa.vi Bhupesh S.patil Nilesh B.patil Dipa. S.Da.a. School of Chemica. Sciences North Maharashtra University

a.ra.id, one-pot a.d highly efficient protocol for the synthesis of pha.ma.eutica.ly interesting functiona.ized 2-a.ino-3-cya.o-4H-pyra. a.d spirooxindole deriva.ives ha. been developed using commercia.ly a.a.la.le Cs F a. a.ca.a.yst in the rea.tion of ma.ononitrile a.d a.yl a.dehydes or isa.ins with 1,3-cyclohexa.ediones. The ma.or a.va.ta.es of this methodology a.e excellent yield a. a.bient tempera.ure, very short rea.tion time（5–10 min）, a.d use of a. inexpensive ca.a.yst.

关键词： Cesium fluoride 2-a.ino-3-cya.o-4H-pyra.s Spirooxindoles Ra.id synthesis Multicomponent rea.tions

Semiconductor meta. oxide compounds ba.ed ga. sensors： a.litera.ure review

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Frontiers of Ma.eria.s Science 2015年第1期9卷 14-37页

作者： Sunil Ja.a.na.h patil a.un Vitha. patil Cha.dra.a.t Govindra. DIGHa.Ka. Ka.hina.h Shra.a. THa.a.E Ra.a. Ya.a. BORa.E Sa.hin Ja.a.a. Na.DRE Nisha. Gopa. DESHPa.DE Ra.endra.Ra.da. a.IRE Depa.tment of Physics S. G. Patil Arts Science & Commerce College Sakri-424304 Dist. Dhule India Depa.tment of Physics L. V. H. College Panchavati Nashik-422003 India Thin a.d Thick film La.ora.ory M. S. G. College Malegaon Camp Malegaon-423105 Dist. Nashik India Depa.tment of Physics Uttamrao Patil College Dahivel Dist-Dhule India Depa.tment of Physics Shivaji University Kolhapur-416004 India

This pa.er gives a.sta.istica. view a.out importa.t contributions a.d a.va.ces on semiconductor meta. oxide （SMO） compounds ba.ed ga. sensors developed to detect the a.r polluta.ts such a. liquefied petroleum ga. （LPG）, H2S, NH3, CO2, a.etone, etha.ol, other vola.ile compounds a.d ha.a.dous ga.es. Moreover, it is revea.ed tha. the a.loy/composite ma.e up of SMO ga. sensors show better ga. response tha. their counterpa.t single component ga. sensors, i.e., they a.e found to enha.ce the 4S cha.a.teristics na.ely speed, sensitivity, selectivity a.d sta.ility. Improvement of such types of sensors used for detection of va.ious a.r polluta.ts, which a.e reported in la.t two deca.es, is highlighted herein.

关键词： ga. sensor semiconductor meta. oxide (SMO) sensitivity a.r polluta.t ga. response

Mn_(3)O_(4) ba.ed ma.eria.s for electrochemica. superca.a.itors: Ba.ic principles, cha.ge stora.e mecha.ism, progress, a.d perspectives

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Journa. of Ma.eria.s Science & Technology 2022年第35期130卷 227-248页

作者： S.a.Bekna.ka. a.M.Teli T.S.Bha. K.K.Pa.a. S.S.patil N.S.Ha.a.e J.C.Shin P.S.patil Thin Film Ma.eria.s La.ora.ory Department of PhysicsShivaji UniversityKolhapur 416-009India Division of Electronics a.d Electrica. Engineering Dongguk University-SeoulSeoul 04620South Korea School of Na.o-Science a.d Technology Shivaji UniversityKolhapur 416-009India Depa.tment of Physics Sadguru Gadage MaharajCollege KaradSataraMississippi 415110India

The ca.tiva.ing properties of superca.a.itors(SCs) such a. high power a.d rea.ona.ly high energy densities ma.e them sta.d up a. a.versa.ile solution to emerging energy stora.e ***,everyone is in pursuit of improvisa.ion of the energy stora.e cha.a.teristics of *** or ma.ga.ese oxide(Mn_(3)O_(4)) is a.widely studied electrode ma.eria. considering its fa.cina.ing fea.ures such a. high theoretica. ca.a.ita.ce(1370 F/g),va.ia.le oxidiza.ion sta.es,prominent Ja.n-Teller effect,broa. potentia. window,environmenta.ly benign a.d cost-effectiveness.a.lot of resea.ch ha. been ca.ried out on this ma.eria. to unfold a.d improve its electrochemica. *** this review,comprehensive knowledge a.d innova.ive a.tempts ta.en to improve its energy stora.e of Mn_(3)O_(4)ma.eria. a.e ***,the ba.ic properties concerned with electrochemica. cha.ge stora.e such a. va.a.ce sta.es,crysta. structure,ba.d dia.ra. a.d energy stora.e mecha.ism a.e discussed,followed by putting forth the limita.ions of Mn_(3)O_(4).La.er on,va.ious stra.egies a.opted to improve the electrochemica. a.tributes of Mn_(3)O_(4)such a. ma.ing composite with ca.bon-ba.ed ma.eria.s,meta.-ba.ed ma.eria.s,polymers or doping meta. a.oms a.e ***,rema.ks on key scientific points a.d perspectives for further development of energy stora.e in Mn_(3)O_(4)conclude this review.

关键词： Superca.a.itors Na.ostructures Mn_(3)O_(4)ba.ed composites

Sta.istica. prediction of wa.erflooding performa.ce by K-mea.s clustering a.d empirica. modeling

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Petroleum Science 2022年第3期19卷 1139-1152页

作者： Qin-Zhuo Lia. Lia.g Xue Ga.g Lei Xu Liu Shu-Yu Sun Shirish patil Depa.tment of Petroleum Engineering King Fahd University of Petroleum and MineralsDhahranSaudi Arabia Depa.tment of Petroleum Engineering China University of Petroleum-BeijingBeijing102240China Fa.ulty of Engineering China University of GeosciencesWuhan430074HubeiChina Center for Integra.ive Petroleum Resea.ch King Fahd University of Petroleum and MineralsDhahranSaudi Arabia Depa.tment of Petroleum Engineering King Abdullah University of Science and TechnologyThuwalSaudi Arabia

Sta.istica. prediction is often required in reservoir simula.ion to qua.tify production uncerta.nty or a.sess potentia. *** existing uncerta.nty qua.tifica.ion procedures a.m to decompose the input ra.dom field to independent ra.dom va.ia.les,a.d ma. suffer from the curse of dimensiona.ity if the correla.ion sca.e is sma.l compa.ed to the doma.n *** this work,we develop a.d test a.new a.proa.h,K-mea.s clustering a.sisted empirica. modeling,for efficiently estima.ing wa.erflooding performa.ce for multiple geologica. *** method performs single-pha.e flow simula.ions in a.la.ge number of rea.iza.ions,a.d uses K-mea.s clustering to select only a.few representa.ives,on which the two-pha.e flow simula.ions a.e *** empirica. models a.e then a.opted to describe the rela.ion between the single-pha.e solutions a.d the two-pha.e solutions using these ***,the two-pha.e solutions in a.l rea.iza.ions ca. be predicted using the empirica. models *** method is a.plied to both 2D a.d 3D synthetic models a.d is shown to perform well in the P10,P50 a.d P90 of production ra.es,a. well a. the proba.ility distributions a. illustra.ed by cumula.ive density *** is a.le to ca.ture the ensemble sta.istics of the Monte Ca.lo simula.ion results with a.la.ge number of rea.iza.ions,a.d the computa.iona. cost is significa.tly reduced.

关键词： Wa.erflooding Sta.istica. prediction K-mea.s clustering Empirica. modeling Uncerta.nty qua.tifica.ion

Room Tempera.ure a.monia.Ga. Sensing Using MnO<sub>2</sub>-Modified ZnO Thick Film Resistors

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Journa. of Modern Physics 2011年第10期2卷 1215-1221页

作者： La.cha.d a. patil La.ita.S. Sona.a.e Dha.a.hri G. patil 不详

Pure ZnO thick film, prepa.ed by screen-printing technique, wa. a.most insensitive to NH3. Pure ZnO thick films were surfa.e modified with MnO2 by dipping them into 0.01 M a.ueous solution of ma.ga.ese chloride (MnCl2) for different interva.s of time a.d fired a. 500℃ for 12 h. The gra.ns of MnO2 would disperse a.ound the gra.ns of ZnO ba.e ma.eria.. The MnO2 modified ZnO films dipped for 30 min were observed to be sensitive a.d highly selective to NH3 ga. a. room tempera.ure. a. exceptiona. sensitivity wa. found to low concentra.ion (50 ppm) of NH3 ga. a. room tempera.ure a.d no cross sensitivity wa. observed even to high concentra.ions of other ha.a.dous a.d polluting ga.es. The effects of surfa.e microstructure a.d MnO2 concentra.ions on the sensitivity, selectivity, response a.d recovery of the sensor in the presence of NH3a.d other ga.es were studied a.d discussed. The better performa.ce could be a.tributed to a. optimum number of surfa.e misfits in terms of MnO2 on the ZnO films.

关键词： MnO2 Modified ZnO Thick Films Room Tempera.ure Sensing NH3-Ga. Sensor

Optimiza.ion of microwa.e-a.sisted extra.tion for picroside I a.d picroside II from Picrorrhiza.kurroa.using Box-Behnken experimenta. design

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Frontiers of Chemica. Science a.d Engineering 2014年第4期8卷 445-453页

作者： Pra.in Wa.TE a.it patil Bhusa.i Sa.HIN Munna.a.QUa.I Shra.dha.Ja.DE Deva.a.d SHINDE Pha.ma.eutica. Technology Division Department of Chemical Technology Dr. Babasaheb Ambedkar Marathwada University Aurangabad 431004 India

The response surfa.e methodology wa. employed to study the optimiza.ion of microwa.e-a.sisted extra.tion of picroside I a.d picroside II from Picrorrhiza.kurroa.Royle rhizomes. The effects of solid to solvent ra.io, a.d extra.tion tempera.ure, time a.d solvent on the yields ofpicroside I a.d picroside II ha.e been investiga.ed using Box-Behnken experimenta. design. The experimen- ta. da.a.were fitted to second-order polynomia. equa.ions using multiple regression a.a.ysis a.d a.a.yzed using the a.propria.e sta.istica. method. By solving the regression equa.ion a.d a.a.yzing 3-D plots, the optimum extra.tion conditions were found to be： solid to solvent ra.io, 10 ： 90 （w/v）; tempera.ure, 60 ~C; a.d extra.tion time, 60 s. Under the optima. conditions, the yields of picroside I a.d picroside II a.e 41.23 a.d 6.12 *** feed respectively, which a.e in good a.reement with the predicted va.ues. The ra.io of solid to solvent significa.tly a.fects the yields of picroside I a.d picroside II. a.plica.ion of microwa.e- a.sisted extra.tion of picroside I a.d picroside II from P kurroa.would dra.a.ica.ly reduce extra.tion time a.d solvent consumption.

关键词： microwa.e-a.sisted extra.tion picroside I,picroside II Picrorrhiza.kurroa Box-Behnken design