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Oligomeric and fibrillar species of β-amyloid(Aβ42) both impair mitochondrial function in P301L tau transgenic mice

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世界最新医学信息文摘 2016年第4期 8-8页

作者： Anne Eckert susanne Hauptmann Isabel scherping Jessica Meinhardt Virginie Rhein stefan Drse Ulrich Brandt Marcus Fndrich Walter E.Müller Jiirgen Gtz

We recently provided evidence for a mitochondrial dysfunction in P301L tau transgenic mice,a strain modeling the tau pathology of Alzheimer's disease(AD)and frontotemporal dementia(FTD).In addition to tau aggregates,the AD brain is further characterized by Aβpeptide-containing *** we addressed the role of Aβ,this indicated a synergistic action of tau and Aβpathology on the *** the present study,we compared the toxicity of different Aβ42 conformations in light of recent studies suggesting that oligomeric rather than fibrillar Aβmight be the actual toxic ***,both oligomeric and fibrillar,but not disaggregated(mainly monomeric)Aβ42 caused a decreased mitochondrial membrane potential in cortical brain cells obtained from FTD P301L tau transgenic *** was not observed with cerebellar preparations indicating selective vulnerability of cortical ***,we found reductions in state 3 respiration,the respiratory control ratio,and uncoupled respiration when incubating P301L tau mitochondria either with oligomeric or fibrillar preparations of Aβ***,we found that aging specifically increased the sensitivity of mitochondria to oligomeric Aβ42 damage indicating that oligomeric and fibrillar Aβ42 are both toxic,but exert different degrees of toxicity.

关键词： Alzheimer’s disease Amyloid aggregates Amyloid β-peptide Amyloid toxicity Fibrils Frontotemporal dementia Globulomer Mitochondria Oligomer Protein aggregation Respiration Tau Transgenic mice

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纺织助剂中的甲醛测定

国际纺织导报 2016年第10期44卷 56-57页

作者： M.Geubtner G.Lang J.P.Moldenhauer s.schneider-Müller H.Wünsche R.Zyschka 李梦雅(译) 程心怡(译) 罗艳(校) TEGEWA协会整理工作组德国不详

基于更为严厉的甲醛重新分类的背景,TEGEWA协会整理工作组已开发出一种可确定纺织助剂中游离甲醛含量的新方法。目前此法鉴于其统一的程序,可使因不同的内部测试方法而得出不同观点的测试成为过去。

关键词：纺织助剂甲醛测定

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Oligomeric and fibrillar species of β-amyloid(A β 42) both impair mitochondrial function in P301L tau transgenic mice

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世界最新医学信息文摘 2015年第99期 1-1页

作者： Anne Eckert susanne Hauptmann Isabel scherping Jessica Meinhardt Virginie Rhein stefan Dr?se Ulrich Brandt Marcus F?ndrich Walter E.Müller Jürgen G?tz

We recently provided evidence for a mitochondrial dysfunction in P301L tau transgenic mice, a strain modeling the tau pathology of alzheimer's disease(ad) and frontotemporal dementia(ftd). in addition to tau aggregates, the ad brain is further characterized by Aβ peptide-containing plaques. When we addressed the role of Aβ, this indicated a synergistic action of tau and Aβ pathology on the mitochondria. In the present study, we compared the toxicity of different Aβ42 conformations in light of recent studies suggesting that oligomeric rather than fibrillar Aβ might be the actual toxic species. Interestingly, both oligomeric and fibrillar, but not disaggregated(mainly monomeric) Aβ42 caused a decreased mitochondrial membrane potential in cortical brain cells obtained from FTD P301L tau transgenic mice. This was not observed with cerebellar preparations indicating selective vulnerability of cortical neurons. Furthermore, we found reductions in state 3 respiration, the respiratory control ratio, and uncoupled respiration when incubating P301L tau mitochondria either with oligomeric or fibrillar preparations of Aβ42. Finally, we found that aging specifically increased the sensitivity of mitochondria to oligomeric Aβ42 damage indicating that oligomeric and fibrillar Aβ42 are both toxic, but exert different degrees of toxicity.

关键词： Alzheimer’s disease Amyloid aggregates Amyloid β-peptide Amyloid toxicity Fibrils Frontotemporal dementia Globulomer Mitochondria oligomer Protein aggregation respiration tau transgenic mice

Oligomeric and fibrillar species of β-amyloid(Aβ42) both impair mitochondrial function in P301L tau transgenic mice

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世界最新医学信息文摘 2015年第A期 8-8页

作者： Anne Eckert susanne Hauptmann Isabel scherping Jessica Meinhardt Virginie Rhein stefan Dr?se Ulrich Brandt Marcus F?ndrich Walter E.Müller Jürgen G?tz

We recently provided evidence for a mitochondrial dysfunction in P301 l tau transgenic mice, a strain modeling the tau pathology of alzheimer's disease(ad) and frontotemporal dementia(ftd). in addition to tau aggregates, the ad brain is further characterized by Aβ peptide-containing plaques. When we addressed the role of Aβ, this indicated a synergistic action of tau and Aβ pathology on the mitochondria. In the present study, we compared the toxicity of different Aβ42 conformations in light of recent studies suggesting that oligomeric rather than fibrillar Aβ might be the actual toxic species. Interestingly, both oligomeric and fibrillar, but not disaggregated(mainly monomeric) Aβ42 caused a decreased mitochondrial membrane potential in cortical brain cells obtained from FTD P301 L tau transgenic mice. This was not observed with cerebellar preparations indicating selective vulnerability of cortical neurons. Furthermore, we found reductions in state 3 respiration, the respiratory control ratio, and uncoupled respiration when incubating P301 L tau mitochondria either with oligomeric or fibrillar preparations of Aβ42. Finally, we found that aging specifically increased the sensitivity of mitochondria to oligomeric Aβ42 damage indicating that oligomeric and fibrillar Aβ42 are both toxic, but exert different degrees of toxicity.

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染浴中的抗还原剂

国际纺织导报 2019年第4期47卷 26-28页

作者： D. H?nzi s. Ehret M. J?llenbeck M. Dohmen E. Ham R. Hager R. P?hlig H. Grünewald A. sch?nfeld 范春迎 Archroma Management公司 CHT 德国公司 Clariant公司 M. Dohmen公司 Huntsman公司 Rudolf公司 Pulcra化学品公司 Tanatex化学品公司 Zschimmer & schwarz公司

关于还原敏感染料的问题已有相关报道,例如对PET、PET/CEL,尤其是PET/CV染色的文章。为研制一种可显示染浴中的抗还原剂作用机理的可靠测试方法,TEGEWA染色助剂工作组做了全面的实验室间的测试,该方法适用于聚酯纤维及其与棉或黏胶的混... 详细信息

关于还原敏感染料的问题已有相关报道,例如对PET、PET/CEL,尤其是PET/CV染色的文章。为研制一种可显示染浴中的抗还原剂作用机理的可靠测试方法,TEGEWA染色助剂工作组做了全面的实验室间的测试,该方法适用于聚酯纤维及其与棉或黏胶的混纺织物染色。

关键词：染料抗还原剂聚酯测试

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母亲和父亲患精神疾病与儿童和青少年受伤风险之间的关系:基于瑞典全国登记的队列研究

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英国医学杂志中文版 2022年第7期25卷 377-377页

作者： Alicia Nevriana Matthias Pierce Christina Dalman susanne Wicks Marie Hasselberg Holly Hope Kathryn M Abel Kyriaki Kosidou 彭靖(译) 戴继灿(校) Department of Global Public Health Karolinska Institutet17177 StockholmSweden Centre for Women's Mental Health Division of Psychology and Mental HealthFaculty of BiologyMedicine and Health SciencesUniversity of ManchesterManchesterUK Center for Epidemiology and Community Medicine Stockholm RegionStockholmSweden Greater Manchester Mental Health NHs Foundation Trust ManchesterUK 北京大学第一医院男科中心上海交通大学医学院附属仁济医院

目的确定父母精神疾病与子女受伤风险之间的关系。设计回顾性队列研究。研究地点基于瑞典登记在册的人口。参与者1996-2011年出生的1542000名儿童和与之关联的89334名母亲和873935名父亲。暴露母亲或父亲的精神疾病(非情感性精神疾病、... 详细信息

目的确定父母精神疾病与子女受伤风险之间的关系。设计回顾性队列研究。研究地点基于瑞典登记在册的人口。参与者1996-2011年出生的1542000名儿童和与之关联的89334名母亲和873935名父亲。暴露母亲或父亲的精神疾病(非情感性精神疾病、情感性精神疾病、酒精或药物滥用、情绪障碍、焦虑和压力相关障碍、饮食障碍、人格障碍)通过住院或门诊医疗保健记录确认。

关键词：精神疾病饮食障碍药物滥用回顾性队列研究情绪障碍医疗保健儿童和青少年之间的关系

CODE-EHR:临床研究中运用结构化电子医疗记录的最佳实践框架

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英国医学杂志中文版 2022年第12期25卷 721-729页

作者： Dipak Kotecha Folkert W Asselbergs stephan Achenbach stefan DAnker Dan Atars Colin Baigent Amitava Banerjee Birgit Beger Cunnar Brobert Barbara Casadei Cinzia Ceccarelli Martin R Cowie Filippo Crea Maureen Cronin spiros Denaxas Andrea Derix Donna Fitzsimons Martin Fredriksson Chris PGale Georgios V Ckoutos Wim Goettsch Harry Hemingway Martin Ingvaris Adrian Jonas's Robert Kazmierski susanne Logstrup R Thomas Lumbers Thomas F Lischer Paul McGreavy leana L Pina Lothar Roesiga Carl steinbeisser Mats sundgren Benoit Tyl Chislaine van Thiel Kees van Bochove Panos EVardas Tiago Villanueva Marilena Vrana Wim Weber Franz Weidinger stephan Windecker Angela Wood Diederick E Grobbee 创新药物计划BigData@Heart联盟欧洲心脏病协会 CODE-EHR国际共识小组宋奇繁(译) 汪奕名(译) 不详重庆医药高等专科学校

改善患者生存质量是全球临床医学的发展目标,大数据是实现其发展的关键所在。技术进步使结构化电子医疗记录得以常规化,也可能会改善缺失重要临床证据的问题。虽然大数据及其相关分析在新冠大流行期间发挥了重要作用,但也存在严重的缺... 详细信息

改善患者生存质量是全球临床医学的发展目标,大数据是实现其发展的关键所在。技术进步使结构化电子医疗记录得以常规化,也可能会改善缺失重要临床证据的问题。虽然大数据及其相关分析在新冠大流行期间发挥了重要作用,但也存在严重的缺陷。证实、核验、数据隐私以及对科学研究社会责任的践行是一项重要挑战。欧洲心脏病协会和BigData@Heart联盟已经收集了包括患者代表、临床医生、科研人员、监管机构、期刊编辑和企业代表在内的多元化国际参与者,提出了CODE-EHR的最低标准框架。为改进研究设计、提高信息透明度提供方法手段,同时为实现医疗保健数据的稳健并能够有效运用制定了技术路线图。

关键词：大数据数据隐私 CODE 技术路线图科研人员信息透明度医疗保健最低标准