检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

城市之心，法国巴黎郊区梅伦塞纳特

城市环境设计 2020年第4期126卷 62-63页

作者： Mathis Barz Burkhard Entrup Manfred Hieber stefan Krüger susanne Rath Franz sam Gerald Zugmann COOP HIMMELBLAU

梅伦塞纳特国际城镇规划大赛一等奖规划区域位于巴黎南部边缘地区,时刻面临着来自周边三个小镇肆意扩张的吞并威胁。规划的任务是要合理组织城市发展,从而在这三个小镇间形成一个配备了所有必要基础设施的独特城镇。为此,我们设计了一...

梅伦塞纳特国际城镇规划大赛一等奖规划区域位于巴黎南部边缘地区,时刻面临着来自周边三个小镇肆意扩张的吞并威胁。规划的任务是要合理组织城市发展,从而在这三个小镇间形成一个配备了所有必要基础设施的独特城镇。为此,我们设计了一个分为三阶段的总体战略,主要包括六个策略性步骤。对我们来说,只有当多样性和差异性的感受在可能的建筑构造中具象化地呈现出来的时候,城市才能被称为一座真正的城市,它应当同时具备高与低、密集与空旷、喧闹与安静、热与冷、柔和与坚硬、混乱与清晰等差异。

关键词：

写于赫伯特·W·弗兰克90岁生日之际：即便是一位未来学家也乐于回望

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

装饰 2017年第5期 45-53页

作者：海克·菲勒[德] 苏珊娜·佩希[德](译) 汪芸(译) 不详科技电视台(www.hyperraum.tv) 中国美术学院

酷，维也纳式的魅力，以及惊人的活跃的思维都是赫伯特·W·弗兰克这位奥地利人的显著特点。现在，他与妻子生活在慕尼黑南部乡村田园诗一般的农庄里。他是一位经常去海外旅行的作家，也是一位艺术家和科学家，一直保持着自己的能量与... 详细信息

酷，维也纳式的魅力，以及惊人的活跃的思维都是赫伯特·W·弗兰克这位奥地利人的显著特点。现在，他与妻子生活在慕尼黑南部乡村田园诗一般的农庄里。他是一位经常去海外旅行的作家，也是一位艺术家和科学家，一直保持着自己的能量与好奇心，直至今天。2017年的5月，他将庆祝90岁生日，回顾非常丰富多彩的人生。

关键词：弗兰克生日未来学维也纳奥地利慕尼黑科学家艺术家

大蒜平凡鳞茎中的魔力 the great garlic book

在线全文

学校读者我要写书评

暂无评论

Cryo-EM structure of the plant 26s proteasome

丛书名：食物公社丛书

2006年

作者：（美）切斯特·阿伦（Chester Aaron）苏珊娜·卡斯帕（susanne Kaspar）摄影周金坤译

本书介绍了大蒜的历史与传说，大蒜的健康价值，大蒜的商业价值以及以大蒜为原料所做的食谱。

ISBN: (纸本)7505720317

本书介绍了大蒜的历史与传说，大蒜的健康价值，大蒜的商业价值以及以大蒜为原料所做的食谱。

关键词：大蒜普及读物

来源：汇雅图书（南通市图书馆... 评论

在线全文

汇雅图书（南通市图书馆）

学校读者我要写书评

暂无评论

Plant Communications 2022年第3期3卷 116-126页

作者： susanne Kandolf Irina Grishkovskaya Katarina Belacic Derek L.Bolhuis sascha Amann Brent Foster Richard Imre Karl Mechtler Alexander schleiffer Hemant D.Tagare Ellen D.Zhong Anton Meinhart Nicholas G.Brown David Haselbach Research Institute of Molecular Pathology(IMP) Vienna BioCenter(VBC)Campus-Vienna-BioCenter 11030 ViennaAustria Department of Radiology and Biomedical Imaging Yale UniversityNew HavenCT 06510USA Department of Pharmacology and Lineberger Comprehensive Cancer Center University of North Carolina School of MedicineChapel HillNC 27599USA Computer science and Artificial Intelligence Laboratory Massachusetts Institute of TechnologyCambridgeMA 02139USA Vienna BioCenter PhD Program Doctoral School of the University at Vienna and Medical University of ViennaVienna BioCenter(VBC)ViennaAustria Institute of Physical Chemistry University of FreiburgAlbertstraße 21Freiburg 79104Germany CIBss Centre for Integrative Biological signalling studies University of FreiburgFreiburgGermany

Targeted proteolysis is a hallmark of *** is especially important in long-lived cells that can be found in higher eukaryotes,like *** task is mainly fulfilled by the ubiquitin–proteasome ***,proteolysis by the 26s proteasome is vital to development,immunity,and cell *** the yeast and animal proteasomes are well characterized,there is only limited information on the plant *** determined the first plant 26s proteasome structure from spinacia oleracea by single-particle electron cryogenic microscopy at an overall resolution of 3.3 A°.We found an almost identical overall architecture of the spinach proteasome compared with the known structures from mammals and ***,we noticed a structural difference in the proteolytic active b1 ***,we uncovered an unseen compression state by characterizing the proteasome’s conformational *** suspect that this new conformation of the 20s core protease,in correlation with a partial opening of the unoccupied gate,may contribute to peptide release after *** data provide a structural basis for the plant proteasome,which is crucial for further studies.

关键词： 26s proteasome spinach UPs cryo-EM conformational landscape

Oral but not written test anxiety is related to social anxiety

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Psychiatry 2016年第3期6卷 351-357页

作者： Lisa Laurin-Barantke Jürgen Hoyer Lydia Fehm susanne Knappe Institute of Clinical Psychology and Psychotherapy Technische Universitat Dresden Center for Psychotherapy (ZPHU) Humboldt-Universitat zu Berlin Institute of Clinical Psychology and Psychotherapy Center for Preventive Intervention StudiesTechnische Universitat Dresden

AIM To examine the associations of test anxiety(TA) in written vs oral exam situations with social anxiety(sA).METHODs A convenience sample of 204 students was recruited at the Technische Universit?t Dresden(TU Dresden,Germany) and contacted via e-mail asking to complete a cross-sectional online survey based on established *** study protocol was approved by the ethics committee of the TU *** data of n = 96 students were available for dependent t-tests and correlation analyses on the associations of sA and TA respectively with trigger events,cognitions,safety behaviors,physical symptoms and *** were run using *** Levels of TA were higher for fear in oral exams than for fear in written exams(M = 48.1,sD = 11.5 vs M = 43.7,sD = 10.1 P sA were positively correlated(spearman's r = 0.343,P son's r = 0.38,P sting written TA and sA(spearman's r = 0.17,P > 0.05;Pearson's r = 0.223,P > 0.05).Compared to written TA,triggerevents were more often reported for oral TA(18.2% vs 30.3%,P = 0.007);which was also accompanied more often by test-anxious cognitions(7.9% vs 8.5%,P = 0.001),safety behavior(8.9% vs 10.3%,P sical symptoms(for all,P sION Written,but not oral TA emerged being unrelated to sA and may rather not be considered as a typical facet of sA disorder.

关键词： social anxiety Derealization Test anxiety Depersonalization safety behavior

Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Medicine 2021年第2期15卷 275-291页

作者： Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes stephen Lam Adonina Tardon Chu Chen Gary Goodman stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi rennert susanne Arnold Paul Brennan John KField sanjay shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew Bschabath Melinda CAldrich Victoria Lstevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing shen Department of Epidemiology Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing 211166China state Key Laboratory of Reproductive Medicine Center for Global HealthNanjing Medical UniversityNanjing 211166China Department of Bioinformatics School of Biomedical Engineering and InformaticsNanjing Medical UniversityNanjing 211166China Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer MedicineNanjing Medical UniversityNanjing 211166China China International Cooperation Center for Environment and Human Health School of Public HealthNanjing Medical UniversityNanjing 211166China Division of Cancer Epidemiology and Genetics National Cancer InstituteBethesdaMD 20892-9304USA Department of Integrative Oncology British Columbia Cancer AgencyVancouverBC V5Z 1L3Canada Faculty of Medicine University of Oviedo and CIBERESPOviedo 33006Spain Program in Epidemiology Public Health Sciences DivisionFred Hutchinson Cancer Research CenterSeattleWA 98109-1024USA Public Health sciences Division Swedish Cancer InstituteSeattleWA 98026USA Department of Clinical Biochemistry Copenhagen University HospitalCopenhagen DK-1017Denmark National Cancer Institute BethesdaMD 20892-9304USA Genetic Epidemiology Group International Agency for Research on CancerLyon 69372France Cancer Center Cluster salzburg at PLUs Department of Molecular BiologyUniversity of SalzburgHeidelberg 5020Austria Institute of Medical Informatics Biometry and EpidemiologyChair of EpidemiologyLudwig Maximilians UniversityMunichBavaria 80539Germany Department of Genetic Epidemiology University Medical Center GoettingenGoettingen 37075Germany Technion Faculty of Medicine Carmel Medical CenterHaifa 3448516Israel Markey Cancer Center University of KentuckyLexingtonKY 40506-0054USA Department of Molecular and Clinical Cancer Medicine Roy Castle Lung Cancer Research ProgrammeThe University of Liverpool Institute of Translational MedicineLiverpool L697Z

Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NsCLC)risk,biological mechanisms of these variants remain largely *** integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(sqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility *** identified 3064 credible risk variants for NsCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive *** factor enrichment analysis revealed that UsF1 was AD-specific while CREB1 was *** annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for sqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while sqCC genes were homologous recombination deficiency *** results illustrate the molecular basis of both wellstudied and new susceptibility loci of NsCLC,providing not only novel insights into the genetic heterogeneity between AD and sqCC but also a set of plausible gene targets for post-GWAs functional experiments.

关键词： lung cancer genome-wide association study function annotation immune homologous recombination repair deficiency genetic heterogeneity

在线全文

学校读者我要写书评

暂无评论

商业化织物用黏合剂的检测

国际纺织导报 2017年第5期45卷 51-52页

作者： M.Klcker M.Ellouz A.Ehrmann s.Aumann A.schwarz-Pfeiffer 杨德明 Bielefeld应用科技大学(德国) Niederrhein应用科技大学(德国)

织物用黏合剂常用于小的修补或将2种纺织材料连接在一起。在智能纺织品领域,织物用黏合剂可保护小型电子装置使其免受因临界机械载荷或水洗引起的与织物基材的分离。着眼于黏合剂应用于表面贴装器件(sMD)接点处的应力释放,采用分离测试... 详细信息

织物用黏合剂常用于小的修补或将2种纺织材料连接在一起。在智能纺织品领域,织物用黏合剂可保护小型电子装置使其免受因临界机械载荷或水洗引起的与织物基材的分离。着眼于黏合剂应用于表面贴装器件(sMD)接点处的应力释放,采用分离测试和Martindale耐磨测试对不同的胶接点进行了研究。

关键词：织物用黏合剂纺织材料分离测试 Martindale测试

亲血栓基因多态性在视网膜分支静脉阻塞中的作用

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘(眼科学分册) 2006年第3期 55-55页

作者： Weger M renner W steinbrugger I. 安胜 Department of Ophthalmology Auenbruggerplatz 4 8036 Graz AustriaDr.

Objective: Branch retinal vein occlusion (BRVO) is a common cause of severe visual loss. Numerous risk factors, including arterial hypertension, diabetes mellitus, and arteriosclerosis, have been identified. Gene polymorphisms affecting hemostasismay also play a role in the pathogenesis of BRVO. The present study was therefore done to determine the prevalence of genetic polymorphisms in factors implicated in hypercoagulability among patients with BRVO. Design: Retrospective case-control study. The study cohort consisted of 294 patients with BRVO and 294 control subjects, matched for age and gender. Methods: Determination of genotypes was done by allele-specific digestion of polymerase chain reaction product s, or by 5 exonuclease assay (TaqMan). Main Outcome Parameters: Genotypes of factor V R506Q (factor V Leiden), prothrombin 20210G>A, fibrinogen β-455G> A, factor XII (FXII) 46C>T, and ITGA2 807C>T (platelet glycoprotein Ia GPa 807C > T) and ITGB3 L59P (platelet GPIIIa PlA1/PlA2) polymorphisms. Results: Genotype distributions of the investigated gene polymorphisms did not differ significantly between patients and control subjects. In contrast, significantly increased prevalences of arterial hyper-tension and hypercholesterolemia were found among patients with BRVO. In a logistic regression analysis, the presence of arterial hypertension was associated with an odds ratio (OR) of 2.32 (95%confidence interval CI, 1.62-3.32),whereas hypercholesterolemia yielded an OR of 2.54 (95%CI, 1.74-3.70) for BRVO. Conclusion: Our data indicate that the prevalences of the investigated gene polymorphisms do not differ significantly in patients with BRVO and control subjects. This suggests that these polymorphisms are not major risk factors for BRVO.

关键词：视网膜分支静脉阻塞基因多态性遗传多态性 BRV

基于胶质瘤异种移植模型联合应用DCE-MRI及3D-超高倍显微镜定量研究抗血管生成治疗对组织结构异质性的影响

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

国际医学放射学杂志 2017年第5期 607-607页

作者： M.Dominietto M.Dobosz s.Bürgi A.renner G.Zahlmann W.scheuer 郑永利 Institute for Biomedical Engineering University and ETH Zurich

摘要目的本研究旨在评估抗血管生成治疗,即中和血管内皮生长因子(VEGF)对肿瘤异质性的影响。材料与方法分别于16只小鼠右侧额叶接种小鼠胶质瘤细胞,第1组接

关键词：超高倍显微镜异质性抗血管生成 DCE-MRI